ATE393159T1 - Heterobicyclische pyrazolderivate als kinaseinhibitoren - Google Patents
Heterobicyclische pyrazolderivate als kinaseinhibitorenInfo
- Publication number
- ATE393159T1 ATE393159T1 AT03763818T AT03763818T ATE393159T1 AT E393159 T1 ATE393159 T1 AT E393159T1 AT 03763818 T AT03763818 T AT 03763818T AT 03763818 T AT03763818 T AT 03763818T AT E393159 T1 ATE393159 T1 AT E393159T1
- Authority
- AT
- Austria
- Prior art keywords
- kinase inhibitors
- pyrazole derivatives
- heterobicyclic pyrazole
- heterobicyclic
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/42—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39617402P | 2002-07-17 | 2002-07-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE393159T1 true ATE393159T1 (de) | 2008-05-15 |
Family
ID=30115981
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03763818T ATE393159T1 (de) | 2002-07-17 | 2003-07-11 | Heterobicyclische pyrazolderivate als kinaseinhibitoren |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP1534716B1 (de) |
JP (1) | JP2006501191A (de) |
AR (1) | AR040580A1 (de) |
AT (1) | ATE393159T1 (de) |
AU (1) | AU2003254337A1 (de) |
BR (1) | BR0312722A (de) |
CA (1) | CA2492673A1 (de) |
DE (1) | DE60320560T2 (de) |
ES (1) | ES2304531T3 (de) |
MX (1) | MXPA05000629A (de) |
TW (1) | TWI284645B (de) |
WO (1) | WO2004007504A1 (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200526204A (en) | 2004-02-03 | 2005-08-16 | Pharmacia Italia Spa | 1h-thieno[2,3-c]pyrazole derivatives useful as kinase inhibitors |
ATE479687T1 (de) | 2004-10-15 | 2010-09-15 | Takeda Pharmaceutical | Kinaseinhibitoren |
FR2878442B1 (fr) | 2004-11-29 | 2008-10-24 | Aventis Pharma Sa | THIENO(2,3-c)PYRAZOLES SUBSTITUES, PROCEDE DE PREPARATION, COMPOSITIONS LES CONTENANT ET UTILISATION |
FR2882751B1 (fr) * | 2005-03-04 | 2007-09-14 | Aventis Pharma Sa | Hydrazinocarbonyl-thieno[2,3-c]pyrazoles, procede de preparation, compositions les contenant et utilisation |
EP1904503B1 (de) | 2005-07-19 | 2013-11-06 | Nerviano Medical Sciences S.R.L. | 1h-thieno[2,3-c]-pyrazolverbindungen, die sich als kinaseinhibitoren eignen |
US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
JP2009534307A (ja) | 2006-03-30 | 2009-09-24 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | 特定の耐性腫瘍の治療のためのキナーゼ阻害剤の使用 |
AU2007240496A1 (en) | 2006-04-19 | 2007-11-01 | Novartis Ag | Indazole compounds and methods for inhibition of CDC7 |
JP5303454B2 (ja) * | 2006-05-31 | 2013-10-02 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | キナーゼ阻害薬として有用な1h−フロ[3,2−c]ピラゾール化合物 |
GEP20135728B (en) | 2006-10-09 | 2013-01-25 | Takeda Pharmaceuticals Co | Kinase inhibitors |
JP5379690B2 (ja) | 2007-09-28 | 2013-12-25 | 武田薬品工業株式会社 | 5員複素環化合物 |
EP2058315A1 (de) | 2007-10-30 | 2009-05-13 | Nerviano Medical Sciences S.r.l. | Als Aurora-Kinase-Inhibitoren aktive 1H-Furo[3,2-C]Pyrazole |
DK2692728T3 (en) | 2011-03-31 | 2018-10-08 | Carna Biosciences Inc | UNKNOWN FURANONDERIVATE |
CA2860994A1 (en) | 2012-03-16 | 2013-09-19 | Klaus P. Hoeflich | Methods of treating melanoma with pak1 inhibitors |
WO2015008234A1 (en) * | 2013-07-17 | 2015-01-22 | Glenmark Pharmaceuticals S.A. | Bicyclic heterocyclic compounds as ror gamma modulators |
