WO2004096233A3 - Nucleoside phosphonate conjugates - Google Patents

Nucleoside phosphonate conjugates Download PDF

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Publication number
WO2004096233A3
WO2004096233A3 PCT/US2004/013060 US2004013060W WO2004096233A3 WO 2004096233 A3 WO2004096233 A3 WO 2004096233A3 US 2004013060 W US2004013060 W US 2004013060W WO 2004096233 A3 WO2004096233 A3 WO 2004096233A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleoside phosphonate
phosphonate conjugates
compounds
conjugates
nucleoside
Prior art date
Application number
PCT/US2004/013060
Other languages
French (fr)
Other versions
WO2004096233A2 (en
Inventor
Constantine G Boojamara
James M Chen
Xiaowu Chen
Aesop Cho
Lee S Chong
Maria Fardis
Alan X Huang
Choung X Kim
Thorsten A Kirschberg
Christopher P Lee
David Oare
Vidya K Prasad
Adrian S Ray
Sundaramoorthi Swaminathan
Will Watkins
Original Assignee
Gilead Sciences Inc
Constantine G Boojamara
James M Chen
Xiaowu Chen
Aesop Cho
Lee S Chong
Maria Fardis
Alan X Huang
Choung X Kim
Thorsten A Kirschberg
Christopher P Lee
David Oare
Vidya K Prasad
Adrian S Ray
Sundaramoorthi Swaminathan
Will Watkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc, Constantine G Boojamara, James M Chen, Xiaowu Chen, Aesop Cho, Lee S Chong, Maria Fardis, Alan X Huang, Choung X Kim, Thorsten A Kirschberg, Christopher P Lee, David Oare, Vidya K Prasad, Adrian S Ray, Sundaramoorthi Swaminathan, Will Watkins filed Critical Gilead Sciences Inc
Publication of WO2004096233A2 publication Critical patent/WO2004096233A2/en
Publication of WO2004096233A3 publication Critical patent/WO2004096233A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Abstract

The invention is related to phosphorus substituted nucleoside compounds and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
PCT/US2004/013060 2003-04-25 2004-04-26 Nucleoside phosphonate conjugates WO2004096233A2 (en)

Applications Claiming Priority (130)

