MXPA06009475A - Derivados de quinazolina y usos terapeuticos de los mismos. - Google Patents

Derivados de quinazolina y usos terapeuticos de los mismos.

Info

Publication number
MXPA06009475A
MXPA06009475A MXPA06009475A MXPA06009475A MXPA06009475A MX PA06009475 A MXPA06009475 A MX PA06009475A MX PA06009475 A MXPA06009475 A MX PA06009475A MX PA06009475 A MXPA06009475 A MX PA06009475A MX PA06009475 A MXPA06009475 A MX PA06009475A
Authority
MX
Mexico
Prior art keywords
quinazoline derivatives
therapeutic use
compounds
treatment
disclosed
Prior art date
Application number
MXPA06009475A
Other languages
English (en)
Inventor
Young Bok Lee
Chang Ho Ahn
Original Assignee
Rexahn Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34886161&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MXPA06009475(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rexahn Corp filed Critical Rexahn Corp
Publication of MXPA06009475A publication Critical patent/MXPA06009475A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

Se describen derivados de quinazolina representados por la formula general, sales farmacologicamente aceptables de los mismos, y composiciones que contienen a dichos compuestos. Tambien se describen metodos para utilizar los compuestos para el tratamiento de trastornos hiperproliferativos.
MXPA06009475A 2004-02-19 2005-02-17 Derivados de quinazolina y usos terapeuticos de los mismos. MXPA06009475A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54548704P 2004-02-19 2004-02-19
PCT/US2005/005151 WO2005080352A2 (en) 2004-02-19 2005-02-17 Quinazoline derivatives and therapeutic use thereof

Publications (1)

Publication Number Publication Date
MXPA06009475A true MXPA06009475A (es) 2007-05-15

Family

ID=34886161

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA06009475A MXPA06009475A (es) 2004-02-19 2005-02-17 Derivados de quinazolina y usos terapeuticos de los mismos.

Country Status (11)

Country Link
US (2) US7388014B2 (es)
EP (2) EP2650286A1 (es)
JP (1) JP4934432B2 (es)
KR (1) KR100942865B1 (es)
CN (1) CN1956966B (es)
AU (1) AU2005214373B2 (es)
BR (1) BRPI0507903A (es)
CA (1) CA2557433C (es)
ES (1) ES2554330T3 (es)
MX (1) MXPA06009475A (es)
WO (1) WO2005080352A2 (es)

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WO2007133773A2 (en) * 2006-05-15 2007-11-22 Senex Biotechnology, Inc Identification of cdki pathway inhibitors
WO2008124823A1 (en) * 2007-04-10 2008-10-16 Myriad Genetics, Inc. Method of treating melanoma
CN101120945B (zh) * 2007-07-30 2010-11-24 浙江大学 8-芳胺基-3H-咪唑[4,5-g]喹唑啉类衍生物的用途
PH12012500097A1 (en) * 2009-07-21 2011-01-27 Shanghai Inst Organic Chem Potent small molecule inhibitors of autophagy, and methods of use thereof
US9242991B2 (en) * 2010-07-14 2016-01-26 Betta Pharmaceuticals Co., Ltd Substituted fused heterocycles as c-Met tyrosine kinase inhibitors
SG11201401343YA (en) * 2011-09-13 2014-08-28 Igor Roninson TREATMENT OF DISEASE OR DISORDERS CAUSED BY INDUCED NFkB TRANSCRIPTIONAL ACTIVITY
CN103086984A (zh) * 2011-11-03 2013-05-08 南京大学 一类4-苯氨基喹唑啉类衍生物及其制备方法与用途
WO2013135671A1 (en) 2012-03-13 2013-09-19 Basf Se Fungicidal pyrimidine compounds
CN102659692B (zh) 2012-05-04 2014-04-09 郑州泰基鸿诺药物科技有限公司 双联厄洛替尼及其制备方法
CN102875570B (zh) * 2012-10-23 2015-11-04 浙江大学 喹唑啉衍生物及其制备方法和用途
CN105407894A (zh) 2013-03-14 2016-03-16 康威基内有限公司 用于抑制含布罗莫结构域的蛋白质的方法和组合物
US20160221964A1 (en) 2013-09-16 2016-08-04 Basf Se Fungicidal pyrimidine compounds
WO2015036059A1 (en) 2013-09-16 2015-03-19 Basf Se Fungicidal pyrimidine compounds
EP3046917B1 (en) * 2013-09-19 2017-11-08 Pierre Fabre Medicament Quinazoline derivatives and their use as dna methyltransferase inhibitors
CN104926798B (zh) * 2014-03-21 2019-06-18 江苏豪森药业集团有限公司 阿法替尼中间体的高纯度制备方法
ES2918589T3 (es) 2015-11-25 2022-07-19 Convergene Llc Inhibidores de bromodomios BET bicíclicos y usos de los mismos
JP7191446B2 (ja) * 2017-01-30 2022-12-19 塩野義製薬株式会社 キナゾリン誘導体を含有する固形製剤
JP2022514692A (ja) * 2018-12-21 2022-02-14 ユニバーシティ・オブ・ノートル・ダム・デュ・ラック 抗酸菌症治療のためのｂｄオキシダーゼ阻害剤の発見
JP7178291B2 (ja) 2019-02-26 2022-11-25 日本製鉄株式会社 ガス供給管カプラの締結解除機構
KR102397359B1 (ko) * 2019-09-30 2022-05-11 한국화학연구원 4-아미노-퀴나졸린 유도체 및 이를 포함하는 항바이러스용 조성물
TWI807787B (zh) * 2021-04-19 2023-07-01 大陸商昆藥集團股份有限公司 苯並嘧啶三環衍生物及製備方法和應用

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Also Published As

Publication number Publication date
US20090030021A1 (en) 2009-01-29
BRPI0507903A (pt) 2007-07-10
EP2650286A1 (en) 2013-10-16
US20050187231A1 (en) 2005-08-25
JP4934432B2 (ja) 2012-05-16
KR20070028340A (ko) 2007-03-12
KR100942865B1 (ko) 2010-02-17
WO2005080352A2 (en) 2005-09-01
US8404698B2 (en) 2013-03-26
CN1956966A (zh) 2007-05-02
CA2557433A1 (en) 2005-09-01
US7388014B2 (en) 2008-06-17
WO2005080352A3 (en) 2006-02-16
EP1720841A2 (en) 2006-11-15
AU2005214373A1 (en) 2005-09-01
CN1956966B (zh) 2012-04-18
CA2557433C (en) 2013-05-14
ES2554330T3 (es) 2015-12-18
AU2005214373B2 (en) 2011-07-28
EP1720841B1 (en) 2015-11-04
JP2007523177A (ja) 2007-08-16

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