IS6304A - Kínasólínefnasambönd og lyfjafræðilegar efnasamsetningar sem innihalda þau - Google Patents
Kínasólínefnasambönd og lyfjafræðilegar efnasamsetningar sem innihalda þauInfo
- Publication number
- IS6304A IS6304A IS6304A IS6304A IS6304A IS 6304 A IS6304 A IS 6304A IS 6304 A IS6304 A IS 6304A IS 6304 A IS6304 A IS 6304A IS 6304 A IS6304 A IS 6304A
- Authority
- IS
- Iceland
- Prior art keywords
- pharmaceutical compositions
- compositions containing
- quinazoline compounds
- quinazoline
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9922156.6A GB9922156D0 (en) | 1999-09-21 | 1999-09-21 | Chemical compounds |
GBGB9922152.5A GB9922152D0 (en) | 1999-09-21 | 1999-09-21 | Chemical compounds |
GBGB9922159.0A GB9922159D0 (en) | 1999-09-21 | 1999-09-21 | Chemical compounds |
PCT/GB2000/003556 WO2001021594A1 (en) | 1999-09-21 | 2000-09-18 | Quinazoline compounds and pharmaceutical compositions containing them |
Publications (1)
Publication Number | Publication Date |
---|---|
IS6304A true IS6304A (is) | 2002-03-18 |
Family
ID=27269803
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IS6304A IS6304A (is) | 1999-09-21 | 2002-03-18 | Kínasólínefnasambönd og lyfjafræðilegar efnasamsetningar sem innihalda þau |
Country Status (20)
Country | Link |
---|---|
US (1) | US7081461B1 (is) |
EP (1) | EP1218356A1 (is) |
JP (1) | JP2003509497A (is) |
KR (1) | KR20020032608A (is) |
CN (1) | CN1391561A (is) |
AU (1) | AU763242B2 (is) |
BG (1) | BG106491A (is) |
BR (1) | BR0014133A (is) |
CA (1) | CA2384282A1 (is) |
CZ (1) | CZ20021010A3 (is) |
EE (1) | EE200200149A (is) |
HK (1) | HK1046688A1 (is) |
HU (1) | HUP0204413A3 (is) |
IL (1) | IL148489A0 (is) |
IS (1) | IS6304A (is) |
NO (1) | NO20021401L (is) |
PL (1) | PL354923A1 (is) |
SK (1) | SK3832002A3 (is) |
TR (1) | TR200200749T2 (is) |
WO (1) | WO2001021594A1 (is) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001047890A1 (fr) | 1999-12-24 | 2001-07-05 | Kirin Beer Kabushiki Kaisha | Quinoline, derives de la quinazoline et medicaments contenant ces substances |
UA73993C2 (uk) | 2000-06-06 | 2005-10-17 | Астразенека Аб | Хіназолінові похідні для лікування пухлин та фармацевтична композиція |
SK2142003A3 (en) | 2000-08-21 | 2003-07-01 | Astrazeneca Ab | Quinazoline derivatives, process for their preparation, pharmaceutical composition comprising same and their use |
US6939866B2 (en) | 2000-10-13 | 2005-09-06 | Astrazeneca Ab | Quinazoline derivatives |
WO2002030924A1 (en) | 2000-10-13 | 2002-04-18 | Astrazeneca Ab | Quinazoline derivatives with anti-tumour activity |
WO2002036587A2 (en) | 2000-11-01 | 2002-05-10 | Cor Therapeutics, Inc. | Process for the production of 4-quinazolinylpiperazin-1-carboxylic acid phenylamides |
DE60229046D1 (de) | 2001-04-19 | 2008-11-06 | Astrazeneca Ab | Chinazolin derivate |
EP1408980A4 (en) | 2001-06-21 | 2004-10-20 | Ariad Pharma Inc | NEW QUINAZOLINES AND THEIR USE |
EP1447405A4 (en) | 2001-10-17 | 2005-01-12 | Kirin Brewery | QUINOLINE OR QUINAZOLINE DERIVATIVES INHIBITING THE AUTOPHOSPHORYLATION OF FIBROBLAST GROWTH FACTOR RECEPTORS |
WO2003044176A2 (en) * | 2001-11-19 | 2003-05-30 | Interleukin Genetics, Inc. | Functional polymorphisms of the interleukin-1 locus affecting transcription and susceptibility to inflammatory and infectious diseases |
