DE60321808D1 - Flavon derivate als inhibitoren von cyclin-abhängigen kinasen - Google Patents
Flavon derivate als inhibitoren von cyclin-abhängigen kinasenInfo
- Publication number
- DE60321808D1 DE60321808D1 DE60321808T DE60321808T DE60321808D1 DE 60321808 D1 DE60321808 D1 DE 60321808D1 DE 60321808 T DE60321808 T DE 60321808T DE 60321808 T DE60321808 T DE 60321808T DE 60321808 D1 DE60321808 D1 DE 60321808D1
- Authority
- DE
- Germany
- Prior art keywords
- cyclin
- inhibitors
- dependent kinases
- flavon
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN616MU2002 | 2002-07-08 | ||
PCT/IN2003/000234 WO2004004632A2 (en) | 2002-07-08 | 2003-07-07 | Flavone derivatives as inhibitors of cyclin-dependent kinases |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60321808D1 true DE60321808D1 (de) | 2008-08-07 |
Family
ID=30012269
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60321808T Expired - Lifetime DE60321808D1 (de) | 2002-07-08 | 2003-07-07 | Flavon derivate als inhibitoren von cyclin-abhängigen kinasen |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP1556375B1 (de) |
JP (1) | JP4860148B2 (de) |
KR (1) | KR100991920B1 (de) |
CN (1) | CN1668613B (de) |
AR (1) | AR041184A1 (de) |
AT (1) | ATE399162T1 (de) |
AU (1) | AU2003272070B2 (de) |
BR (1) | BR0312633A (de) |
CA (1) | CA2492130C (de) |
DE (1) | DE60321808D1 (de) |
DK (1) | DK1556375T3 (de) |
ES (1) | ES2309338T3 (de) |
IL (1) | IL166153A (de) |
MX (1) | MXPA05000388A (de) |
NZ (1) | NZ537518A (de) |
PT (1) | PT1556375E (de) |
RU (1) | RU2334746C2 (de) |
TW (1) | TWI331034B (de) |
WO (1) | WO2004004632A2 (de) |
ZA (1) | ZA200500138B (de) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7915301B2 (en) | 2002-07-08 | 2011-03-29 | Piramal Life Science Limited | Inhibitors of cyclin dependent kinases and their use |
BRPI0621777A2 (pt) * | 2006-06-21 | 2013-03-12 | Piramal Life Sciences Ltd | derivados de flavona enantiomericamente puros para o tratamento de distérbios proliferativos e processos para sua preparaÇço |
WO2008007169A1 (en) | 2006-07-07 | 2008-01-17 | Piramal Life Sciences Limited | An enantioselective synthesis of pyrrolidine-substituted flavones |
KR101403100B1 (ko) * | 2007-05-15 | 2014-06-19 | 피라말 라이프 사이언시스 리미티드 | 상승 효과가 있는 암 치료용 약제 조합물 |
CN101333205A (zh) * | 2008-07-10 | 2008-12-31 | 大连理工大学 | 周期素依赖蛋白激酶抑制剂黄芩素哌嗪衍生物及其制法 |
TWI461194B (zh) | 2009-05-05 | 2014-11-21 | Piramal Entpr Ltd | 吡咯啶取代黃酮作為輻射致敏劑 |
US20120121692A1 (en) * | 2009-05-08 | 2012-05-17 | Shandong University | Compounds and compositions comprising cdk inhibitors and methods for treating cancer |
US7928067B2 (en) | 2009-05-14 | 2011-04-19 | Ischemix Llc | Compositions and methods for treating ischemia and ischemia-reperfusion injury |
NZ602636A (en) * | 2010-02-26 | 2014-08-29 | Piramal Entpr Ltd | Pyrrolidine substituted flavones for the treatment of inflammatory disorders |
US8815937B2 (en) | 2010-11-18 | 2014-08-26 | Ischemix Llc | Lipoyl compounds and their use for treating ischemic injury |
WO2012069972A1 (en) | 2010-11-19 | 2012-05-31 | Piramal Life Sciences Limited | A pharmaceutical combination for the treatment of breast cancer |
US20130237582A1 (en) * | 2010-11-19 | 2013-09-12 | Piramal Enterprises Limited | Pharmaceutical combination of paclitaxel and a cdk inhibitor |
WO2012123889A1 (en) | 2011-03-14 | 2012-09-20 | Piramal Healthcare Limited | A synergistic pharmaceutical combination for the treatment of pancreatic cancer |
UY34013A (es) * | 2011-04-13 | 2012-11-30 | Astrazeneca Ab | ?compuestos de cromenona con actividad anti-tumoral?. |
TW201300105A (zh) * | 2011-05-31 | 2013-01-01 | Piramal Life Sciences Ltd | 治療頭頸鱗狀細胞癌之相乘藥物組合物 |
WO2012176163A2 (en) | 2011-06-24 | 2012-12-27 | Piramal Enterprises Limited | Compounds for the treatment of cancers associated with human papillomavirus |
