BR0312633A - Composto, uso do composto, composição farmacêutica, processo para a preparação de um composto - Google Patents
Composto, uso do composto, composição farmacêutica, processo para a preparação de um compostoInfo
- Publication number
- BR0312633A BR0312633A BR0312633-1A BR0312633A BR0312633A BR 0312633 A BR0312633 A BR 0312633A BR 0312633 A BR0312633 A BR 0312633A BR 0312633 A BR0312633 A BR 0312633A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- compounds
- combination
- present
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
"COMPOSTO, USO DO COMPOSTO, COMPOSIçãO FARMACêUTICA, PROCESSO PARA A PREPARAçãO DE UM COMPOSTO". A presente invenção refere-se a novos compostos para a inibição de quinases dependentes de ciclina e, mais particularmente, a derivados de cromenona tendo a fórmula (Ia), na qual R~ 1~, R~ 2~, R~ 3~, R~ 4~, R~ 5~, R~ 6~, R~ 7~ e A apresentam os significados indicados nas reivindicações. A presente invenção se refere também a processos para a preparação dos referidos compostos, a métodos de inibição de quinases dependente de ciclina e de inibição de proliferação celular, ao uso dos referidos compostos no tratamento e profilaxia de doenças, e ao uso dos compostos na preparação de medicamentos a serem aplicados nas referidas doenças. A presente invenção adicionalmente se refere-composições contendo os referidos compostos, seja isolada ou em combinação com outro agente ativo, em mistura ou então em associação com um veículo inerte, em particular composições farmacêuticas contendo os referidos compostos sejam isolados ou em combinação com outro agente ativo, junto com as substâncias veículos e substâncias auxiliares farmaceuticamente aceitáveis.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN616MU2002 | 2002-07-08 | ||
| PCT/IN2003/000234 WO2004004632A2 (en) | 2002-07-08 | 2003-07-07 | Flavone derivatives as inhibitors of cyclin-dependent kinases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0312633A true BR0312633A (pt) | 2005-07-19 |
Family
ID=30012269
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0312633-1A BR0312633A (pt) | 2002-07-08 | 2003-07-07 | Composto, uso do composto, composição farmacêutica, processo para a preparação de um composto |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1556375B1 (pt) |
| JP (1) | JP4860148B2 (pt) |
| KR (1) | KR100991920B1 (pt) |
| CN (1) | CN1668613B (pt) |
| AR (1) | AR041184A1 (pt) |
| AT (1) | ATE399162T1 (pt) |
| AU (1) | AU2003272070B2 (pt) |
| BR (1) | BR0312633A (pt) |
| CA (1) | CA2492130C (pt) |
| DE (1) | DE60321808D1 (pt) |
| DK (1) | DK1556375T3 (pt) |
| ES (1) | ES2309338T3 (pt) |
| IL (1) | IL166153A (pt) |
| MX (1) | MXPA05000388A (pt) |
| NZ (1) | NZ537518A (pt) |
| PT (1) | PT1556375E (pt) |
| RU (1) | RU2334746C2 (pt) |
| TW (1) | TWI331034B (pt) |
| WO (1) | WO2004004632A2 (pt) |
| ZA (1) | ZA200500138B (pt) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7915301B2 (en) | 2002-07-08 | 2011-03-29 | Piramal Life Science Limited | Inhibitors of cyclin dependent kinases and their use |
| NZ574266A (en) * | 2006-06-21 | 2011-10-28 | Piramal Life Sciences Ltd | Enantiomerically pure flavone derivatives for the treatment of poliferative disorders and processes for their preparation |