US9974795B2 (en) | 2014-01-31 | 2018-05-22 | Carna Biosciences, Inc. | Anticancer agent composition |
WO2017144546A1 (en) | 2016-02-23 | 2017-08-31 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of nasopharyngeal carcinoma |
US11466024B2 (en) | 2017-08-01 | 2022-10-11 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Bicylic compound acting as an inhibitor |
EP3956446A1 (de) | 2019-04-17 | 2022-02-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Verfahren und zusammensetzungen zur behandlung von durch nlrp3-inflammasom vermittelten il-1-beta-abhängigen erkrankungen |
WO2021198511A1 (en) | 2020-04-03 | 2021-10-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treatment of sars-cov-2 infection |
WO2022008597A1 (en) | 2020-07-08 | 2022-01-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical composition for the treatment of infectious diseases |
CN113072562B (zh) * | 2021-04-06 | 2022-01-14 | 山东大学 | 一种GSK-3β抑制剂及其制备方法与应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4140785A (en) * | 1978-05-08 | 1979-02-20 | E. I. Du Pont De Nemours And Company | N-(benzothienopyrazol)amide antirhinoviral agents |
US4420476A (en) * | 1982-05-24 | 1983-12-13 | Averst McKenna & Harrison, Inc. | Benzofuro[3,2-c]pyrazol-3-amine derivatives |
ZA200301813B (en) * | 2000-08-10 | 2004-06-22 | Pharmacia Italia Spa | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them. |
AP2001002266A0 (en) * | 2000-08-31 | 2001-09-30 | Pfizer Prod Inc | Pyrazole derivatives. |
EP1317450B1 (de) * | 2000-09-15 | 2006-11-22 | Vertex Pharmaceuticals Incorporated | Pyrazolverbindungen als protein-kinasehemmer |
AU2002353186A1 (en) * | 2001-12-19 | 2003-06-30 | Smithkline Beecham P.L.C. | (1-h-indazol-3-yl) -amide derivatives as gsk-3 inhibitors |
-
2003
- 2003-07-11 CA CA002492673A patent/CA2492673A1/en not_active Abandoned
- 2003-07-11 EP EP03763818A patent/EP1534716B1/de not_active Expired - Lifetime
- 2003-07-11 ES ES03763818T patent/ES2304531T3/es not_active Expired - Lifetime
- 2003-07-11 WO PCT/EP2003/007529 patent/WO2004007504A1/en active IP Right Grant
- 2003-07-11 JP JP2004520596A patent/JP2006501191A/ja not_active Abandoned
- 2003-07-11 AU AU2003254337A patent/AU2003254337A1/en not_active Abandoned
- 2003-07-11 MX MXPA05000629A patent/MXPA05000629A/es not_active Application Discontinuation
- 2003-07-11 AT AT03763818T patent/ATE393159T1/de not_active IP Right Cessation
- 2003-07-11 BR BR0312722-2A patent/BR0312722A/pt not_active IP Right Cessation
- 2003-07-11 DE DE60320560T patent/DE60320560T2/de not_active Expired - Fee Related
- 2003-07-14 TW TW092119120A patent/TWI284645B/zh not_active IP Right Cessation
- 2003-07-16 AR AR20030102551A patent/AR040580A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
CA2492673A1 (en) | 2004-01-22 |
WO2004007504A1 (en) | 2004-01-22 |
DE60320560D1 (de) | 2008-06-05 |
ES2304531T3 (es) | 2008-10-16 |
MXPA05000629A (es) | 2005-04-25 |
BR0312722A (pt) | 2005-05-10 |
AU2003254337A1 (en) | 2004-02-02 |
EP1534716A1 (de) | 2005-06-01 |
AR040580A1 (es) | 2005-04-13 |
JP2006501191A (ja) | 2006-01-12 |
DE60320560T2 (de) | 2008-12-11 |
TW200413389A (en) | 2004-08-01 |
EP1534716B1 (de) | 2008-04-23 |
TWI284645B (en) | 2007-08-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |