DK2791134T3 - Kemisk forbindelse, der er anvendelig som mellemprodukt til fremstilling af en catechol-o-methyltransferasehæmmer - Google Patents
Kemisk forbindelse, der er anvendelig som mellemprodukt til fremstilling af en catechol-o-methyltransferasehæmmer Download PDFInfo
- Publication number
- DK2791134T3 DK2791134T3 DK12806720T DK12806720T DK2791134T3 DK 2791134 T3 DK2791134 T3 DK 2791134T3 DK 12806720 T DK12806720 T DK 12806720T DK 12806720 T DK12806720 T DK 12806720T DK 2791134 T3 DK2791134 T3 DK 2791134T3
- Authority
- DK
- Denmark
- Prior art keywords
- transpherase
- catechol
- inhibitors
- methyl
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161570141P | 2011-12-13 | 2011-12-13 | |
| GBGB1121413.7A GB201121413D0 (en) | 2011-12-13 | 2011-12-13 | Chemical compounds and processes |
| US201261593625P | 2012-02-01 | 2012-02-01 | |
| GBGB1201758.8A GB201201758D0 (en) | 2012-02-01 | 2012-02-01 | Chemical compounds and processes |
| US201261718589P | 2012-10-25 | 2012-10-25 | |
| PCT/PT2012/000048 WO2013089573A1 (en) | 2011-12-13 | 2012-12-12 | Chemical compound useful as intermediate for preparing a catechol-o-methyltransferase inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2791134T3 true DK2791134T3 (da) | 2019-12-09 |
Family
ID=48612903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12806720T DK2791134T3 (da) | 2011-12-13 | 2012-12-12 | Kemisk forbindelse, der er anvendelig som mellemprodukt til fremstilling af en catechol-o-methyltransferasehæmmer |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US9126988B2 (da) |
| EP (2) | EP3604299B1 (da) |
| JP (3) | JP6456143B2 (da) |
| BR (1) | BR112014014341A2 (da) |
| CA (2) | CA2858025C (da) |
| CY (1) | CY1122580T1 (da) |
| DK (1) | DK2791134T3 (da) |
| ES (2) | ES2758659T3 (da) |
| HR (1) | HRP20192133T8 (da) |
| HU (1) | HUE047856T2 (da) |
| PL (1) | PL2791134T3 (da) |
| PT (2) | PT2791134T (da) |
| RS (1) | RS59666B1 (da) |
| SI (1) | SI2791134T1 (da) |
| WO (1) | WO2013089573A1 (da) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007013830A1 (en) | 2005-07-26 | 2007-02-01 | Portela & Ca. S.A. | Nitrocatechol derivatives as comt inhibitors |
| EP1845097A1 (en) | 2006-04-10 | 2007-10-17 | Portela & Ca., S.A. | Oxadiazole derivatives as COMT inhibitors |
| LT2481410T (lt) | 2007-01-31 | 2016-11-10 | Bial - Portela & Ca., S.A. | Nitrokatecholio dariniai kaip komt inhibitoriai vartojami konkrečiu dozavimo režimu |
| MX2010009610A (es) | 2008-03-17 | 2010-09-30 | Bial Portela & Ca Sa | Formas de cristal de 5-[3-(2,5-dicloro-4,6-dimetil-1-oxi-piridin-3 -il)-[1,2,4]oxadiazol-5-il]-3-nitrobenceno-1,2-diol. |
| CA2757411C (en) | 2009-04-01 | 2017-06-27 | Teofilo Cardoso De Vasconcelos | Pharmaceutical formulations comprising nitrocatechol derivatives and methods of making thereof |
| US20140045900A1 (en) | 2011-02-11 | 2014-02-13 | Bial-Portela & Ca, S.A. | Administration regime for nitrocatechols |
| ES2758659T3 (es) | 2011-12-13 | 2020-05-06 | BIAL PORTELA & Cª S A | Compuesto químico útil como intermediario para preparar un inhibidor de catecol-o-metiltransferasa |
