UA90659C2 - Аналоги хиназолина как ингибиторы рецепторных тирозинкиназ - Google Patents
Аналоги хиназолина как ингибиторы рецепторных тирозинкиназInfo
- Publication number
- UA90659C2 UA90659C2 UAA200602710A UAA200602710A UA90659C2 UA 90659 C2 UA90659 C2 UA 90659C2 UA A200602710 A UAA200602710 A UA A200602710A UA A200602710 A UAA200602710 A UA A200602710A UA 90659 C2 UA90659 C2 UA 90659C2
- Authority
- UA
- Ukraine
- Prior art keywords
- tyrosine kinase
- kinase inhibitors
- receptor tyrosine
- quinazoline analogs
- analogs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Ceramic Engineering (AREA)
- Manufacturing & Machinery (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Materials Engineering (AREA)
- Structural Engineering (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Данное изобретение касается аналогов хиназолина Формулы И:,где А прикреплено к по меньшей мере одному из углеродов в положении 5, 6, 7 или 8 бициклического кольца, и кольцо замещено как минимум двумя независимыми группами R.Изобретение также включает способы применения соединений Формулы И как ингибиторов рецепторной тирозинкиназы типа И и для лечения гиперпролиферативных заболеваний, таких как рак.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/642,440 US7501427B2 (en) | 2003-08-14 | 2003-08-14 | Quinazoline analogs as receptor tyrosine kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
UA90659C2 true UA90659C2 (ru) | 2010-05-25 |
Family
ID=34549763
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200602710A UA90659C2 (ru) | 2003-08-14 | 2004-08-10 | Аналоги хиназолина как ингибиторы рецепторных тирозинкиназ |
Country Status (6)
Country | Link |
---|---|
US (7) | US7501427B2 (ru) |
EP (1) | EP2377539A1 (ru) |
CN (1) | CN1852714A (ru) |
SI (1) | SI1660090T1 (ru) |
UA (1) | UA90659C2 (ru) |
ZA (1) | ZA200601333B (ru) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7501427B2 (en) * | 2003-08-14 | 2009-03-10 | Array Biopharma, Inc. | Quinazoline analogs as receptor tyrosine kinase inhibitors |
CN103664802B (zh) * | 2003-08-14 | 2015-08-05 | 阿雷生物药品公司 | 作为受体酪氨酸激酶抑制剂的喹唑啉类似物 |
US20050287593A1 (en) * | 2004-05-03 | 2005-12-29 | Schering Corporation | Use of cytokine expression to predict skin inflammation; methods of treatment |
US7501247B2 (en) * | 2004-05-03 | 2009-03-10 | Schering Corporation | Method of treating skin inflammation |
US8648087B2 (en) | 2005-11-15 | 2014-02-11 | Array Biopharma, Inc. | N4-phenyl-quinazoline-4-amine derivatives and related compounds as ErbB type I receptor tyrosine kinase inhibitors for the treatment of hyperproliferative diseases |
CA2720987A1 (en) * | 2007-04-10 | 2008-10-16 | Myrexis, Inc. | Dosages and methods for the treatment of cancer |
WO2011049625A1 (en) | 2009-10-20 | 2011-04-28 | Mansour Samadpour | Method for aflatoxin screening of products |
PL2496567T3 (pl) | 2009-11-05 | 2018-01-31 | Rhizen Pharmaceuticals S A | Nowe benzopiranowe modulatory kinazy |
SG194718A1 (en) | 2011-05-04 | 2013-12-30 | Rhizen Pharmaceuticals Sa | Novel compounds as modulators of protein kinases |
JP5944514B2 (ja) | 2011-10-14 | 2016-07-05 | アレイ バイオファーマ、インコーポレイテッド | 固体分散体 |
JP2014530243A (ja) | 2011-10-14 | 2014-11-17 | アレイ バイオファーマ、インコーポレイテッド | Arry−380の多形体、選択的herb2阻害剤、およびそれらを含有する薬学的組成物 |
ES2647416T3 (es) | 2012-07-04 | 2017-12-21 | Rhizen Pharmaceuticals S.A. | Inhibidores de PI3K delta selectivos |
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US2583774A (en) * | 1948-04-30 | 1952-01-29 | Merck & Co Inc | Vitamin b6 derivatives |
BE795970A (fr) * | 1972-02-29 | 1973-08-27 | Pfizer | Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant |
