ATE374201T1 - 6-alkoxypyridopyrimidine als inhibitoren der p-38-map-kinase - Google Patents
6-alkoxypyridopyrimidine als inhibitoren der p-38-map-kinaseInfo
- Publication number
- ATE374201T1 ATE374201T1 AT03784102T AT03784102T ATE374201T1 AT E374201 T1 ATE374201 T1 AT E374201T1 AT 03784102 T AT03784102 T AT 03784102T AT 03784102 T AT03784102 T AT 03784102T AT E374201 T1 ATE374201 T1 AT E374201T1
- Authority
- AT
- Austria
- Prior art keywords
- alkoxypyridopyrimidines
- inhibitors
- map kinase
- kinase
- map
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 title 1
- 108010068338 p38 Mitogen-Activated Protein Kinases Proteins 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Biotechnology (AREA)
- Psychiatry (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40149102P | 2002-08-06 | 2002-08-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE374201T1 true ATE374201T1 (de) | 2007-10-15 |
Family
ID=31715709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03784102T ATE374201T1 (de) | 2002-08-06 | 2003-07-29 | 6-alkoxypyridopyrimidine als inhibitoren der p-38-map-kinase |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US6965030B2 (de) |
| EP (1) | EP1539755B1 (de) |
| JP (1) | JP4252534B2 (de) |
| CN (1) | CN100432073C (de) |
| AR (1) | AR040787A1 (de) |
| AT (1) | ATE374201T1 (de) |
| AU (1) | AU2003251661A1 (de) |
| BR (1) | BR0313297A (de) |
| CA (1) | CA2492112A1 (de) |
| DE (1) | DE60316581T2 (de) |
| ES (1) | ES2293064T3 (de) |
| MX (1) | MXPA05001332A (de) |
| PL (1) | PL375403A1 (de) |
| RU (1) | RU2324695C2 (de) |
| WO (1) | WO2004014907A1 (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1620105B1 (de) * | 2003-04-16 | 2007-01-10 | F. Hoffmann-La Roche Ag | (6-(phenoxy)-pyrido¬3,4-d|pyrimidin-2-yl)-amin derivate als p38 kinase inhibitoren zur behandlung von entzündlichen erkrankungen wie rheumatoider arthritis |
| KR100843526B1 (ko) | 2004-02-27 | 2008-07-03 | 에프. 호프만-라 로슈 아게 | 피라졸의 접합 유도체 |
| DE102004018198A1 (de) | 2004-04-15 | 2005-11-03 | Merck Patent Gmbh | Sulfonamide |
| CA2620257A1 (en) * | 2005-08-25 | 2007-03-01 | F. Hoffmann-La Roche Ag | P38 map kinase inhibitors and methods for using the same |
| US20090221600A1 (en) * | 2005-09-28 | 2009-09-03 | Ashwani Kumar Verma | Pyrido-pyridimidine derivatives useful as antiinflammatory agents |
| US20090192164A1 (en) * | 2006-06-28 | 2009-07-30 | Aska Pharmaceutical Co., Ltd. | Treating agent of inflammatory bowel disease |
| US7835569B2 (en) * | 2006-10-13 | 2010-11-16 | Apple Inc. | System and method for raw image processing using conversion matrix interpolated from predetermined camera characterization matrices |
| KR101434706B1 (ko) | 2007-02-16 | 2014-08-26 | 아스카 세이야쿠 가부시키가이샤 | 미립자 유성 현탁액을 포함하는 의약 조성물 |
| ES2324083B1 (es) * | 2007-10-22 | 2010-05-31 | Consejo Superior De Investigaciones Cientificas | Procedimiento para el diagnostico y tratamiento de enfermedades que cursan con alteracion de la quinasa p38, elementos necesarios para llevarlo a cabo y sus aplicaciones. |
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| ES2984771T3 (es) | 2012-06-13 | 2024-10-31 | Incyte Holdings Corp | Compuestos tricíclicos sustituidos como inhibidores de FGFR |
| WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
| GB201216017D0 (en) * | 2012-09-07 | 2012-10-24 | Cancer Rec Tech Ltd | Inhibitor compounds |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| CN103145626B (zh) * | 2013-02-28 | 2015-02-11 | 山东大学 | 一种合成4-氨基-2-甲巯基嘧啶-5-甲醛的方法 |
| CN103145632B (zh) * | 2013-03-26 | 2015-07-08 | 浙江普洛得邦制药有限公司 | 一种1h-1,2,4-三氮唑-3-甲酸甲酯的制备方法 |