| RU2017120184A (ru) | 2014-11-28 | 2018-12-28 | БИАЛ - ПОРТЕЛА ЭНД Ка, С.А. | Лекарства для замедления течения болезни паркинсона |
| GB2563858A (en) * | 2017-06-27 | 2019-01-02 | Azad Pharmaceutical Ingredients Ag | New route of synthesis for opicapone |
| AU2018392845A1 (en) * | 2017-12-18 | 2020-06-18 | Unichem Laboratories Ltd | Process for the preparation of opicapone and intermediates thereof |
| WO2020072884A1 (en) | 2018-10-05 | 2020-04-09 | Neurocrine Biosciences, Inc. | Methods for the administration of comt inhibitors |
| US20210338651A1 (en) | 2018-10-05 | 2021-11-04 | Neurocrine Biosciences, Inc. | Methods for the administration of comt inhibitors |
| CN109529881A (zh) * | 2018-11-12 | 2019-03-29 | 刘晓菊 | 一种治疗帕金森药物用中间体5-硝基香草酸的制备方法 |
| US20230147302A1 (en) | 2020-03-13 | 2023-05-11 | Bial - Portela & Ca, S.A. | Particle size control |
| GB202011709D0 (en) | 2020-07-28 | 2020-09-09 | Bial Portela & Ca Sa | Solid dispersion of opicapone |
| GB202016425D0 (en) | 2020-10-16 | 2020-12-02 | Bial Portela & Ca Sa | Treatment regimens for parkinson's disease |
| CN112375014A (zh) * | 2020-12-17 | 2021-02-19 | 重庆柳江医药科技有限公司 | 一种奥匹卡朋工艺杂质及制备方法和用途 |
| KR20230118933A (ko) | 2020-12-17 | 2023-08-14 | 바이알 - 포르텔라 앤드 씨에이 에스에이 | 초기 특발성 파킨슨병에 대한 치료 요법 |
| WO2022180649A1 (en) * | 2021-02-26 | 2022-09-01 | Msn Laboratories Private Limited, R&D Center | Novel process for the preparation of 2,5-dichloro-3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-4,6-dimethylpyridine-1-oxide |
| CN113292489B (zh) * | 2021-06-16 | 2022-08-30 | 泓博智源(开原)药业有限公司 | 二氯代二烷基烟腈的制备方法 |
| GB202204798D0 (en) | 2022-04-01 | 2022-05-18 | Bial Portela & Ca Sa | Prodrugs of opicapone |
| GB202212082D0 (en) | 2022-08-18 | 2022-10-05 | Bial Portela & Ca Sa | Treatment regimens for parkinson's disease |
Family Cites Families (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1532178A (en) | 1921-07-25 | 1925-04-07 | Louis A Godbold | Lubricator |
| FR1260080A (fr) | 1960-03-22 | 1961-05-05 | Materiel De Forage Soc De Fab | Trépan à molettes étanche |
| IL31990A (en) | 1968-04-26 | 1974-05-16 | Chinoin Gyogyszer Es Vegyeszet | Pyridyl 1,2,4-oxadiazole derivatives,process for the preparation thereof and pharmaceutical compositions containing same |
| US4022901A (en) | 1975-03-05 | 1977-05-10 | E. R. Squibb & Sons, Inc. | 3-Pyridinyl-5-isothiocyanophenyl oxadiazoles |
| US4264573A (en) | 1979-05-21 | 1981-04-28 | Rowell Laboratories, Inc. | Pharmaceutical formulation for slow release via controlled surface erosion |
| US4386668A (en) | 1980-09-19 | 1983-06-07 | Hughes Tool Company | Sealed lubricated and air cooled rock bit bearing |
| US5236952A (en) | 1986-03-11 | 1993-08-17 | Hoffmann-La Roche Inc. | Catechol derivatives |
| DK175069B1 (da) | 1986-03-11 | 2004-05-24 | Hoffmann La Roche | Pyrocatecholderivater |
| YU213587A (en) | 1986-11-28 | 1989-06-30 | Orion Yhtymae Oy | Process for obtaining new pharmacologic active cateholic derivatives |
| DE3840954A1 (de) | 1988-12-05 | 1990-06-07 | Shell Int Research | Herstellung von 2-chlornicotinsaeureestern |
