MXPA05000388A - Derivados de flavona como inhibidores de cinasas dependientes de la ciclina. - Google Patents
Derivados de flavona como inhibidores de cinasas dependientes de la ciclina.Info
- Publication number
- MXPA05000388A MXPA05000388A MXPA05000388A MXPA05000388A MXPA05000388A MX PA05000388 A MXPA05000388 A MX PA05000388A MX PA05000388 A MXPA05000388 A MX PA05000388A MX PA05000388 A MXPA05000388 A MX PA05000388A MX PA05000388 A MXPA05000388 A MX PA05000388A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- cyclin
- dependent kinases
- relates
- diseases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
La presente invencion se relaciona con compuestos novedosos para la inhibicion de las cinasas dependientes de la ciclina, y mas particularmente, con derivados de cromenona de formula (la), en donde R1, R2, R3, R4, R5, R6, R7 y A tienen los significados indicados en las reivindicaciones. La invencion tambien se relaciona con los procesos para la preparacion de tales compuestos, metodos para inhibir las cinasas dependientes de la ciclina y para inhibir la proliferacion celular, el uso de tales compuestos en el tratamiento y profilaxis de enfermedades, y con el uso de los compuestos en la preparacion de medicamentos a ser aplicados en tales enfermedades. La invencion se relaciona ademas con composiciones que contienen tales compuestos, ya sea solos o en combinacion con otro agente activo, en mezcla o de otra manera, en asociacion con un portador inerte, en particular, con composiciones farmaceuticas que contienen tales compuestos ya sea solos o en combinacion con otro agente activo, junto bon sustancias portadoras farmaceuticamente aceptables y sustancias auxiliares.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN616MU2002 | 2002-07-08 | ||
| PCT/IN2003/000234 WO2004004632A2 (en) | 2002-07-08 | 2003-07-07 | Flavone derivatives as inhibitors of cyclin-dependent kinases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA05000388A true MXPA05000388A (es) | 2005-09-30 |
Family
ID=30012269
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA05000388A MXPA05000388A (es) | 2002-07-08 | 2003-07-07 | Derivados de flavona como inhibidores de cinasas dependientes de la ciclina. |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1556375B1 (es) |
| JP (1) | JP4860148B2 (es) |
| KR (1) | KR100991920B1 (es) |
| CN (1) | CN1668613B (es) |
| AR (1) | AR041184A1 (es) |
| AT (1) | ATE399162T1 (es) |
| AU (1) | AU2003272070B2 (es) |
| BR (1) | BR0312633A (es) |
| CA (1) | CA2492130C (es) |
| DE (1) | DE60321808D1 (es) |
| DK (1) | DK1556375T3 (es) |
| ES (1) | ES2309338T3 (es) |
| IL (1) | IL166153A (es) |
| MX (1) | MXPA05000388A (es) |
| NZ (1) | NZ537518A (es) |
| PT (1) | PT1556375E (es) |
| RU (1) | RU2334746C2 (es) |
| TW (1) | TWI331034B (es) |
| WO (1) | WO2004004632A2 (es) |
| ZA (1) | ZA200500138B (es) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7915301B2 (en) | 2002-07-08 | 2011-03-29 | Piramal Life Science Limited | Inhibitors of cyclin dependent kinases and their use |
| WO2007148158A1 (en) * | 2006-06-21 | 2007-12-27 | Piramal Life Sciences Limited | Enantiomerically pure flavone derivatives for the treatment of poliferative disorders and processes for their preparation |
| JP5006396B2 (ja) | 2006-07-07 | 2012-08-22 | ピラマル・ライフ・サイエンシーズ・リミテッド | ピロリジン置換フラボンのエナンチオ選択的合成 |