US20140348950A1 (en) | 2012-01-13 | 2014-11-27 | Piramal Enterprises Limited | Pyrrolidine- substituted flavone derivatives for prevention or treatment of oral mucositis |
WO2014049515A1 (en) * | 2012-09-25 | 2014-04-03 | Piramal Enterprises Limited | Pyrrolidine substituted flavones for treatment of renal cystic diseases |
US11007174B2 (en) | 2013-07-12 | 2021-05-18 | Piramal Enterprises Limited | Pharmaceutical combination for the treatment of melanoma |
ES2873959T3 (es) | 2014-05-28 | 2021-11-04 | Piramal Entpr Ltd | Combinación farmacéutica que comprende un inhibidor de CDK y un inhibidor de tiorredoxina reductasa para el tratamiento del cáncer |
US20180180994A1 (en) * | 2015-06-23 | 2018-06-28 | Covestro Deutschland Ag | Substituted triazines |
CA3103604C (en) | 2016-03-28 | 2023-09-26 | Presage Biosciences, Inc. | Pharmaceutical combinations for the treatment of cancer |
EP3804724B1 (de) | 2016-10-20 | 2022-12-07 | Pfizer Inc. | Cdk-inhibitoren zur behandlung von pah |
CA3061203A1 (en) | 2017-04-25 | 2018-11-01 | Ischemix Llc | Compositions and methods for treating traumatic brain injury |
CN107573270B (zh) * | 2017-09-29 | 2019-11-29 | 河南师范大学 | 一种α-甲酰基吡咯烷类化合物的合成方法 |
CN110028475B (zh) * | 2019-05-13 | 2022-07-01 | 中国药科大学 | 基于苯并吡喃结构的新型cdk9抑制剂、其制备方法及应用 |
AR121719A1 (es) | 2020-04-03 | 2022-06-29 | Petra Pharma Corp | Inhibidores alostéricos de cromenona del fosfoinosítido 3-quinasa (pi3k) para el tratamiento de enfermedades |
IL307950A (en) | 2021-05-03 | 2023-12-01 | Petra Pharma Corp | Allosteric chromanone inhibitors of PHOSPHOINOSITIDE 3-KINASE (PI3K) for the treatment of diseases |
AU2022282380A1 (en) | 2021-05-27 | 2023-12-07 | Petra Pharma Corporation | Allosteric chromenone inhibitors of phosphoinositide 3-kinase (pi3k) for the treatment of cancer |
CN113549044B (zh) * | 2021-07-23 | 2024-01-23 | 中国药科大学 | 8-氮杂环取代色酮类衍生物及其制备方法与制药用途 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3836676A1 (de) * | 1988-10-28 | 1990-05-03 | Hoechst Ag | Die verwendung von 4h-1-benzopyran-4-on-derivaten, neue 4h-1-benzopyran-4-on-derivate und diese enthaltende arzneimittel |
US5733920A (en) * | 1995-10-31 | 1998-03-31 | Mitotix, Inc. | Inhibitors of cyclin dependent kinases |
US5849733A (en) * | 1996-05-10 | 1998-12-15 | Bristol-Myers Squibb Co. | 2-thio or 2-oxo flavopiridol analogs |
CA2407796A1 (en) * | 2000-05-03 | 2001-11-08 | Hyun Ho Chung | Cdk inhibitors having 3-hydroxychromen-4-one structure |
-
2003
- 2003-06-24 TW TW092117185A patent/TWI331034B/zh not_active IP Right Cessation
- 2003-07-04 AR ARP030102432A patent/AR041184A1/es unknown
- 2003-07-07 PT PT03753911T patent/PT1556375E/pt unknown
- 2003-07-07 WO PCT/IN2003/000234 patent/WO2004004632A2/en active IP Right Grant
- 2003-07-07 CN CN038163241A patent/CN1668613B/zh not_active Expired - Lifetime
- 2003-07-07 AT AT03753911T patent/ATE399162T1/de active
- 2003-07-07 DE DE60321808T patent/DE60321808D1/de not_active Expired - Lifetime
- 2003-07-07 RU RU2005102939/04A patent/RU2334746C2/ru not_active IP Right Cessation
- 2003-07-07 NZ NZ537518A patent/NZ537518A/en not_active IP Right Cessation
- 2003-07-07 EP EP03753911A patent/EP1556375B1/de not_active Expired - Lifetime
- 2003-07-07 CA CA2492130A patent/CA2492130C/en not_active Expired - Fee Related
- 2003-07-07 ES ES03753911T patent/ES2309338T3/es not_active Expired - Lifetime
- 2003-07-07 JP JP2004519151A patent/JP4860148B2/ja not_active Expired - Lifetime
- 2003-07-07 MX MXPA05000388A patent/MXPA05000388A/es active IP Right Grant
- 2003-07-07 KR KR1020057000401A patent/KR100991920B1/ko not_active IP Right Cessation
- 2003-07-07 DK DK03753911T patent/DK1556375T3/da active
- 2003-07-07 BR BR0312633-1A patent/BR0312633A/pt not_active IP Right Cessation