| EA035095B1 (ru) | 2013-04-19 | 2020-04-27 | Инсайт Холдингс Корпорейшн | Бициклические гетероциклы в качестве ингибиторов fgfr |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| EA038045B1 (ru) | 2015-02-20 | 2021-06-28 | Инсайт Корпорейшн | Бициклические гетероциклы в качестве ингибиторов fgfr |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| WO2017151409A1 (en) | 2016-02-29 | 2017-09-08 | University Of Florida Research Foundation, Incorporated | Chemotherapeutic methods |
| SG10202110804WA (en) * | 2017-04-04 | 2021-11-29 | Kinarus Ag | Methods of preventing or treating ophthalmic diseases |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| EP3692144A1 (de) | 2017-10-05 | 2020-08-12 | Fulcrum Therapeutics, Inc. | Verwendung von p38-inhibitoren zur verringerung der expression von dux4 |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| US11174257B2 (en) | 2018-05-04 | 2021-11-16 | Incyte Corporation | Salts of an FGFR inhibitor |
| RS66310B1 (sr) | 2018-05-04 | 2025-01-31 | Incyte Corp | Čvrsti oblici inhibitora fgfr i procesi za njegovu pripremu |
| MA55141A (fr) | 2018-11-20 | 2021-09-29 | Nflection Therapeutics Inc | Composés cyanoaryl-aniline pour le traitement d'affections de la peau |
| CA3120337A1 (en) * | 2018-11-20 | 2020-05-28 | Nflection Therapeutics, Inc. | Naphthyridinone-aniline compounds for treatment of dermal disorders |
| WO2020106305A1 (en) | 2018-11-20 | 2020-05-28 | Nflection Therapeutics, Inc. | Thienyl-aniline compounds for treatment of dermal disorders |
| WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
| WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| PH12022550892A1 (en) | 2019-10-14 | 2023-05-03 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
| US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| AU2020395185A1 (en) | 2019-12-04 | 2022-06-02 | Incyte Corporation | Derivatives of an FGFR inhibitor |
| EP4069696A1 (de) | 2019-12-04 | 2022-10-12 | Incyte Corporation | Tricyclische heterocyclen als fgfr-inhibitoren |
| US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| JP2024513575A (ja) | 2021-04-12 | 2024-03-26 | インサイト・コーポレイション | Fgfr阻害剤及びネクチン-4標的化剤を含む併用療法 |
| WO2022261160A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| TW202313610A (zh) | 2021-06-09 | 2023-04-01 | 美商英塞特公司 | 作為fgfr抑制劑之三環雜環 |
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| US55513A (en) * | 1866-06-12 | Improvement in squeezers | ||
| US4215216A (en) * | 1979-04-18 | 1980-07-29 | American Home Products Corporation | 7,8-Dihydro-2,5,8-trisubstituted-7-oxo-pyrido[2,3-d]pyrimidine-6-carboxylic acid derivatives |
| US5037826A (en) * | 1986-10-15 | 1991-08-06 | Schering Corporation | 1-substituted naphthyridine and pyridopyrazine derivatives |
| EP0278686A1 (de) | 1987-02-07 | 1988-08-17 | The Wellcome Foundation Limited | Pyridopyrimidine, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitungen davon |
| WO1993017682A1 (en) | 1992-03-04 | 1993-09-16 | Abbott Laboratories | Angiotensin ii receptor antagonists |
| ES2146782T3 (es) | 1994-11-14 | 2000-08-16 | Warner Lambert Co | 6-aril-pirido(2,3-d)pirimidinas y naftiridinas para la inhibicion de la proliferacion celular inducida por la proteina tirosina quinasa. |
| IL115256A0 (en) * | 1994-11-14 | 1995-12-31 | Warner Lambert Co | 6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use |
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| US5620981A (en) * | 1995-05-03 | 1997-04-15 | Warner-Lambert Company | Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation |
| IL117923A (en) | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
| US5945422A (en) * | 1997-02-05 | 1999-08-31 | Warner-Lambert Company | N-oxides of amino containing pyrido 2,3-D! pyrimidines |
