ATE502928T1 - Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung - Google Patents

Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung

Info

Publication number
ATE502928T1
ATE502928T1 AT01992708T AT01992708T ATE502928T1 AT E502928 T1 ATE502928 T1 AT E502928T1 AT 01992708 T AT01992708 T AT 01992708T AT 01992708 T AT01992708 T AT 01992708T AT E502928 T1 ATE502928 T1 AT E502928T1
Authority
AT
Austria
Prior art keywords
kinases
containing heterocyclic
nitrogen
heterocyclic compounds
production
Prior art date
Application number
AT01992708T
Other languages
English (en)
Inventor
James Kanter
Anjali Pandey
James Robinson
Robert Scarborough
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Application granted granted Critical
Publication of ATE502928T1 publication Critical patent/ATE502928T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT01992708T 2000-11-01 2001-11-01 Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung ATE502928T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24465500P 2000-11-01 2000-11-01
US25985901P 2001-01-08 2001-01-08
PCT/US2001/045400 WO2002036587A2 (en) 2000-11-01 2001-11-01 Process for the production of 4-quinazolinylpiperazin-1-carboxylic acid phenylamides

Publications (1)

Publication Number Publication Date
ATE502928T1 true ATE502928T1 (de) 2011-04-15

Family

ID=26936702

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01992708T ATE502928T1 (de) 2000-11-01 2001-11-01 Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung

Country Status (7)

Country Link
US (4) US6951937B2 (de)
EP (1) EP1330444B1 (de)
JP (1) JP4564713B2 (de)
AT (1) ATE502928T1 (de)
AU (1) AU2002217999A1 (de)
DE (1) DE60144284D1 (de)
WO (1) WO2002036587A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002217999A1 (en) 2000-11-01 2002-05-15 Cor Therapeutics, Inc. Process for the production of 4-quinazolinylpiperazin-1-carboxylic acid phenylamides
WO2003051849A1 (fr) * 2001-12-19 2003-06-26 Ube Industries, Ltd. Procede de production de quinazoline-4-one et derive de celle-ci
JP4389204B2 (ja) * 2002-01-28 2009-12-24 宇部興産株式会社 キナゾリン−４−オン誘導体の製造方法
WO2005097137A2 (en) * 2004-03-31 2005-10-20 The Scripps Research Institute Advanced quinazoline based protein kinase inhibitors
EP1778224B1 (de) * 2004-07-19 2014-03-26 The Johns-Hopkins University Flt3-inhibitoren zur immunsuppression
US20100179162A1 (en) * 2005-07-20 2010-07-15 Millennium Pharmaceuticals , Inc. Crystal forms of 4-[6-methoxy-7(3-piperidin-1-yl-propoxy) quinazoline-4yl) piperazine-1-carboxylic acid (4-isopropoxyphenyl)-amide
DK1951254T3 (da) * 2005-11-03 2012-05-07 Portola Pharm Inc (4-(6-halo-7-substitueret-2,4-dioxo-1,4-dihydro-2h-quinazolin-3-yl)-phenyl)¨-5-chlorthiophen-2-yl-sulfonylureaer og former og fremgangsmåder der er relateret dertil
MX2008010953A (es) * 2006-02-28 2008-09-08 Amgen Inc Derivados de cinolina y quinoxalina como inhibidores de la fosfodiesterasa 10.
EP2076510A2 (de) * 2007-05-02 2009-07-08 Portola Pharmaceuticals, Inc. [4-(6-fluor-7-methylamino-2,4-dioxo-1,4-dihydro-2h-chinazolin-3-yl)phenyl]-chlorthiophen-2-yl-sulfonylharnstoffsalze in verschiedenen kristallinen formen, pharmazeutische zusammensetzungen davon und formulierungen davon zur behandlung von thrombose und thromboseähnlichen leiden
WO2010059239A2 (en) 2008-11-21 2010-05-27 Millennium Pharmaceuticals, Inc Lactate salt of 4-(6-methoxy-7-(3-piperidin-1-yl-propoxy)quinazolin-4-yl]piperazine-1-carboxylic acid(4-isopropoxyphenyl)-amide and pharmaceutical compositions thereof for the treatment of cancer and other diseases or disorders
CN103242245B (zh) * 2013-05-22 2015-05-20 苏州明锐医药科技有限公司 坦度替尼的制备方法
WO2015009889A1 (en) 2013-07-18 2015-01-22 Concert Pharmaceuticals, Inc. Deuterated intedanib derivatives and their use for the treatment of proliferative disorders
CN104193688A (zh) * 2014-09-04 2014-12-10 埃斯特维华义制药有限公司 厄洛替尼中间体的合成方法
CN104496915B (zh) * 2014-12-19 2017-05-03 华侨大学 一种喹唑啉酮芳香化合物的合成方法

