ATE502928T1 - Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung - Google Patents

Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung

Info

Publication number
ATE502928T1
ATE502928T1 AT01992708T AT01992708T ATE502928T1 AT E502928 T1 ATE502928 T1 AT E502928T1 AT 01992708 T AT01992708 T AT 01992708T AT 01992708 T AT01992708 T AT 01992708T AT E502928 T1 ATE502928 T1 AT E502928T1
Authority
AT
Austria
Prior art keywords
kinases
containing heterocyclic
nitrogen
heterocyclic compounds
production
Prior art date
Application number
AT01992708T
Other languages
English (en)
Inventor
James Kanter
Anjali Pandey
James Robinson
Robert Scarborough
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Application granted granted Critical
Publication of ATE502928T1 publication Critical patent/ATE502928T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT01992708T 2000-11-01 2001-11-01 Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung ATE502928T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24465500P 2000-11-01 2000-11-01
US25985901P 2001-01-08 2001-01-08
PCT/US2001/045400 WO2002036587A2 (en) 2000-11-01 2001-11-01 Process for the production of 4-quinazolinylpiperazin-1-carboxylic acid phenylamides

Publications (1)

Publication Number Publication Date
ATE502928T1 true ATE502928T1 (de) 2011-04-15

Family

ID=26936702

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01992708T ATE502928T1 (de) 2000-11-01 2001-11-01 Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung

Country Status (7)

Country Link
US (4) US6951937B2 (de)
EP (1) EP1330444B1 (de)
JP (1) JP4564713B2 (de)
AT (1) ATE502928T1 (de)
AU (1) AU2002217999A1 (de)
DE (1) DE60144284D1 (de)
WO (1) WO2002036587A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60144284D1 (de) 2000-11-01 2011-05-05 Millennium Pharm Inc Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung
WO2003051849A1 (en) 2001-12-19 2003-06-26 Ube Industries, Ltd. Process for producing quinazolin-4-one and derivative thereof
US8367824B2 (en) 2002-01-28 2013-02-05 Ube Industries Ltd. Process for producing quinazolin-4-one derivative
WO2005097134A2 (en) * 2004-03-31 2005-10-20 The Scripps Research Institute Quinazoline based protein kinase inhibitors
AU2005274852B2 (en) * 2004-07-19 2011-12-08 The Johns Hopkins University FLT3 inhibitors for immune suppression
JP2009502804A (ja) * 2005-07-20 2009-01-29 ミレニアム・ファーマシューティカルズ・インコーポレイテッド ４−［６−メトキシ−７−（３−ピペリジン−１−イル−プロポキシ）キナゾリン−４−イル］ピペラジン−１−カルボン酸（４−イソプロポキシフェニル）−アミドの新規な結晶形
CN101300013B (zh) * 2005-11-03 2012-11-28 博尔托拉制药公司 [4-(6-卤代-7-取代的-2,4-二氧代-1,4-二氢-2h-喹唑啉-3-基)-苯基]-5-氯-噻吩-2-基磺酰脲类及与其相关的形式和方法
US20070287707A1 (en) * 2006-02-28 2007-12-13 Arrington Mark P Phosphodiesterase 10 inhibitors
WO2008137809A2 (en) * 2007-05-02 2008-11-13 Portola Pharmaceuticals, Inc. [4-(6-fluoro-7-methylamino-2,4-dioxo-1,4-dihydro-2h-quinazolin-3-yl)-phenyl] -5-chloro-thiophen-2-yl-sulfonylurea salts, in different crystalline forms, pharmaceutical compositions thereof
EP2370417A2 (de) 2008-11-21 2011-10-05 Millennium Pharmaceuticals, Inc. Lactatsalz von 4-[6-methoxy-7-(3-piperidin-1-yl-propoxy)chinazolin-4-yl]piperazin-1-carbonsäure-(4-isopropoxyphenyl)amid und pharmazeutische zusammensetzungen davon zur behandlung von krebs und anderen krankheiten bzw. störungen
CN103242245B (zh) * 2013-05-22 2015-05-20 苏州明锐医药科技有限公司 坦度替尼的制备方法
WO2015009889A1 (en) 2013-07-18 2015-01-22 Concert Pharmaceuticals, Inc. Deuterated intedanib derivatives and their use for the treatment of proliferative disorders
CN104193688A (zh) * 2014-09-04 2014-12-10 埃斯特维华义制药有限公司 厄洛替尼中间体的合成方法
CN104496915B (zh) * 2014-12-19 2017-05-03 华侨大学 一种喹唑啉酮芳香化合物的合成方法