| US6498163B1 (en) * | 1997-02-05 | 2002-12-24 | Warner-Lambert Company | Pyrido[2,3-D]pyrimidines and 4-aminopyrimidines as inhibitors of cellular proliferation |
| ES2301194T3 (es) * | 1997-02-05 | 2008-06-16 | Warner-Lambert Company Llc | Pirido 2,3-d pirimidinas y 4-aminopirimidinas como inhibidores de la proliferacion celular. |
| KR20010023089A (ko) * | 1997-08-20 | 2001-03-26 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | 단백질 티로신 키나제 및 세포주기 키나제 매개의 세포증식 억제용 나프티리디논 |
| PL340412A1 (en) * | 1997-10-20 | 2001-01-29 | Hoffmann La Roche | Bicyclic kinase inhibitors |
| CN1138778C (zh) | 1998-05-26 | 2004-02-18 | 沃尼尔·朗伯公司 | 用作细胞增殖抑制剂的二环嘧啶及二环3,4-二氢嘧啶化合物及用途 |
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| HUP0203477A3 (en) * | 1999-10-21 | 2004-12-28 | Hoffmann La Roche | Alkylamino substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase, pharmaceutical compositions containing them and their preparations |
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| US6518276B2 (en) * | 2000-08-31 | 2003-02-11 | Syntex (U.S.A.) Llc | 7-oxo-pyridopyrimidines (II) |
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| ATE305303T1 (de) * | 2001-02-12 | 2005-10-15 | Hoffmann La Roche | 6-substituierte pyridopyrimidine |
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2003
- 2003-07-29 RU RU2005106202/04A patent/RU2324695C2/ru not_active IP Right Cessation
- 2003-07-29 DE DE60316581T patent/DE60316581T2/de not_active Expired - Fee Related
- 2003-07-29 CA CA002492112A patent/CA2492112A1/en not_active Abandoned
- 2003-07-29 PL PL03375403A patent/PL375403A1/xx not_active Application Discontinuation
- 2003-07-29 CN CNB038186888A patent/CN100432073C/zh not_active Expired - Fee Related
- 2003-07-29 AT AT03784102T patent/ATE374201T1/de not_active IP Right Cessation
- 2003-07-29 JP JP2004526812A patent/JP4252534B2/ja not_active Expired - Fee Related
- 2003-07-29 MX MXPA05001332A patent/MXPA05001332A/es active IP Right Grant
- 2003-07-29 WO PCT/EP2003/008357 patent/WO2004014907A1/en not_active Ceased
- 2003-07-29 EP EP03784102A patent/EP1539755B1/de not_active Expired - Lifetime
- 2003-07-29 AU AU2003251661A patent/AU2003251661A1/en not_active Abandoned
- 2003-07-29 BR BR0313297-8A patent/BR0313297A/pt not_active IP Right Cessation
- 2003-07-29 ES ES03784102T patent/ES2293064T3/es not_active Expired - Lifetime
- 2003-08-05 AR AR20030102800A patent/AR040787A1/es unknown
- 2003-08-05 US US10/634,936 patent/US6965030B2/en not_active Expired - Fee Related
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Also Published As
| Publication number | Publication date |
|---|---|
| US7196097B2 (en) | 2007-03-27 |
| RU2005106202A (ru) | 2006-05-10 |
| BR0313297A (pt) | 2005-06-21 |
| US20040038999A1 (en) | 2004-02-26 |
| US20070167484A1 (en) | 2007-07-19 |
| US20050203300A1 (en) | 2005-09-15 |
| JP2006507236A (ja) | 2006-03-02 |
| RU2324695C2 (ru) | 2008-05-20 |
| EP1539755A1 (de) | 2005-06-15 |
| DE60316581D1 (de) | 2007-11-08 |
| DE60316581T2 (de) | 2008-07-03 |
| PL375403A1 (en) | 2005-11-28 |
| US7105525B2 (en) | 2006-09-12 |
| US7320987B2 (en) | 2008-01-22 |
| ES2293064T3 (es) | 2008-03-16 |
| JP4252534B2 (ja) | 2009-04-08 |
| US20060276646A1 (en) | 2006-12-07 |
| EP1539755B1 (de) | 2007-09-26 |
| AR040787A1 (es) | 2005-04-20 |
| MXPA05001332A (es) | 2005-04-28 |
| CN100432073C (zh) | 2008-11-12 |
| AU2003251661A1 (en) | 2004-02-25 |
| US6965030B2 (en) | 2005-11-15 |
| WO2004014907A1 (en) | 2004-02-19 |
| CN1675207A (zh) | 2005-09-28 |
| CA2492112A1 (en) | 2004-02-19 |
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