Family Cites Families (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3800039A (en) 1970-10-21 1974-03-26 Mead Johnson & Co Antithrombogenic process employing substituted 6,7-dialkoxyquinazolines
JPS5677265A (en) * 1979-11-28 1981-06-25 Mitsubishi Yuka Yakuhin Kk Novel quinazoline derivative
US4607034A (en) * 1979-10-29 1986-08-19 Mitsubishi Yuka Pharmaceutical Co., Ltd. Quinazoline derivatives and pharmaceutical composition thereof
JPS58172379A (ja) * 1982-04-02 1983-10-11 Showa Denko Kk 新規なキナゾリン誘導体
JPS60120872A (ja) * 1983-12-01 1985-06-28 Kyowa Hakko Kogyo Co Ltd 新規なヘテロ環状化合物及び強心剤
US4797419A (en) 1986-11-03 1989-01-10 Warner-Lambert Company Method of treating the symptoms of senile cognitive decline employing di- or trisubstituted urea cholinergic agents
CA1338012C (en) 1987-04-27 1996-01-30 John Michael Mccall Pharmaceutically active amines
US5120843A (en) 1987-04-27 1992-06-09 Upjohn Pharmaceutically active amines
IT1222867B (it) 1987-10-12 1990-09-12 Zambon Spa Ftalazino derivati ad attivita' farmaceutica
JPH02167277A (ja) 1988-09-19 1990-06-27 Kyowa Hakko Kogyo Co Ltd 新規なジアジン化合物
JPH0413669A (ja) 1990-04-27 1992-01-17 Mitsui Toatsu Chem Inc 新規ピリミジンジオン誘導体及び該化合物を含有する抗不整脈剤
WO1992020642A1 (en) 1991-05-10 1992-11-26 Rhone-Poulenc Rorer International (Holdings) Inc. Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit egf and/or pdgf receptor tyrosine kinase
NZ243082A (en) 1991-06-28 1995-02-24 Ici Plc 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
US5308850A (en) 1991-09-30 1994-05-03 Merck Frosst Canada, Inc. (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5290798A (en) 1991-09-30 1994-03-01 Merck Frosst Canada, Inc. (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
AU661533B2 (en) 1992-01-20 1995-07-27 Astrazeneca Ab Quinazoline derivatives
TW225528B (de) 1992-04-03 1994-06-21 Ciba Geigy Ag
US5308852A (en) 1992-06-29 1994-05-03 Merck Frosst Canada, Inc. Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis
GB9321557D0 (en) 1992-11-03 1993-12-08 Zeneca Ltd Carboxamide derivatives
JPH08504194A (ja) 1992-12-01 1996-05-07 メルク エンド カンパニー インコーポレーテッド フィブリノーゲンレセプターアンタゴニスト
JP3229693B2 (ja) * 1993-02-22 2001-11-19 協和醗酵工業株式会社 ピペラジン誘導体
ES2141197T3 (es) 1993-03-19 2000-03-16 Merck & Co Inc Derivados del acido fenoxifenilacetico.
DK0825184T3 (da) 1993-03-29 2001-09-10 Astrazeneca Ab Heterocykliske derivater som blodpladeaggregeringsinhibitorer
EP0723658A1 (de) 1993-10-15 1996-07-31 MERCK PATENT GmbH Test-verfahren
US5446062A (en) 1993-11-12 1995-08-29 Abbott Laboratories ((4-alkoxypyran-4-yl) substituted) ether, arylalkyl-, arylalkenyl-, and arylalkynyl)urea inhibitors of 5-lipoxygenase
US6403577B1 (en) 1993-11-17 2002-06-11 Eli Lilly And Company Hexamethyleneiminyl tachykinin receptor antagonists
US5496857A (en) 1994-03-17 1996-03-05 Targosz; Eugene F. Whitefly insecticide
US5538991A (en) 1994-09-14 1996-07-23 Merck & Co., Inc. Endothelin antagonists bearing 5-membered heterocyclic amides
GB9510757D0 (en) 1994-09-19 1995-07-19 Wellcome Found Therapeuticaly active compounds
WO1996009818A1 (en) 1994-09-27 1996-04-04 Merck & Co., Inc. Endothelin receptor antagonists for the treatment of emesis
CA2133231A1 (en) 1994-09-29 1996-03-30 Kuen-Yuan Hwang Process for preparing carbonate compounds
TW321649B (de) 1994-11-12 1997-12-01 Zeneca Ltd
