TW200630090A - Triazoles useful as inhibitors of protein kinases - Google Patents
Triazoles useful as inhibitors of protein kinasesInfo
- Publication number
- TW200630090A TW200630090A TW094137050A TW94137050A TW200630090A TW 200630090 A TW200630090 A TW 200630090A TW 094137050 A TW094137050 A TW 094137050A TW 94137050 A TW94137050 A TW 94137050A TW 200630090 A TW200630090 A TW 200630090A
- Authority
- TW
- Taiwan
- Prior art keywords
- inhibitors
- protein kinases
- triazoles useful
- triazoles
- useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Virology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62127004P | 2004-10-21 | 2004-10-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW200630090A true TW200630090A (en) | 2006-09-01 |
Family
ID=35809788
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW094137050A TW200630090A (en) | 2004-10-21 | 2005-10-21 | Triazoles useful as inhibitors of protein kinases |
Country Status (26)
Country | Link |
---|---|
US (1) | US7645775B2 (zh) |
EP (1) | EP1811998B1 (zh) |
JP (1) | JP5085330B2 (zh) |
KR (1) | KR20070085407A (zh) |
CN (1) | CN101072556A (zh) |
AR (1) | AR054088A1 (zh) |
AT (1) | ATE485042T1 (zh) |
AU (1) | AU2005299816B2 (zh) |
BR (1) | BRPI0517435A (zh) |
CA (1) | CA2584752A1 (zh) |
CY (1) | CY1111197T1 (zh) |
DE (1) | DE602005024293D1 (zh) |
DK (1) | DK1811998T3 (zh) |
ES (1) | ES2352453T3 (zh) |
HR (1) | HRP20100715T1 (zh) |
IL (1) | IL182664A0 (zh) |
MX (1) | MX2007004841A (zh) |
NO (1) | NO20072567L (zh) |
NZ (1) | NZ555088A (zh) |
PL (1) | PL1811998T3 (zh) |
PT (1) | PT1811998E (zh) |
RU (1) | RU2393155C2 (zh) |
SI (1) | SI1811998T1 (zh) |
TW (1) | TW200630090A (zh) |
WO (1) | WO2006047256A1 (zh) |
ZA (1) | ZA200703950B (zh) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101611035A (zh) | 2006-12-28 | 2009-12-23 | 大正制药株式会社 | 吡唑并嘧啶化合物 |
AU2014200824B2 (en) * | 2006-12-29 | 2016-12-15 | Rigel Pharmaceuticals, Inc. | Substituted triazoles useful as Axl inhibitors |
CA2710043C (en) | 2006-12-29 | 2016-02-09 | Rigel Pharmaceuticals, Inc. | Bicyclic aryl and bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
ES2404668T3 (es) | 2006-12-29 | 2013-05-28 | Rigel Pharmaceuticals, Inc. | Triazoles sustituidos con arilo bicíclico puenteado y heteroarilo bicíclico puenteado, útiles como agentes inhibidores del axl |
EP2079736B1 (en) * | 2006-12-29 | 2017-10-18 | Rigel Pharmaceuticals, Inc. | Substituted triazoles useful as axl inhibitors |
AU2016259396B2 (en) * | 2006-12-29 | 2018-11-08 | Rigel Pharmaceuticals, Inc. | Substituted triazoles useful as Axl inhibitors |
EP2484679B1 (en) | 2006-12-29 | 2016-09-28 | Rigel Pharmaceuticals, Inc. | N3-heteroaryl substituted triazoles and n5-heteroaryl substitued triazoles useful as axl inhibitors |
JO2784B1 (en) | 2007-10-18 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | 5,3,1 - Triazole substitute derivative |
WO2009050186A1 (en) | 2007-10-18 | 2009-04-23 | Janssen Pharmaceutica Nv | Trisubstituted 1,2,4-triazoles |
ES2442932T3 (es) | 2008-03-19 | 2014-02-14 | Janssen Pharmaceutica N.V. | 1,2,4-Triazoles trisustituidos como moduladores de receptores nicotínicos de acetilcolina |
EA018187B1 (ru) | 2008-05-09 | 2013-06-28 | Янссен Фармацевтика Нв | Тризамещенные пиразолы в качестве модуляторов рецепторов ацетилхолина |
SI2328888T1 (sl) | 2008-07-09 | 2013-03-29 | Rigel Pharmaceuticals, Inc. | Premoščeni biciklični heteroaril substituirani triazoli, uporabni kot inhibitorji Axl |
ES2555982T3 (es) | 2009-01-15 | 2016-01-12 | Rigel Pharmaceuticals, Inc. | Inhibidores de la proteína quinasa C y usos de los mismos |
US8546433B2 (en) | 2009-01-16 | 2013-10-01 | Rigel Pharmaceuticals, Inc. | Axl inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer |
AR081383A1 (es) | 2010-05-11 | 2012-08-29 | Sanofi Aventis | N-heteroaril bipirrolidin carboxamidas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas para el tratamiento de enfermedades del sistema nervioso central. |
TW201202251A (en) | 2010-05-11 | 2012-01-16 | Sanofi Aventis | Substituted N-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof |
JP5784110B2 (ja) | 2010-05-11 | 2015-09-24 | サノフイ | 置換されたn−ヘテロアリールテトラヒドロ−イソキノリン誘導体、その製造及び治療上の使用 |
TW201206939A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof |
AR081498A1 (es) | 2010-05-11 | 2012-09-19 | Sanofi Aventis | Derivados de n-alquil -y n-acil-tetrahidroisoquinolina sustituidos, preparacion y su uso terapeutico de los mismos |