| BRPI0621851A2 (pt) * | 2006-07-07 | 2013-01-29 | Piramal Life Sciences Ltd | sÍntese enantiosseletiva de pirrolidinas substituÍdas com flavonas, e intermediÁrios das mesmas |
| NZ581183A (en) * | 2007-05-15 | 2012-03-30 | Piramal Life Sciences Ltd | Combination of a cytotoxic antineoplastic agent and a cyclin dependent kinase (CDK) inhibitor for the treatment of cancer |
| CN101333205A (zh) * | 2008-07-10 | 2008-12-31 | 大连理工大学 | 周期素依赖蛋白激酶抑制剂黄芩素哌嗪衍生物及其制法 |
| TWI461194B (zh) | 2009-05-05 | 2014-11-21 | Piramal Entpr Ltd | 吡咯啶取代黃酮作為輻射致敏劑 |
| CN102438452B (zh) * | 2009-05-08 | 2015-02-25 | 乔治亚州大学研究基金会 | 包含cdk抑制剂的化合物和组合物以及用于癌症治疗的方法 |
| US7928067B2 (en) | 2009-05-14 | 2011-04-19 | Ischemix Llc | Compositions and methods for treating ischemia and ischemia-reperfusion injury |
| EP2538941A1 (en) * | 2010-02-26 | 2013-01-02 | Piramal Enterprises Limited | Pyrrolidine substituted flavones for the treatment of inflammatory disorders |
| CN103561770B (zh) | 2010-11-18 | 2016-11-09 | 艾雪米克斯公司 | 硫辛酰基化合物及其用于治疗缺血性伤害的用途 |
| JP2013542979A (ja) * | 2010-11-19 | 2013-11-28 | ピラマル エンタープライジーズ リミテッド | パクリタキセルとｃｄｋ阻害剤の薬学的組合せ |
| WO2012069972A1 (en) | 2010-11-19 | 2012-05-31 | Piramal Life Sciences Limited | A pharmaceutical combination for the treatment of breast cancer |
| WO2012123889A1 (en) | 2011-03-14 | 2012-09-20 | Piramal Healthcare Limited | A synergistic pharmaceutical combination for the treatment of pancreatic cancer |
| US8530470B2 (en) * | 2011-04-13 | 2013-09-10 | Astrazeneca Ab | Chromenone derivatives |
| TW201300105A (zh) | 2011-05-31 | 2013-01-01 | Piramal Life Sciences Ltd | 治療頭頸鱗狀細胞癌之相乘藥物組合物 |
| BR112013033311A2 (pt) | 2011-06-24 | 2017-08-22 | Piramal Entpr Ltd | Compostos para o tratamento de cânceres associados com papilomavírus humano |
| US20140348950A1 (en) | 2012-01-13 | 2014-11-27 | Piramal Enterprises Limited | Pyrrolidine- substituted flavone derivatives for prevention or treatment of oral mucositis |
| WO2014049515A1 (en) * | 2012-09-25 | 2014-04-03 | Piramal Enterprises Limited | Pyrrolidine substituted flavones for treatment of renal cystic diseases |
| CN105530931B (zh) * | 2013-07-12 | 2019-11-08 | 皮拉马尔企业有限公司 | 用于治疗黑素瘤的药物组合 |
| WO2015181737A1 (en) | 2014-05-28 | 2015-12-03 | Piramal Enterprises Limited | Pharmaceutical combination for the treatment of cancer |
| EP3313827B1 (de) * | 2015-06-23 | 2019-11-06 | Covestro Deutschland AG | Substituierte triazine |
| RU2020121147A (ru) | 2016-03-28 | 2021-11-03 | Пресидж Байосайенсиз, Инк. | Фармацевтические комбинации для лечения злокачественной опухоли |
| ES2934846T3 (es) | 2016-10-20 | 2023-02-27 | Pfizer | Inhibidores de CDK para tratamiento de PAH |
| ES2952834T3 (es) | 2017-04-25 | 2023-11-06 | Ischemix Llc | Lipoil-Glu-Ala para el tratamiento de daño neurodegenerativo producido por traumatismo craneoencefálico |
| CN107573270B (zh) * | 2017-09-29 | 2019-11-29 | 河南师范大学 | 一种α-甲酰基吡咯烷类化合物的合成方法 |
| US11993591B2 (en) | 2018-10-19 | 2024-05-28 | Hoffmann-La Roche Inc. | Chromen-4-one derivatives for the treatment and prophylaxis of hepatitis B virus disease |
| CN110028475B (zh) * | 2019-05-13 | 2022-07-01 | 中国药科大学 | 基于苯并吡喃结构的新型cdk9抑制剂、其制备方法及应用 |