EP0796252A4 (de) 1994-12-09 1998-02-04 Smithkline Beecham Corp Bicyclische fibrinogen antagonisten
EP2295415A1 (de) 1995-03-30 2011-03-16 OSI Pharmaceuticals, Inc. Chinazolinderivate
GB9508538D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
US5972955A (en) 1995-06-06 1999-10-26 Dr. Reddy's Research Foundation Water soluble C-ring analogues of 20(S)-camptothecin
US5747498A (en) 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
SI9620099A (sl) 1995-06-29 1998-08-31 Novartis Ag Diglikozilirani 1,2-dioli kot mimetiki sialil-Lewis X in sialil-Lewis A
GB9514265D0 (en) 1995-07-13 1995-09-13 Wellcome Found Hetrocyclic compounds
GB9516709D0 (en) 1995-08-15 1995-10-18 Zeneca Ltd Medicament
WO1997012613A1 (en) 1995-10-05 1997-04-10 Warner-Lambert Company Method for treating and preventing inflammation and atherosclerosis
HUT76265A (en) 1995-10-19 1997-07-28 Gyogyszerkutato Intezet Pyrimidine derivatives, pharmaceutical compositions containing them, process for producing them and their use
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
FR2744450A1 (fr) 1996-02-02 1997-08-08 Pf Medicament Nouvelles naphtylpiperazines derivees de cycloazanes substitues, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments
AR005600A1 (es) 1996-02-02 1999-06-23 Syngenta Ltd Composiciones herbicidas quimicamente estables de quelatos metalicos de dionas herbicidas, y proceso para su produccion
FR2744449B1 (fr) 1996-02-02 1998-04-24 Pf Medicament Nouvelles piperazines aromatiques derivees de cycloazanes substitues, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments
CZ291386B6 (cs) 1996-02-13 2003-02-12 Zeneca Limited Chinazolinové deriváty jako inhibitory VEGF, způsob jejich přípravy a farmaceutický prostředek, který je obsahuje
NZ331191A (en) 1996-03-05 2000-03-27 Zeneca Ltd 4-anilinoquinazoline derivatives and pharmaceutical compositions thereof
GB9707800D0 (en) 1996-05-06 1997-06-04 Zeneca Ltd Chemical compounds
KR19980018486A (ko) 1996-08-09 1998-06-05 다께다 구니오 디메틸프로판디올 화합물
EP0954315A2 (de) 1996-09-13 1999-11-10 Sugen, Inc. Verwendung von quinazolinderivate zur herstellung eines arzneimittels zur behandlung hyperproliferativer hautkrankheiten
US6004967A (en) 1996-09-13 1999-12-21 Sugen, Inc. Psoriasis treatment with quinazoline compounds
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
ES2351684T3 (es) 1996-10-01 2011-02-09 Kyowa Hakko Kirin Co., Ltd. Compuestos heterocíclicos nitrogenados.
AU740324B2 (en) 1997-01-17 2001-11-01 Naeja Pharmaceutical Inc. New triazoles as therapeutic agents for fungal infections
AU5999798A (en) 1997-02-13 1998-09-08 Zeneca Limited Heterocyclic compounds useful as oxido-squalene cyclase inhibitors
EP1005470B1 (de) 1997-08-22 2007-08-01 AstraZeneca AB Oxindolylchinazolinderivate als angiogenesehemmer
JPH1180131A (ja) * 1997-09-01 1999-03-26 Mitsubishi Chem Corp エチニルピリミジン誘導体
DE19743435A1 (de) 1997-10-01 1999-04-08 Merck Patent Gmbh Benzamidinderivate
EP1019391A1 (de) 1997-10-02 2000-07-19 Merck & Co. Inc. Inhibitoren der prenyl-protein transferase
CA2326324C (en) 1998-03-31 2010-05-11 Kyowa Hakko Kogyo Co., Ltd. Nitrogen-containing heterocyclic compound
EP1077929A1 (de) 1998-05-12 2001-02-28 American Home Products Corporation 2,3,5-substituierte biphenyle nützlich in die behandlung von insulinresistenz und hyperglykämie
PE20000564A1 (es) 1998-06-08 2000-07-05 Schering Corp Antagonistas receptores y5 de neuropeptidos