| BRPI0721626A2 (pt) * | 2007-05-15 | 2013-01-22 | Piramal Life Sciences Ltd | combinaÇço farmacÊutica sinergÍstica para o tratamento de cÂncer |
| CN101333205A (zh) * | 2008-07-10 | 2008-12-31 | 大连理工大学 | 周期素依赖蛋白激酶抑制剂黄芩素哌嗪衍生物及其制法 |
| TWI461194B (zh) | 2009-05-05 | 2014-11-21 | Piramal Entpr Ltd | 吡咯啶取代黃酮作為輻射致敏劑 |
| CN102438452B (zh) * | 2009-05-08 | 2015-02-25 | 乔治亚州大学研究基金会 | 包含cdk抑制剂的化合物和组合物以及用于癌症治疗的方法 |
| US7928067B2 (en) | 2009-05-14 | 2011-04-19 | Ischemix Llc | Compositions and methods for treating ischemia and ischemia-reperfusion injury |
| NZ602636A (en) * | 2010-02-26 | 2014-08-29 | Piramal Entpr Ltd | Pyrrolidine substituted flavones for the treatment of inflammatory disorders |
| WO2012067947A1 (en) | 2010-11-18 | 2012-05-24 | Ischemix Llc | Lipoyl compounds and their use for treating ischemic injury |
| RU2013127655A (ru) * | 2010-11-19 | 2014-12-27 | Пирамал Энтерпрайзис Лимитед | Фармацевтическая комбинация паклитаксела и ингибитора cdk |
| WO2012069972A1 (en) | 2010-11-19 | 2012-05-31 | Piramal Life Sciences Limited | A pharmaceutical combination for the treatment of breast cancer |
| TW201242597A (en) | 2011-03-14 | 2012-11-01 | Piramal Life Sciences Ltd | A synergistic pharmaceutical combination for the treatment of pancreatic cancer |
| US8530470B2 (en) * | 2011-04-13 | 2013-09-10 | Astrazeneca Ab | Chromenone derivatives |
| TW201300105A (zh) | 2011-05-31 | 2013-01-01 | Piramal Life Sciences Ltd | 治療頭頸鱗狀細胞癌之相乘藥物組合物 |
| AU2012274990A1 (en) | 2011-06-24 | 2014-02-06 | Piramal Enterprises Limited | Compounds for the treatment of cancers associated with human papillomavirus |
| IN2014MN01546A (es) | 2012-01-13 | 2015-05-08 | Piramal Entpr Ltd | |
| WO2014049515A1 (en) * | 2012-09-25 | 2014-04-03 | Piramal Enterprises Limited | Pyrrolidine substituted flavones for treatment of renal cystic diseases |
| EP3019166B1 (en) | 2013-07-12 | 2019-05-08 | Piramal Enterprises Limited | A pharmaceutical combination for the treatment of melanoma |
| US10555931B2 (en) | 2014-05-28 | 2020-02-11 | Piramal Enterprises Limited | Pharmaceutical combination for the treatment of cancer |
| EP3313826B1 (de) * | 2015-06-23 | 2020-01-08 | Covestro Deutschland AG | Substituierte triazine und ein verfahren zu ihrer herstellung |
| EP3436002A4 (en) | 2016-03-28 | 2019-12-04 | Presage Biosciences, Inc. | PHARMACEUTICAL COMBINATIONS FOR THE TREATMENT OF CANCER |
| SG11201902523UA (en) | 2016-10-20 | 2019-05-30 | Pfizer | Anti-proliferative agents for treating pah |
| JP7203756B2 (ja) | 2017-04-25 | 2023-01-13 | イスケミックス エルエルシー | 外傷性脳傷害を治療するための組成物および方法 |
| CN107573270B (zh) * | 2017-09-29 | 2019-11-29 | 河南师范大学 | 一种α-甲酰基吡咯烷类化合物的合成方法 |
| JP2022512711A (ja) | 2018-10-19 | 2022-02-07 | エフ．ホフマン－ラ ロシュ アーゲー | Ｂ型肝炎ウイルス疾患の処置及び予防のための、クロメン－４－オン誘導体 |
| CN110028475B (zh) * | 2019-05-13 | 2022-07-01 | 中国药科大学 | 基于苯并吡喃结构的新型cdk9抑制剂、其制备方法及应用 |
| AR121719A1 (es) | 2020-04-03 | 2022-06-29 | Petra Pharma Corp | Inhibidores alostéricos de cromenona del fosfoinosítido 3-quinasa (pi3k) para el tratamiento de enfermedades |
| KR20240004865A (ko) | 2021-05-03 | 2024-01-11 | 페트라 파마 코포레이션 | 질환의 치료를 위한 포스포이노시티드 3-키나제 (pi3k)의 알로스테릭 크로메논 억제제 |
| EP4347040A1 (en) | 2021-05-27 | 2024-04-10 | Petra Pharma Corporation | Allosteric chromenone inhibitors of phosphoinositide 3-kinase (pi3k) for the treatment of cancer |
