DE602005024293D1 - Triazole als hemmer von proteinkinasen - Google Patents
Triazole als hemmer von proteinkinasenInfo
- Publication number
- DE602005024293D1 DE602005024293D1 DE602005024293T DE602005024293T DE602005024293D1 DE 602005024293 D1 DE602005024293 D1 DE 602005024293D1 DE 602005024293 T DE602005024293 T DE 602005024293T DE 602005024293 T DE602005024293 T DE 602005024293T DE 602005024293 D1 DE602005024293 D1 DE 602005024293D1
- Authority
- DE
- Germany
- Prior art keywords
- triazole
- inhibitor
- protein kinases
- kinases
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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-
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Virology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Tropical Medicine & Parasitology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62127004P | 2004-10-21 | 2004-10-21 | |
PCT/US2005/037830 WO2006047256A1 (en) | 2004-10-21 | 2005-10-21 | Triazoles useful as inhibitors of protein kinases |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602005024293D1 true DE602005024293D1 (de) | 2010-12-02 |
Family
ID=35809788
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602005024293T Active DE602005024293D1 (de) | 2004-10-21 | 2005-10-21 | Triazole als hemmer von proteinkinasen |
Country Status (26)
Country | Link |
---|---|
US (1) | US7645775B2 (de) |
EP (1) | EP1811998B1 (de) |
JP (1) | JP5085330B2 (de) |
KR (1) | KR20070085407A (de) |
CN (1) | CN101072556A (de) |
AR (1) | AR054088A1 (de) |
AT (1) | ATE485042T1 (de) |
AU (1) | AU2005299816B2 (de) |
BR (1) | BRPI0517435A (de) |
CA (1) | CA2584752A1 (de) |
CY (1) | CY1111197T1 (de) |
DE (1) | DE602005024293D1 (de) |
DK (1) | DK1811998T3 (de) |
ES (1) | ES2352453T3 (de) |
HR (1) | HRP20100715T1 (de) |
IL (1) | IL182664A0 (de) |
MX (1) | MX2007004841A (de) |
NO (1) | NO20072567L (de) |
NZ (1) | NZ555088A (de) |
PL (1) | PL1811998T3 (de) |
PT (1) | PT1811998E (de) |
RU (1) | RU2393155C2 (de) |
SI (1) | SI1811998T1 (de) |
TW (1) | TW200630090A (de) |
WO (1) | WO2006047256A1 (de) |
ZA (1) | ZA200703950B (de) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100298557A1 (en) | 2006-12-28 | 2010-11-25 | Taisho Pharmaceutical Co., Ltd | Pyrazolopyrimidine compound |
EP2114954B1 (de) | 2006-12-29 | 2013-02-13 | Rigel Pharmaceuticals, Inc. | Durch bicyclisches aryl bzw. bicyclisches heteroaryl substituierte triazole, die sich als axl-inihibitoren eignen |
JP5567837B2 (ja) | 2006-12-29 | 2014-08-06 | ライジェル ファーマシューティカルズ, インコーポレイテッド | Axlインヒビターとして有用なN3−ヘテロアリール置換トリアゾールおよびN5−ヘテロアリール置換トリアゾール |
AU2016259396B2 (en) * | 2006-12-29 | 2018-11-08 | Rigel Pharmaceuticals, Inc. | Substituted triazoles useful as Axl inhibitors |
CN110551105B (zh) * | 2006-12-29 | 2022-10-18 | 里格尔制药公司 | 用作axl抑制剂的取代三唑 |
EP2114955B1 (de) | 2006-12-29 | 2013-02-13 | Rigel Pharmaceuticals, Inc. | Durch verbrücktes bicyclisches aryl bzw. verbrücktes bicyclisches heteroaryl substituierte triazole, die sich als axl-inhibitoren eignen |
