TR200200749T2 - Kinazolin bileşikleri ve bunları içeren farmasötik bileşikler. - Google Patents
Kinazolin bileşikleri ve bunları içeren farmasötik bileşikler.Info
- Publication number
- TR200200749T2 TR200200749T2 TR2002/00749T TR200200749T TR200200749T2 TR 200200749 T2 TR200200749 T2 TR 200200749T2 TR 2002/00749 T TR2002/00749 T TR 2002/00749T TR 200200749 T TR200200749 T TR 200200749T TR 200200749 T2 TR200200749 T2 TR 200200749T2
- Authority
- TR
- Turkey
- Prior art keywords
- pharmaceutical compositions
- compositions containing
- formula
- quinazoline compounds
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
X'in O ya da S,S(O) ya da S(O)2, NH ya da R8'in hidrojen ya da C1-6 alkil oldugu NR8; Ra'nin, bir 3-kinolin grubu ya da R5,R6 ve R7'nin degisik spesifik organik gruplardan oldugu bir alt formül (I) grubu oldugu formül I bilesiginin ya da bunun bir tuzunun, esterinin ya da amidinin arora 2 kinazin inhibisyonunda kullanilmak üzere bir ilacin hazirlanmasinda kullanimi. Kanser tedavisinde yararli olan yeni formül (I) bilesikleri ve farmasötik bilesimleri de anlatilmakta ve istem olarak sunulmaktadir.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9922152.5A GB9922152D0 (en) | 1999-09-21 | 1999-09-21 | Chemical compounds |
| GBGB9922156.6A GB9922156D0 (en) | 1999-09-21 | 1999-09-21 | Chemical compounds |
| GBGB9922159.0A GB9922159D0 (en) | 1999-09-21 | 1999-09-21 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200200749T2 true TR200200749T2 (tr) | 2002-06-21 |
Family
ID=27269803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2002/00749T TR200200749T2 (tr) | 1999-09-21 | 2000-09-18 | Kinazolin bileşikleri ve bunları içeren farmasötik bileşikler. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7081461B1 (tr) |
| EP (1) | EP1218356A1 (tr) |
| JP (1) | JP2003509497A (tr) |
| KR (1) | KR20020032608A (tr) |
| CN (1) | CN1391561A (tr) |
| AU (1) | AU763242B2 (tr) |
| BG (1) | BG106491A (tr) |
| BR (1) | BR0014133A (tr) |
| CA (1) | CA2384282A1 (tr) |
| CZ (1) | CZ20021010A3 (tr) |
| EE (1) | EE200200149A (tr) |
| HK (1) | HK1046688A1 (tr) |
| HU (1) | HUP0204413A3 (tr) |
| IL (1) | IL148489A0 (tr) |
| IS (1) | IS6304A (tr) |
| NO (1) | NO20021401L (tr) |
| PL (1) | PL354923A1 (tr) |
| SK (1) | SK3832002A3 (tr) |
| TR (1) | TR200200749T2 (tr) |
| WO (1) | WO2001021594A1 (tr) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2223201A (en) * | 1999-12-24 | 2001-07-09 | Kirin Beer Kabushiki Kaisha | Quinoline and quinazoline derivatives and drugs containing the same |
| UA73993C2 (uk) | 2000-06-06 | 2005-10-17 | Астразенека Аб | Хіназолінові похідні для лікування пухлин та фармацевтична композиція |
| BR0113358A (pt) | 2000-08-21 | 2003-07-01 | Astrazeneca Ab | Derivado de quinazolina ou de um seu sal farmaceuticamente aceitável, processo para a sua preparação, composição farmacêutica, e, uso do derivado ou de um seu sal farmaceuticamente aceitável |
| JP2004511479A (ja) | 2000-10-13 | 2004-04-15 | アストラゼネカ アクチボラグ | キナゾリン誘導体 |
| US6939866B2 (en) | 2000-10-13 | 2005-09-06 | Astrazeneca Ab | Quinazoline derivatives |
| ATE502928T1 (de) | 2000-11-01 | 2011-04-15 | Millennium Pharm Inc | Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung |
| WO2002085895A1 (en) * | 2001-04-19 | 2002-10-31 | Astrazeneca Ab | Quinazoline derivatives |
