ATE443706T1 - Pyrrolotriazinverbindungen als kinaseinhibitoren - Google Patents
Pyrrolotriazinverbindungen als kinaseinhibitorenInfo
- Publication number
- ATE443706T1 ATE443706T1 AT04815269T AT04815269T ATE443706T1 AT E443706 T1 ATE443706 T1 AT E443706T1 AT 04815269 T AT04815269 T AT 04815269T AT 04815269 T AT04815269 T AT 04815269T AT E443706 T1 ATE443706 T1 AT E443706T1
- Authority
- AT
- Austria
- Prior art keywords
- kinase inhibitors
- pyrrolotriazine compounds
- pyrrolotriazine
- compounds
- kinase
- Prior art date
Links
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 150000003921 pyrrolotriazines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53333503P | 2003-12-29 | 2003-12-29 | |
| PCT/US2004/043169 WO2005066176A1 (en) | 2003-12-29 | 2004-12-23 | Pyrrolotriazine compounds as kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE443706T1 true ATE443706T1 (de) | 2009-10-15 |
Family
ID=34748887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04815269T ATE443706T1 (de) | 2003-12-29 | 2004-12-23 | Pyrrolotriazinverbindungen als kinaseinhibitoren |
Country Status (31)
| Country | Link |
|---|---|
| US (4) | US7141571B2 (de) |
| EP (2) | EP1699797B1 (de) |
| JP (1) | JP4740878B2 (de) |
| KR (1) | KR100839716B1 (de) |
| CN (1) | CN1922182B (de) |
| AR (1) | AR047076A1 (de) |
| AT (1) | ATE443706T1 (de) |
| AU (1) | AU2004312413C1 (de) |
| BR (1) | BRPI0418231A (de) |
| CA (1) | CA2552107C (de) |
| CL (1) | CL2009001492A1 (de) |
| CY (1) | CY1109662T1 (de) |
| DE (1) | DE602004023324D1 (de) |
| DK (1) | DK1699797T3 (de) |
| ES (1) | ES2331842T3 (de) |
| GE (1) | GEP20105081B (de) |
| HR (1) | HRP20090601T1 (de) |
| IL (1) | IL176450A0 (de) |
| MX (1) | MXPA06007038A (de) |
| MY (1) | MY145634A (de) |
| NO (1) | NO20062763L (de) |
| NZ (2) | NZ548070A (de) |
| PE (1) | PE20050679A1 (de) |
| PL (1) | PL1699797T3 (de) |
| PT (1) | PT1699797E (de) |
| RU (1) | RU2373209C2 (de) |
| SI (1) | SI1699797T1 (de) |
| TW (1) | TWI332840B (de) |
| UA (1) | UA89038C2 (de) |
| WO (1) | WO2005066176A1 (de) |
| ZA (1) | ZA200605160B (de) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6867300B2 (en) * | 2000-11-17 | 2005-03-15 | Bristol-Myers Squibb Company | Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors |
| BR0309669A (pt) * | 2002-04-23 | 2005-03-01 | Bristol Myers Squibb Co | Compostos de anilina de pirrolo-triazina úteis como inibidores de cinase |
| US20060014741A1 (en) * | 2003-12-12 | 2006-01-19 | Dimarco John D | Synthetic process, and crystalline forms of a pyrrolotriazine compound |
| MY145634A (en) * | 2003-12-29 | 2012-03-15 | Bristol Myers Squibb Co | Pyrrolotriazine compounds as kinase inhibitors |
| US7102002B2 (en) | 2004-06-16 | 2006-09-05 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| US7173031B2 (en) * | 2004-06-28 | 2007-02-06 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| TW200600513A (en) * | 2004-06-30 | 2006-01-01 | Bristol Myers Squibb Co | A method for preparing pyrrolotriazine compounds |