Application Number Priority Date Filing Date Title
US46546703P 2003-04-25 2003-04-25
US46540003P 2003-04-25 2003-04-25
US46582103P 2003-04-25 2003-04-25
US46560203P 2003-04-25 2003-04-25
US46546303P 2003-04-25 2003-04-25
US46575903P 2003-04-25 2003-04-25
US46553703P 2003-04-25 2003-04-25
US46555903P 2003-04-25 2003-04-25
US46555303P 2003-04-25 2003-04-25
US46555003P 2003-04-25 2003-04-25
US46561003P 2003-04-25 2003-04-25
US46566703P 2003-04-25 2003-04-25
US46563303P 2003-04-25 2003-04-25
US46534703P 2003-04-25 2003-04-25
US46572003P 2003-04-25 2003-04-25
US46560803P 2003-04-25 2003-04-25
US46554403P 2003-04-25 2003-04-25
US46558403P 2003-04-25 2003-04-25
US46556103P 2003-04-25 2003-04-25
US46563403P 2003-04-25 2003-04-25
US46558703P 2003-04-25 2003-04-25
US46555403P 2003-04-25 2003-04-25
US46559103P 2003-04-25 2003-04-25
US46569603P 2003-04-25 2003-04-25
US46554803P 2003-04-25 2003-04-25
US46568403P 2003-04-25 2003-04-25
US46569803P 2003-04-25 2003-04-25
US46560003P 2003-04-25 2003-04-25
US46557403P 2003-04-25 2003-04-25
US60/465,548 2003-04-25
US60/465,587 2003-04-25
US60/465,608 2003-04-25
US60/465,602 2003-04-25
US60/465,600 2003-04-25
US60/465,347 2003-04-25
US60/465,554 2003-04-25
US60/465,591 2003-04-25
US60/465,400 2003-04-25
US60/465,463 2003-04-25
US60/465,821 2003-04-25
US60/465,537 2003-04-25
US60/465,544 2003-04-25
US60/465,667 2003-04-25
US60/465,553 2003-04-25
US60/465,561 2003-04-25
US60/465,759 2003-04-25
US60/465,559 2003-04-25
US60/465,696 2003-04-25
US60/465,684 2003-04-25
US60/465,698 2003-04-25
US60/465,634 2003-04-25
US60/465,550 2003-04-25
US60/465,720 2003-04-25
US60/465,584 2003-04-25
US60/465,610 2003-04-25
US60/465,574 2003-04-25
US60/465,633 2003-04-25
US60/465,467 2003-04-25
US49559203P 2003-08-15 2003-08-15
US49538703P 2003-08-15 2003-08-15
US49567103P 2003-08-15 2003-08-15
US49569603P 2003-08-15 2003-08-15
US49549003P 2003-08-15 2003-08-15
US49531703P 2003-08-15 2003-08-15
US49563103P 2003-08-15 2003-08-15
US49527303P 2003-08-15 2003-08-15
US49552503P 2003-08-15 2003-08-15
US49568403P 2003-08-15 2003-08-15
US49563303P 2003-08-15 2003-08-15
US49534303P 2003-08-15 2003-08-15
US49545303P 2003-08-15 2003-08-15
US49577203P 2003-08-15 2003-08-15
US49533403P 2003-08-15 2003-08-15
US49527703P 2003-08-15 2003-08-15
US49527803P 2003-08-15 2003-08-15
US49534403P 2003-08-15 2003-08-15
US49576003P 2003-08-15 2003-08-15
US49576303P 2003-08-15 2003-08-15
US49580503P 2003-08-15 2003-08-15
US49556403P 2003-08-15 2003-08-15
US49553903P 2003-08-15 2003-08-15
US49596403P 2003-08-15 2003-08-15
US49541703P 2003-08-15 2003-08-15
US49549103P 2003-08-15 2003-08-15
US49560003P 2003-08-15 2003-08-15
US49534903P 2003-08-15 2003-08-15
US60/495,760 2003-08-15
US60/495,490 2003-08-15
US60/495,278 2003-08-15
US60/495,273 2003-08-15
US60/495,343 2003-08-15
US60/495,453 2003-08-15
US60/495,387 2003-08-15
US60/495,964 2003-08-15
US60/495,592 2003-08-15
US60/495,564 2003-08-15
US60/495,805 2003-08-15
US60/495,417 2003-08-15
US60/495,772 2003-08-15
US60/495,763 2003-08-15
US60/495,334 2003-08-15
US60/495,317 2003-08-15
US60/495,600 2003-08-15
US60/495,491 2003-08-15
US60/495,633 2003-08-15
US60/495,631 2003-08-15
US60/495,349 2003-08-15
US60/495,696 2003-08-15
US60/495,684 2003-08-15
US60/495,277 2003-08-15
US60/495,525 2003-08-15
US60/495,671 2003-08-15
US60/495,344 2003-08-15
US60/495,539 2003-08-15
US51024503P 2003-10-10 2003-10-10
US60/510,245 2003-10-10
US51415903P 2003-10-24 2003-10-24
US51392603P 2003-10-24 2003-10-24
US51393203P 2003-10-24 2003-10-24
US51414403P 2003-10-24 2003-10-24
US51408303P 2003-10-24 2003-10-24
US51394903P 2003-10-24 2003-10-24
US60/513,949 2003-10-24
US60/513,926 2003-10-24
US60/514,144 2003-10-24
US60/514,159 2003-10-24
US60/513,932 2003-10-24
US60/514,083 2003-10-24
US53194003P 2003-12-22 2003-12-22
US60/531,940 2003-12-22

Publications (2)

Publication Number Publication Date
WO2004096233A2 WO2004096233A2 (en) 2004-11-11
WO2004096233A3 true WO2004096233A3 (en) 2005-06-16

Family

ID=33425963

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/013060 WO2004096233A2 (en) 2003-04-25 2004-04-26 Nucleoside phosphonate conjugates

Country Status (1)