| AU2002350105A1 (en) | 2001-06-21 | 2003-01-08 | Ariad Pharmaceuticals, Inc. | Novel quinazolines and uses thereof |
| US7495104B2 (en) | 2001-10-17 | 2009-02-24 | Kirin Beer Kabushiki Kaisha | Quinoline or quinazoline derivatives inhibiting auto-phosphorylation of fibroblast growth factor receptors |
| KR101019131B1 (ko) * | 2001-11-19 | 2011-03-07 | 인터레우킨 제네틱스, 인코포레이티드 | 염증성 질환 및 감염성 질환에 대한 감수성 및 전사에영향을 미치는 인터루킨-1 좌의 기능적 다형성 |
| MXPA04006882A (es) | 2002-01-17 | 2004-12-06 | Neurogen Corp | Analogos substituidos de quinazolin-4-ilamina como moduladores de receptores de capsaicina. |
| US6924285B2 (en) | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
| DE60327323D1 (de) * | 2002-07-09 | 2009-06-04 | Astrazeneca Ab | Chinazoline derivative und ihre anwendung in der krebsbehandlung |
| EP1521747B1 (en) | 2002-07-15 | 2018-09-05 | Symphony Evolution, Inc. | Receptor-type kinase modulators and methods of use |
| WO2004018430A1 (ja) * | 2002-08-23 | 2004-03-04 | Kirin Beer Kabushiki Kaisha | ＴＧＦβ阻害活性を有する化合物およびそれを含んでなる医薬組成物 |
| SI1562955T1 (sl) | 2002-11-04 | 2008-06-30 | Astrazeneca Ab | Derivati kinazolina kot inhibitorji Src-triozin kinaze |
| US7488823B2 (en) * | 2003-11-10 | 2009-02-10 | Array Biopharma, Inc. | Cyanoguanidines and cyanoamidines as ErbB2 and EGFR inhibitors |
| AU2003294142A1 (en) * | 2002-12-24 | 2004-07-22 | Astrazeneca Ab | Therapeutic quinazoline derivatives |
| MXPA05012839A (es) | 2003-05-27 | 2006-05-17 | Pfizer Prod Inc | Quinazolinas y pirido[3,4-d] pirimidinas como inhibidores de receptores tirosina quinasa. |
| US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
| US7329664B2 (en) | 2003-07-16 | 2008-02-12 | Neurogen Corporation | Substituted (7-pyridyl-4-phenylamino-quinazolin-2-yl)-methanol analogues |
| GB0317665D0 (en) | 2003-07-29 | 2003-09-03 | Astrazeneca Ab | Qinazoline derivatives |
| CN102432552B (zh) | 2003-08-14 | 2016-01-20 | 阿雷生物药品公司 | 作为受体酪氨酸激酶抑制剂的喹唑啉类似物 |
| US7501427B2 (en) | 2003-08-14 | 2009-03-10 | Array Biopharma, Inc. | Quinazoline analogs as receptor tyrosine kinase inhibitors |
| US20090099165A1 (en) | 2003-10-14 | 2009-04-16 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Protein Kinase Inhibitors |
| DE602004022318D1 (de) * | 2003-10-14 | 2009-09-10 | Supergen Inc | Proteinkinaseinhibitoren |
| CA2540342A1 (en) * | 2003-10-31 | 2005-05-12 | Neurogen Corporation | 4-amino (aza) quinoline derivatives as capsaicin receptor agonists |
| WO2005048948A2 (en) * | 2003-11-13 | 2005-06-02 | Ambit Biosciences Corporation | Urea derivatives as kinase modulators |
| BRPI0400869B8 (pt) * | 2004-03-02 | 2021-05-25 | Univ Estadual Campinas Unicamp | novos compostos derivados de 4-anilinoquinazolinas com propriedade inibidora de adenosinacinases |
| ME01267B (me) | 2004-05-06 | 2013-06-20 | Warner Lambert Co | 4-fenilaminokinazolin-6-ilamidi |
| TW200624431A (en) | 2004-09-24 | 2006-07-16 | Hoffmann La Roche | Phthalazinone derivatives, their manufacture and use as pharmaceutical agents |
| US7285569B2 (en) | 2004-09-24 | 2007-10-23 | Hoff Hoffmann-La Roche Inc. | Tricycles, their manufacture and use as pharmaceutical agents |
| US20070054916A1 (en) * | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