| US7253167B2 (en) * | 2004-06-30 | 2007-08-07 | Bristol-Myers Squibb Company | Tricyclic-heteroaryl compounds useful as kinase inhibitors |
| US7504521B2 (en) * | 2004-08-05 | 2009-03-17 | Bristol-Myers Squibb Co. | Methods for the preparation of pyrrolotriazine compounds |
| US7148348B2 (en) | 2004-08-12 | 2006-12-12 | Bristol-Myers Squibb Company | Process for preparing pyrrolotriazine aniline compounds useful as kinase inhibitors |
| TW200635927A (en) * | 2004-12-22 | 2006-10-16 | Bristol Myers Squibb Co | Synthetic process |
| ES2319462T3 (es) | 2005-03-28 | 2009-05-07 | Bristol-Myers Squibb Company | Inhibidores competitivos de atp cinasas. |
| US20060235020A1 (en) * | 2005-04-18 | 2006-10-19 | Soojin Kim | Process for preparing salts of 4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide and novel stable forms produced therein |
| MY150958A (en) | 2005-06-16 | 2014-03-31 | Astrazeneca Ab | Compounds for the treatment of multi-drug resistant bacterial infections |
| JP5193876B2 (ja) * | 2005-12-02 | 2013-05-08 | バイエル・ヘルスケア・エルエルシー | オーロラキナーゼの阻害により癌を処置するために有用なピロロトリアジン誘導体 |
| US8063208B2 (en) * | 2006-02-16 | 2011-11-22 | Bristol-Myers Squibb Company | Crystalline forms of (3R,4R)-4-amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol |
| WO2008057863A1 (en) * | 2006-11-01 | 2008-05-15 | Bristol-Myers Squibb Company | Therapeutic combination of a panher/vegfr2 kinase inhibitor and a platinum compound |
| US7820421B2 (en) | 2007-02-08 | 2010-10-26 | Codexis, Inc. | Ketoreductases and uses thereof |
| US20090076034A1 (en) * | 2007-09-14 | 2009-03-19 | Protia, Llc | Deuterium-enriched bms-690514 |
| PL2231662T3 (pl) * | 2007-12-19 | 2011-11-30 | Genentech Inc | 8-anilinoimidazopirydyny oraz ich zastosowanie jako czynników przeciwnowotworowych i/lub przeciwzapalnych |
| JP2010209058A (ja) * | 2008-09-29 | 2010-09-24 | Sumitomo Chemical Co Ltd | １−置換−トランス−４−（置換アミノ）ピペリジン−３−オールの製造方法 |
| CN102245610B (zh) * | 2008-10-08 | 2014-04-30 | 百时美施贵宝公司 | 吡咯并三嗪激酶抑制剂 |
| WO2010071885A1 (en) | 2008-12-19 | 2010-06-24 | Cephalon, Inc. | Pyrrolotriazines as alk and jak2 inhibitors |
| US8716280B2 (en) | 2009-01-21 | 2014-05-06 | Basilea Pharmaceutica Ag | Bicyclic antibiotics |
| KR20120065321A (ko) * | 2009-07-28 | 2012-06-20 | 우베 고산 가부시키가이샤 | 피롤로〔2,3-ｄ〕피리미딘 유도체 |
| ES2550667T3 (es) | 2010-02-18 | 2015-11-11 | Vtv Therapeutics Llc | Derivados de fenilheteroarilo y métodos de uso de los mismos |
| PL2589592T3 (pl) | 2010-06-30 | 2019-03-29 | Fujifilm Corporation | Nowe pochodne nikotynamidu lub ich sole |
| CN102153558B (zh) * | 2011-02-23 | 2012-11-21 | 扬州永济医药新技术有限公司 | 多靶点抗肿瘤抑制剂2-氨吡咯-三嗪的衍生物及其合成方法 |
| DE102011119127A1 (de) * | 2011-11-22 | 2013-05-23 | Merck Patent Gmbh | 3-Cyanaryl-1H-pyrrolo[2.3-b]pyridin-Derivate |
| US9724352B2 (en) | 2012-05-31 | 2017-08-08 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Pyrrolo[2,1-F[1,2,4]triazine compounds, preparation methods and applications thereof |
| CN103450204B (zh) | 2012-05-31 | 2016-08-17 | 中国科学院上海药物研究所 | 吡咯[2，1-f][1，2，4]并三嗪类化合物，其制备方法及用途 |