| CN113549044B (zh) * | 2021-07-23 | 2024-01-23 | 中国药科大学 | 8-氮杂环取代色酮类衍生物及其制备方法与制药用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3836676A1 (de) * | 1988-10-28 | 1990-05-03 | Hoechst Ag | Die verwendung von 4h-1-benzopyran-4-on-derivaten, neue 4h-1-benzopyran-4-on-derivate und diese enthaltende arzneimittel |
| US5733920A (en) * | 1995-10-31 | 1998-03-31 | Mitotix, Inc. | Inhibitors of cyclin dependent kinases |
| US5849733A (en) * | 1996-05-10 | 1998-12-15 | Bristol-Myers Squibb Co. | 2-thio or 2-oxo flavopiridol analogs |
| WO2001083469A1 (en) * | 2000-05-03 | 2001-11-08 | Lg Life Sciences Ltd. | Cdk inhibitors having 3-hydroxychromen-4-one structure |
-
2003
- 2003-06-24 TW TW092117185A patent/TWI331034B/zh not_active IP Right Cessation
- 2003-07-04 AR ARP030102432A patent/AR041184A1/es unknown
- 2003-07-07 EP EP03753911A patent/EP1556375B1/en not_active Expired - Lifetime
- 2003-07-07 PT PT03753911T patent/PT1556375E/pt unknown
- 2003-07-07 RU RU2005102939/04A patent/RU2334746C2/ru not_active IP Right Cessation
- 2003-07-07 BR BR0312633-1A patent/BR0312633A/pt not_active IP Right Cessation
- 2003-07-07 NZ NZ537518A patent/NZ537518A/en not_active IP Right Cessation
- 2003-07-07 DK DK03753911T patent/DK1556375T3/da active
- 2003-07-07 CN CN038163241A patent/CN1668613B/zh not_active Expired - Lifetime
- 2003-07-07 DE DE60321808T patent/DE60321808D1/de not_active Expired - Lifetime
- 2003-07-07 AU AU2003272070A patent/AU2003272070B2/en not_active Ceased
- 2003-07-07 KR KR1020057000401A patent/KR100991920B1/ko not_active IP Right Cessation
- 2003-07-07 ES ES03753911T patent/ES2309338T3/es not_active Expired - Lifetime
- 2003-07-07 AT AT03753911T patent/ATE399162T1/de active
- 2003-07-07 CA CA2492130A patent/CA2492130C/en not_active Expired - Fee Related
- 2003-07-07 JP JP2004519151A patent/JP4860148B2/ja not_active Expired - Lifetime
- 2003-07-07 MX MXPA05000388A patent/MXPA05000388A/es active IP Right Grant
- 2003-07-07 WO PCT/IN2003/000234 patent/WO2004004632A2/en active IP Right Grant
-
2005
- 2005-01-05 IL IL166153A patent/IL166153A/en active IP Right Grant
- 2005-01-06 ZA ZA200500138A patent/ZA200500138B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW200406202A (en) | 2004-05-01 |
| WO2004004632A2 (en) | 2004-01-15 |
| WO2004004632A3 (en) | 2004-09-16 |
| CA2492130C (en) | 2011-09-06 |
| NZ537518A (en) | 2008-02-29 |
| DK1556375T3 (da) | 2008-11-03 |
| CN1668613B (zh) | 2012-07-04 |
| KR20050017110A (ko) | 2005-02-21 |
| EP1556375A2 (en) | 2005-07-27 |
| ES2309338T3 (es) | 2008-12-16 |
| JP4860148B2 (ja) | 2012-01-25 |
| KR100991920B1 (ko) | 2010-11-04 |
| RU2334746C2 (ru) | 2008-09-27 |
| ATE399162T1 (de) | 2008-07-15 |
| EP1556375B1 (en) | 2008-06-25 |
| WO2004004632A8 (en) | 2005-03-24 |
| ZA200500138B (en) | 2006-02-22 |
| BR0312633A (pt) | 2005-07-19 |
| TWI331034B (en) | 2010-10-01 |
| AU2003272070A1 (en) | 2004-01-23 |
| AU2003272070B2 (en) | 2009-02-26 |
| DE60321808D1 (de) | 2008-08-07 |
| IL166153A0 (en) | 2006-01-15 |
| JP2006502109A (ja) | 2006-01-19 |
| CA2492130A1 (en) | 2004-01-15 |
| IL166153A (en) | 2009-11-18 |
| CN1668613A (zh) | 2005-09-14 |
| PT1556375E (pt) | 2008-10-03 |
| AR041184A1 (es) | 2005-05-04 |
| RU2005102939A (ru) | 2005-09-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| GB | Transfer or rights | ||
| HC | Change of company name or juridical status | ||
| GB | Transfer or rights | ||
| HC | Change of company name or juridical status |