| CR20220236A (es) | 2019-11-28 | 2022-10-03 | Bayer Pharma AG | Aminoquinolonas sustituidas como inhibidores de dgk alfa para la activación inmune |
| AR121719A1 (es) | 2020-04-03 | 2022-06-29 | Petra Pharma Corp | Inhibidores alostéricos de cromenona del fosfoinosítido 3-quinasa (pi3k) para el tratamiento de enfermedades |
| IL307950A (en) | 2021-05-03 | 2023-12-01 | Petra Pharma Corp | Allosteric chromanone inhibitors of PHOSPHOINOSITIDE 3-KINASE (PI3K) for the treatment of diseases |
| BR112023022890A2 (pt) | 2021-05-27 | 2024-01-23 | Petra Pharma Corp | Inibidores de cromenona alostéricos de fosfoinositídio 3-cinase (pi3k), composições farmacêuticas que os compreendem e usos dos mesmos |
| CN113549044B (zh) * | 2021-07-23 | 2024-01-23 | 中国药科大学 | 8-氮杂环取代色酮类衍生物及其制备方法与制药用途 |
| TW202329930A (zh) | 2021-09-30 | 2023-08-01 | 美商佩特拉製藥公司 | 用於治療疾病之磷酸肌醇3-激酶(pi3k)之異位色烯酮抑制劑 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3836676A1 (de) * | 1988-10-28 | 1990-05-03 | Hoechst Ag | Die verwendung von 4h-1-benzopyran-4-on-derivaten, neue 4h-1-benzopyran-4-on-derivate und diese enthaltende arzneimittel |
| US5733920A (en) * | 1995-10-31 | 1998-03-31 | Mitotix, Inc. | Inhibitors of cyclin dependent kinases |
| US5849733A (en) * | 1996-05-10 | 1998-12-15 | Bristol-Myers Squibb Co. | 2-thio or 2-oxo flavopiridol analogs |
| JP2003531899A (ja) * | 2000-05-03 | 2003-10-28 | エルジー ライフ サイエンス リミテッド | ３−ヒドロキシクロメン−４−オン構造を有するｃｄｋ阻害剤 |
-
2003
- 2003-06-24 TW TW092117185A patent/TWI331034B/zh not_active IP Right Cessation
- 2003-07-04 AR ARP030102432A patent/AR041184A1/es unknown
- 2003-07-07 CA CA2492130A patent/CA2492130C/en not_active Expired - Fee Related
- 2003-07-07 DE DE60321808T patent/DE60321808D1/de not_active Expired - Lifetime
- 2003-07-07 KR KR1020057000401A patent/KR100991920B1/ko not_active IP Right Cessation
- 2003-07-07 AT AT03753911T patent/ATE399162T1/de active
- 2003-07-07 WO PCT/IN2003/000234 patent/WO2004004632A2/en active IP Right Grant
- 2003-07-07 RU RU2005102939/04A patent/RU2334746C2/ru not_active IP Right Cessation
- 2003-07-07 ES ES03753911T patent/ES2309338T3/es not_active Expired - Lifetime
- 2003-07-07 AU AU2003272070A patent/AU2003272070B2/en not_active Ceased
- 2003-07-07 PT PT03753911T patent/PT1556375E/pt unknown
- 2003-07-07 CN CN038163241A patent/CN1668613B/zh not_active Expired - Lifetime
- 2003-07-07 MX MXPA05000388A patent/MXPA05000388A/es active IP Right Grant
- 2003-07-07 BR BR0312633-1A patent/BR0312633A/pt not_active IP Right Cessation
- 2003-07-07 EP EP03753911A patent/EP1556375B1/en not_active Expired - Lifetime
- 2003-07-07 JP JP2004519151A patent/JP4860148B2/ja not_active Expired - Lifetime
- 2003-07-07 NZ NZ537518A patent/NZ537518A/en not_active IP Right Cessation
- 2003-07-07 DK DK03753911T patent/DK1556375T3/da active
-
2005
- 2005-01-05 IL IL166153A patent/IL166153A/en active IP Right Grant
- 2005-01-06 ZA ZA200500138A patent/ZA200500138B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003272070A1 (en) | 2004-01-23 |
| ATE399162T1 (de) | 2008-07-15 |
| ES2309338T3 (es) | 2008-12-16 |
| JP2006502109A (ja) | 2006-01-19 |
| TW200406202A (en) | 2004-05-01 |
