MX369576B - Imidazoles 2-piridilo sustituidos como inhibidores de alk5 y/o alk4. - Google Patents

Imidazoles 2-piridilo sustituidos como inhibidores de alk5 y/o alk4.

Info

Publication number
MX369576B
MX369576B MX2014000309A MX2014000309A MX369576B MX 369576 B MX369576 B MX 369576B MX 2014000309 A MX2014000309 A MX 2014000309A MX 2014000309 A MX2014000309 A MX 2014000309A MX 369576 B MX369576 B MX 369576B
Authority
MX
Mexico
Prior art keywords
alk5
pyridyl substituted
alk4
substituted imidazoles
receptor
Prior art date
Application number
MX2014000309A
Other languages
English (en)
Other versions
MX2014000309A (es
Inventor
Young Lee Ju
Ryu Keun-Ho
Kim Jae-Sun
Kim Yong-Hyuk
Chul Shin Dong
Lee Bong-Yong
Kang Sang-Hwan
Jung Lee Hyun
Jung Hoechul
Ah Shin Young
Park Euisun
Ahn Jaesung
Original Assignee
Tiumbio Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tiumbio Co Ltd filed Critical Tiumbio Co Ltd
Publication of MX2014000309A publication Critical patent/MX2014000309A/es
Publication of MX369576B publication Critical patent/MX369576B/es

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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Public Health (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
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  • Diabetes (AREA)
  • Hematology (AREA)
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  • Endocrinology (AREA)
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  • Ophthalmology & Optometry (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención proporciona un derivado imidazol 2-piridilo sustituido novedoso, o una sal o solvato farmacéuticamente aceptable del mismo, el cual inhibe selectivamente el receptor (ALK5) de tipo I del factor de crecimiento transformante ß (TGF-ß) y/o el receptor (ALK4) de tipo I de activina; una composición farmacéutica que comprende lo mismo como un ingrediente activo; y un uso del derivado imidazol 2-piridilo sustituido para la fabricación de un medicamento para prevenir o tratar una enfermedad mediada por los receptores ALK5 y/o ALK4 en un mamífero.
MX2014000309A 2011-07-13 2012-07-13 Imidazoles 2-piridilo sustituidos como inhibidores de alk5 y/o alk4. MX369576B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161507305P 2011-07-13 2011-07-13
PCT/KR2012/005617 WO2013009140A2 (en) 2011-07-13 2012-07-13 2-pyridyl substituted imidazoles as alk5 and/or alk4 inhibitors

Publications (2)

Publication Number Publication Date
MX2014000309A MX2014000309A (es) 2014-02-27
MX369576B true MX369576B (es) 2019-11-13

Family

ID=47506748

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014000309A MX369576B (es) 2011-07-13 2012-07-13 Imidazoles 2-piridilo sustituidos como inhibidores de alk5 y/o alk4.

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US (1) US10155763B2 (es)
EP (1) EP2731949B1 (es)
JP (1) JP6094975B2 (es)
KR (1) KR101938368B1 (es)
CN (1) CN103764655B (es)
AU (1) AU2012281281B2 (es)
BR (1) BR112014000774B1 (es)
CA (1) CA2841252C (es)
DK (1) DK2731949T3 (es)
ES (1) ES2671581T3 (es)
MX (1) MX369576B (es)
NO (1) NO2861601T3 (es)
PL (1) PL2731949T3 (es)
PT (1) PT2731949T (es)
RU (1) RU2612958C2 (es)
TR (1) TR201808033T4 (es)
WO (1) WO2013009140A2 (es)

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ES2984546T3 (es) 2020-07-15 2024-10-29 Chiesi Farm Spa Derivados de amino pirido-oxazina como inhibidores de ALK5
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Publication number Publication date
KR20140050048A (ko) 2014-04-28
AU2012281281B2 (en) 2017-06-01
PT2731949T (pt) 2018-06-15
EP2731949A4 (en) 2014-12-17
RU2612958C2 (ru) 2017-03-14
ES2671581T3 (es) 2018-06-07
WO2013009140A2 (en) 2013-01-17
BR112014000774A8 (pt) 2017-10-10
WO2013009140A3 (en) 2013-04-11
CN103764655A (zh) 2014-04-30
KR101938368B1 (ko) 2019-01-14
RU2014105169A (ru) 2015-08-20
BR112014000774B1 (pt) 2022-03-29
CA2841252C (en) 2019-02-26
TR201808033T4 (tr) 2018-06-21
US10155763B2 (en) 2018-12-18
NO2861601T3 (es) 2018-07-07
BR112014000774A2 (pt) 2016-08-23
PL2731949T3 (pl) 2018-10-31
US20130018052A1 (en) 2013-01-17
JP6094975B2 (ja) 2017-03-15
DK2731949T3 (en) 2018-06-14
EP2731949A2 (en) 2014-05-21
CA2841252A1 (en) 2013-01-17
AU2012281281A1 (en) 2014-03-06
EP2731949B1 (en) 2018-04-04
CN103764655B (zh) 2017-04-12
MX2014000309A (es) 2014-02-27
JP2014520846A (ja) 2014-08-25

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