AU2014200824B2 (en) * | 2006-12-29 | 2016-12-15 | Rigel Pharmaceuticals, Inc. | Substituted triazoles useful as Axl inhibitors |
JO2784B1 (en) | 2007-10-18 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | 5,3,1 - Triazole substitute derivative |
RU2474579C2 (ru) * | 2007-10-18 | 2013-02-10 | Янссен Фармацевтика Нв | Тризамещенные 1,2,4-триазолы |
AU2009226988B2 (en) | 2008-03-19 | 2013-05-23 | Janssen Pharmaceutica Nv | Trisubstituted 1, 2, 4 -triazoles as nicotinic acetylcholine receptor modulators |
JP5486591B2 (ja) | 2008-05-09 | 2014-05-07 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | アセチルコリン受容体モジュレーターとしての三置換ピラゾール |
WO2010005879A1 (en) | 2008-07-09 | 2010-01-14 | Rigel Pharmaceuticals, Inc. | Bridged bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
CN102292333B (zh) * | 2009-01-15 | 2015-05-13 | 里格尔药品股份有限公司 | 蛋白激酶c抑制剂及其用途 |
ES2528032T3 (es) | 2009-01-16 | 2015-02-03 | Rigel Pharmaceuticals, Inc. | Inhibidores de Axl para su uso en terapia de combinación para prevenir, tratar o manejar cáncer metastásico |
WO2011143145A1 (en) | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-alkyl and n-acyl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof |
WO2011143162A1 (en) | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heteroaryl bipyrrolidine carboxamides, preparation and therapeutic use thereof |
EP2569304A1 (de) | 2010-05-11 | 2013-03-20 | Sanofi | Substituierte n-heteroaryl-spirolactambipyrrolidine, ihre zubereitung und therapeutische verwendung |
WO2011143155A1 (en) | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heteroaryl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof |
WO2011143161A1 (en) | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heterocycloalkyl bipyrrolidinylphenyl amide derivatives, preparation and therapeutic use thereof |
AR083718A1 (es) | 2010-05-11 | 2013-03-20 | Sanofi Aventis | Fenil cicloalquil pirrolidina (piperidina) espirolactamas y amidas sustituidas, preparacion y uso terapeutico de las mismas |
CN102787094B (zh) * | 2011-05-17 | 2015-09-23 | 李晖 | 培养基、细胞培养用试剂盒及细胞培养方法 |
MX2015011125A (es) | 2013-03-05 | 2015-11-11 | Hoffmann La Roche | Compuestos antivirales. |
EP3302465A1 (de) | 2015-06-05 | 2018-04-11 | Vertex Pharmaceuticals Incorporated | Triazole zur behandlung von demyelinisierenden erkrankungen |
KR20220042127A (ko) * | 2019-06-28 | 2022-04-04 | 상하이 파마슈티컬스 홀딩 컴퍼니 리미티드 | 피라졸로피리미딘 화합물, 그의 제조 방법 및 그의 응용 |
JP7503456B2 (ja) | 2020-09-02 | 2024-06-20 | 三菱鉛筆株式会社 | 筆記具 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1355889E (pt) * | 2000-12-22 | 2006-09-29 | Ortho Mcneil Pharm Inc | Derivados diamina triazole substituidos como inibidores de cinase |
DE10123586A1 (de) * | 2001-05-08 | 2002-11-28 | Schering Ag | 3,5-Diamino-1,2,4-triazole als Kinase Inhibitoren |
TWI335913B (en) * | 2002-11-15 | 2011-01-11 | Vertex Pharma | Diaminotriazoles useful as inhibitors of protein kinases |
US7226920B2 (en) * | 2003-08-06 | 2007-06-05 | Vertex Pharmaceuticals Inc. | Aminotriazole compounds useful as inhibitors of protein kinases |
