CY1116328T1 - Παραγωγα 4 - αμινοπυριμιδινης και η χρηση τους ως ανταγωνιστων α2α υποδοχεων αδενοσινης - Google Patents

Παραγωγα 4 - αμινοπυριμιδινης και η χρηση τους ως ανταγωνιστων α2α υποδοχεων αδενοσινης

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Publication number
CY1116328T1
CY1116328T1 CY20151100352T CY151100352T CY1116328T1 CY 1116328 T1 CY1116328 T1 CY 1116328T1 CY 20151100352 T CY20151100352 T CY 20151100352T CY 151100352 T CY151100352 T CY 151100352T CY 1116328 T1 CY1116328 T1 CY 1116328T1
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CY
Cyprus
Prior art keywords
adenosine
receptor antagonists
aminopyrimidine
derivative
compounds
Prior art date
Application number
CY20151100352T
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English (en)
Inventor
Gómez Juan Alberto Camacho
Laria Julio Cesar Castro-Palomino
Original Assignee
Palobiofarma S.L.
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Publication date
Application filed by Palobiofarma S.L. filed Critical Palobiofarma S.L.
Publication of CY1116328T1 publication Critical patent/CY1116328T1/el

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract

Νέα παράγωγα 4-αμινο-πυριμιδίνης ως ισχυροί ανταγωνιστές του A2a υποδοχέα αδενοσίνης του τύπου (I). Η εφεύρεση παρέχει επίσης μέθοδο για την παρασκευή τέτοιων ενώσεων, φαρμακευτικών συνθέσεων που περιέχουν αποτελεσματική ποσότητα αυτών των ενώσεων και τη χρήση τέτοιων ενώσεων στην κατασκευή φαρμάκου για τη θεραπευτική αγωγή παθήσεων που μπορούν να βελτιωθούν μέσω ανταγωνισμού του A2a υποδοχέα αδενοσίνης.
CY20151100352T 2010-03-31 2015-04-16 Παραγωγα 4 - αμινοπυριμιδινης και η χρηση τους ως ανταγωνιστων α2α υποδοχεων αδενοσινης CY1116328T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES201030489A ES2365960B1 (es) 2010-03-31 2010-03-31 Nuevos antagonistas de los receptores de adenosina.
EP11719879.6A EP2552909B1 (en) 2010-03-31 2011-03-29 4-aminopyrimidine derivatives and their as as adenosine a2a receptor antagonists

Publications (1)

Publication Number Publication Date
CY1116328T1 true CY1116328T1 (el) 2017-02-08

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Family Applications (1)

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CY20151100352T CY1116328T1 (el) 2010-03-31 2015-04-16 Παραγωγα 4 - αμινοπυριμιδινης και η χρηση τους ως ανταγωνιστων α2α υποδοχεων αδενοσινης

Country Status (22)

Country Link
US (1) US8796284B2 (el)
EP (1) EP2552909B1 (el)
JP (1) JP5725383B2 (el)
KR (1) KR101441781B1 (el)
CN (1) CN102892761B (el)
AU (1) AU2011234144B2 (el)
BR (1) BR112012024870B1 (el)
CA (1) CA2795009C (el)
CY (1) CY1116328T1 (el)
DK (1) DK2552909T3 (el)
EA (1) EA021565B1 (el)
ES (2) ES2365960B1 (el)
HR (1) HRP20150366T1 (el)
ME (1) ME02100B (el)
MX (1) MX2012011240A (el)
PL (1) PL2552909T3 (el)
PT (1) PT2552909E (el)
RS (1) RS53939B1 (el)
SI (1) SI2552909T1 (el)
SM (1) SMT201500097B (el)
WO (1) WO2011121418A1 (el)
ZA (1) ZA201207259B (el)

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