EA200702073A1 - Способ получения пиридо[2,3-d]пиримидин-7-оновых и 3,4-дигидропиримидо[4,5-d]пиримидин-2(1н)-оновых производных - Google Patents

Способ получения пиридо[2,3-d]пиримидин-7-оновых и 3,4-дигидропиримидо[4,5-d]пиримидин-2(1н)-оновых производных

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Publication number
EA200702073A1
EA200702073A1 EA200702073A EA200702073A EA200702073A1 EA 200702073 A1 EA200702073 A1 EA 200702073A1 EA 200702073 A EA200702073 A EA 200702073A EA 200702073 A EA200702073 A EA 200702073A EA 200702073 A1 EA200702073 A1 EA 200702073A1
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EA
Eurasian Patent Office
Prior art keywords
alkyl
formula
onovy
dihidropyrimido
pyrmidin
Prior art date
Application number
EA200702073A
Other languages
English (en)
Inventor
Джеймс Фрэнсис Каллахан
Джеффри С. Боэм
Цзехун Вань
Хунсин Янь
Original Assignee
Глэксо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Глэксо Груп Лимитед filed Critical Глэксо Груп Лимитед
Publication of EA200702073A1 publication Critical patent/EA200702073A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

Данное изобретение относится к новому способу получения 2,4,8-тризамещенных пиридо[2,3-d]пиримидин-7-оновых фармакофоров формулы (II) или (IIa), где GHs CHOr NH:G2 обозначает СН или азот; Rx обозначает хлор, бром, иод или O-S(O)CF; Rg обозначает Cалкил; m обозначает 0 или целое число, имеющее значение 1 или 2; Rобозначает Cалкил, Cциклоалкил, Сциклоалкил Cалкил, арил, арил Cалкил, гетероарил, гетероарил Cалкил, гетероциклический фрагмент или гетероциклил Cалкил, где каждый из указанных фрагментов может быть необязательно замещен, данный способ включает в себя взаимодействие соединения формулы: в котором Ry обозначает хлор, бром, иод или O-S(O)CF; а Rg обозначает Cалкил; в присутствии олефинобразующего реагента в подходящем основании с получением соединения формулы (II) или (IIa) , где m=0, и окисление серы, если это необходимо или желательно.
EA200702073A 2005-03-25 2006-03-24 Способ получения пиридо[2,3-d]пиримидин-7-оновых и 3,4-дигидропиримидо[4,5-d]пиримидин-2(1н)-оновых производных EA200702073A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66515405P 2005-03-25 2005-03-25
PCT/US2006/010859 WO2006104917A2 (en) 2005-03-25 2006-03-24 Process for preparing pyrido[2,3-d]pyrimidin-7-one and 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one derivatives

Publications (1)

Publication Number Publication Date
EA200702073A1 true EA200702073A1 (ru) 2008-12-30

Family

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Family Applications (1)

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EA200702073A EA200702073A1 (ru) 2005-03-25 2006-03-24 Способ получения пиридо[2,3-d]пиримидин-7-оновых и 3,4-дигидропиримидо[4,5-d]пиримидин-2(1н)-оновых производных

Country Status (18)

Country Link
US (3) US7479558B2 (ru)
EP (1) EP1865959A2 (ru)
JP (1) JP2008537937A (ru)
KR (1) KR20080002865A (ru)
CN (1) CN101495475A (ru)
AR (1) AR059937A1 (ru)
AU (1) AU2006229995A1 (ru)
CA (1) CA2603163A1 (ru)
EA (1) EA200702073A1 (ru)
IL (1) IL186422A0 (ru)
MA (1) MA29391B1 (ru)
MX (1) MX2007012951A (ru)
NO (1) NO20075232L (ru)
NZ (1) NZ562433A (ru)
SG (1) SG160438A1 (ru)
TW (1) TW200735876A (ru)
WO (1) WO2006104917A2 (ru)
ZA (1) ZA200708524B (ru)

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US20060258687A1 (en) 2006-11-16
MX2007012951A (es) 2008-01-11
AR059937A1 (es) 2008-05-14
KR20080002865A (ko) 2008-01-04
EP1865959A2 (en) 2007-12-19
WO2006104917A2 (en) 2006-10-05
SG160438A1 (en) 2010-04-29
CA2603163A1 (en) 2006-10-05
US20090048444A1 (en) 2009-02-19
MA29391B1 (fr) 2008-04-01
ZA200708524B (en) 2009-08-26
TW200735876A (en) 2007-10-01
IL186422A0 (en) 2009-02-11
AU2006229995A1 (en) 2006-10-05
WO2006104917A3 (en) 2009-04-16
CN101495475A (zh) 2009-07-29
JP2008537937A (ja) 2008-10-02
US20080096905A1 (en) 2008-04-24

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