ATE455546T1 - Aminotriazol-verbindungen als proteinkinase- hemmer - Google Patents
Aminotriazol-verbindungen als proteinkinase- hemmerInfo
- Publication number
- ATE455546T1 ATE455546T1 AT04780381T AT04780381T ATE455546T1 AT E455546 T1 ATE455546 T1 AT E455546T1 AT 04780381 T AT04780381 T AT 04780381T AT 04780381 T AT04780381 T AT 04780381T AT E455546 T1 ATE455546 T1 AT E455546T1
- Authority
- AT
- Austria
- Prior art keywords
- protein kinase
- kinase inhibitors
- aminotriazole compounds
- aminotriazole
- compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49278703P | 2003-08-06 | 2003-08-06 | |
PCT/US2004/025539 WO2005013982A1 (en) | 2003-08-06 | 2004-08-06 | Aminotriazole compounds useful as inhibitors of protein kinases |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE455546T1 true ATE455546T1 (de) | 2010-02-15 |
Family
ID=34135157
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04780381T ATE455546T1 (de) | 2003-08-06 | 2004-08-06 | Aminotriazol-verbindungen als proteinkinase- hemmer |
Country Status (11)
Country | Link |
---|---|
US (2) | US7226920B2 (de) |
EP (1) | EP1663211B1 (de) |
JP (1) | JP4889489B2 (de) |
AR (1) | AR045731A1 (de) |
AT (1) | ATE455546T1 (de) |
AU (1) | AU2004263148B2 (de) |
CA (1) | CA2534921C (de) |
DE (1) | DE602004025258D1 (de) |
PE (1) | PE20050338A1 (de) |
TW (1) | TW200514776A (de) |
WO (1) | WO2005013982A1 (de) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE455546T1 (de) * | 2003-08-06 | 2010-02-15 | Vertex Pharma | Aminotriazol-verbindungen als proteinkinase- hemmer |
JP2007522233A (ja) | 2004-02-11 | 2007-08-09 | アムジエン・インコーポレーテツド | バニロイド受容体リガンド及び治療におけるそれらの使用 |
CN101039933B (zh) * | 2004-09-17 | 2012-06-06 | 沃泰克斯药物股份有限公司 | 可用作蛋白激酶抑制剂的二氨基三唑化合物 |
AR054088A1 (es) * | 2004-10-21 | 2007-06-06 | Vertex Pharma | Triazoles como inhibidores de proteinquinasas. composiciones farmaceuticas |
CN100334084C (zh) * | 2005-04-26 | 2007-08-29 | 武汉大学 | 联三唑化合物及其制备方法和用途 |
US7576053B2 (en) | 2005-06-13 | 2009-08-18 | Rigel Pharmaceuticals, Inc. | Methods and compositions for treating degenerative bone disorders |
KR101370280B1 (ko) | 2005-07-26 | 2014-03-06 | 바이알 - 포르텔라 앤드 씨에이 에스에이 | Comt 억제제로서의 니트로카테콜 유도체 |
ES2397275T3 (es) * | 2005-08-04 | 2013-03-05 | Sirtris Pharmaceuticals, Inc. | Derivados de imidazopiridina como agentes moduladores de la sirtuína |
JP2009507080A (ja) | 2005-09-07 | 2009-02-19 | リゲル ファーマシューティカルズ,インコーポレーテッド | Axl阻害剤として有用なトリアゾール誘導体 |
EP1845097A1 (de) | 2006-04-10 | 2007-10-17 | Portela & Ca., S.A. | Oxadiazolderivate als COMT Inihibitoren |
WO2008042282A2 (en) * | 2006-09-28 | 2008-04-10 | Exelixis, Inc. | Imidazole-4, 5-dicarboxamide derivatives as jak-2 modulators |
JP5153777B2 (ja) | 2006-10-02 | 2013-02-27 | アイアールエム・リミテッド・ライアビリティ・カンパニー | タンパク質キナーゼとしての化合物および組成物 |
CA2701959C (en) * | 2006-11-15 | 2016-01-05 | Ym Biosciences Australia Pty Ltd | Inhibitors of kinase activity |
US20100168182A1 (en) * | 2006-12-11 | 2010-07-01 | Irm Llc | Compounds and compositions as kinase inhibitors |
EP2484679B1 (de) | 2006-12-29 | 2016-09-28 | Rigel Pharmaceuticals, Inc. | N3-heteroaryl substituierte Triazole und N5-heteroaryl-substituierte Triazole, die als AXL-Hemmer nützlich sind |
EP2114954B1 (de) | 2006-12-29 | 2013-02-13 | Rigel Pharmaceuticals, Inc. | Durch bicyclisches aryl bzw. bicyclisches heteroaryl substituierte triazole, die sich als axl-inihibitoren eignen |
EP2476679B1 (de) | 2006-12-29 | 2015-10-14 | Rigel Pharmaceuticals, Inc. | Substituierte Triazole als AXL-Hemmer |
RS53281B (en) | 2006-12-29 | 2014-08-29 | Rigel Pharmaceuticals Inc. | POLYCYCLIC HETEROaryl SUBSTITUTED TRIAZOLES USED AS AXL INHIBITORS |
DK2114955T3 (da) | 2006-12-29 | 2013-05-06 | Rigel Pharmaceuticals Inc | Broforbundet, bicyklisk aryl og broforbundet, bicyklisk heteroaryl subsitiuerede triazoler, der er anvendelige som axl-inhibitorer |
JP5517629B2 (ja) | 2007-01-31 | 2014-06-11 | ノヴィファーマ,エス.アー. | Comt阻害剤用の投薬計画 |
EP2205592B1 (de) | 2007-10-26 | 2013-05-08 | Rigel Pharmaceuticals, Inc. | Durch polycyclisches aryl substituierte triazole und durch polycyclisches heteroaryl substituierte triazole, die sich als axl-inhibitoren eignen |
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2004
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- 2004-08-06 WO PCT/US2004/025539 patent/WO2005013982A1/en active Application Filing
- 2004-08-06 AU AU2004263148A patent/AU2004263148B2/en not_active Ceased
- 2004-08-06 JP JP2006522766A patent/JP4889489B2/ja not_active Expired - Fee Related
- 2004-08-06 EP EP04780381A patent/EP1663211B1/de not_active Not-in-force
- 2004-08-06 PE PE2004000768A patent/PE20050338A1/es not_active Application Discontinuation
- 2004-08-06 TW TW093123755A patent/TW200514776A/zh unknown
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CA2534921C (en) | 2011-06-14 |
CA2534921A1 (en) | 2005-02-17 |
TW200514776A (en) | 2005-05-01 |
US7598245B2 (en) | 2009-10-06 |
JP4889489B2 (ja) | 2012-03-07 |
JP2007501257A (ja) | 2007-01-25 |
AU2004263148B2 (en) | 2008-08-21 |
US20050261268A1 (en) | 2005-11-24 |
US7226920B2 (en) | 2007-06-05 |
EP1663211B1 (de) | 2010-01-20 |
PE20050338A1 (es) | 2005-05-16 |
WO2005013982A1 (en) | 2005-02-17 |
DE602004025258D1 (de) | 2010-03-11 |
US20080096901A1 (en) | 2008-04-24 |
AU2004263148A1 (en) | 2005-02-17 |
AR045731A1 (es) | 2005-11-09 |
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