YU73300A - Biciklični pirimidini i biciklični 3,4-dihidropirimidini kao inhibitori ćelijske proliferacije - Google Patents
Biciklični pirimidini i biciklični 3,4-dihidropirimidini kao inhibitori ćelijske proliferacijeInfo
- Publication number
- YU73300A YU73300A YU73300A YU73300A YU73300A YU 73300 A YU73300 A YU 73300A YU 73300 A YU73300 A YU 73300A YU 73300 A YU73300 A YU 73300A YU 73300 A YU73300 A YU 73300A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- bicyclic
- pyrimidines
- compounds
- kinases
- provides
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Ovaj pronalazak daje biciklicne heterocikle koji su korisni za upotrebu u proizvodnji lekova za lecenje celijskih proliferativnih poremecaja, kao sto su rak i restenoza, zatim angiogeneza i ateroskleroza. Otkrivena je grupa biciklicnih jedinjenja koja su potencijalni inhibitori ciklin-zavisnih kinaza (cdk), kinaza posredovanih faktorom rasta i nereceptorskih kinaza. Ova jedinjenja se lako sintetizuju. Pronalazak daje jedinjenja formule (I). gde Z predstavlja N ili CH; G je N ili CH; W je NH, S, SO ili SO2, R1 je fenil ili supstituisani fenil, R2 je alkil ili cikloalkil, R3 je alkil i vodonik, R8 i R9 su vodonik i alkil, i njihove farmaceutski prihvatljive soli. Ovaj pronalazak takodje daje farmaceutske formulacije koje sadrze jedinjenje formule (I) zajedno sa farmaceutski prihvatljivim nosacem, razblazivacem ili dodatkom.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8670898P | 1998-05-26 | 1998-05-26 | |
US12615899P | 1999-03-25 | 1999-03-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
YU73300A true YU73300A (sh) | 2003-08-29 |
Family
ID=26775058
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU73300A YU73300A (sh) | 1998-05-26 | 1999-05-10 | Biciklični pirimidini i biciklični 3,4-dihidropirimidini kao inhibitori ćelijske proliferacije |
Country Status (29)
Country | Link |
---|---|
US (1) | US7501425B1 (sh) |
EP (1) | EP1080092B1 (sh) |
JP (1) | JP2002516327A (sh) |
KR (1) | KR20010043829A (sh) |
CN (1) | CN1138778C (sh) |
AP (1) | AP2000001964A0 (sh) |
AT (1) | ATE402177T1 (sh) |
AU (1) | AU763839B2 (sh) |
BG (1) | BG104960A (sh) |
BR (1) | BR9911590A (sh) |
CA (1) | CA2329703C (sh) |
DE (1) | DE69939168D1 (sh) |
EA (1) | EA003640B1 (sh) |
EE (1) | EE200000706A (sh) |
ES (1) | ES2310039T3 (sh) |
GE (1) | GEP20033093B (sh) |
HK (1) | HK1039483A1 (sh) |
HR (1) | HRP20000799A2 (sh) |
HU (1) | HUP0102514A3 (sh) |
ID (1) | ID27589A (sh) |
IL (1) | IL139599A0 (sh) |
IS (1) | IS5687A (sh) |
NO (1) | NO20005928D0 (sh) |
NZ (1) | NZ508268A (sh) |
PL (1) | PL344248A1 (sh) |
SK (1) | SK17532000A3 (sh) |
TR (1) | TR200003429T2 (sh) |
WO (1) | WO1999061444A2 (sh) |
YU (1) | YU73300A (sh) |
Families Citing this family (105)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR9911590A (pt) | 1998-05-26 | 2001-02-13 | Warner Lambert Co | Pirimidinas bicìclicas e 3,4-diidropirimidinas bicìclicas como inibidores da proliferação celular |
CZ20011394A3 (cs) * | 1998-10-23 | 2001-12-12 | F. Hoffmann-La Roche Ag | Derivát bicyklických, dusík obsahujících heterocyklických sloučenin, způsob jeho přípravy a farmaceutický prostředek, který ho obsahuje |
JP3961830B2 (ja) | 1999-10-21 | 2007-08-22 | エフ.ホフマン−ラ ロシュ アーゲー | p38プロテインキナーゼのインヒビターとしてのヘテロアルキルアミノ置換二環式窒素複素環 |