| WO2004004632A2 (en) | 2004-01-15 |
| PT1556375E (pt) | 2008-10-03 |
| CN1668613A (zh) | 2005-09-14 |
| IL166153A0 (en) | 2006-01-15 |
| TWI331034B (en) | 2010-10-01 |
| WO2004004632A3 (en) | 2004-09-16 |
| JP4860148B2 (ja) | 2012-01-25 |
| AU2003272070B2 (en) | 2009-02-26 |
| KR100991920B1 (ko) | 2010-11-04 |
| EP1556375B1 (en) | 2008-06-25 |
| IL166153A (en) | 2009-11-18 |
| CA2492130A1 (en) | 2004-01-15 |
| EP1556375A2 (en) | 2005-07-27 |
| NZ537518A (en) | 2008-02-29 |
| CN1668613B (zh) | 2012-07-04 |
| KR20050017110A (ko) | 2005-02-21 |
| RU2334746C2 (ru) | 2008-09-27 |
| WO2004004632A8 (en) | 2005-03-24 |
| CA2492130C (en) | 2011-09-06 |
| ZA200500138B (en) | 2006-02-22 |
| MXPA05000388A (es) | 2005-09-30 |
| DK1556375T3 (da) | 2008-11-03 |
| DE60321808D1 (de) | 2008-08-07 |
| AR041184A1 (es) | 2005-05-04 |
| RU2005102939A (ru) | 2005-09-10 |
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Legal Events
| Date | Code | Title | Description |
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| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
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Free format text: PARA INT.CL: C07D 405/04, C07D 405/14, A61P 35/00 Ipc: C07D 405/04 (2011.01) |
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| B25C | Requirement related to requested transfer of rights |
Owner name: NICHOLAS PIRAMAL INDIA LIMITED (IN) Free format text: A FIM DE ATENDER A TRANSFERENCIA REQUERIDA ATRAVES DA PETICAO NO 020100053597/RJ DE 15/06/2010, E NECESSARIO APRESENTAR A DOCUMENTACAO COM A DEVIDA LEGALIZACAO CONSULAR, ALEM DE GUIA REFERENTE A UMA ALTERACAO DE NOME, BEM COMO A GUIA DE CUMPRIMENTO DE EXIGENCIA. |
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| B25D | Requested change of name of applicant approved |
Owner name: PIRAMAL HEALTHCARE LIMITED (IN) Free format text: NOME ALTERADO DE: NICHOLAS PIRAMAL INDIA LIMITED |
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| B25G | Requested change of headquarter approved |
Owner name: PIRAMAL HEALTHCARE LIMITED (IN) Free format text: ENDERECO ALTERADO CONFORME SOLICITADO NA PETICAO NO 020110084023/RJ DE 11/08/2011. |
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| B25A | Requested transfer of rights approved |
Owner name: PIRAMAL LIFE SCIENCES LIMITED (IN) Free format text: TRANSFERIDO DE: PIRAMAL HEALTHCARE LIMITED |
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B25C | Requirement related to requested transfer of rights |
Owner name: PIRAMAL LIFE SCIENCES LIMITED (IN) Free format text: A FIM DE ATENDER A TRANSFERENCIA, REQUERIDA ATRAVES DA PETICAO NO 20140005905/RJ DE 11/02/2014, E NECESSARIO APRESENTAR O DOCUMENTO DE CESSAO COM A DEVIDA LEGALIZACAO CONSULAR. |
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| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
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| B06G | Technical and formal requirements: other requirements [chapter 6.7 patent gazette] |
Free format text: PARA QUE SEJA ACEITA A PETICAO 02016000230 DE 14/01/2016,O INTERESSADO DEVERA COMPROVAR O RECOLHIMENTO DA 12A ANUIDADE NO PRAZO EXTRAORDINARIO |
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