| TW201414737A (zh) | 2012-07-13 | 2014-04-16 | 必治妥美雅史谷比公司 | 作爲激酶抑制劑之咪唑并三□甲腈 |
| JP6473146B2 (ja) | 2013-10-11 | 2019-02-20 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | ピロロトリアジンキナーゼ阻害剤 |
| PT3466955T (pt) * | 2014-01-13 | 2021-01-29 | Aurigene Discovery Tech Ltd | Método de preparação de derivados de oxazolo[4,5-b] piridina e tiazolo[4,5-b] piridina como inibidores de irak-4 para o tratamento do cancro |
| US9459267B2 (en) * | 2014-05-12 | 2016-10-04 | Quest Diagnostics Investments Incorporated | Quantitation of tamoxifen and metabolites thereof by mass spectrometry |
| AR112027A1 (es) | 2017-06-15 | 2019-09-11 | Biocryst Pharm Inc | Inhibidores de alk 2 quinasa que contienen imidazol |
| CN112105618B (zh) * | 2018-05-08 | 2022-05-31 | 南京明德新药研发有限公司 | 作为选择性HER2抑制剂的吡咯并[2,1-f][1,2,4]三嗪类衍生物及其应用 |
| SI3953357T1 (sl) | 2019-04-12 | 2024-08-30 | Blueprint Medicines Corporation | Pirolotriazinski derivati za zdravljenje bolezni, posredovanih s KIT in PDGFRA |
| WO2021088987A1 (zh) * | 2019-11-08 | 2021-05-14 | 南京明德新药研发有限公司 | 作为选择性her2抑制剂的盐型、晶型及其应用 |
| EP4200301B1 (de) * | 2020-08-24 | 2025-02-26 | Gilead Sciences, Inc. | Phospholipidverbindungen und verwendungen davon |
| WO2024044570A1 (en) * | 2022-08-22 | 2024-02-29 | Iambic Therapeutics, Inc. | Compounds and methods for modulating her2 |
| US20250345339A1 (en) * | 2024-02-20 | 2025-11-13 | Iambic Therapeutics, Inc. | Doses and regimens of her2 inhibitors |
| CN120271495B (zh) * | 2025-06-12 | 2025-09-19 | 成都道合尔医药技术有限公司 | 一种(3r,4r)-n-pg-4-氨基-3-甲基哌啶的合成方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ283281B6 (cs) * | 1992-09-25 | 1998-02-18 | Eli Lilly And Company | Způsob přípravy v poloze 5 substituovaných pyrrolo(2,3-d)pyrimidinů |
| CA2163399A1 (en) | 1994-11-24 | 1996-05-25 | Katsuhiro Kawano | Triazine derivative, chymase activity inhibitor and nitric oxide production inhibitor |
| ES2273369T3 (es) | 1996-08-28 | 2007-05-01 | Pfizer Inc. | Derivados 6,5 heterobiciclicos sustituidos. |
| ES2258459T3 (es) | 1999-05-21 | 2006-09-01 | Bristol-Myers Squibb Company | Pirrolotriazinas inhibidoras de quinasas. |
| US6982265B1 (en) | 1999-05-21 | 2006-01-03 | Bristol Myers Squibb Company | Pyrrolotriazine inhibitors of kinases |
| WO2001014378A1 (en) | 1999-08-23 | 2001-03-01 | Shionogi & Co., Ltd. | PYRROLOTRIAZINE DERIVATIVES HAVING sPLA2-INHIBITORY ACTIVITIES |
| US6670357B2 (en) | 2000-11-17 | 2003-12-30 | Bristol-Myers Squibb Company | Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors |
| US6867300B2 (en) | 2000-11-17 | 2005-03-15 | Bristol-Myers Squibb Company | Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors |
| DK1363910T3 (da) | 2000-11-17 | 2006-06-26 | Bristol Myers Squibb Co | Fremgangsmåder til behandling af P39-kinase-associerede tilstande og pyrrolotriazinforbindelser, der er anvendelige som kinase-inhibitorer |
| TW200300350A (en) | 2001-11-14 | 2003-06-01 | Bristol Myers Squibb Co | C-5 modified indazolylpyrrolotriazines |