| US5206372A (en) | 1990-06-05 | 1993-04-27 | Shell Research Limited | Preparation of 2-chloropyridine derivatives |
| ATE113202T1 (de) | 1990-11-29 | 1994-11-15 | Wei Ming Pharmaceutical Mfg Co | Hilfsträger für direkte verpressung. |
| CA2126976A1 (en) | 1991-12-31 | 1993-07-08 | Hisashi Takasugi | Oxadiazole derivatives having acetylcholinesterase-inhibitory and muscarinic agonist activity |
| FR2730322B1 (fr) | 1995-02-02 | 1997-04-30 | Imago | Monture de lunettes metallique |
| DE19628617A1 (de) | 1996-07-16 | 1998-01-22 | Basf Ag | Direkttablettierhilfsmittel |
| US6206110B1 (en) | 1996-09-09 | 2001-03-27 | Smith International, Inc. | Protected lubricant reservoir with pressure control for sealed bearing earth boring drill bit |
| JP2002526482A (ja) | 1998-09-18 | 2002-08-20 | バーテックス ファーマシューティカルズ インコーポレイテッド | ｐ３８のインヒビター |
| GB2344819A (en) | 1998-12-18 | 2000-06-21 | Portela & Ca Sa | 2-Phenyl-1-(3,4-dihydroxy-5-nitrophenyl)-1-ethanones |
| FI109453B (fi) | 1999-06-30 | 2002-08-15 | Orion Yhtymae Oyj | Farmaseuttinen koostumus |
| CZ2002599A3 (cs) | 1999-08-19 | 2002-06-12 | Nps Pharmaceuticals Inc. | Heteropolycyklické sloučeniny a jejich pouľití jako antagonistů metabotropního receptoru glutamátu |
| US6660753B2 (en) | 1999-08-19 | 2003-12-09 | Nps Pharmaceuticals, Inc. | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| FI20000635A0 (fi) | 2000-03-17 | 2000-03-17 | Orion Yhtymae Oyj | COMT-inhibiittoreiden käyttö analgeettina |
| SE0001438D0 (sv) | 2000-04-18 | 2000-04-18 | Axon Chemicals Bv | New chemical compounds and their use in therapy |
| DE10029201A1 (de) | 2000-06-19 | 2001-12-20 | Basf Ag | Verfahren zur Herstellung fester oraler Darreichungsformen mit retardierender Wirkstoffreisetzung |
| GB2363792A (en) | 2000-06-21 | 2002-01-09 | Portela & Ca Sa | Nitrocatechols |
| CN1166626C (zh) | 2000-08-30 | 2004-09-15 | 李凌松 | 三或四取代苯基化合物、其制备方法及应用 |
| CA2430485A1 (en) | 2000-11-28 | 2002-06-06 | Zymogenetics, Inc. | Cytonkine receptor zcytor19 |
| US20040097555A1 (en) | 2000-12-26 | 2004-05-20 | Shinegori Ohkawa | Concomitant drugs |
| EP1354603A1 (en) | 2000-12-26 | 2003-10-22 | Takeda Chemical Industries, Ltd. | Concomitant drugs |
| CN1853630A (zh) | 2001-02-21 | 2006-11-01 | Nps制药公司 | 杂多环化合物及其在亲代谢的谷氨酸受体拮抗剂中的应用 |
| JP2004534779A (ja) | 2001-05-30 | 2004-11-18 | エルジー ライフサイエンス リミテッド | 疾病治療用プロテインキナーゼ阻害剤 |
| RU2003138074A (ru) | 2001-06-08 | 2005-02-20 | Цитови Инк. (US) | Замещенные 3-арил-5-арил-[1,2,4]-оксадиазолы и их аналоги в качестве активаторов каспаз и индукторов апоптоза, а также их применение |
| US7872030B2 (en) | 2001-07-26 | 2011-01-18 | Merck Patent Gmbh | Use of 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane and its physiologically acceptable salts |
| JP4379853B2 (ja) | 2001-10-05 | 2009-12-09 | 惠民製藥股▲分▼有限公司 | 直接錠剤化用調合物および補助剤の調合方法 |
| AU2003303373B8 (en) | 2002-12-18 | 2010-06-10 | Cytovia, Inc. | 3,5-disubstituted-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| WO2005006945A2 (en) | 2003-07-03 | 2005-01-27 | The Salk Institute For Biological Studies | Methods for treating neural disorders and compounds useful therefor |