- 2003-07-07 AU AU2003272070A patent/AU2003272070B2/en not_active Ceased
-
2005
- 2005-01-05 IL IL166153A patent/IL166153A/en active IP Right Grant
- 2005-01-06 ZA ZA200500138A patent/ZA200500138B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA2492130A1 (en) | 2004-01-15 |
ES2309338T3 (es) | 2008-12-16 |
WO2004004632A3 (en) | 2004-09-16 |
IL166153A (en) | 2009-11-18 |
AU2003272070B2 (en) | 2009-02-26 |
JP2006502109A (ja) | 2006-01-19 |
WO2004004632A8 (en) | 2005-03-24 |
CA2492130C (en) | 2011-09-06 |
TWI331034B (en) | 2010-10-01 |
IL166153A0 (en) | 2006-01-15 |
MXPA05000388A (es) | 2005-09-30 |
CN1668613A (zh) | 2005-09-14 |
EP1556375A2 (de) | 2005-07-27 |
JP4860148B2 (ja) | 2012-01-25 |
PT1556375E (pt) | 2008-10-03 |
DK1556375T3 (da) | 2008-11-03 |
AR041184A1 (es) | 2005-05-04 |
RU2005102939A (ru) | 2005-09-10 |
ATE399162T1 (de) | 2008-07-15 |
AU2003272070A1 (en) | 2004-01-23 |
KR100991920B1 (ko) | 2010-11-04 |
RU2334746C2 (ru) | 2008-09-27 |
TW200406202A (en) | 2004-05-01 |
WO2004004632A2 (en) | 2004-01-15 |
KR20050017110A (ko) | 2005-02-21 |
ZA200500138B (en) | 2006-02-22 |
EP1556375B1 (de) | 2008-06-25 |
NZ537518A (en) | 2008-02-29 |
BR0312633A (pt) | 2005-07-19 |
CN1668613B (zh) | 2012-07-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60321808D1 (de) | Flavon derivate als inhibitoren von cyclin-abhängigen kinasen | |
DE602004008303D1 (de) | Triazolopyrimidinderivate als inhibitoren von glycogensynthasekinase-3 | |
NO20045220L (no) | Heterocykliske inhibitorer for kinaser | |
ATE413404T1 (de) | Triazolopyrimidin derivate als inhibitoren von glycogen synthase kinase-3 | |
ATE416171T1 (de) | 2-hydroxy-3-heteroarylindole derivate als gsk3 inhibitoren | |
ATE404564T1 (de) | Diazepinoindolderivate als kinaseinhibitoren | |
ATE346070T1 (de) | Purinderivate als kinaseinhibitoren | |
ATE370137T1 (de) | 4-(6-gliedriger)-heteroaryl-acyl-pyrrolidin derivate als hcv-inhibitoren | |
NO20050636L (no) | Inhibitorer av tyrosinkinaser | |
DE602005025733D1 (de) | Pyrazolopyrimidinderivate als inhibitoren der cyclinabhängigen kinase | |
DK1562589T3 (da) | Diaminotriazoler der er nyttige som inhibitorer af proteinkinaser | |
ATE369356T1 (de) | Pyridazinon-derivate als cdk2-hemmer | |
NO20050072L (no) | Nye inhibitorer av kinaser | |
ATE375336T1 (de) | Triazolderivate als inhibitoren von11-beta- hydroxysteroid-dehydrogenase-1 | |
ATE452891T1 (de) | Pyrimidopyrimidone als kinaseinhibitoren | |
DE60315862D1 (de) | Dihydropyridinonderivate als hne-inhibitoren | |
NO20043158L (no) | Substituerte kinazolinderivater som inhibitorer av aurorakinaser | |
ATE426599T1 (de) | Thiazolylpiperidin derivate als mtp inhibitoren | |
NO20043726L (no) | Heteroarylforbindelser anvendelige som inhibitorer av GSK-3 | |
DE60305061D1 (de) | 2-pyridonderivate als inhibitoren von neutrophiler elastase | |
NO20043642L (no) | Heterocykiske tripeptider som hepatitt C inhibitorer | |
ATE374201T1 (de) | 6-alkoxypyridopyrimidine als inhibitoren der p-38-map-kinase | |
ATE398107T1 (de) | N-pyrrolidin-3-yl-amide-derivate als inhibitoren der serotonin- und noradrenalin-wiederaufnahme | |
ATE382048T1 (de) | Pyrazolopyrimdine als hemmstoffe cyclin abhängiger kinasen | |
ATE393159T1 (de) | Heterobicyclische pyrazolderivate als kinaseinhibitoren |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: PIRAMAL LIVE SCIENCE LTD., MAHARASHTRA, IN |
|
R081 | Change of applicant/patentee |
Ref document number: 1556375 Country of ref document: EP Owner name: PIRAMAL ENTERPRISES LTD., IN Free format text: FORMER OWNER: PIRAMAL LIVE SCIENCE LTD., MAHARASHTRA, IN Effective date: 20121031 |
|
R082 | Change of representative |
Ref document number: 1556375 Country of ref document: EP Representative=s name: MUELLER SCHUPFNER & PARTNER PATENT- UND RECHTS, DE Effective date: 20121031 |