UA89038C2 - Pyrrolotriazine compounds as kinase inhibitors - Google Patents

Pyrrolotriazine compounds as kinase inhibitors

Info

Publication number
UA89038C2
UA89038C2 UAA200608400A UAA200608400A UA89038C2 UA 89038 C2 UA89038 C2 UA 89038C2 UA A200608400 A UAA200608400 A UA A200608400A UA A200608400 A UAA200608400 A UA A200608400A UA 89038 C2 UA89038 C2 UA 89038C2
Authority
UA
Ukraine
Prior art keywords
compounds
formula
kinase inhibitors
useful
growth factor
Prior art date
Application number
UAA200608400A
Other languages
English (en)
Ukrainian (uk)
Inventor
Брайен Е. Финк
Ашвиникумар В. Гаваи
Григори Д. Вайт
Пинг Чен
Гарольд Масталерц
Дерек Дж. Норрис
Джон С. Токарски
Юфен Жао
Вен-Чинг Хан
Original Assignee
Бристол-Майэрс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бристол-Майэрс Сквибб Компани filed Critical Бристол-Майэрс Сквибб Компани
Publication of UA89038C2 publication Critical patent/UA89038C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Данное изобретение обеспечивает соединения формулы () и их фармацевтически приемлемые соли. Соединения формулы () ингибируют активность тирозинкиназы рецепторов фактора роста, таких как HER1, HER2 и HER4, что делает их полезными в роли антипролиферативных агентов. Соединения формулы () также являются полезными для лечения других заболеваний, связанных с путями преобразования сигнала, которые привлекают рецепторы фактора роста.
UAA200608400A 2003-12-29 2004-12-23 Pyrrolotriazine compounds as kinase inhibitors UA89038C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53333503P 2003-12-29 2003-12-29

Publications (1)

Publication Number Publication Date
UA89038C2 true UA89038C2 (en) 2009-12-25

Family

ID=34748887

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200608400A UA89038C2 (en) 2003-12-29 2004-12-23 Pyrrolotriazine compounds as kinase inhibitors

Country Status (32)

Country Link
US (4) US7141571B2 (ru)
EP (2) EP2058314A1 (ru)
JP (1) JP4740878B2 (ru)
KR (1) KR100839716B1 (ru)
CN (1) CN1922182B (ru)
AR (1) AR047076A1 (ru)
AT (1) ATE443706T1 (ru)
AU (1) AU2004312413C1 (ru)
BR (1) BRPI0418231A (ru)
CA (1) CA2552107C (ru)
CL (1) CL2009001492A1 (ru)
CY (1) CY1109662T1 (ru)
DE (1) DE602004023324D1 (ru)
DK (1) DK1699797T3 (ru)
ES (1) ES2331842T3 (ru)
GE (1) GEP20105081B (ru)
HK (1) HK1088332A1 (ru)
HR (1) HRP20090601T1 (ru)
IL (1) IL176450A0 (ru)
MX (1) MXPA06007038A (ru)
MY (1) MY145634A (ru)
NO (1) NO20062763L (ru)
NZ (2) NZ548070A (ru)
PE (1) PE20050679A1 (ru)
PL (1) PL1699797T3 (ru)
PT (1) PT1699797E (ru)
RU (1) RU2373209C2 (ru)
SI (1) SI1699797T1 (ru)
TW (1) TWI332840B (ru)
UA (1) UA89038C2 (ru)
WO (1) WO2005066176A1 (ru)
ZA (1) ZA200605160B (ru)

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US8445676B2 (en) * 2008-10-08 2013-05-21 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
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CN102482281A (zh) * 2009-07-28 2012-05-30 宇部兴产株式会社 吡咯并[2，3-d]嘧啶衍生物
ES2550667T3 (es) 2010-02-18 2015-11-11 Vtv Therapeutics Llc Derivados de fenilheteroarilo y métodos de uso de los mismos
MX2012015023A (es) 2010-06-30 2013-04-03 Fujifilm Corp Derivado novedoso de nicotinamida o sal del mismo.
CN102153558B (zh) * 2011-02-23 2012-11-21 扬州永济医药新技术有限公司 多靶点抗肿瘤抑制剂2-氨吡咯-三嗪的衍生物及其合成方法
DE102011119127A1 (de) * 2011-11-22 2013-05-23 Merck Patent Gmbh 3-Cyanaryl-1H-pyrrolo[2.3-b]pyridin-Derivate
CN103450204B (zh) 2012-05-31 2016-08-17 中国科学院上海药物研究所 吡咯[2，1-f][1，2，4]并三嗪类化合物，其制备方法及用途
US9724352B2 (en) 2012-05-31 2017-08-08 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Pyrrolo[2,1-F[1,2,4]triazine compounds, preparation methods and applications thereof
TW201414737A (zh) 2012-07-13 2014-04-16 必治妥美雅史谷比公司 作爲激酶抑制劑之咪唑并三□甲腈
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Also Published As

Publication number Publication date
CN1922182A (zh) 2007-02-28
WO2005066176A1 (en) 2005-07-21
SI1699797T1 (sl) 2010-04-30
IL176450A0 (en) 2006-10-05
US20060264438A1 (en) 2006-11-23
CY1109662T1 (el) 2014-08-13
RU2373209C2 (ru) 2009-11-20
NZ548070A (en) 2009-02-28
US20050182058A1 (en) 2005-08-18
AR047076A1 (es) 2006-01-04
EP1699797B1 (en) 2009-09-23
JP4740878B2 (ja) 2011-08-03
CN1922182B (zh) 2010-08-18
ATE443706T1 (de) 2009-10-15
PT1699797E (pt) 2009-12-29
CA2552107A1 (en) 2005-07-21
US7141571B2 (en) 2006-11-28
MXPA06007038A (es) 2006-08-31
NZ573544A (en) 2010-04-30
MY145634A (en) 2012-03-15
HRP20090601T1 (hr) 2009-12-31
PE20050679A1 (es) 2005-09-25
US20090048244A1 (en) 2009-02-19
GEP20105081B (en) 2010-09-27
US20110039838A1 (en) 2011-02-17
NO20062763L (no) 2006-09-11
EP2058314A1 (en) 2009-05-13
US7297695B2 (en) 2007-11-20
TW200526226A (en) 2005-08-16
DK1699797T3 (da) 2010-01-04
CL2009001492A1 (es) 2010-01-15
AU2004312413C1 (en) 2011-01-27
TWI332840B (en) 2010-11-11
KR20060107828A (ko) 2006-10-16
CA2552107C (en) 2011-10-18
BRPI0418231A (pt) 2007-04-27
US7846931B2 (en) 2010-12-07
AU2004312413A1 (en) 2005-07-21
EP1699797A1 (en) 2006-09-13
ES2331842T3 (es) 2010-01-18
JP2007518721A (ja) 2007-07-12
DE602004023324D1 (de) 2009-11-05
KR100839716B1 (ko) 2008-06-19
ZA200605160B (en) 2007-12-27
RU2006127396A (ru) 2008-02-10
PL1699797T3 (pl) 2010-02-26
HK1088332A1 (en) 2006-11-03
AU2004312413B2 (en) 2010-07-22

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