AR081382A1 (es) | 2010-05-11 | 2012-08-29 | Sanofi Aventis | Derivados de n-heterocicloalquil bipirrolidinilfenil amida sustituidos, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades del sistema nervioso central. |
CN102787092B (zh) * | 2011-05-17 | 2018-01-09 | 李晖 | 培养基、细胞培养用试剂盒及细胞培养方法 |
EP2964633B1 (en) | 2013-03-05 | 2017-04-19 | F. Hoffmann-La Roche AG | Antiviral compounds |
EP3302465A1 (en) | 2015-06-05 | 2018-04-11 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of demyelinating diseases |
CA3145344A1 (en) * | 2019-06-28 | 2020-12-30 | Shanghai Pharmaceuticals Holding Co., Ltd. | Pyrazolopyrimidine compound, preparation method for same and applications thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL363316A1 (en) | 2000-12-22 | 2004-11-15 | Ortho Mc Neil Pharmaceutical, Inc. | Substituted triazole diamine derivatives as kinase inhibitors |
DE10123586A1 (de) * | 2001-05-08 | 2002-11-28 | Schering Ag | 3,5-Diamino-1,2,4-triazole als Kinase Inhibitoren |
CL2003002353A1 (es) * | 2002-11-15 | 2005-02-04 | Vertex Pharma | Compuestos derivados de diaminotriazoles, inhibidores d ela proteina quinasa; composicion farmaceutica; procedimiento de preparacion; y su uso del compuesto en el tratamiento de enfermedades de desordenes alergicos, proliferacion, autoinmunes, condic |
ATE455546T1 (de) * | 2003-08-06 | 2010-02-15 | Vertex Pharma | Aminotriazol-verbindungen als proteinkinase- hemmer |
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2005
- 2005-10-21 PL PL05815914T patent/PL1811998T3/pl unknown
- 2005-10-21 PT PT05815914T patent/PT1811998E/pt unknown
- 2005-10-21 AU AU2005299816A patent/AU2005299816B2/en not_active Ceased
- 2005-10-21 RU RU2007118687/04A patent/RU2393155C2/ru not_active IP Right Cessation
- 2005-10-21 DE DE602005024293T patent/DE602005024293D1/de active Active
- 2005-10-21 TW TW094137050A patent/TW200630090A/zh unknown
- 2005-10-21 ES ES05815914T patent/ES2352453T3/es active Active
- 2005-10-21 MX MX2007004841A patent/MX2007004841A/es unknown
- 2005-10-21 AR ARP050104417A patent/AR054088A1/es not_active Application Discontinuation
- 2005-10-21 AT AT05815914T patent/ATE485042T1/de active
- 2005-10-21 US US11/255,569 patent/US7645775B2/en not_active Expired - Fee Related
- 2005-10-21 ZA ZA200703950A patent/ZA200703950B/en unknown
- 2005-10-21 EP EP05815914A patent/EP1811998B1/en active Active
- 2005-10-21 SI SI200531181T patent/SI1811998T1/sl unknown
- 2005-10-21 WO PCT/US2005/037830 patent/WO2006047256A1/en active Application Filing
- 2005-10-21 CA CA002584752A patent/CA2584752A1/en not_active Abandoned
- 2005-10-21 BR BRPI0517435-0A patent/BRPI0517435A/pt not_active IP Right Cessation
- 2005-10-21 KR KR1020077011405A patent/KR20070085407A/ko not_active Application Discontinuation
- 2005-10-21 CN CNA2005800420882A patent/CN101072556A/zh active Pending
- 2005-10-21 DK DK05815914.6T patent/DK1811998T3/da active
- 2005-10-21 NZ NZ555088A patent/NZ555088A/en not_active IP Right Cessation
- 2005-10-21 JP JP2007538052A patent/JP5085330B2/ja not_active Expired - Fee Related
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2007
- 2007-04-19 IL IL182664A patent/IL182664A0/en unknown
- 2007-05-21 NO NO20072567A patent/NO20072567L/no not_active Application Discontinuation
-
2010
- 2010-12-22 HR HR20100715T patent/HRP20100715T1/hr unknown
-
2011
- 2011-01-04 CY CY20111100005T patent/CY1111197T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
JP5085330B2 (ja) | 2012-11-28 |
IL182664A0 (en) | 2007-09-20 |
EP1811998B1 (en) | 2010-10-20 |
WO2006047256A1 (en) | 2006-05-04 |
ZA200703950B (en) | 2008-07-30 |
RU2007118687A (ru) | 2008-11-27 |
JP2008517923A (ja) | 2008-05-29 |
AU2005299816A2 (en) | 2006-05-04 |
PL1811998T3 (pl) | 2011-05-31 |
CY1111197T1 (el) | 2015-06-11 |
ATE485042T1 (de) | 2010-11-15 |
MX2007004841A (es) | 2007-05-21 |
US20070270410A1 (en) | 2007-11-22 |
RU2393155C2 (ru) | 2010-06-27 |
DK1811998T3 (da) | 2011-02-14 |
CA2584752A1 (en) | 2006-05-04 |
BRPI0517435A (pt) | 2008-10-07 |
KR20070085407A (ko) | 2007-08-27 |
DE602005024293D1 (de) | 2010-12-02 |
CN101072556A (zh) | 2007-11-14 |
AU2005299816A1 (en) | 2006-05-04 |
AR054088A1 (es) | 2007-06-06 |
EP1811998A1 (en) | 2007-08-01 |
AU2005299816B2 (en) | 2011-09-01 |
PT1811998E (pt) | 2010-12-23 |
NO20072567L (no) | 2007-07-17 |
US7645775B2 (en) | 2010-01-12 |
SI1811998T1 (sl) | 2011-01-31 |
NZ555088A (en) | 2009-08-28 |
HRP20100715T1 (hr) | 2011-02-28 |
ES2352453T3 (es) | 2011-02-18 |
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