Family Cites Families (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3800039A (en) 1970-10-21 1974-03-26 Mead Johnson & Co Antithrombogenic process employing substituted 6,7-dialkoxyquinazolines
JPS5677265A (en) * 1979-11-28 1981-06-25 Mitsubishi Yuka Yakuhin Kk Novel quinazoline derivative
US4607034A (en) * 1979-10-29 1986-08-19 Mitsubishi Yuka Pharmaceutical Co., Ltd. Quinazoline derivatives and pharmaceutical composition thereof
JPS58172379A (ja) * 1982-04-02 1983-10-11 Showa Denko Kk 新規なキナゾリン誘導体
JPS60120872A (ja) * 1983-12-01 1985-06-28 Kyowa Hakko Kogyo Co Ltd 新規なヘテロ環状化合物及び強心剤
US4797419A (en) 1986-11-03 1989-01-10 Warner-Lambert Company Method of treating the symptoms of senile cognitive decline employing di- or trisubstituted urea cholinergic agents
CA1338012C (en) 1987-04-27 1996-01-30 John Michael Mccall Pharmaceutically active amines
US5120843A (en) 1987-04-27 1992-06-09 Upjohn Pharmaceutically active amines
IT1222867B (it) 1987-10-12 1990-09-12 Zambon Spa Ftalazino derivati ad attivita' farmaceutica
JPH02167277A (ja) 1988-09-19 1990-06-27 Kyowa Hakko Kogyo Co Ltd 新規なジアジン化合物
JPH0413669A (ja) 1990-04-27 1992-01-17 Mitsui Toatsu Chem Inc 新規ピリミジンジオン誘導体及び該化合物を含有する抗不整脈剤
AU658646B2 (en) 1991-05-10 1995-04-27 Rhone-Poulenc Rorer International (Holdings) Inc. Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
NZ243082A (en) 1991-06-28 1995-02-24 Ici Plc 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
US5290798A (en) 1991-09-30 1994-03-01 Merck Frosst Canada, Inc. (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5308850A (en) 1991-09-30 1994-05-03 Merck Frosst Canada, Inc. (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
AU661533B2 (en) 1992-01-20 1995-07-27 Astrazeneca Ab Quinazoline derivatives
TW225528B (de) 1992-04-03 1994-06-21 Ciba Geigy Ag
US5308852A (en) 1992-06-29 1994-05-03 Merck Frosst Canada, Inc. Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis
GB9321557D0 (en) 1992-11-03 1993-12-08 Zeneca Ltd Carboxamide derivatives
CA2150550A1 (en) 1992-12-01 1994-06-09 Melissa S. Egbertson Fibrinogen receptor antagonists
JP3229693B2 (ja) * 1993-02-22 2001-11-19 協和醗酵工業株式会社 ピペラジン誘導体
ES2141197T3 (es) 1993-03-19 2000-03-16 Merck & Co Inc Derivados del acido fenoxifenilacetico.
ATE202345T1 (de) 1993-03-29 2001-07-15 Astrazeneca Ab Heterozyklische derivate als plätchenaggregationsinhibitoren
JPH09503666A (ja) 1993-10-15 1997-04-15 メルク・パテント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツンク アッセイ方法
US5446062A (en) 1993-11-12 1995-08-29 Abbott Laboratories ((4-alkoxypyran-4-yl) substituted) ether, arylalkyl-, arylalkenyl-, and arylalkynyl)urea inhibitors of 5-lipoxygenase
US6403577B1 (en) 1993-11-17 2002-06-11 Eli Lilly And Company Hexamethyleneiminyl tachykinin receptor antagonists
US5496857A (en) 1994-03-17 1996-03-05 Targosz; Eugene F. Whitefly insecticide
US5538991A (en) 1994-09-14 1996-07-23 Merck & Co., Inc. Endothelin antagonists bearing 5-membered heterocyclic amides
GB9510757D0 (en) 1994-09-19 1995-07-19 Wellcome Found Therapeuticaly active compounds
WO1996009818A1 (en) 1994-09-27 1996-04-04 Merck & Co., Inc. Endothelin receptor antagonists for the treatment of emesis