EP0982300A3 (de) 1998-07-29 2000-03-08 Societe Civile Bioprojet Alkylamine ohne Imidazolring als Histamin-H3-antagonisten und deren therapeutische Anwendung
PT1117653E (pt) 1998-10-01 2003-06-30 Astrazeneca Ab Derivados de quinolina e quinazolina e sua utilizacao como inibidores de doencas mediadas pela citosina
DK1119567T3 (da) 1998-10-08 2005-07-25 Astrazeneca Ab Quinazolinderivater
DE69919212T2 (de) 1998-12-23 2005-07-28 Eli Lilly And Co., Indianapolis Aromatische amiden
US6146560A (en) 1999-01-22 2000-11-14 Behi; Mohammad Process for forming an article from recycled ceramic molding compound
US7074800B1 (en) 1999-02-10 2006-07-11 Astrazeneca Ab Quinazoline derivatives as angiogenesis inhibitors
DE19911509A1 (de) 1999-03-15 2000-09-21 Boehringer Ingelheim Pharma Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
JP2003504360A (ja) 1999-07-07 2003-02-04 アストラゼネカ ユーケイ リミテッド キナゾリン誘導体
SK3832002A3 (en) 1999-09-21 2002-11-06 Astrazeneca Ab Quinazoline compounds and pharmaceutical compositions containing them
GB9922173D0 (en) 1999-09-21 1999-11-17 Zeneca Ltd Chemical compounds
CZ20021009A3 (cs) 1999-09-21 2002-06-12 Astrazeneca Ab Deriváty chinazolinu, způsob jejich přípravy a jejich pouľití jako léčiv
GB9922171D0 (en) 1999-09-21 1999-11-17 Zeneca Ltd Chemical compounds
UA74803C2 (uk) 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
US7498335B2 (en) 2000-03-06 2009-03-03 Astrazeneca Ab Method of producing an antiangiogenic or vascular permeability reducing effect
AU779695B2 (en) 2000-04-07 2005-02-10 Astrazeneca Ab Quinazoline compounds
UA73993C2 (uk) 2000-06-06 2005-10-17 Астразенека Аб Хіназолінові похідні для лікування пухлин та фармацевтична композиція
WO2002000644A1 (en) 2000-06-24 2002-01-03 Astrazeneca Ab Guanidine derivatives of quinazoline and quinoline for use in the treatment of autoimmune diseases
AU2002216758A1 (en) 2000-07-03 2002-01-14 Astrazeneca Ab Quinazolines with therapeutic use
KR100831116B1 (ko) * 2000-08-18 2008-05-20 밀레니엄 파머슈티컬스 인코퍼레이티드 키나아제 억제제로서의 퀴나졸린 유도체
DK1309569T3 (da) * 2000-08-18 2011-01-24 Millennium Pharm Inc N-aryl-{4-[7-(alkoxy)quinazolin-4-yl]piperazinyl}carboxamidderivater som PDGFRs-inhibitorer
US7329655B2 (en) 2000-08-18 2008-02-12 Millennium Pharmaceuticals, Inc. Nitrogenous heterocyclic compounds
EP1309567A2 (de) * 2000-08-18 2003-05-14 Millennium Pharmaceuticals, Inc. Stickstoffhaltige heterozyklische verbindungen
CN100347169C (zh) 2000-08-21 2007-11-07 阿斯特拉曾尼卡有限公司 喹唑啉衍生物
DE10042059A1 (de) 2000-08-26 2002-03-07 Boehringer Ingelheim Pharma Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
JP2004511479A (ja) 2000-10-13 2004-04-15 アストラゼネカ　アクチボラグ キナゾリン誘導体
US6939866B2 (en) 2000-10-13 2005-09-06 Astrazeneca Ab Quinazoline derivatives
WO2002034744A1 (en) 2000-10-25 2002-05-02 Astrazeneca Ab Quinazoline derivatives
AU2002217999A1 (en) 2000-11-01 2002-05-15 Cor Therapeutics, Inc. Process for the production of 4-quinazolinylpiperazin-1-carboxylic acid phenylamides
CA2435883A1 (en) 2001-01-26 2002-08-01 Sankyo Company, Limited Benzylamine analogue
TWI245761B (en) 2001-03-01 2005-12-21 Telik Inc Antagonists of MCP-1 function and methods of use thereof
US6960580B2 (en) 2001-03-08 2005-11-01 Millennium Pharmaceuticals, Inc. Nitrogenous heterocyclic substituted quinoline compounds
JP4307843B2 (ja) 2001-04-19 2009-08-05 アストラゼネカ アクチボラグ キナゾリン誘導体