CA1340821C (en) * | 1988-10-06 | 1999-11-16 | Nobuyuki Fukazawa | Heterocyclic compounds and anticancer-drug reinforcing agents containing them as effective components |
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GB9424233D0 (en) | 1994-11-30 | 1995-01-18 | Zeneca Ltd | Quinazoline derivatives |
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EP0880508B1 (en) * | 1996-02-13 | 2003-04-16 | AstraZeneca AB | Quinazoline derivatives as vegf inhibitors |
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CN1104139C (zh) | 1996-10-02 | 2003-03-26 | 索尼公司 | 电视接收机、设置接收频道的方法和图像显示方法 |
US6225318B1 (en) * | 1996-10-17 | 2001-05-01 | Pfizer Inc | 4-aminoquinazolone derivatives |
ZA986732B (en) * | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
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PL340589A1 (en) | 1997-11-11 | 2001-02-12 | Pfizer Prod Inc | Derivatives of thienepyrimidine and thienepyridine useful as anticarcinogenic agents |
JP2002505288A (ja) | 1998-03-02 | 2002-02-19 | コセンシス,インコーポレイテッド | 置換キナゾリンおよびアナログならびにそれらの使用 |
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WO2004106308A1 (en) * | 2003-05-27 | 2004-12-09 | Pfizer Products Inc. | Quinazolines and pyrido [3,4-d] pyrimidines as receptor tyrosine kinase inhibitors |
US7501427B2 (en) | 2003-08-14 | 2009-03-10 | Array Biopharma, Inc. | Quinazoline analogs as receptor tyrosine kinase inhibitors |
CN103664802B (zh) | 2003-08-14 | 2015-08-05 | 阿雷生物药品公司 | 作为受体酪氨酸激酶抑制剂的喹唑啉类似物 |
JP2007502807A (ja) * | 2003-08-18 | 2007-02-15 | ファイザー・プロダクツ・インク | Erbb2抗がん剤の投与スケジュール |
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KR100735639B1 (ko) * | 2004-12-29 | 2007-07-04 | 한미약품 주식회사 | 암세포 성장 억제 효과를 갖는 퀴나졸린 유도체 및 이의제조방법 |
US8648087B2 (en) | 2005-11-15 | 2014-02-11 | Array Biopharma, Inc. | N4-phenyl-quinazoline-4-amine derivatives and related compounds as ErbB type I receptor tyrosine kinase inhibitors for the treatment of hyperproliferative diseases |
-
2003
- 2003-08-14 US US10/642,440 patent/US7501427B2/en active Active
-
2004
- 2004-08-10 EP EP11158158A patent/EP2377539A1/en not_active Withdrawn
- 2004-08-10 SI SI200431985T patent/SI1660090T1/sl unknown
- 2004-08-10 CN CNA2004800264589A patent/CN1852714A/zh active Pending
- 2004-08-10 UA UAA200602710A patent/UA90659C2/ru unknown
- 2004-08-10 ZA ZA200601333A patent/ZA200601333B/en unknown
-
2008
- 2008-04-21 US US12/081,725 patent/US7585975B2/en not_active Expired - Lifetime
-
2009
- 2009-07-02 US US12/496,973 patent/US7777032B2/en not_active Expired - Fee Related
-
2012
- 2012-09-07 US US13/607,016 patent/US9676791B2/en not_active Expired - Lifetime
-
2017
- 2017-05-26 US US15/606,928 patent/US10221194B2/en not_active Expired - Lifetime
-
2019
- 2019-01-31 US US16/264,194 patent/US11174273B2/en not_active Expired - Lifetime
-
2020
- 2020-10-13 US US17/069,224 patent/US20210269455A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20190161500A1 (en) | 2019-05-30 |
US20210284656A9 (en) | 2021-09-16 |
US7585975B2 (en) | 2009-09-08 |
US20170260202A1 (en) | 2017-09-14 |
CN1852714A (zh) | 2006-10-25 |
US9676791B2 (en) | 2017-06-13 |
US20210269455A1 (en) | 2021-09-02 |
US20130245256A1 (en) | 2013-09-19 |
ZA200601333B (en) | 2007-05-30 |
US11174273B2 (en) | 2021-11-16 |
US7501427B2 (en) | 2009-03-10 |
US20090270621A1 (en) | 2009-10-29 |
US20050101616A1 (en) | 2005-05-12 |
US20080194558A1 (en) | 2008-08-14 |
EP2377539A1 (en) | 2011-10-19 |
US7777032B2 (en) | 2010-08-17 |
US10221194B2 (en) | 2019-03-05 |
SI1660090T1 (sl) | 2013-02-28 |
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