CA2133231A1 (en) 1994-09-29 1996-03-30 Kuen-Yuan Hwang Process for preparing carbonate compounds
TW321649B (de) 1994-11-12 1997-12-01 Zeneca Ltd
EP0796252A4 (de) 1994-12-09 1998-02-04 Smithkline Beecham Corp Bicyclische fibrinogen antagonisten
DE69522717T2 (de) 1995-03-30 2002-02-14 Pfizer Inc., New York Chinazolinderivate
GB9508538D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
US5972955A (en) 1995-06-06 1999-10-26 Dr. Reddy's Research Foundation Water soluble C-ring analogues of 20(S)-camptothecin
US5747498A (en) 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
BR9609285A (pt) 1995-06-29 1999-05-11 Novartis Ag Dióis-1,2 diglicosilados como miméticos do sialil-lewis x e do sialil-lewis a
GB9514265D0 (en) 1995-07-13 1995-09-13 Wellcome Found Hetrocyclic compounds
GB9516709D0 (en) 1995-08-15 1995-10-18 Zeneca Ltd Medicament
AU6966696A (en) 1995-10-05 1997-04-28 Warner-Lambert Company Method for treating and preventing inflammation and atherosclerosis
HUT76265A (en) 1995-10-19 1997-07-28 Gyogyszerkutato Intezet Pyrimidine derivatives, pharmaceutical compositions containing them, process for producing them and their use
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
FR2744450A1 (fr) 1996-02-02 1997-08-08 Pf Medicament Nouvelles naphtylpiperazines derivees de cycloazanes substitues, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments
AR005600A1 (es) 1996-02-02 1999-06-23 Syngenta Ltd Composiciones herbicidas quimicamente estables de quelatos metalicos de dionas herbicidas, y proceso para su produccion
FR2744449B1 (fr) 1996-02-02 1998-04-24 Pf Medicament Nouvelles piperazines aromatiques derivees de cycloazanes substitues, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments
JP4471404B2 (ja) 1996-02-13 2010-06-02 アストラゼネカ ユーケイ リミテッド Ｖｅｇｆインヒビターとしてのキナゾリン誘導体
ATE211134T1 (de) 1996-03-05 2002-01-15 4-anilinochinazolin derivate
GB9707800D0 (en) 1996-05-06 1997-06-04 Zeneca Ltd Chemical compounds
TW397809B (en) 1996-08-09 2000-07-11 Takeda Chemical Industries Ltd Dimethylpropanediol compounds
WO1998010767A2 (en) 1996-09-13 1998-03-19 Sugen, Inc. Use of quinazoline derivatives for the manufacture of a medicament in the treatment of hyperproliferative skin disorders
US6004967A (en) 1996-09-13 1999-12-21 Sugen, Inc. Psoriasis treatment with quinazoline compounds
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
AU719392B2 (en) 1996-10-01 2000-05-11 Kyowa Hakko Kirin Co., Ltd. Nitrogen-containing heterocyclic compounds
KR20000064644A (ko) 1997-01-17 2000-11-06 믹에티취 알.지. 진균 감염 치료제로서의 신규한 트리아졸
ATE242774T1 (de) 1997-02-13 2003-06-15 Astrazeneca Ab Heterozyklische verbindungen die als oxido- squalen-zyklase-inhibitoren anwendung finden
ATE368665T1 (de) 1997-08-22 2007-08-15 Astrazeneca Ab Oxindolylchinazolinderivate als angiogenesehemmer
JPH1180131A (ja) * 1997-09-01 1999-03-26 Mitsubishi Chem Corp エチニルピリミジン誘導体
DE19743435A1 (de) 1997-10-01 1999-04-08 Merck Patent Gmbh Benzamidinderivate
JP2001519345A (ja) 1997-10-02 2001-10-23 メルク エンド カムパニー インコーポレーテッド プレニルタンパク質トランスフェラーゼの阻害剤
ES2356886T3 (es) 1998-03-31 2011-04-14 Kyowa Hakko Kirin Co., Ltd. Compuestos heterocíclicos nitrogenados.
