BR0309669A - Compostos de anilina de pirrolo-triazina úteis como inibidores de cinase - Google Patents

Compostos de anilina de pirrolo-triazina úteis como inibidores de cinase

Info

Publication number
BR0309669A
BR0309669A BR0309669-6A BR0309669A BR0309669A BR 0309669 A BR0309669 A BR 0309669A BR 0309669 A BR0309669 A BR 0309669A BR 0309669 A BR0309669 A BR 0309669A
Authority
BR
Brazil
Prior art keywords
kinase inhibitors
pyrrolo
compounds useful
aniline compounds
triazine
Prior art date
Application number
BR0309669-6A
Other languages
English (en)
Inventor
Alaric Dyckman
John Hynes
Katherina Leftheris
Chunjian Liu
Stephen T Wrobleski
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of BR0309669A publication Critical patent/BR0309669A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
    • C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines

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  • Health & Medical Sciences (AREA)
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Abstract

"COMPOSTOS DE ANILINA DE PIRROLO-TRIAZINA úTEIS COMO INIBIDORES DE CINASE". A presente invenção refere-se a compostos tendo a fórmula (1), e sais farmaceuticamente aceitáveis, pró-drogas, e solvatos dos mesmos, são úteis como inibidores de cinase, em que R~ 1~, R~ 2~, R~ 3~, R~ 4~, R~ 5~, R~ 6~, X e Z são como descritos no relatório descritivo.
BR0309669-6A 2002-04-23 2003-04-15 Compostos de anilina de pirrolo-triazina úteis como inibidores de cinase BR0309669A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37493802P 2002-04-23 2002-04-23
PCT/US2003/012426 WO2003090912A1 (en) 2002-04-23 2003-04-15 Pyrrolo-triazine aniline compounds useful as kinase inhibitors

Publications (1)

Publication Number Publication Date
BR0309669A true BR0309669A (pt) 2005-03-01

Family

ID=29270573

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0309669-6A BR0309669A (pt) 2002-04-23 2003-04-15 Compostos de anilina de pirrolo-triazina úteis como inibidores de cinase

Country Status (30)

Country Link
US (5) US7160883B2 (pt)
EP (2) EP2289894A3 (pt)
JP (2) JP4669225B2 (pt)
KR (1) KR101025675B1 (pt)
CN (2) CN102093363B (pt)
AR (1) AR039649A1 (pt)
AU (1) AU2003231034B2 (pt)
BR (1) BR0309669A (pt)
CA (1) CA2483164C (pt)
DK (1) DK1497019T3 (pt)
ES (1) ES2543711T3 (pt)
GE (1) GEP20074148B (pt)
HR (1) HRP20040988A2 (pt)
HU (1) HUE025353T2 (pt)
IL (2) IL164573A (pt)
IS (1) IS7505A (pt)
MX (1) MXPA04010379A (pt)
MY (1) MY132094A (pt)
NO (1) NO329503B1 (pt)
NZ (1) NZ536014A (pt)
PE (1) PE20040590A1 (pt)
PL (1) PL219736B1 (pt)
PT (1) PT1497019E (pt)
RS (1) RS92004A (pt)
RU (1) RU2375363C2 (pt)
SI (1) SI1497019T1 (pt)
TW (1) TWI312782B (pt)
UA (1) UA78562C2 (pt)
WO (1) WO2003090912A1 (pt)
ZA (1) ZA200408541B (pt)

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TW200400034A (en) 2002-05-20 2004-01-01 Bristol Myers Squibb Co Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors
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US7459562B2 (en) * 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
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US7432373B2 (en) * 2004-06-28 2008-10-07 Bristol-Meyers Squibb Company Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors
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PE20060421A1 (es) * 2004-08-12 2006-06-01 Bristol Myers Squibb Co Procedimiento para preparar un compuesto de pirrolotriazina anilina como inhibidores de cinasa
US7151176B2 (en) * 2004-10-21 2006-12-19 Bristol-Myers Squibb Company Pyrrolotriazine compounds
ATE480542T1 (de) * 2004-10-26 2010-09-15 Novartis Ag Pyrroloä1,2-düä1,2-4ütriazin als inhibitoren von c-jun-n-terminal-kinasen (jnk) und p-38-kinasen
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