Country Link
WO (1) WO2004096233A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9243025B2 (en) 2011-03-31 2016-01-26 Idenix Pharmaceuticals, Llc Compounds and pharmaceutical compositions for the treatment of viral infections
US9579332B2 (en) 2004-07-27 2017-02-28 Gilead Sciences, Inc. Phosphonate analogs of HIV inhibitor compounds

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EP1628685B1 (en) 2003-04-25 2010-12-08 Gilead Sciences, Inc. Antiviral phosphonate analogs
CA2556829C (en) 2004-03-04 2014-10-14 K.U. Leuven Research & Development Phosponate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production
WO2006037090A2 (en) * 2004-09-28 2006-04-06 Purdue Research Foundation Drug-phosphate conjugates as prodrugs
SI1824482T1 (en) 2004-12-17 2014-06-30 Anadys Pharmaceuticals, Inc. 3, 5-DISUBSTITUTED AND 3,5,7-TRISUBSTITUTED-3H-OXAZOLO AND 3H-THIAZOLO Š4,5-dĆPYRIMIDIN-2-ONE COMPOUNDS AND PRODRUGS THEREOF
AU2006272521A1 (en) * 2005-07-27 2007-02-01 Gilead Sciences, Inc. Antiviral phosphonate conjugates for inhibition of HIV
NZ544187A (en) * 2005-12-15 2008-07-31 Ind Res Ltd Deazapurine analogs of 1'-aza-l-nucleosides
US8895531B2 (en) 2006-03-23 2014-11-25 Rfs Pharma Llc 2′-fluoronucleoside phosphonates as antiviral agents
US7842672B2 (en) 2006-07-07 2010-11-30 Gilead Sciences, Inc. Phosphonate inhibitors of HCV
US20080261913A1 (en) 2006-12-28 2008-10-23 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of liver disorders
US8658617B2 (en) 2008-07-08 2014-02-25 Gilead Sciences, Inc. Salts of HIV inhibitor compounds
KR101881596B1 (en) 2008-12-02 2018-07-24 웨이브 라이프 사이언시스 재팬 인코포레이티드 Method for the synthesis of phosphorous atom modified nucleic acids
IN2012DN00720A (en) 2009-07-06 2015-06-19 Ontorii Inc
CA2795054A1 (en) 2010-04-01 2011-10-06 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of viral infections
US10428019B2 (en) 2010-09-24 2019-10-01 Wave Life Sciences Ltd. Chiral auxiliaries
BR112014001244A2 (en) 2011-07-19 2017-02-21 Wave Life Sciences Pte Ltd methods for the synthesis of functionalized nucleic acids
BR112015000784A8 (en) 2012-07-13 2018-04-03 Wave Life Sciences Japan ASYMMETRICAL AUXILIARY GROUP
KR20230152178A (en) 2014-01-16 2023-11-02 웨이브 라이프 사이언시스 리미티드 Chiral design
JP7125144B2 (en) * 2016-09-09 2022-08-24 キャリセラ バイオサイエンシーズ， インコーポレイテッド Ectonucleotidase inhibitors and methods of use thereof
JP7184761B2 (en) 2016-10-03 2022-12-06 アーカス バイオサイエンシズ インコーポレイティド Inhibitors of adenosine 5'-nucleotidase
CN110402249A (en) 2016-12-22 2019-11-01 卡利泰拉生物科技公司 Extracellular nucleotides enzyme inhibitor and its application method
US10851125B2 (en) 2017-08-01 2020-12-01 Gilead Sciences, Inc. Crystalline forms of ethyl ((S)-((((2R,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl)oxy)methyl)(phenoxy)phosphoryl(-L-alaninate
AU2019288495B2 (en) 2018-06-21 2024-02-08 Antengene Therapeutics Limited Ectonucleotidase inhibitors and methods of use thereof

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9579332B2 (en) 2004-07-27 2017-02-28 Gilead Sciences, Inc. Phosphonate analogs of HIV inhibitor compounds
US9243025B2 (en) 2011-03-31 2016-01-26 Idenix Pharmaceuticals, Llc Compounds and pharmaceutical compositions for the treatment of viral infections

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