RS63204A (en) | 2002-01-17 | 2006-10-27 | Neurogen Corporation | Substituted quinazolin-4-ylamine analogues as modulators of capsaicin |
US6924285B2 (en) * | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
ATE429230T1 (de) * | 2002-07-09 | 2009-05-15 | Astrazeneca Ab | Chinazoline derivative und ihre anwendung in der krebsbehandlung |
EP1521747B1 (en) | 2002-07-15 | 2018-09-05 | Symphony Evolution, Inc. | Receptor-type kinase modulators and methods of use |
WO2004018430A1 (ja) * | 2002-08-23 | 2004-03-04 | Kirin Beer Kabushiki Kaisha | TGFβ阻害活性を有する化合物およびそれを含んでなる医薬組成物 |
JP4593464B2 (ja) | 2002-11-04 | 2010-12-08 | アストラゼネカ アクチボラグ | Srcチロシンキナーゼ阻害剤としてのキナゾリン誘導体 |
US7488823B2 (en) * | 2003-11-10 | 2009-02-10 | Array Biopharma, Inc. | Cyanoguanidines and cyanoamidines as ErbB2 and EGFR inhibitors |
ATE412657T1 (de) * | 2002-12-24 | 2008-11-15 | Astrazeneca Ab | Therapeutische quinazolin-derivate |
WO2004106308A1 (en) * | 2003-05-27 | 2004-12-09 | Pfizer Products Inc. | Quinazolines and pyrido [3,4-d] pyrimidines as receptor tyrosine kinase inhibitors |
US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
US7329664B2 (en) | 2003-07-16 | 2008-02-12 | Neurogen Corporation | Substituted (7-pyridyl-4-phenylamino-quinazolin-2-yl)-methanol analogues |
GB0317665D0 (en) | 2003-07-29 | 2003-09-03 | Astrazeneca Ab | Qinazoline derivatives |
CN103664802B (zh) * | 2003-08-14 | 2015-08-05 | 阿雷生物药品公司 | 作为受体酪氨酸激酶抑制剂的喹唑啉类似物 |
US7501427B2 (en) * | 2003-08-14 | 2009-03-10 | Array Biopharma, Inc. | Quinazoline analogs as receptor tyrosine kinase inhibitors |
US20090099165A1 (en) | 2003-10-14 | 2009-04-16 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Protein Kinase Inhibitors |
ES2344007T3 (es) * | 2003-10-14 | 2010-08-16 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Inhibidores proteina quinasa. |
CN1890223A (zh) * | 2003-10-31 | 2007-01-03 | 神经能质公司 | 辣椒素受体促效剂 |
JP2007512255A (ja) * | 2003-11-13 | 2007-05-17 | アンビット バイオサイエンシス コーポレーション | キナーゼ調節因子としての尿素誘導体 |
BRPI0400869B8 (pt) * | 2004-03-02 | 2021-05-25 | Univ Estadual Campinas Unicamp | novos compostos derivados de 4-anilinoquinazolinas com propriedade inibidora de adenosinacinases |
JP4205757B2 (ja) | 2004-05-06 | 2009-01-07 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 4−フェニルアミノ−キナゾリン−6−イル−アミド |
US7285569B2 (en) | 2004-09-24 | 2007-10-23 | Hoff Hoffmann-La Roche Inc. | Tricycles, their manufacture and use as pharmaceutical agents |
TW200624431A (en) | 2004-09-24 | 2006-07-16 | Hoffmann La Roche | Phthalazinone derivatives, their manufacture and use as pharmaceutical agents |
US20070054916A1 (en) * | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
US8153643B2 (en) * | 2004-10-12 | 2012-04-10 | Astrazeneca Ab | Quinazoline derivatives |
EP1812439B2 (en) | 2004-10-15 | 2017-12-06 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
CA2587642C (en) * | 2004-11-30 | 2013-04-09 | Amgen Inc. | Substituted heterocycles and methods of use |
US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
CA2592900A1 (en) | 2005-01-03 | 2006-07-13 | Myriad Genetics Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
PT1854789E (pt) | 2005-02-23 | 2013-10-23 | Shionogi & Co | Derivado de quinazolina possuindo actividade inibidora de tirosina-cinase |