| MX2007004403A (es) | 2004-10-12 | 2007-04-27 | Astrazeneca Ab | Derivados de quinazolina. |
| EP1812439B2 (en) | 2004-10-15 | 2017-12-06 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| CA2587642C (en) * | 2004-11-30 | 2013-04-09 | Amgen Inc. | Substituted heterocycles and methods of use |
| CA2592900A1 (en) | 2005-01-03 | 2006-07-13 | Myriad Genetics Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
| US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
| PT1854789E (pt) | 2005-02-23 | 2013-10-23 | Shionogi & Co | Derivado de quinazolina possuindo actividade inibidora de tirosina-cinase |
| KR20070113286A (ko) | 2005-04-14 | 2007-11-28 | 에프. 호프만-라 로슈 아게 | 아미노피라졸 유도체, 이의 제조 및 약학 제제로서의 용도 |
| JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| GB0509224D0 (en) * | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Inhibitors of intracellular enzymatic activity |
| US7732613B2 (en) | 2005-09-14 | 2010-06-08 | Bristol-Myers Squibb Company | Met kinase inhibitors |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
| GB2431927B (en) | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
| US8399666B2 (en) | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| ES2364901T3 (es) * | 2005-11-15 | 2011-09-16 | Array Biopharma, Inc. | Procesos e intermedios para la preparación de derivados de n4-fenil-quinazolin-4-amina. |
| CN101003514A (zh) | 2006-01-20 | 2007-07-25 | 上海艾力斯医药科技有限公司 | 喹唑啉衍生物、其制备方法及用途 |
| UY30183A1 (es) * | 2006-03-02 | 2007-10-31 | Astrazeneca Ab | Derivados de quinolina |
| JP2010505962A (ja) | 2006-10-09 | 2010-02-25 | 武田薬品工業株式会社 | キナーゼ阻害剤 |
| EP1921070A1 (de) | 2006-11-10 | 2008-05-14 | Boehringer Ingelheim Pharma GmbH & Co. KG | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung |
| JP5377332B2 (ja) | 2007-02-06 | 2013-12-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 二環式へテロ環、それらの化合物を含む薬剤、その使用及びその製法 |
| WO2009030224A2 (de) * | 2007-09-07 | 2009-03-12 | Schebo Biotech Ag | Neue chinazolin- verbindungen und ihre verwendung zur therapie von krebserkrankungen |
| US20090291971A1 (en) * | 2007-11-01 | 2009-11-26 | Wyeth | Heteroaryl ethers and processes for their preparation |
| PL2245026T3 (pl) | 2008-02-07 | 2013-01-31 | Boehringer Ingelheim Int | Spirocykliczne heterocykle, leki zawierające te związki, ich zastosowanie i sposób ich produkcji |
| ES2444128T3 (es) | 2008-05-13 | 2014-02-24 | Astrazeneca Ab | Nueva SAL-554 |
| KR20160129109A (ko) | 2008-05-23 | 2016-11-08 | 아미라 파마슈티칼스 인코포레이티드 | 5-리폭시게나아제 활성화 단백질 억제제 |
| CA2733153C (en) | 2008-08-08 | 2016-11-08 | Boehringer Ingelheim International Gmbh | Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them |
| CN101857588B (zh) * | 2010-06-08 | 2013-11-27 | 东南大学 | 4-芳香胺基喹唑啉类衍生物及其用途 |
| CN102850280B (zh) * | 2011-06-30 | 2015-06-10 | 陕西师范大学 | 6,7-二烷氧基-4-取代苯基氨基喹唑啉类化合物及其制备方法 |
| MY186126A (en) | 2013-03-06 | 2021-06-24 | Astrazeneca Ab | Quinazoline inhibitors of activating mutant forms of epidermal growth factor receptor |
| US10548897B2 (en) | 2015-04-16 | 2020-02-04 | Icahn School Of Medicine At Mount Sinai | KSR antagonists |
| CN108473435A (zh) | 2015-10-05 | 2018-08-31 | 纽约市哥伦比亚大学理事会 | 自噬潮和磷脂酶d的活化剂以及包括tau的蛋白聚集体的清除和蛋白质病的治疗 |
