EA201071288A1 - Тризамещенные пиразолы в качестве модуляторов рецепторов ацетилхолина - Google Patents

Тризамещенные пиразолы в качестве модуляторов рецепторов ацетилхолина

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Publication number
EA201071288A1
EA201071288A1 EA201071288A EA201071288A EA201071288A1 EA 201071288 A1 EA201071288 A1 EA 201071288A1 EA 201071288 A EA201071288 A EA 201071288A EA 201071288 A EA201071288 A EA 201071288A EA 201071288 A1 EA201071288 A1 EA 201071288A1
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Prior art keywords
acetylcholine receptors
modulators
pyrazoles
triple
relates
Prior art date
Application number
EA201071288A
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English (en)
Other versions
EA018187B1 (ru
Inventor
Йоханнес Вильхельмус Йохн Ф. Тюринг
Грегор Джеймс Макдональд
Вэй Чжуан
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Янссен Фармацевтика Нв
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39800623&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201071288(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Янссен Фармацевтика Нв filed Critical Янссен Фармацевтика Нв
Publication of EA201071288A1 publication Critical patent/EA201071288A1/ru
Publication of EA018187B1 publication Critical patent/EA018187B1/ru

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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

Настоящее изобретение относится к производным 1-алкил-3-анилин-5-арилпиразола формулы (I) и к их фармацевтически приемлемым солям, способам их получения, фармацевтическим композициям, их содержащих, и к их применению в терапии. В особенности, изобретение относится к положительным аллостерическим модуляторам никотиновых рецепторов ацетилхолина, проявляющим способность повышать эффективность агонистов никотиновых рецепторов.
EA201071288A 2008-05-09 2009-05-08 Тризамещенные пиразолы в качестве модуляторов рецепторов ацетилхолина EA018187B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08155991 2008-05-09
PCT/EP2009/055617 WO2009135944A1 (en) 2008-05-09 2009-05-08 Trisubstituted pyrazoles as acetylcholine receptor modulators

Publications (2)

Publication Number Publication Date
EA201071288A1 true EA201071288A1 (ru) 2011-04-29
EA018187B1 EA018187B1 (ru) 2013-06-28

Family

ID=39800623

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201071288A EA018187B1 (ru) 2008-05-09 2009-05-08 Тризамещенные пиразолы в качестве модуляторов рецепторов ацетилхолина

Country Status (14)

Country Link
US (1) US8779158B2 (ru)
EP (1) EP2280945B1 (ru)
JP (1) JP5486591B2 (ru)
KR (1) KR20110007234A (ru)
CN (1) CN102015655A (ru)
AR (1) AR071763A1 (ru)
AU (1) AU2009245715B2 (ru)
BR (1) BRPI0912196A2 (ru)
CA (1) CA2722805A1 (ru)
CL (1) CL2009001125A1 (ru)
EA (1) EA018187B1 (ru)
ES (1) ES2525132T3 (ru)
TW (1) TWI440634B (ru)
WO (1) WO2009135944A1 (ru)

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AU2009245715B2 (en) 2014-01-09
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KR20110007234A (ko) 2011-01-21
TW201006812A (en) 2010-02-16
JP5486591B2 (ja) 2014-05-07
BRPI0912196A2 (pt) 2015-10-06
CL2009001125A1 (es) 2011-02-11
AU2009245715A1 (en) 2009-11-12
US8779158B2 (en) 2014-07-15
EA018187B1 (ru) 2013-06-28
WO2009135944A1 (en) 2009-11-12
AR071763A1 (es) 2010-07-14
US20110065683A1 (en) 2011-03-17
ES2525132T3 (es) 2014-12-17
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EP2280945A1 (en) 2011-02-09
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