| BR0309669A (pt) | 2002-04-23 | 2005-03-01 | Bristol Myers Squibb Co | Compostos de anilina de pirrolo-triazina úteis como inibidores de cinase |
| WO2003091229A1 (en) | 2002-04-23 | 2003-11-06 | Bristol-Myers Squibb Company | Aryl ketone pyrrolo-triazine compounds useful as kinase inhibitors |
| US6894066B2 (en) | 2002-05-09 | 2005-05-17 | Bernard Charles Sherman | Magnesium salt of S-omeprazole |
| TW200407143A (en) | 2002-05-21 | 2004-05-16 | Bristol Myers Squibb Co | Pyrrolotriazinone compounds and their use to treat diseases |
| TWI329112B (en) | 2002-07-19 | 2010-08-21 | Bristol Myers Squibb Co | Novel inhibitors of kinases |
| US6933386B2 (en) | 2002-07-19 | 2005-08-23 | Bristol Myers Squibb Company | Process for preparing certain pyrrolotriazine compounds |
| US6951859B2 (en) | 2002-08-02 | 2005-10-04 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| TW200420565A (en) | 2002-12-13 | 2004-10-16 | Bristol Myers Squibb Co | C-6 modified indazolylpyrrolotriazines |
| US7102001B2 (en) | 2003-12-12 | 2006-09-05 | Bristol-Myers Squibb Company | Process for preparing pyrrolotriazine |
| MY145634A (en) * | 2003-12-29 | 2012-03-15 | Bristol Myers Squibb Co | Pyrrolotriazine compounds as kinase inhibitors |
| US7064203B2 (en) * | 2003-12-29 | 2006-06-20 | Bristol Myers Squibb Company | Di-substituted pyrrolotriazine compounds |
| US7102002B2 (en) | 2004-06-16 | 2006-09-05 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| US7102003B2 (en) | 2004-07-01 | 2006-09-05 | Bristol-Myers Squibb Company | Pyrrolotriazine compounds |
| US7151176B2 (en) | 2004-10-21 | 2006-12-19 | Bristol-Myers Squibb Company | Pyrrolotriazine compounds |
-
2004
- 2004-12-09 MY MYPI20045093A patent/MY145634A/en unknown
- 2004-12-22 US US11/019,901 patent/US7141571B2/en not_active Expired - Lifetime
- 2004-12-22 TW TW093140035A patent/TWI332840B/zh not_active IP Right Cessation
- 2004-12-23 PT PT04815269T patent/PT1699797E/pt unknown
- 2004-12-23 DK DK04815269T patent/DK1699797T3/da active
- 2004-12-23 UA UAA200608400A patent/UA89038C2/ru unknown
- 2004-12-23 PL PL04815269T patent/PL1699797T3/pl unknown
- 2004-12-23 GE GEAP20049544A patent/GEP20105081B/en unknown
- 2004-12-23 ES ES04815269T patent/ES2331842T3/es not_active Expired - Lifetime
- 2004-12-23 AU AU2004312413A patent/AU2004312413C1/en not_active Ceased
- 2004-12-23 JP JP2006547328A patent/JP4740878B2/ja not_active Expired - Fee Related
- 2004-12-23 WO PCT/US2004/043169 patent/WO2005066176A1/en not_active Ceased
- 2004-12-23 CN CN2004800421984A patent/CN1922182B/zh not_active Expired - Fee Related
- 2004-12-23 NZ NZ548070A patent/NZ548070A/en unknown
- 2004-12-23 NZ NZ573544A patent/NZ573544A/en unknown
- 2004-12-23 EP EP04815269A patent/EP1699797B1/de not_active Expired - Lifetime
- 2004-12-23 EP EP09153694A patent/EP2058314A1/de not_active Withdrawn
- 2004-12-23 AT AT04815269T patent/ATE443706T1/de active
- 2004-12-23 MX MXPA06007038A patent/MXPA06007038A/es active IP Right Grant
- 2004-12-23 HR HR20090601T patent/HRP20090601T1/hr unknown