-
2005
- 2005-10-21 EP EP05815914A patent/EP1811998B1/de active Active
- 2005-10-21 ES ES05815914T patent/ES2352453T3/es active Active
- 2005-10-21 MX MX2007004841A patent/MX2007004841A/es unknown
- 2005-10-21 US US11/255,569 patent/US7645775B2/en not_active Expired - Fee Related
- 2005-10-21 PT PT05815914T patent/PT1811998E/pt unknown
- 2005-10-21 KR KR1020077011405A patent/KR20070085407A/ko not_active Application Discontinuation
- 2005-10-21 TW TW094137050A patent/TW200630090A/zh unknown
- 2005-10-21 BR BRPI0517435-0A patent/BRPI0517435A/pt not_active IP Right Cessation
- 2005-10-21 DE DE602005024293T patent/DE602005024293D1/de active Active
- 2005-10-21 AR ARP050104417A patent/AR054088A1/es not_active Application Discontinuation
- 2005-10-21 CN CNA2005800420882A patent/CN101072556A/zh active Pending
- 2005-10-21 NZ NZ555088A patent/NZ555088A/en not_active IP Right Cessation
- 2005-10-21 SI SI200531181T patent/SI1811998T1/sl unknown
- 2005-10-21 WO PCT/US2005/037830 patent/WO2006047256A1/en active Application Filing
- 2005-10-21 CA CA002584752A patent/CA2584752A1/en not_active Abandoned
- 2005-10-21 PL PL05815914T patent/PL1811998T3/pl unknown
- 2005-10-21 JP JP2007538052A patent/JP5085330B2/ja not_active Expired - Fee Related
- 2005-10-21 ZA ZA200703950A patent/ZA200703950B/en unknown
- 2005-10-21 AU AU2005299816A patent/AU2005299816B2/en not_active Ceased
- 2005-10-21 RU RU2007118687/04A patent/RU2393155C2/ru not_active IP Right Cessation
- 2005-10-21 DK DK05815914.6T patent/DK1811998T3/da active
- 2005-10-21 AT AT05815914T patent/ATE485042T1/de active
-
2007
- 2007-04-19 IL IL182664A patent/IL182664A0/en unknown
- 2007-05-21 NO NO20072567A patent/NO20072567L/no not_active Application Discontinuation
-
2010
- 2010-12-22 HR HR20100715T patent/HRP20100715T1/hr unknown
-
2011
- 2011-01-04 CY CY20111100005T patent/CY1111197T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
SI1811998T1 (sl) | 2011-01-31 |
BRPI0517435A (pt) | 2008-10-07 |
WO2006047256A1 (en) | 2006-05-04 |
KR20070085407A (ko) | 2007-08-27 |
AR054088A1 (es) | 2007-06-06 |
CY1111197T1 (el) | 2015-06-11 |
JP5085330B2 (ja) | 2012-11-28 |
NZ555088A (en) | 2009-08-28 |
US20070270410A1 (en) | 2007-11-22 |
ATE485042T1 (de) | 2010-11-15 |
NO20072567L (no) | 2007-07-17 |
EP1811998B1 (de) | 2010-10-20 |
PT1811998E (pt) | 2010-12-23 |
HRP20100715T1 (hr) | 2011-02-28 |
ZA200703950B (en) | 2008-07-30 |
AU2005299816B2 (en) | 2011-09-01 |
RU2393155C2 (ru) | 2010-06-27 |
TW200630090A (en) | 2006-09-01 |
CN101072556A (zh) | 2007-11-14 |
DK1811998T3 (da) | 2011-02-14 |
ES2352453T3 (es) | 2011-02-18 |
CA2584752A1 (en) | 2006-05-04 |
AU2005299816A1 (en) | 2006-05-04 |
AU2005299816A2 (en) | 2006-05-04 |
JP2008517923A (ja) | 2008-05-29 |
IL182664A0 (en) | 2007-09-20 |
MX2007004841A (es) | 2007-05-21 |
EP1811998A1 (de) | 2007-08-01 |
US7645775B2 (en) | 2010-01-12 |
PL1811998T3 (pl) | 2011-05-31 |
RU2007118687A (ru) | 2008-11-27 |
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