JP2002516305A (ja) 1998-05-12 2002-06-04 アメリカン・ホーム・プロダクツ・コーポレイション インスリン抵抗性および高血糖症の治療に有用な２，３，５−置換ビフェニル
IL139913A0 (en) 1998-06-08 2002-02-10 Schering Corp Neuropeptide y5 receptor antagonists
EP0982300A3 (de) 1998-07-29 2000-03-08 Societe Civile Bioprojet Alkylamine ohne Imidazolring als Histamin-H3-antagonisten und deren therapeutische Anwendung
DK1117653T3 (da) 1998-10-01 2003-05-26 Astrazeneca Ab Quinolin- og quinazolinderivater og deres anvendelse som inhibitorer af cykokin-merierede sygdomme
DK1119567T3 (da) 1998-10-08 2005-07-25 Astrazeneca Ab Quinazolinderivater
WO2000039118A1 (en) 1998-12-23 2000-07-06 Eli Lilly And Company Aromatic amides
US6146560A (en) 1999-01-22 2000-11-14 Behi; Mohammad Process for forming an article from recycled ceramic molding compound
DK1553097T3 (da) 1999-02-10 2010-12-13 Astrazeneca Ab Quinazolinderivat som angiogeneseinhibitor og mellemprodukter dertil
DE19911509A1 (de) 1999-03-15 2000-09-21 Boehringer Ingelheim Pharma Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE60036812T2 (de) 1999-07-07 2008-07-17 Astrazeneca Uk Ltd. Chinazolin derivate
GB9922173D0 (en) 1999-09-21 1999-11-17 Zeneca Ltd Chemical compounds
GB9922171D0 (en) 1999-09-21 1999-11-17 Zeneca Ltd Chemical compounds
CZ20021010A3 (cs) 1999-09-21 2002-06-12 Astrazeneca Ab Nové sloučeniny chinazolinu a farmaceutické kompozice, které je obsahují
CN1391562A (zh) 1999-09-21 2003-01-15 阿斯特拉曾尼卡有限公司 用作药物的喹唑啉衍生物
UA74803C2 (uk) 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
JP2003525897A (ja) 2000-03-06 2003-09-02 アストラゼネカ アクチボラグ 治 療
AU779695B2 (en) 2000-04-07 2005-02-10 Astrazeneca Ab Quinazoline compounds
UA73993C2 (uk) 2000-06-06 2005-10-17 Астразенека Аб Хіназолінові похідні для лікування пухлин та фармацевтична композиція
DE60136459D1 (de) 2000-06-24 2008-12-18 Astrazeneca Ab Guanidin-derivate von chinazoin zur behandlung von autoimmunkrankheiten
WO2002002534A1 (en) 2000-07-03 2002-01-10 Astrazeneca Ab Quinazolines with therapeutic use
WO2002016360A2 (en) * 2000-08-18 2002-02-28 Cor Therapeutics, Inc. Nitrogenous heterocyclic compounds
EP2277877A1 (de) * 2000-08-18 2011-01-26 Millennium Pharmaceuticals, Inc. Quinazolinderivate als Kinasehemmer
US6956039B2 (en) * 2000-08-18 2005-10-18 Millennium Pharmaceuticals, Inc. Nitrogenous heterocylic compounds
AU2001293208A1 (en) 2000-08-18 2002-03-04 Cor Therapeutics, Inc. Nitrogenous heterocyclic compounds
AU2001278609B2 (en) 2000-08-21 2005-04-14 Astrazeneca Ab Quinazoline derivatives
DE10042059A1 (de) 2000-08-26 2002-03-07 Boehringer Ingelheim Pharma Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
AU2001292138A1 (en) 2000-10-13 2002-04-22 Astrazeneca Ab Quinazoline derivatives with anti-tumour activity
WO2002030926A1 (en) 2000-10-13 2002-04-18 Astrazeneca Ab Quinazoline derivatives
JP2004512335A (ja) 2000-10-25 2004-04-22 アストラゼネカ　アクチボラグ キナゾリン誘導体
DE60144284D1 (de) * 2000-11-01 2011-05-05 Millennium Pharm Inc Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung
CA2435883A1 (en) 2001-01-26 2002-08-01 Sankyo Company, Limited Benzylamine analogue
