DE60305061D1 - 2-pyridonderivate als inhibitoren von neutrophiler elastase - Google Patents

2-pyridonderivate als inhibitoren von neutrophiler elastase

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Publication number
DE60305061D1
DE60305061D1 DE60305061T DE60305061T DE60305061D1 DE 60305061 D1 DE60305061 D1 DE 60305061D1 DE 60305061 T DE60305061 T DE 60305061T DE 60305061 T DE60305061 T DE 60305061T DE 60305061 D1 DE60305061 D1 DE 60305061D1
Authority
DE
Germany
Prior art keywords
neutrophiler
elastase
inhibitors
pyridone derivatives
pyridone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60305061T
Other languages
English (en)
Other versions
DE60305061T2 (de
Inventor
Hakan Bladh
Tomas Klingstedt
Joakim Larsson
Karolina Lawitz
Matti Lepistoe
Hans Loenn
Grigorios Nikitidis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0203348A external-priority patent/SE0203348D0/xx
Priority claimed from SE0300388A external-priority patent/SE0300388D0/xx
Priority claimed from SE0302120A external-priority patent/SE0302120D0/xx
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of DE60305061D1 publication Critical patent/DE60305061D1/de
Application granted granted Critical
Publication of DE60305061T2 publication Critical patent/DE60305061T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C07ORGANIC CHEMISTRY
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    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/63One oxygen atom
    • C07D213/64One oxygen atom attached in position 2 or 6
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86Oxygen atoms
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D239/22Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
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    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • C07D239/54Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/557Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
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    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
DE60305061T 2002-11-12 2003-11-11 2-pyridonderivate als inhibitoren von neutrophiler elastase Expired - Fee Related DE60305061T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
SE0203348 2002-11-12
SE0203348A SE0203348D0 (sv) 2002-11-12 2002-11-12 Novel compounds
SE0300388A SE0300388D0 (sv) 2003-02-12 2003-02-12 Novel compounds
SE0300388 2003-02-12
SE0302120 2003-07-22
SE0302120A SE0302120D0 (sv) 2003-07-22 2003-07-22 Novel compounds
PCT/SE2003/001739 WO2004043924A1 (en) 2002-11-12 2003-11-11 2-pyridone derivatives as inhibitors of neutrophile elastase

Publications (2)

Publication Number Publication Date
DE60305061D1 true DE60305061D1 (de) 2006-06-08
DE60305061T2 DE60305061T2 (de) 2006-12-07

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
DE60305061T Expired - Fee Related DE60305061T2 (de) 2002-11-12 2003-11-11 2-pyridonderivate als inhibitoren von neutrophiler elastase

Country Status (25)

Country Link
US (1) US20060035938A1 (de)
EP (1) EP1562902B1 (de)
JP (1) JP2006513261A (de)
KR (1) KR20050086516A (de)
AR (1) AR042024A1 (de)
AT (1) ATE325096T1 (de)
AU (1) AU2003276802B2 (de)
BR (1) BR0316081A (de)
CA (1) CA2504766A1 (de)
CY (1) CY1106130T1 (de)
DE (1) DE60305061T2 (de)
DK (1) DK1562902T3 (de)
ES (1) ES2262029T3 (de)
HK (1) HK1079200A1 (de)
IS (1) IS2478B (de)
MX (1) MXPA05004818A (de)
MY (1) MY137133A (de)
NO (1) NO20052818L (de)
NZ (1) NZ539787A (de)
PL (1) PL376957A1 (de)
PT (1) PT1562902E (de)
RU (1) RU2328486C2 (de)
SI (1) SI1562902T1 (de)
TW (1) TW200500341A (de)
WO (1) WO2004043924A1 (de)

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TW200700392A (en) * 2005-03-16 2007-01-01 Astrazeneca Ab Novel compounds
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TW200808771A (en) * 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds II
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