DE60008524D1 - Furanonderivate als inhibitoren von cathepsin s - Google Patents
Furanonderivate als inhibitoren von cathepsin sInfo
- Publication number
- DE60008524D1 DE60008524D1 DE60008524T DE60008524T DE60008524D1 DE 60008524 D1 DE60008524 D1 DE 60008524D1 DE 60008524 T DE60008524 T DE 60008524T DE 60008524 T DE60008524 T DE 60008524T DE 60008524 D1 DE60008524 D1 DE 60008524D1
- Authority
- DE
- Germany
- Prior art keywords
- furanon
- cathepsin
- inhibitors
- derivatives
- furanon derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/22—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9911417 | 1999-05-18 | ||
GBGB9911417.5A GB9911417D0 (en) | 1999-05-18 | 1999-05-18 | Furanone derivatives as inhibitors of cathepsin s |
PCT/GB2000/001894 WO2000069855A2 (en) | 1999-05-18 | 2000-05-18 | Furanone derivatives as inhibitors of cathepsin s |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60008524D1 true DE60008524D1 (de) | 2004-04-01 |
DE60008524T2 DE60008524T2 (de) | 2004-12-23 |
Family
ID=10853598
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60008524T Expired - Fee Related DE60008524T2 (de) | 1999-05-18 | 2000-05-18 | Furanonderivate als inhibitoren von cathepsin s |
Country Status (16)
Country | Link |
---|---|
EP (2) | EP1413580A1 (de) |
JP (1) | JP2002544274A (de) |
AR (1) | AR024040A1 (de) |
AT (1) | ATE260274T1 (de) |
AU (1) | AU763694B2 (de) |
BR (1) | BR0010553A (de) |
CA (1) | CA2374297A1 (de) |
DE (1) | DE60008524T2 (de) |
DK (1) | DK1178986T3 (de) |
ES (1) | ES2215048T3 (de) |
GB (1) | GB9911417D0 (de) |
IL (2) | IL146409A (de) |
MX (1) | MXPA01011872A (de) |
MY (1) | MY130768A (de) |
PT (1) | PT1178986E (de) |
WO (1) | WO2000069855A2 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004512261A (ja) * | 2000-05-17 | 2004-04-22 | メディヴァー ユーケイ リミテッド | 分枝鎖アミノ酸 |
ES2261341T3 (es) * | 2000-11-17 | 2006-11-16 | Medivir Ab | Inhibidor de cisteina proteasa. |
JP2004523506A (ja) | 2000-12-22 | 2004-08-05 | アクシス・ファーマシューティカルズ・インコーポレイテッド | カテプシン阻害剤としての新規な化合物と組成物 |
US7030116B2 (en) | 2000-12-22 | 2006-04-18 | Aventis Pharmaceuticals Inc. | Compounds and compositions as cathepsin inhibitors |
NZ526914A (en) * | 2001-01-17 | 2005-02-25 | Amura Therapeutics Ltd | Cyclic 2-carbonylaminoketones as inhibitors of cruzipain and other cysteine proteases |
NZ526912A (en) * | 2001-01-17 | 2005-02-25 | Amura Therapeutics Ltd | Inhibitors of cruzipain and other cysteine proteases |
NZ526913A (en) * | 2001-01-17 | 2004-12-24 | Amura Therapeutics Ltd | Inhibitors of cruzipain and other cysteine proteases |
US7132449B2 (en) | 2001-01-17 | 2006-11-07 | Amura Therapeutics Limited | Inhibitors of cruzipain and other cysteine proteases |
EP1436255A1 (de) | 2001-09-14 | 2004-07-14 | Aventis Pharmaceuticals, Inc. | Neue verbindungen und zusammensetzungen als cathepsininhibitoren |
CA2463770A1 (en) | 2001-10-29 | 2003-05-08 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as reversible inhibitors of cysteine proteases |
KR20050044497A (ko) | 2001-11-14 | 2005-05-12 | 아벤티스 파마슈티칼스 인크. | 올리고펩티드 및 카텝신 s 억제제로서 이를 포함하는조성물 |
EP1483241A4 (de) | 2002-03-08 | 2006-12-13 | Bristol Myers Squibb Co | Cyclische derivate als modulatoren der chemokinrezeptoraktivität |
NZ537853A (en) * | 2002-07-16 | 2007-02-23 | Amura Therapeutics Ltd | Inhibitors of cathepsin K and related cysteine protesases of the CA clan |
PL408347A1 (pl) | 2002-09-24 | 2014-08-18 | Novartis Ag | Kombinacja, zastosowanie kombinacji oraz zastosowanie agonisty receptora S1P |
US7297714B2 (en) * | 2003-10-21 | 2007-11-20 | Irm Llc | Inhibitors of cathepsin S |