TWI245761B (en) 2001-03-01 2005-12-21 Telik Inc Antagonists of MCP-1 function and methods of use thereof
AU2002254152A1 (en) 2001-03-08 2002-09-24 Millennium Pharmaceuticals (homo) piperazine substituted quinolines for inhibiting the phosphorylation of kinases
EP1381599B1 (de) 2001-04-19 2008-09-24 Astrazeneca AB Chinazolin derivate
GB0110797D0 (en) 2001-05-02 2001-06-27 Celltech R&D Ltd Chemical compounds
WO2002092578A1 (en) 2001-05-14 2002-11-21 Astrazeneca Ab Quinazoline derivatives
WO2002092577A1 (en) 2001-05-14 2002-11-21 Astrazeneca Ab Quinazoline derivatives
WO2002092579A1 (en) 2001-05-14 2002-11-21 Astrazeneca Ab 4-anilinoquinazoline derivatives
EP1408980A4 (de) 2001-06-21 2004-10-20 Ariad Pharma Inc Neue chinazoline und ihre verwendungszwecke
PL367680A1 (en) 2001-06-28 2005-03-07 Pfizer Products Inc. Triamide-substituted indoles, benzofuranes and benzothiophenes as inhibitors of microsomal triglyceride transfer protein (mtp) and/or apolipoprotein b (apo b) secretion
GB0128109D0 (en) 2001-11-23 2002-01-16 Astrazeneca Ab Therapeutic use
GB0128122D0 (en) 2001-11-23 2002-01-16 Astrazeneca Ab Therapeutic use
AU2002351573A1 (en) 2001-12-12 2003-07-09 Paradata Systems Inc. Global integrated payment system
WO2003051849A1 (en) 2001-12-19 2003-06-26 Ube Industries, Ltd. Process for producing quinazolin-4-one and derivative thereof
ES2333702T3 (es) 2001-12-24 2010-02-26 Astrazeneca Ab Derivados de quinazolina sustituidos que actuan como unhibidores de cinasas aurora.
US8367824B2 (en) 2002-01-28 2013-02-05 Ube Industries Ltd. Process for producing quinazolin-4-one derivative
JP4389205B2 (ja) 2002-02-06 2009-12-24 宇部興産株式会社 ４−アミノキナゾリン化合物の製法
US7148249B2 (en) 2002-09-12 2006-12-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments
GB0223532D0 (en) 2002-10-09 2002-11-13 British Biotech Pharm Antibacterial agents
AR041198A1 (es) 2002-10-11 2005-05-04 Otsuka Pharma Co Ltd Compuesto 2,3-dihidro-6-nitroimidazo[2,1-b] oxaxol, y composiciones farmaceuticas que lo contienen
SE0203828D0 (sv) 2002-12-20 2002-12-20 Astrazeneca Ab Chemical compounds
EP1590327A1 (de) 2002-12-23 2005-11-02 Millennium Pharmaceuticals, Inc. Ccr8 inhibitoren
TW200510311A (en) 2002-12-23 2005-03-16 Millennium Pharm Inc CCr8 inhibitors
US7138412B2 (en) * 2003-03-11 2006-11-21 Bristol-Myers Squibb Company Tetrahydroquinoline derivatives useful as serine protease inhibitors
JP2006523681A (ja) 2003-03-24 2006-10-19 ルイトポルド・ファーマシューティカルズ・インコーポレーテッド Ｄｎａ−ｐｋ阻害剤としてのキサントン、チオキサントンおよびアクリジノン
WO2004089918A1 (ja) 2003-04-09 2004-10-21 Japan Tobacco Inc. 複素芳香５員環化合物及びその医薬用途
WO2004101562A2 (en) 2003-05-13 2004-11-25 Schering Corporation Bridged n-arylsulfonylpiperidines as gamma-secretase inhibitors
US7253164B2 (en) 2003-07-31 2007-08-07 Irm Llc Bicyclic compounds and compositions as PDF inhibitors
US7456189B2 (en) 2003-09-30 2008-11-25 Boehringer Ingelheim International Gmbh Bicyclic heterocycles, medicaments containing these compounds, their use and processes for their preparation
WO2005042497A2 (en) 2003-10-28 2005-05-12 Vertex Pharmaceuticals, Incorporated Benzimidazoles useful as modulators of ion channels
JP5208911B2 (ja) 2009-12-09 2013-06-12 株式会社東芝 空調制御装置および空調制御方法