| WO2005013982A1 (en) | 2003-08-06 | 2005-02-17 | Vertex Pharmaceuticals Incorporated | Aminotriazole compounds useful as inhibitors of protein kinases |
| DE10338174A1 (de) | 2003-08-20 | 2005-03-24 | Lts Lohmann Therapie-Systeme Ag | Transdermale Arzneimittelzubereitungen mit Wirkstoffkombinationen zur Behandlung der Parkinson-Krankheit |
| US7300406B2 (en) | 2003-09-30 | 2007-11-27 | Carter Vandette B | Medical examination apparatus |
| GB0325956D0 (en) | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
| US7531556B2 (en) | 2004-04-28 | 2009-05-12 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of rock and other protein kinases |
| GB0510143D0 (en) | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds A1 |
| JP2008519811A (ja) | 2004-11-10 | 2008-06-12 | オリオン コーポレーション | 下肢静止不能症候群の治療 |
| WO2006061697A1 (en) | 2004-12-06 | 2006-06-15 | Themis Laboratories Private Limited | Sulfonylurea compositions and a process for its preparation |
| WO2006071184A1 (en) | 2004-12-28 | 2006-07-06 | Astrazeneca Ab | Aryl sulphonamide modulators |
| US20080051441A1 (en) | 2004-12-28 | 2008-02-28 | Astrazeneca Ab | Aryl Sulphonamide Modulators |
| MX2007013263A (es) | 2005-04-26 | 2008-01-22 | Neurosearch As | Novedosos derivados oxadiazol y su uso medico. |
| US20060257473A1 (en) | 2005-05-11 | 2006-11-16 | Porranee Puranajoti | Extended release tablet |
| GB0510139D0 (en) | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B1 |
| US7553964B2 (en) | 2005-06-03 | 2009-06-30 | Abbott Laboratories | Cyclobutyl amine derivatives |
| JP2007024970A (ja) | 2005-07-12 | 2007-02-01 | Miyakawa:Kk | 液晶表示装置の開口効率を上昇させるための樹脂レンズ製造法及びその製造装置 |
| US20090000437A1 (en) | 2005-07-14 | 2009-01-01 | Provo Craft And Novelty, Inc. | Methods for Cutting |
| WO2007013830A1 (en) | 2005-07-26 | 2007-02-01 | Portela & Ca. S.A. | Nitrocatechol derivatives as comt inhibitors |
| FR2889525A1 (fr) | 2005-08-04 | 2007-02-09 | Palumed Sa | Nouveaux derives de polyquinoleines et leur utilisation therapeutique. |
| US20070048384A1 (en) | 2005-08-26 | 2007-03-01 | Joerg Rosenberg | Pharmaceutical compositions |
| EP1954137A4 (en) | 2005-11-18 | 2008-12-17 | Janssen Pharmaceutica Nv | 2-KETO-OXAZOLE AS MODULATORS OF FATTY ACID AMIDHYDROLASE |
| JP4738419B2 (ja) | 2005-11-30 | 2011-08-03 | 富士フイルムＲｉファーマ株式会社 | アミロイドの凝集及び／又は沈着に起因する疾患の診断薬及び治療薬 |
| GB0606774D0 (en) | 2006-04-03 | 2006-05-10 | Novartis Ag | Organic compounds |
| EP1845097A1 (en) * | 2006-04-10 | 2007-10-17 | Portela & Ca., S.A. | Oxadiazole derivatives as COMT inhibitors |
| PE20080906A1 (es) | 2006-08-17 | 2008-07-05 | Kemia Inc | Derivados heteroarilo como inhibidores de citocina |
| US20080167286A1 (en) | 2006-12-12 | 2008-07-10 | Abbott Laboratories | Pharmaceutical compositions and their methods of use |
| US8486979B2 (en) | 2006-12-12 | 2013-07-16 | Abbvie Inc. | 1,2,4 oxadiazole compounds and methods of use thereof |
| LT2481410T (lt) * | 2007-01-31 | 2016-11-10 | Bial - Portela & Ca., S.A. | Nitrokatecholio dariniai kaip komt inhibitoriai vartojami konkrečiu dozavimo režimu |
