WO2006047507A3 - Phosphonate substituted kinase inhibitors - Google Patents

Phosphonate substituted kinase inhibitors Download PDF

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Publication number
WO2006047507A3
WO2006047507A3 PCT/US2005/038348 US2005038348W WO2006047507A3 WO 2006047507 A3 WO2006047507 A3 WO 2006047507A3 US 2005038348 W US2005038348 W US 2005038348W WO 2006047507 A3 WO2006047507 A3 WO 2006047507A3
Authority
WO
WIPO (PCT)
Prior art keywords
kinase inhibitors
conjugates
phosphonate substituted
substituted kinase
phosphonate
Prior art date
Application number
PCT/US2005/038348
Other languages
French (fr)
Other versions
WO2006047507A2 (en
Inventor
William J Watkins
Original Assignee
Gilead Sciences Inc
William J Watkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc, William J Watkins filed Critical Gilead Sciences Inc
Priority to AU2005299504A priority Critical patent/AU2005299504A1/en
Priority to JP2007539037A priority patent/JP2008518015A/en
Priority to EP05812489A priority patent/EP1809299A2/en
Priority to CA002585281A priority patent/CA2585281A1/en
Publication of WO2006047507A2 publication Critical patent/WO2006047507A2/en
Publication of WO2006047507A3 publication Critical patent/WO2006047507A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • C07F9/65128—Six-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention is related to phosphorus substituted kinase inhibitory conjugates, compositions containing such conjugates, and therapeutic methods that include the administration of such conjugates, as well as to processes and intermediates useful for preparing such conjugates.
PCT/US2005/038348 2004-10-26 2005-10-25 Phosphonate substituted kinase inhibitors WO2006047507A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2005299504A AU2005299504A1 (en) 2004-10-26 2005-10-25 Phosphonate substituted kinase inhibitors
JP2007539037A JP2008518015A (en) 2004-10-26 2005-10-25 Phosphonate-substituted kinase inhibitor
EP05812489A EP1809299A2 (en) 2004-10-26 2005-10-25 Phosphonate substituted kinase inhibitors
CA002585281A CA2585281A1 (en) 2004-10-26 2005-10-25 Phosphonate substituted kinase inhibitors

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US62288104P 2004-10-26 2004-10-26
US62281104P 2004-10-26 2004-10-26
US62299204P 2004-10-26 2004-10-26
US62294204P 2004-10-26 2004-10-26
US62294304P 2004-10-26 2004-10-26
US62296004P 2004-10-26 2004-10-26
US62309804P 2004-10-26 2004-10-26
US60/623,098 2004-10-26
US60/622,942 2004-10-26
US60/622,811 2004-10-26
US60/622,881 2004-10-26
US60/622,960 2004-10-26
US60/622,992 2004-10-26
US60/622,943 2004-10-26

Publications (2)

Publication Number Publication Date
WO2006047507A2 WO2006047507A2 (en) 2006-05-04
WO2006047507A3 true WO2006047507A3 (en) 2009-04-16

Family

ID=36228375

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/038348 WO2006047507A2 (en) 2004-10-26 2005-10-25 Phosphonate substituted kinase inhibitors

Country Status (5)

Country Link
EP (1) EP1809299A2 (en)
JP (1) JP2008518015A (en)
AU (1) AU2005299504A1 (en)
CA (1) CA2585281A1 (en)
WO (1) WO2006047507A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106749223B (en) * 2015-11-25 2019-12-20 中国科学院广州生物医药与健康研究院 Tyrosine kinase inhibitor and preparation method and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040235834A1 (en) * 2003-03-25 2004-11-25 Farmer Luc J. Thiazoles useful as inhibitors of protein kinases
US20060069101A1 (en) * 2004-09-27 2006-03-30 Kim Kyoung S Prodrugs of protein tyrosine kinase inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040235834A1 (en) * 2003-03-25 2004-11-25 Farmer Luc J. Thiazoles useful as inhibitors of protein kinases
US20060069101A1 (en) * 2004-09-27 2006-03-30 Kim Kyoung S Prodrugs of protein tyrosine kinase inhibitors

Also Published As

Publication number Publication date
CA2585281A1 (en) 2006-05-04
WO2006047507A2 (en) 2006-05-04
JP2008518015A (en) 2008-05-29
AU2005299504A1 (en) 2006-05-04
EP1809299A2 (en) 2007-07-25

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