BRPI0608178A2 (pt) | 2005-04-14 | 2009-11-17 | Hoffmann La Roche | derivados de aminopirazol, sua fabricação, composição farmacêutica e uso como agentes farmacêuticos |
JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
GB0509224D0 (en) * | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Inhibitors of intracellular enzymatic activity |
US7732613B2 (en) | 2005-09-14 | 2010-06-08 | Bristol-Myers Squibb Company | Met kinase inhibitors |
US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
US8399666B2 (en) | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
GB2431927B (en) | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
US8648087B2 (en) | 2005-11-15 | 2014-02-11 | Array Biopharma, Inc. | N4-phenyl-quinazoline-4-amine derivatives and related compounds as ErbB type I receptor tyrosine kinase inhibitors for the treatment of hyperproliferative diseases |
CN101003514A (zh) * | 2006-01-20 | 2007-07-25 | 上海艾力斯医药科技有限公司 | 喹唑啉衍生物、其制备方法及用途 |
UY30183A1 (es) | 2006-03-02 | 2007-10-31 | Astrazeneca Ab | Derivados de quinolina |
EA200970361A1 (ru) | 2006-10-09 | 2010-02-26 | Такеда Фармасьютикал Компани Лимитед | Ингибиторы киназы |
EP1921070A1 (de) * | 2006-11-10 | 2008-05-14 | Boehringer Ingelheim Pharma GmbH & Co. KG | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung |
KR20090116782A (ko) * | 2007-02-06 | 2009-11-11 | 베링거 인겔하임 인터내셔날 게엠베하 | 바이사이클릭 헤테로사이클, 당해 화합물을 함유하는 약물, 이의 용도 및 이의 제조방법 |
WO2009030224A2 (de) * | 2007-09-07 | 2009-03-12 | Schebo Biotech Ag | Neue chinazolin- verbindungen und ihre verwendung zur therapie von krebserkrankungen |
US20090291971A1 (en) * | 2007-11-01 | 2009-11-26 | Wyeth | Heteroaryl ethers and processes for their preparation |
KR20100111291A (ko) | 2008-02-07 | 2010-10-14 | 베링거 인겔하임 인터내셔날 게엠베하 | 스피로사이클릭 헤테로사이클, 상기 화합물을 함유하는 약제, 이의 용도 및 이의 제조 방법 |
US8088782B2 (en) | 2008-05-13 | 2012-01-03 | Astrazeneca Ab | Crystalline 4-(3-chloro-2-fluoroanilino)-7 methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline difumarate form A |
MX2010012814A (es) | 2008-05-23 | 2010-12-20 | Amira Pharmaceuticals Inc | Inhibidor de proteina activadora de 5-lipoxigenasa. |
US8648191B2 (en) * | 2008-08-08 | 2014-02-11 | Boehringer Ingelheim International Gmbh | Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them |
CN101857588B (zh) * | 2010-06-08 | 2013-11-27 | 东南大学 | 4-芳香胺基喹唑啉类衍生物及其用途 |
CN102850280B (zh) * | 2011-06-30 | 2015-06-10 | 陕西师范大学 | 6,7-二烷氧基-4-取代苯基氨基喹唑啉类化合物及其制备方法 |
MY186126A (en) | 2013-03-06 | 2021-06-24 | Astrazeneca Ab | Quinazoline inhibitors of activating mutant forms of epidermal growth factor receptor |
US10548897B2 (en) | 2015-04-16 | 2020-02-04 | Icahn School Of Medicine At Mount Sinai | KSR antagonists |
BR112018006873A2 (pt) | 2015-10-05 | 2018-11-06 | The Trustees Of Columbia University In The City Of New York | ativadores do fluxo autofágico e fosfolipase d e depuração de agregados de proteína incluindo tau e tratamento de proteinopatias |
CN113354591B (zh) * | 2021-06-09 | 2023-03-24 | 广东湛江海洋医药研究院 | 烷氨基喹唑啉的合成及其抗肿瘤活性 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5409930A (en) * | 1991-05-10 | 1995-04-25 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