- 2004-12-23 SI SI200431286T patent/SI1699797T1/sl unknown
- 2004-12-23 BR BRPI0418231-6A patent/BRPI0418231A/pt not_active IP Right Cessation
- 2004-12-23 RU RU2006127396/04A patent/RU2373209C2/ru not_active IP Right Cessation
- 2004-12-23 DE DE602004023324T patent/DE602004023324D1/de not_active Expired - Lifetime
- 2004-12-23 CA CA2552107A patent/CA2552107C/en not_active Expired - Fee Related
- 2004-12-23 KR KR1020067012936A patent/KR100839716B1/ko not_active Expired - Fee Related
- 2004-12-29 AR ARP040104947A patent/AR047076A1/es not_active Application Discontinuation
-
2005
- 2005-01-03 PE PE2005000015A patent/PE20050679A1/es not_active Application Discontinuation
-
2006
- 2006-06-13 NO NO20062763A patent/NO20062763L/no not_active Application Discontinuation
- 2006-06-20 IL IL176450A patent/IL176450A0/en unknown
- 2006-06-22 ZA ZA200605160A patent/ZA200605160B/en unknown
- 2006-06-26 US US11/426,479 patent/US7297695B2/en not_active Expired - Lifetime
-
2008
- 2008-09-24 US US11/869,910 patent/US7846931B2/en not_active Expired - Lifetime
-
2009
- 2009-06-26 CL CL2009001492A patent/CL2009001492A1/es unknown
- 2009-12-21 CY CY20091101326T patent/CY1109662T1/el unknown
-
2010
- 2010-10-25 US US12/911,299 patent/US20110039838A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE443706T1 (de) | Pyrrolotriazinverbindungen als kinaseinhibitoren | |
| DE602004025258D1 (de) | Aminotriazol-verbindungen als proteinkinase-hemmer | |
| ATE452891T1 (de) | Pyrimidopyrimidone als kinaseinhibitoren | |
| ATE404564T1 (de) | Diazepinoindolderivate als kinaseinhibitoren | |
| ATE418546T1 (de) | Als kinase inhibitoren geeignete arylketonpyrrolotriazin-verbindungen | |
| ATE437876T1 (de) | Hexahydropyridoisochinoline als dpp-iv- inhibitoren | |
| ATE520671T1 (de) | Pyrimidin-harnstoff-derivate als kinase-hemmer | |
| DE602005020465D1 (de) | Enantiomerenreine aminoheteroaryl-verbindungen als proteinkinasehemmer | |
| DE60313872D1 (de) | Pyrazoloä1,5-aüpyrimidine als hemmstoffe cyclin-abhängiger kinasen | |
| DK1605897T3 (da) | Polyethelen-glycol-link-glp-1-forbindelser | |
| ATE478868T1 (de) | Pyrrolodihydroisochinoline als pde10- inhibitoren | |
| SE0301569D0 (sv) | Novel compounds | |
| IS8108A (is) | Ný efnasambönd | |
| ECSP066436A (es) | Compuestos heterociclicos fusionados | |
| ATE411306T1 (de) | Biarylsulfonamide als mmp-inhibitoren | |
| DE602004026905D1 (de) | 2-aminoaryloxazol-verbindungen als tyrosinkinase-hemmer | |
| DE502004006055D1 (de) | 6-arylamino-5-cyano-4-pyrimidinone als pde9a-inhibitoren | |
| IS8228A (is) | Ný asetídínefnasambönd | |
| ATE455768T1 (de) | Triazolsubstituierte aminobenzophenonverbindungen | |
| IS8089A (is) | Efnasambönd | |
| IS8292A (is) | Ný efnasambönd | |
| ATE411027T1 (de) | Benzazepin-derivate als mao-b-hemmer | |
| DE60328233D1 (de) | Sulfamatbenzothiophenderivate als steroidsulfataseinhibitoren | |
| NO20031736D0 (no) | Forbindelser | |
| NO20033173D0 (no) | Forbindelser |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1699797 Country of ref document: EP |