| CA2696609C (en) | 2007-08-27 | 2017-09-05 | Helicon Therapeutics, Inc. | Therapeutic isoxazole compounds |
| KR20100126452A (ko) | 2008-02-28 | 2010-12-01 | 바이알 - 포르텔라 앤드 씨에이 에스에이 | 난용성 약물용 약학적 조성물 |
| MX2010009610A (es) * | 2008-03-17 | 2010-09-30 | Bial Portela & Ca Sa | Formas de cristal de 5-[3-(2,5-dicloro-4,6-dimetil-1-oxi-piridin-3 -il)-[1,2,4]oxadiazol-5-il]-3-nitrobenceno-1,2-diol. |
| CA2729288C (en) | 2008-07-29 | 2017-01-17 | Bial - Portela & C.A., S.A. | Administration regime for nitrocatechols |
| CA2757411C (en) | 2009-04-01 | 2017-06-27 | Teofilo Cardoso De Vasconcelos | Pharmaceutical formulations comprising nitrocatechol derivatives and methods of making thereof |
| WO2010114405A2 (en) | 2009-04-01 | 2010-10-07 | Bial - Portela & Ca., S.A. | Pharmaceutical formulations comprising nitrocatechol derivatives and methods of making the same |
| BR112012018256A8 (pt) | 2010-03-04 | 2017-12-19 | Orion Corp | método de tratamento de doença de parkinson |
| US20140045900A1 (en) | 2011-02-11 | 2014-02-13 | Bial-Portela & Ca, S.A. | Administration regime for nitrocatechols |
| ES2758659T3 (es) * | 2011-12-13 | 2020-05-06 | BIAL PORTELA & Cª S A | Compuesto químico útil como intermediario para preparar un inhibidor de catecol-o-metiltransferasa |
-
2012
- 2012-12-12 ES ES12806720T patent/ES2758659T3/es active Active
- 2012-12-12 WO PCT/PT2012/000048 patent/WO2013089573A1/en active Application Filing
- 2012-12-12 CA CA2858025A patent/CA2858025C/en active Active
- 2012-12-12 CA CA3088684A patent/CA3088684C/en active Active
- 2012-12-12 ES ES19194756T patent/ES2960805T3/es active Active
- 2012-12-12 PT PT128067204T patent/PT2791134T/pt unknown
- 2012-12-12 HU HUE12806720A patent/HUE047856T2/hu unknown
- 2012-12-12 PT PT191947563T patent/PT3604299T/pt unknown
- 2012-12-12 DK DK12806720T patent/DK2791134T3/da active
- 2012-12-12 BR BR112014014341A patent/BR112014014341A2/pt not_active Application Discontinuation
- 2012-12-12 US US14/365,265 patent/US9126988B2/en active Active
- 2012-12-12 EP EP19194756.3A patent/EP3604299B1/en active Active
- 2012-12-12 EP EP12806720.4A patent/EP2791134B1/en active Active
- 2012-12-12 SI SI201231703T patent/SI2791134T1/sl unknown
- 2012-12-12 PL PL12806720T patent/PL2791134T3/pl unknown
- 2012-12-12 JP JP2014547135A patent/JP6456143B2/ja active Active
- 2012-12-12 RS RS20191562A patent/RS59666B1/sr unknown
-
2015
- 2015-07-31 US US14/814,603 patent/US9630955B2/en active Active
-
2017
- 2017-10-27 JP JP2017207738A patent/JP6721558B2/ja active Active
-
2019
- 2019-11-27 HR HRP20192133TT patent/HRP20192133T8/hr unknown
- 2019-11-27 CY CY20191101241T patent/CY1122580T1/el unknown
- 2019-11-27 JP JP2019214566A patent/JP2020059729A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US9126988B2 (en) | 2015-09-08 |
| CA2858025A1 (en) | 2013-06-20 |
| ES2758659T3 (es) | 2020-05-06 |
| US20160009700A1 (en) | 2016-01-14 |
| HUE047856T2 (hu) | 2020-05-28 |
| SI2791134T1 (sl) | 2020-01-31 |
| CA2858025C (en) | 2020-09-22 |