WO2005082876A1 (en) * | 2004-03-01 | 2005-09-09 | Medivir Uk Ltd | C-5 substituted furanone dipeptide cathepsin s inhibitors |
WO2006064286A1 (en) * | 2004-12-13 | 2006-06-22 | Medivir Uk Ltd | Cathepsin s inhibitors |
GB0614042D0 (en) | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
EP1916248A1 (de) * | 2006-10-24 | 2008-04-30 | Medivir Ab | Furanonderivate als Inhibitoren der Cysteinprotease |
CA2678717A1 (en) * | 2007-02-28 | 2008-09-04 | Sanofi-Aventis | Imaging probes |
JP5587790B2 (ja) | 2008-01-09 | 2014-09-10 | アミュラ セラピューティクス リミティド | 化合物 |
WO2009155475A1 (en) | 2008-06-20 | 2009-12-23 | Novartis Ag | Paediatric compositions for treating1 multiple sclerosis |
US20220193048A1 (en) | 2019-04-05 | 2022-06-23 | Universite De Bretagne Occidentale | Protease-activated receptor-2 inhibitors for the treatment of sensory neuropathy induced by a marine neurotoxic poisoning |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2111930A1 (en) * | 1992-12-25 | 1994-06-26 | Ryoichi Ando | Aminoketone derivatives |
CA2251714A1 (en) * | 1996-04-22 | 1997-10-30 | Massachusetts Institute Of Technology | Suppression of immune response via inhibition of cathepsin s |
AR013079A1 (es) * | 1997-05-06 | 2000-12-13 | Smithkline Beecham Corp | Derivados sustituidos de tetrahidrofurano-3-onas, de tetrahidropirano-3- onas y tetrahidrotiofen-3-onas, un procedimiento para su preparacion unacomposicion farmaceutica de un medicamento util como inhibidores de proteasas e intermediarios |
-
1999
- 1999-05-18 GB GBGB9911417.5A patent/GB9911417D0/en not_active Ceased
-
2000
- 2000-05-17 MY MYPI20002178A patent/MY130768A/en unknown
- 2000-05-18 AT AT00929721T patent/ATE260274T1/de not_active IP Right Cessation
- 2000-05-18 JP JP2000618272A patent/JP2002544274A/ja active Pending
- 2000-05-18 ES ES00929721T patent/ES2215048T3/es not_active Expired - Lifetime
- 2000-05-18 IL IL14640900A patent/IL146409A/xx not_active IP Right Cessation
- 2000-05-18 IL IL14640988A patent/IL146409A0/xx unknown
- 2000-05-18 PT PT00929721T patent/PT1178986E/pt unknown
- 2000-05-18 MX MXPA01011872A patent/MXPA01011872A/es active IP Right Grant
- 2000-05-18 WO PCT/GB2000/001894 patent/WO2000069855A2/en active IP Right Grant
- 2000-05-18 DE DE60008524T patent/DE60008524T2/de not_active Expired - Fee Related
- 2000-05-18 EP EP20040002432 patent/EP1413580A1/de not_active Withdrawn
- 2000-05-18 CA CA002374297A patent/CA2374297A1/en not_active Abandoned
- 2000-05-18 AU AU47722/00A patent/AU763694B2/en not_active Ceased
- 2000-05-18 EP EP00929721A patent/EP1178986B1/de not_active Expired - Lifetime
- 2000-05-18 BR BR0010553-8A patent/BR0010553A/pt not_active Withdrawn
- 2000-05-18 DK DK00929721T patent/DK1178986T3/da active
- 2000-05-19 AR ARP000102445A patent/AR024040A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2002544274A (ja) | 2002-12-24 |
IL146409A0 (en) | 2002-07-25 |
ES2215048T3 (es) | 2004-10-01 |
EP1178986B1 (de) | 2004-02-25 |
CA2374297A1 (en) | 2000-11-23 |
WO2000069855A3 (en) | 2001-02-08 |
ATE260274T1 (de) | 2004-03-15 |
EP1413580A1 (de) | 2004-04-28 |
AR024040A1 (es) | 2002-09-04 |
MY130768A (en) | 2007-07-31 |
DK1178986T3 (da) | 2004-07-05 |
AU4772200A (en) | 2000-12-05 |
AU763694B2 (en) | 2003-07-31 |
WO2000069855A2 (en) | 2000-11-23 |
GB9911417D0 (en) | 1999-07-14 |
BR0010553A (pt) | 2002-07-02 |
MXPA01011872A (es) | 2003-09-04 |
IL146409A (en) | 2005-11-20 |
PT1178986E (pt) | 2004-07-30 |
DE60008524T2 (de) | 2004-12-23 |
EP1178986A2 (de) | 2002-02-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |