TR200003429T2 - Hücresel çoğalma inhibitörleri olarak bisiklik pirimidinler ve bisiklik 3,4-dihidropirimidinler. - Google Patents

Hücresel çoğalma inhibitörleri olarak bisiklik pirimidinler ve bisiklik 3,4-dihidropirimidinler.

Info

Publication number
TR200003429T2
TR200003429T2 TR2000/03429T TR200003429T TR200003429T2 TR 200003429 T2 TR200003429 T2 TR 200003429T2 TR 2000/03429 T TR2000/03429 T TR 2000/03429T TR 200003429 T TR200003429 T TR 200003429T TR 200003429 T2 TR200003429 T2 TR 200003429T2
Authority
TR
Turkey
Prior art keywords
bicyclic
alkyl
compounds
formula
kinases
Prior art date
Application number
TR2000/03429T
Other languages
English (en)
Inventor
Myra Dobrusin Ellen
Marino Hamby James
Bernard Kramer James
Conrad Schroeder Mel
Daniel Hollis Showalter Howard
Laurence Toogood Peter
A. Trumpp-Kallmeyer Susanne
Original Assignee
Warner-Lambert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26775058&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR200003429(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of TR200003429T2 publication Critical patent/TR200003429T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

(FORMÜL VAR) Bu bulus, kanser ve restenozun yani sira anjiyojenez ve ateroskleroz gibi hücre çogalmasi hastaliklarinin tedavi edilmesinde faydali olan bisiklik heterosikller saglar. Sikline bagimli kinazlarin, büyüme faktörünün aracilik ettigi kinazlarin ve reseptör olmayan kinazlarin etkili inhibitörleri olan bir grup bisiklik bilesigi kesfettik. Bilesikler, kolaylikla sentezlenirler ve oral uygulama dahil olmak üzere çesitli yollardan uygulanabilirler ve klinik kullanim için yeterli biyolojik kullanisliliga sahiptirler.Bulus, Z'nin N veya GH; G'nin N veya CH; W'nin NH, S,SO veya SO2 oldugu; R1'in fenil ve ikameli fenili; R2'nin alkil ve sikloalkili; R3'ün alkil ve hidrojeni; R8 ve R9'un hidrojen ve alkili içerdigi Formül (I) bilesiklerini ve bunlarin farmasötik olarak kabul edilebilir tuzlarini içerir. Bulus ayrica farmasötik olarak kabul edilebilir bir tasiyici, seyreltici veya eksipiyanla birlikte Formül (I)'in bir bilesigini içeren farmasötik formülasyonlar da saglar.
TR2000/03429T 1998-05-26 1999-05-10 Hücresel çoğalma inhibitörleri olarak bisiklik pirimidinler ve bisiklik 3,4-dihidropirimidinler. TR200003429T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8670898P 1998-05-26 1998-05-26
US12615899P 1999-03-25 1999-03-25

Publications (1)

Publication Number Publication Date
TR200003429T2 true TR200003429T2 (tr) 2001-07-23

Family

ID=26775058

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/03429T TR200003429T2 (tr) 1998-05-26 1999-05-10 Hücresel çoğalma inhibitörleri olarak bisiklik pirimidinler ve bisiklik 3,4-dihidropirimidinler.

Country Status (29)

Country Link
US (1) US7501425B1 (tr)
EP (1) EP1080092B1 (tr)
JP (1) JP2002516327A (tr)
KR (1) KR20010043829A (tr)
CN (1) CN1138778C (tr)
AP (1) AP2000001964A0 (tr)
AT (1) ATE402177T1 (tr)
AU (1) AU763839B2 (tr)
BG (1) BG104960A (tr)
BR (1) BR9911590A (tr)
CA (1) CA2329703C (tr)
DE (1) DE69939168D1 (tr)
EA (1) EA003640B1 (tr)
EE (1) EE200000706A (tr)
ES (1) ES2310039T3 (tr)
GE (1) GEP20033093B (tr)
HK (1) HK1039483A1 (tr)
HR (1) HRP20000799A2 (tr)
HU (1) HUP0102514A3 (tr)
ID (1) ID27589A (tr)
IL (1) IL139599A0 (tr)
IS (1) IS5687A (tr)
NO (1) NO20005928D0 (tr)
NZ (1) NZ508268A (tr)
PL (1) PL344248A1 (tr)
SK (1) SK17532000A3 (tr)
TR (1) TR200003429T2 (tr)
WO (1) WO1999061444A2 (tr)
YU (1) YU73300A (tr)

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ID27589A (id) 2001-04-12
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