GB0110797D0 (en) 2001-05-02 2001-06-27 Celltech R&D Ltd Chemical compounds
WO2002092578A1 (en) 2001-05-14 2002-11-21 Astrazeneca Ab Quinazoline derivatives
WO2002092579A1 (en) 2001-05-14 2002-11-21 Astrazeneca Ab 4-anilinoquinazoline derivatives
WO2002092577A1 (en) 2001-05-14 2002-11-21 Astrazeneca Ab Quinazoline derivatives
US7132427B2 (en) 2001-06-21 2006-11-07 Ariad Pharmaceuticals, Inc. Quinazolines and uses thereof
BR0210616A (pt) 2001-06-28 2004-09-28 Pfizer Prod Inc Indóis, benzofuranos e benzotiofenos substituìdos com triamida, composição farmacêutica, uso dos referidos compostos, bem como processo para preparação dos mesmos
GB0128122D0 (en) 2001-11-23 2002-01-16 Astrazeneca Ab Therapeutic use
GB0128109D0 (en) 2001-11-23 2002-01-16 Astrazeneca Ab Therapeutic use
WO2003054819A2 (en) 2001-12-12 2003-07-03 Paradata Systems Inc. Global integrated payment system
WO2003051849A1 (fr) 2001-12-19 2003-06-26 Ube Industries, Ltd. Procede de production de quinazoline-4-one et derive de celle-ci
RU2323215C2 (ru) 2001-12-24 2008-04-27 Астразенека Аб Замещенные производные хиназолина как ингибиторы ауроракиназы
JP4389204B2 (ja) 2002-01-28 2009-12-24 宇部興産株式会社 キナゾリン−４−オン誘導体の製造方法
AU2003207291A1 (en) 2002-02-06 2003-09-02 Ube Industries, Ltd. Process for producing 4-aminoquinazoline compound
US7148249B2 (en) 2002-09-12 2006-12-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments
GB0223532D0 (en) 2002-10-09 2002-11-13 British Biotech Pharm Antibacterial agents
TWI347946B (en) 2002-10-11 2011-09-01 Otsuka Pharma Co Ltd 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound
SE0203828D0 (sv) 2002-12-20 2002-12-20 Astrazeneca Ab Chemical compounds
TW200510311A (en) 2002-12-23 2005-03-16 Millennium Pharm Inc CCr8 inhibitors
US7378525B2 (en) 2002-12-23 2008-05-27 Millennium Pharmaceuticals, Inc. CCR8 inhibitors
US7138412B2 (en) * 2003-03-11 2006-11-21 Bristol-Myers Squibb Company Tetrahydroquinoline derivatives useful as serine protease inhibitors
AU2004223866A1 (en) 2003-03-24 2004-10-07 Luitpold Pharmaceuticals, Inc. Xanthones, thioxanthones and acridinones as DNA-PK inhibitors
JP3819415B2 (ja) 2003-04-09 2006-09-06 日本たばこ産業株式会社 複素芳香５員環化合物及びその医薬用途
WO2004101562A2 (en) 2003-05-13 2004-11-25 Schering Corporation Bridged n-arylsulfonylpiperidines as gamma-secretase inhibitors
CN100471856C (zh) 2003-07-31 2009-03-25 Irm责任有限公司 作为pdf抑制剂的二环化合物和组合物
US7456189B2 (en) 2003-09-30 2008-11-25 Boehringer Ingelheim International Gmbh Bicyclic heterocycles, medicaments containing these compounds, their use and processes for their preparation
US7309716B2 (en) 2003-10-28 2007-12-18 Vertex Pharmaceuticals Incorporated Benzimidazoles useful as modulators of ion channels
JP5208911B2 (ja) 2009-12-09 2013-06-12 株式会社東芝 空調制御装置および空調制御方法

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Publication number Publication date
WO2002036587A3 (en) 2002-08-22
US8536184B2 (en) 2013-09-17
EP1330444B1 (de) 2011-03-23
AU2002217999A1 (en) 2002-05-15
JP2004513126A (ja) 2004-04-30
US7709640B2 (en) 2010-05-04
WO2002036587A2 (en) 2002-05-10
JP4564713B2 (ja) 2010-10-20
US20020091130A1 (en) 2002-07-11
EP1330444A2 (de) 2003-07-30
DE60144284D1 (de) 2011-05-05
US20100240893A1 (en) 2010-09-23
USRE43098E1 (en) 2012-01-10
US20060167011A1 (en) 2006-07-27
US6951937B2 (en) 2005-10-04

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