| US20140350057A1 (en) | 2014-11-27 |
| PL2791134T3 (pl) | 2020-03-31 |
| JP6456143B2 (ja) | 2019-01-23 |
| EP3604299B1 (en) | 2023-07-26 |
| ES2960805T3 (es) | 2024-03-06 |
| JP2020059729A (ja) | 2020-04-16 |
| CA3088684A1 (en) | 2013-06-20 |
| WO2013089573A1 (en) | 2013-06-20 |
| CA3088684C (en) | 2021-10-26 |
| BR112014014341A2 (pt) | 2017-08-22 |
| EP3604299A1 (en) | 2020-02-05 |
| EP2791134B1 (en) | 2019-09-25 |
| PT3604299T (pt) | 2023-10-31 |
| US9630955B2 (en) | 2017-04-25 |
| RS59666B1 (sr) | 2020-01-31 |
| CY1122580T1 (el) | 2021-01-27 |
| JP6721558B2 (ja) | 2020-07-15 |
| EP2791134A1 (en) | 2014-10-22 |
| JP2015500335A (ja) | 2015-01-05 |
| HRP20192133T8 (hr) | 2021-02-19 |
| HRP20192133T1 (hr) | 2020-02-21 |
| PT2791134T (pt) | 2019-12-18 |
| JP2018052949A (ja) | 2018-04-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK2791134T3 (da) | Kemisk forbindelse, der er anvendelig som mellemprodukt til fremstilling af en catechol-o-methyltransferasehæmmer | |
| DK2693881T3 (da) | Substituerede n-phenylpyrimidin-2-amin-analoger som inhibitorer af axl-kinase | |
| SMT201600308B (it) | Composti di benzene arile-o eteroarile-sostituiti | |
| DK2678329T3 (da) | Triazolopyridinforbindelser som pim-kinase-hæmmere | |
| DK3181567T3 (da) | Pyrazolopyrimidinforbindelser som kinasehæmmere | |
| DK2916860T3 (da) | En sammensætning til behandling af diabetes, som omfatter oxyntomodulinanalog | |
| BR112014000260A2 (pt) | composto, e, uso de um composto | |
| CR20140259A (es) | Compuestos novedosos de benzopirano, composiciones y usos de los mismos | |
| DK3511330T3 (da) | Syntetisk mellemprodukt, der er anvendeligt til fremstilling af triazolopyridin-c-met-inhibitorer | |
| DK3196202T3 (da) | Heterocyclylaminer som pi3k-inhibitorer | |
| DK3269802T3 (da) | Forbindelser til forbedret virustransduktion | |
| DK2710018T3 (da) | Makrocykliske forbindelser som proteinkinasehæmmere | |
| BR112014029530A2 (pt) | compostos, composição farmacêutica e uso de um composto | |
| DK3520805T3 (da) | Sammensætninger til behandling af myelofibrose | |
| DK2470546T3 (da) | HEXAHYDROOXAZINOPTERIDIN- forbindelser til anvendelse som mTOR INHIBITORER | |
| SMT201600328B (it) | Nuovi composti come inibitori di diacilglicerolo aciltransferasi | |
| DK2714922T3 (da) | Fremgangsmåde til detektering af mikroorganismer, der er resistente over for et terapeutisk middel | |
| DK2665486T3 (da) | Sammensætninger til modulering af gamma-c-cytokin-aktivitet | |
| BR112014005669A2 (pt) | composto, composição farmacêutica e uso de um composto | |
| DK2658851T3 (da) | Heterocykliske forbindelser, som er egnede til behandling af dyslipidæmi | |
| DK3181133T3 (da) | Nye kondenserede pyridinforbindelser som casein-kinasehæmmere | |
| DK3233843T3 (da) | Isoxazol-hydraxamsyreforbindelser som LPXC-hæmmere | |
| BR112014011685A2 (pt) | composto, utilização de um composto e método | |
| CO6960548A2 (es) | Polimorfos de arry-380, un inhibidor selectivo de herb2 y composiciones farmacéuticas que los contienen | |
| BR112013029206A2 (pt) | composto, e, uso de um composto |