MX2010010127A - 1,2,4-triazoles trisustituidos como moduladores de receptores de acetilcolina nicotinicos. - Google Patents

1,2,4-triazoles trisustituidos como moduladores de receptores de acetilcolina nicotinicos.

Info

Publication number
MX2010010127A
MX2010010127A MX2010010127A MX2010010127A MX2010010127A MX 2010010127 A MX2010010127 A MX 2010010127A MX 2010010127 A MX2010010127 A MX 2010010127A MX 2010010127 A MX2010010127 A MX 2010010127A MX 2010010127 A MX2010010127 A MX 2010010127A
Authority
MX
Mexico
Prior art keywords
nicotinic acetylcholine
trisubstituted
triazoles
receptor modulators
acetylcholine receptor
Prior art date
Application number
MX2010010127A
Other languages
English (en)
Inventor
Yves Emiel Maria Van Roosbroeck
Johannes Wilhelmus John F Thuring
Gregor James Macdonald
Wei Zhuang
Keybus Frans Alfons Maria Van Den
Pauline Carol Stanislawski
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX2010010127A publication Critical patent/MX2010010127A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

La presente invención se refiere a derivados de 1-ariI-3-anilina-5-alquil-1,2,4-triazol y análogos o sus sales aceptables para uso farmacéutico; a procesos para su preparación; composiciones farmacéuticas que contienen dichos compuestos; y su uso en tratamientos, de acuerdo con la Fórmula (I); la invención se refiere, en particular, a potentes moduladores alostéricos positivos de receptores de acetilcolina nicotínicos, donde dichos moduladores alostéricos positivos tienen la capacidad de incrementar la eficacia de agonistas de receptores nicotínicos. (ver fórmula (I)).
MX2010010127A 2008-03-19 2009-03-18 1,2,4-triazoles trisustituidos como moduladores de receptores de acetilcolina nicotinicos. MX2010010127A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08152987 2008-03-19
PCT/EP2009/053186 WO2009115547A1 (en) 2008-03-19 2009-03-18 Trisubstituted 1, 2, 4 -triazoiies as nicotinic acetylcholine receptor modulators

Publications (1)

Publication Number Publication Date
MX2010010127A true MX2010010127A (es) 2010-10-25

Family

ID=39670401

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010010127A MX2010010127A (es) 2008-03-19 2009-03-18 1,2,4-triazoles trisustituidos como moduladores de receptores de acetilcolina nicotinicos.

Country Status (21)

Country Link
US (1) US8778974B2 (es)
EP (1) EP2257535B1 (es)
JP (1) JP5383788B2 (es)
KR (1) KR101564303B1 (es)
CN (1) CN102066343B (es)
AR (1) AR070936A1 (es)
AU (1) AU2009226988B2 (es)
CA (1) CA2714662C (es)
CL (1) CL2009000662A1 (es)
EA (1) EA018186B1 (es)
ES (1) ES2442932T3 (es)
IL (1) IL208181A (es)
MX (1) MX2010010127A (es)
MY (1) MY152486A (es)
NZ (1) NZ587669A (es)
PE (1) PE20091618A1 (es)
TW (1) TWI433847B (es)
UA (1) UA102681C2 (es)
UY (1) UY31721A1 (es)
WO (1) WO2009115547A1 (es)
ZA (1) ZA201006690B (es)

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US11912687B2 (en) 2017-05-12 2024-02-27 Board of Trustees of the Southern Illinois University 3,4,5-trisubstituted-1,2,4-triazoles and 3,4,5-trisubstituted-3-thio-1,2,4-triazoles and uses thereof
US11136312B2 (en) 2017-05-12 2021-10-05 Board of Trustees of the Southern Illinois University 3,4,5-trisubstituted-1,2,4-triazoles and 3,4,5-trisubstituted-3-thio-1,2,4-triazoles and uses thereof
HU231333B1 (hu) 2018-07-13 2023-01-28 Richter Gedeon Nyrt Spirokromán származékok
HU231478B1 (hu) 2018-07-13 2024-02-28 Richter Gedeon Nyrt. Szubsztituált (aza)indol származékok
HU231414B1 (hu) 2018-07-13 2023-08-28 Richter Gedeon Nyrt. Tiadiazin származékok

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Also Published As

Publication number Publication date
TWI433847B (zh) 2014-04-11
IL208181A0 (en) 2010-12-30
CN102066343A (zh) 2011-05-18
JP5383788B2 (ja) 2014-01-08
PE20091618A1 (es) 2009-10-23
UA102681C2 (ru) 2013-08-12
CA2714662C (en) 2016-05-10
US8778974B2 (en) 2014-07-15
US20100324053A1 (en) 2010-12-23
IL208181A (en) 2013-10-31
CL2009000662A1 (es) 2010-02-05
MY152486A (en) 2014-10-15
EA018186B1 (ru) 2013-06-28
NZ587669A (en) 2011-07-29
EP2257535B1 (en) 2013-11-06
UY31721A1 (es) 2009-09-30
ZA201006690B (en) 2012-03-28
WO2009115547A1 (en) 2009-09-24
ES2442932T3 (es) 2014-02-14
AR070936A1 (es) 2010-05-12
AU2009226988B2 (en) 2013-05-23
KR20100124258A (ko) 2010-11-26
CA2714662A1 (en) 2009-09-24
JP2011515367A (ja) 2011-05-19
EP2257535A1 (en) 2010-12-08
EA201071094A1 (ru) 2011-02-28
AU2009226988A1 (en) 2009-09-24
CN102066343B (zh) 2013-12-04
TW201000471A (en) 2010-01-01
WO2009115547A8 (en) 2009-11-26
KR101564303B1 (ko) 2015-11-06

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