| CN113354591B (zh) * | 2021-06-09 | 2023-03-24 | 广东湛江海洋医药研究院 | 烷氨基喹唑啉的合成及其抗肿瘤活性 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG64322A1 (en) | 1991-05-10 | 1999-04-27 | Rhone Poulenc Rorer Int | Bis mono and bicyclic aryl and heteroaryl compounds which inhibit egf and/or pdgf receptor tyrosine kinase |
| AU661533B2 (en) * | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
| JP2994165B2 (ja) * | 1992-06-26 | 1999-12-27 | ゼネカ・リミテッド | キナゾリン誘導体、その製造法および該キナゾリン誘導体を含有する抗癌作用を得るための医薬調剤 |
| GB9510757D0 (en) | 1994-09-19 | 1995-07-19 | Wellcome Found | Therapeuticaly active compounds |
| TW321649B (tr) * | 1994-11-12 | 1997-12-01 | Zeneca Ltd | |
| CA2216796C (en) * | 1995-03-30 | 2003-09-02 | Pfizer Inc. | Quinazoline derivatives |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| EP0880508B1 (en) * | 1996-02-13 | 2003-04-16 | AstraZeneca AB | Quinazoline derivatives as vegf inhibitors |
| GB9603095D0 (en) * | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
| ATE211134T1 (de) * | 1996-03-05 | 2002-01-15 | 4-anilinochinazolin derivate | |
| EP1082311A1 (en) * | 1998-05-28 | 2001-03-14 | Parker Hughes Institute | Quinazolines for treating brain tumor |
-
2000
- 2000-09-18 PL PL00354923A patent/PL354923A1/xx not_active Application Discontinuation
- 2000-09-18 CN CN00816007A patent/CN1391561A/zh active Pending
- 2000-09-18 CZ CZ20021010A patent/CZ20021010A3/cs unknown
- 2000-09-18 EE EEP200200149A patent/EE200200149A/xx unknown
- 2000-09-18 TR TR2002/00749T patent/TR200200749T2/tr unknown
- 2000-09-18 SK SK383-2002A patent/SK3832002A3/sk unknown
- 2000-09-18 AU AU74325/00A patent/AU763242B2/en not_active Ceased
- 2000-09-18 KR KR1020027003678A patent/KR20020032608A/ko not_active Application Discontinuation
- 2000-09-18 HU HU0204413A patent/HUP0204413A3/hu unknown
- 2000-09-18 CA CA002384282A patent/CA2384282A1/en not_active Abandoned
- 2000-09-18 EP EP00962677A patent/EP1218356A1/en not_active Withdrawn
- 2000-09-18 WO PCT/GB2000/003556 patent/WO2001021594A1/en active IP Right Grant
- 2000-09-18 US US10/088,854 patent/US7081461B1/en not_active Expired - Fee Related
- 2000-09-18 JP JP2001524973A patent/JP2003509497A/ja active Pending
- 2000-09-18 IL IL14848900A patent/IL148489A0/xx unknown
- 2000-09-18 BR BR0014133-0A patent/BR0014133A/pt not_active IP Right Cessation
-
2002
- 2002-03-07 BG BG106491A patent/BG106491A/bg unknown
- 2002-03-18 IS IS6304A patent/IS6304A/is unknown
- 2002-03-20 NO NO20021401A patent/NO20021401L/no not_active Application Discontinuation
- 2002-11-19 HK HK02108374.7A patent/HK1046688A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0204413A2 (en) | 2003-05-28 |
| NO20021401L (no) | 2002-05-21 |
| HUP0204413A3 (en) | 2003-07-28 |
| IL148489A0 (en) | 2002-09-12 |
| AU7432500A (en) | 2001-04-24 |
| BG106491A (bg) | 2002-12-29 |
| KR20020032608A (ko) | 2002-05-03 |
| NO20021401D0 (no) | 2002-03-20 |
| WO2001021594A1 (en) | 2001-03-29 |
| EP1218356A1 (en) | 2002-07-03 |
| PL354923A1 (en) | 2004-03-22 |
| JP2003509497A (ja) | 2003-03-11 |
| SK3832002A3 (en) | 2002-11-06 |
| HK1046688A1 (zh) | 2003-01-24 |
| BR0014133A (pt) | 2002-06-11 |
| CZ20021010A3 (cs) | 2002-06-12 |
| US7081461B1 (en) | 2006-07-25 |
| AU763242B2 (en) | 2003-07-17 |
| CN1391561A (zh) | 2003-01-15 |
| CA2384282A1 (en) | 2001-03-29 |
| IS6304A (is) | 2002-03-18 |
| EE200200149A (et) | 2003-04-15 |
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