GB9300059D0 (en) | 1992-01-20 | 1993-03-03 | Zeneca Ltd | Quinazoline derivatives |
JP2994165B2 (ja) * | 1992-06-26 | 1999-12-27 | ゼネカ・リミテッド | キナゾリン誘導体、その製造法および該キナゾリン誘導体を含有する抗癌作用を得るための医薬調剤 |
GB9510757D0 (en) * | 1994-09-19 | 1995-07-19 | Wellcome Found | Therapeuticaly active compounds |
TW321649B (is) * | 1994-11-12 | 1997-12-01 | Zeneca Ltd | |
EP1110953B1 (en) | 1995-03-30 | 2009-10-28 | Pfizer Products Inc. | Quinazoline derivatives |
GB9624482D0 (en) * | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
EP0880508B1 (en) * | 1996-02-13 | 2003-04-16 | AstraZeneca AB | Quinazoline derivatives as vegf inhibitors |
GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
IL125954A (en) * | 1996-03-05 | 2003-06-24 | Zeneca Ltd | Quinazoline derivatives, processes for their preparation, pharmaceutical compositions containing them and use thereof in the manufacture of medicaments having an antiangiogenic and/or vascular permeability reducing effect |
IL139641A0 (en) * | 1998-05-28 | 2002-02-10 | Parker Hughes Inst | Quinazolines for treating brain tumor |
-
2000
- 2000-09-18 AU AU74325/00A patent/AU763242B2/en not_active Ceased
- 2000-09-18 HU HU0204413A patent/HUP0204413A3/hu unknown
- 2000-09-18 CA CA002384282A patent/CA2384282A1/en not_active Abandoned
- 2000-09-18 IL IL14848900A patent/IL148489A0/xx unknown
- 2000-09-18 BR BR0014133-0A patent/BR0014133A/pt not_active IP Right Cessation
- 2000-09-18 CN CN00816007A patent/CN1391561A/zh active Pending
- 2000-09-18 TR TR2002/00749T patent/TR200200749T2/xx unknown
- 2000-09-18 KR KR1020027003678A patent/KR20020032608A/ko not_active Application Discontinuation
- 2000-09-18 EP EP00962677A patent/EP1218356A1/en not_active Withdrawn
- 2000-09-18 US US10/088,854 patent/US7081461B1/en not_active Expired - Fee Related
- 2000-09-18 EE EEP200200149A patent/EE200200149A/xx unknown
- 2000-09-18 WO PCT/GB2000/003556 patent/WO2001021594A1/en active IP Right Grant
- 2000-09-18 SK SK383-2002A patent/SK3832002A3/sk unknown
- 2000-09-18 JP JP2001524973A patent/JP2003509497A/ja active Pending
- 2000-09-18 PL PL00354923A patent/PL354923A1/xx not_active Application Discontinuation
- 2000-09-18 CZ CZ20021010A patent/CZ20021010A3/cs unknown
-
2002
- 2002-03-07 BG BG106491A patent/BG106491A/bg unknown
- 2002-03-18 IS IS6304A patent/IS6304A/is unknown
- 2002-03-20 NO NO20021401A patent/NO20021401L/no not_active Application Discontinuation
- 2002-11-19 HK HK02108374.7A patent/HK1046688A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CA2384282A1 (en) | 2001-03-29 |
HUP0204413A2 (en) | 2003-05-28 |
AU7432500A (en) | 2001-04-24 |
TR200200749T2 (tr) | 2002-06-21 |
JP2003509497A (ja) | 2003-03-11 |
BG106491A (bg) | 2002-12-29 |
BR0014133A (pt) | 2002-06-11 |
PL354923A1 (en) | 2004-03-22 |
HUP0204413A3 (en) | 2003-07-28 |
US7081461B1 (en) | 2006-07-25 |
AU763242B2 (en) | 2003-07-17 |
CZ20021010A3 (cs) | 2002-06-12 |
CN1391561A (zh) | 2003-01-15 |
NO20021401D0 (no) | 2002-03-20 |
SK3832002A3 (en) | 2002-11-06 |
EE200200149A (et) | 2003-04-15 |
IL148489A0 (en) | 2002-09-12 |
HK1046688A1 (zh) | 2003-01-24 |
KR20020032608A (ko) | 2002-05-03 |
EP1218356A1 (en) | 2002-07-03 |
NO20021401L (no) | 2002-05-21 |
WO2001021594A1 (en) | 2001-03-29 |
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