DE602004025258D1 - Aminotriazol-verbindungen als proteinkinase-hemmer - Google Patents

Aminotriazol-verbindungen als proteinkinase-hemmer

Info

Publication number
DE602004025258D1
DE602004025258D1 DE602004025258T DE602004025258T DE602004025258D1 DE 602004025258 D1 DE602004025258 D1 DE 602004025258D1 DE 602004025258 T DE602004025258 T DE 602004025258T DE 602004025258 T DE602004025258 T DE 602004025258T DE 602004025258 D1 DE602004025258 D1 DE 602004025258D1
Authority
DE
Germany
Prior art keywords
aminotriazol
compounds
protein kinase
kinase inhibitors
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004025258T
Other languages
English (en)
Inventor
Michael J Arnost
Guy W Bemis
Robert J Davies
Cornelia J Forster
Ronald Grey Jr
Brian Ledford
Craig Marhefka
David Messersmith
Albert C Pierce
Francesco Salituro
Jian Wang
Mark W Ledeboer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of DE602004025258D1 publication Critical patent/DE602004025258D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
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  • Psychology (AREA)
DE602004025258T 2003-08-06 2004-08-06 Aminotriazol-verbindungen als proteinkinase-hemmer Expired - Lifetime DE602004025258D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49278703P 2003-08-06 2003-08-06
PCT/US2004/025539 WO2005013982A1 (en) 2003-08-06 2004-08-06 Aminotriazole compounds useful as inhibitors of protein kinases

Publications (1)

Publication Number Publication Date
DE602004025258D1 true DE602004025258D1 (de) 2010-03-11

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DE602004025258T Expired - Lifetime DE602004025258D1 (de) 2003-08-06 2004-08-06 Aminotriazol-verbindungen als proteinkinase-hemmer

Country Status (11)

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US (2) US7226920B2 (de)
EP (1) EP1663211B1 (de)
JP (1) JP4889489B2 (de)
AR (1) AR045731A1 (de)
AT (1) ATE455546T1 (de)
AU (1) AU2004263148B2 (de)
CA (1) CA2534921C (de)
DE (1) DE602004025258D1 (de)
PE (1) PE20050338A1 (de)
TW (1) TW200514776A (de)
WO (1) WO2005013982A1 (de)

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JP4889489B2 (ja) * 2003-08-06 2012-03-07 バーテックス ファーマシューティカルズ インコーポレイテッド プロテインキナーゼのインヒビターとして有用なアミノトリアゾール化合物
CA2556239A1 (en) 2004-02-11 2005-08-25 Amgen Inc. Vanilloid receptor ligands and their use in treatments
EP1791830B1 (de) 2004-09-17 2010-12-29 Vertex Pharmaceuticals Incorporated Als proteinkinaseinhibitoren geeignete diaminotriazolverbindungen
KR20070085407A (ko) 2004-10-21 2007-08-27 버텍스 파마슈티칼스 인코포레이티드 단백질 키나아제의 억제제로서 유용한 트리아졸
CN100334084C (zh) * 2005-04-26 2007-08-29 武汉大学 联三唑化合物及其制备方法和用途
CA2607901C (en) 2005-06-13 2016-08-16 Rigel Pharmaceuticals, Inc. Methods and compositions for treating degenerative bone disorders using a syk inhibitory 2,4-pyrimidinediamine
KR101370280B1 (ko) 2005-07-26 2014-03-06 바이알 - 포르텔라 앤드 씨에이 에스에이 Ｃｏｍｔ 억제제로서의 니트로카테콜 유도체
EP2388263A1 (de) * 2005-08-04 2011-11-23 Sirtris Pharmaceuticals, Inc. Imidazo[2,1-b]thiazol-Derivate als Sirtuin-Modulatoren
US7884119B2 (en) 2005-09-07 2011-02-08 Rigel Pharmaceuticals, Inc. Triazole derivatives useful as Axl inhibitors
EP1845097A1 (de) 2006-04-10 2007-10-17 Portela & Ca., S.A. Oxadiazolderivate als COMT Inihibitoren
US8088767B2 (en) 2006-09-28 2012-01-03 Exelixis, Inc. JAK-2 modulators and methods of use
MX2009003456A (es) 2006-10-02 2009-04-14 Irm Llc Compuestos y composiciones como inhibidores de proteina cinasa.
SI2848610T1 (en) * 2006-11-15 2018-02-28 Ym Biosciences Australia Pty Ltd Inhibitors of kinase activity
WO2008073480A1 (en) * 2006-12-11 2008-06-19 Irm Llc Compounds and compositions as kinase inhibitors
JP2010514810A (ja) 2006-12-29 2010-05-06 ライジェル ファーマシューティカルズ， インコーポレイテッド Ａｘｌインヒビターとして有用な置換トリアゾール
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