BR0315988A - Derivados de diidropirimido[4,5-d]pirimidinona substituìda por amino, sua produção e uso como agentes farmacêuticos - Google Patents

Derivados de diidropirimido[4,5-d]pirimidinona substituìda por amino, sua produção e uso como agentes farmacêuticos

Info

Publication number
BR0315988A
BR0315988A BR0315988-4A BR0315988A BR0315988A BR 0315988 A BR0315988 A BR 0315988A BR 0315988 A BR0315988 A BR 0315988A BR 0315988 A BR0315988 A BR 0315988A
Authority
BR
Brazil
Prior art keywords
production
amino
substituted
pharmaceutical agents
dihydropyrimidate
Prior art date
Application number
BR0315988-4A
Other languages
English (en)
Inventor
Jianping Cai
Nikolaos Dimoudis
Konrad Honold
Kin-Chun Luk
Stefan Scheiblich
Hilke Sudergat
Georg Tiefenthaler
Oliver Tonn
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0315988A publication Critical patent/BR0315988A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Abstract

"DERIVADOS DE DIIDROPIRIMIDO¢4,5-d!PIRIMIDINONA SUBSTITUìDA POR AMINO, SUA PRODUçãO E USO COMO AGENTES FARMACêUTICOS". A presente invenção refere-se a compostos da fórmula geral (I), um processo para a sua produção, medicamentos contendo-os e sua produção assim como o uso destes compostos como agentes farmaceuticamente ativos. Os referidos compostos apresentam atividade como inibidores de proteína cinase, em particular inibidores de tirosina cinase da família src, e podem por conseguinte ser úteis para o tratamento de doenças mediadas pelas referidas tirosina cinases.
BR0315988-4A 2002-11-04 2003-11-03 Derivados de diidropirimido[4,5-d]pirimidinona substituìda por amino, sua produção e uso como agentes farmacêuticos BR0315988A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02024573 2002-11-04
PCT/EP2003/012203 WO2004041823A1 (en) 2002-11-04 2003-11-03 Novel amino-substituted dihydropyrimido[4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents

Publications (1)

Publication Number Publication Date
BR0315988A true BR0315988A (pt) 2005-09-20

Family

ID=32116230

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0315988-4A BR0315988A (pt) 2002-11-04 2003-11-03 Derivados de diidropirimido[4,5-d]pirimidinona substituìda por amino, sua produção e uso como agentes farmacêuticos

Country Status (18)

Country Link
US (1) US7091345B2 (pt)
EP (1) EP1560831A1 (pt)
JP (1) JP2006506408A (pt)
KR (1) KR100755770B1 (pt)
CN (1) CN1711265A (pt)
AR (1) AR041740A1 (pt)
AU (1) AU2003287982A1 (pt)
BR (1) BR0315988A (pt)
CA (1) CA2502477A1 (pt)
GT (1) GT200300240A (pt)
MX (1) MXPA05004212A (pt)
PA (1) PA8587101A1 (pt)
PE (1) PE20040593A1 (pt)
PL (1) PL377239A1 (pt)
RU (1) RU2005117342A (pt)
TW (1) TW200413381A (pt)
UY (1) UY28059A1 (pt)
WO (1) WO2004041823A1 (pt)

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JP2007500725A (ja) 2003-07-29 2007-01-18 アイアールエム・リミテッド・ライアビリティ・カンパニー プロテインキナーゼ阻害剤としての化合物および組成物
FR2873118B1 (fr) * 2004-07-15 2007-11-23 Sanofi Synthelabo Derives de pyrido-pyrimidine, leur application en therapeutique
RU2007111758A (ru) 2004-08-31 2008-10-10 Ф.Хоффманн-Ля Рош Аг (Ch) Аминопроизводные 7- амино-3-фенилдигидропиримидо [4,5-d] пиримидинонов, их получение и применение в качестве ингибиторов протеинкиназ
EP1789416B1 (en) * 2004-08-31 2009-03-11 F. Hoffmann-la Roche AG Amide derivatives of 3-phenyl dihydropyrimido[4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents
AR053346A1 (es) * 2005-03-25 2007-05-02 Glaxo Group Ltd Compuesto derivado de 8h -pirido (2,3-d) pirimidin -7 ona 2,4,8- trisustituida composicion farmaceutica y uso para preparar una composicion para tratamiento y profilxis de una enfermedad mediada por la quinasa csbp/ rk/p38
EA200702073A1 (ru) * 2005-03-25 2008-12-30 Глэксо Груп Лимитед Способ получения пиридо[2,3-d]пиримидин-7-оновых и 3,4-дигидропиримидо[4,5-d]пиримидин-2(1н)-оновых производных
KR20080083046A (ko) 2006-01-31 2008-09-12 에프. 호프만-라 로슈 아게 7ｈ-피리도[3,4-ｄ]피리미딘-8-온, 이의 제조 및 단백질키나아제 억제제로서의 용도
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AU2007254491A1 (en) * 2006-05-15 2007-11-29 Irm Llc Compositions and methods for FGF receptor kinases inhibitors
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TW200942537A (en) 2008-02-01 2009-10-16 Irm Llc Compounds and compositions as kinase inhibitors
JP5535931B2 (ja) 2008-10-27 2014-07-02 武田薬品工業株式会社 二環性化合物
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WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
LT3495367T (lt) 2012-06-13 2021-02-25 Incyte Holdings Corporation Pakeistieji tricikliniai junginiai, kaip fgfr inhibitoriai
KR20150034209A (ko) 2012-06-26 2015-04-02 델 마 파마슈티컬스 인코포레이티드 디안하이드로갈락티톨, 디아세틸디안하이드로갈락티톨, 디브로모둘시톨, 또는 그의 유사체 또는 유도체를 이용하여 유전학적 다형성이 있는 환자에 있어서 티로신-키나아제-억제제 내성 악성종양, ahi1 조절곤란 또는 돌연변이를 치료하는 방법
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
CN102816164A (zh) * 2012-08-31 2012-12-12 北京理工大学 一种合成7-氨基-2,3-二氢嘧啶[4,5-d]嘧啶-4(1H)-酮的方法
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
EA036160B1 (ru) * 2013-03-15 2020-10-08 Селджен Кар Ллс Гетероарильные соединения и их применение
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Also Published As

Publication number Publication date
AR041740A1 (es) 2005-05-26
UY28059A1 (es) 2004-04-30
KR100755770B1 (ko) 2007-09-05
US7091345B2 (en) 2006-08-15
CN1711265A (zh) 2005-12-21
CA2502477A1 (en) 2004-05-21
MXPA05004212A (es) 2005-06-08
KR20050067433A (ko) 2005-07-01
EP1560831A1 (en) 2005-08-10
PL377239A1 (pl) 2006-01-23
PE20040593A1 (es) 2004-09-09
GT200300240A (es) 2004-09-02
TW200413381A (en) 2004-08-01
AU2003287982A1 (en) 2004-06-07
RU2005117342A (ru) 2006-01-20
US20040087600A1 (en) 2004-05-06
PA8587101A1 (es) 2004-09-16
JP2006506408A (ja) 2006-02-23
WO2004041823A1 (en) 2004-05-21

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2082 DE 30/11/2010.