TR200201058T2 (tr) * | 1999-10-21 | 2002-07-22 | F.Hoffmann-La Roche Ag | P38 protein kinaz inhibitörleri olarak, alkilaminoyla ornatılmış bisiklik, azotlu heterosikller |
EA005585B1 (ru) | 2000-01-24 | 2005-04-28 | Уорнер-Ламберт Компани | 3-аминохиназолин-2,4-дионовые антибактериальные агенты |
PE20011066A1 (es) * | 2000-01-25 | 2001-10-22 | Warner Lambert Co | PIRIDO [2,3-d] PIRIMIDIN-2,7-DIAMINAS INHIBIDORES DE CINASAS |
US7053070B2 (en) | 2000-01-25 | 2006-05-30 | Warner-Lambert Company | Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors |
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AP2002002643A0 (en) * | 2000-03-06 | 2002-12-31 | Warner Lambert Co | 5-alkylpyrido[2,3-d]pyrimidines tyrosine kinase inhibitors |
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US6506749B2 (en) | 2000-08-31 | 2003-01-14 | Syntex (U.S.A.) Llc | 7-oxo-pyridopyrimidines (I) |
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GB0029015D0 (en) | 2000-11-28 | 2001-01-10 | Univ London | Medical device |
ATE320255T1 (de) | 2001-01-19 | 2006-04-15 | Smithkline Beecham Corp | Tie2 rezeptor-kinase-inhibitoren zur behandlung von angiogenen erkrankungen |
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1999
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- 1999-05-10 AU AU40734/99A patent/AU763839B2/en not_active Ceased
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- 1999-05-10 YU YU73300A patent/YU73300A/sh unknown
- 1999-05-10 WO PCT/US1999/010187 patent/WO1999061444A2/en not_active Application Discontinuation
- 1999-05-10 CA CA002329703A patent/CA2329703C/en not_active Expired - Fee Related
- 1999-05-10 EE EEP200000706A patent/EE200000706A/xx unknown
- 1999-05-10 AT AT99924165T patent/ATE402177T1/de not_active IP Right Cessation
- 1999-05-10 NZ NZ508268A patent/NZ508268A/xx unknown
- 1999-05-10 ID IDW20002452A patent/ID27589A/id unknown
- 1999-05-10 EP EP99924165A patent/EP1080092B1/en not_active Expired - Lifetime
- 1999-05-10 GE GEAP19995700A patent/GEP20033093B/en unknown
- 1999-05-10 CN CNB998065587A patent/CN1138778C/zh not_active Expired - Fee Related
- 1999-05-10 DE DE69939168T patent/DE69939168D1/de not_active Expired - Fee Related
- 1999-05-10 EA EA200001171A patent/EA003640B1/ru not_active IP Right Cessation
- 1999-05-10 IL IL13959999A patent/IL139599A0/xx unknown
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- 1999-05-10 KR KR1020007013279A patent/KR20010043829A/ko not_active Application Discontinuation
- 1999-05-10 ES ES99924165T patent/ES2310039T3/es not_active Expired - Lifetime
- 1999-05-10 JP JP2000550849A patent/JP2002516327A/ja not_active Abandoned
- 1999-05-10 US US09/623,737 patent/US7501425B1/en not_active Expired - Fee Related
- 1999-05-10 PL PL99344248A patent/PL344248A1/xx not_active Application Discontinuation
- 1999-05-10 SK SK1753-2000A patent/SK17532000A3/sk unknown
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2000
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- 2000-11-17 BG BG104960A patent/BG104960A/xx unknown
- 2000-11-20 HR HR20000799A patent/HRP20000799A2/hr not_active Application Discontinuation
- 2000-11-23 NO NO20005928A patent/NO20005928D0/no not_active Application Discontinuation
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2001
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