Also Published As

Publication number Publication date
US20060167011A1 (en) 2006-07-27
AU2002217999A1 (en) 2002-05-15
US7709640B2 (en) 2010-05-04
US20100240893A1 (en) 2010-09-23
USRE43098E1 (en) 2012-01-10
EP1330444A2 (de) 2003-07-30
US6951937B2 (en) 2005-10-04
US20020091130A1 (en) 2002-07-11
WO2002036587A2 (en) 2002-05-10
US8536184B2 (en) 2013-09-17
JP4564713B2 (ja) 2010-10-20
DE60144284D1 (de) 2011-05-05
WO2002036587A3 (en) 2002-08-22
EP1330444B1 (de) 2011-03-23
JP2004513126A (ja) 2004-04-30

Similar Documents

Publication Publication Date Title
ATE502928T1 (de) Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung
BR0211119A (pt) Composto, método de tratar um paciente que tenha, ou de prevenir um paciente de pegar, uma doença ou condição, uso de um composto, e, método para fabricar um composto
TW200615266A (en) Organic compounds
WO2001078711A3 (en) Pde-v inhibitors for treatment of parkinson's disease
WO2005047244A3 (en) Inhibition of fgfr3 and treatment of multiple myeloma
PL374191A1 (en) 2-ureido-6-heteroaryl-3h-benzoimidazole-4-carboxylic acid derivatives and related compounds as gyrase and/or topoisomerase iv inhibitors for the treatment of bacterial infections
UA83899C2 (uk) Сполуки імідазолу для лікування нейродегенеративних розладів
SG128491A1 (en) Heterocyclic sulfonamide inhibitors of beta amyloid production
LU92323I2 (fr) La combinaison de (a) dextromethorphan ou un de ses sels pharmaceutiquement acceptables, précursers ou dérivés, par ex. hydrobromure de dextromethorphan et en particulier hydrobromure de dextromethorphan monohydrate;et (b) quinidine ou un de ses selspharmacuetiquement acceptables, précurseurs ou dé rivés, par ex. sulfate de quinidine et en particulier sulfate de quinidine dihydrate
MXPA04003245A (es) Hidroxipropilaminas.
WO2001098277A3 (en) Substituted bicyclic derivatives for the treatment of abnormal cell growth
MXPA04005209A (es) Antagonistas del receptor de adenosina a2a.
WO2004056786A3 (en) Pyrimidine derivates for the treatment of abnormal cell growth
MXPA04005156A (es) Antagonistas del receptor de adenosina a2a.
ATE372995T1 (de) Benzo(b)(1,4)dioxepinderivate
TN2022000255A1 (en) Pyrrolopyrimidine amines as complement inhibitors
TW200728260A (en) Substituted-(quinazolinyl)phenyl thiophenyl-sulfonylureas, methods for making and intermediates thereof
TW200736229A (en) Substituted 1H-benzimidazole-4-carboxamides are potent PARP inhibitors
TN2022000092A1 (en) Oral complement factor d inhibitors
PH12022550794A1 (en) Oral complement factor d inhibitors
TW200639159A (en) Treatment of pain
AU2001293209A1 (en) Nitrogenous heterocyclic compounds
AU2001293208A1 (en) Nitrogenous heterocyclic compounds
WO2002094768A3 (en) Aza hydroxylated ethyl amine compounds
NO20032411D0 (no) Anvendelse av substituerte 6-dimetylaminometyl-1-fenyl- cykloheksan-forbindelser for behandling av urininkontinens

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties