AR040787A1 - 6-alcoxi-piridopirimidinas - Google Patents

6-alcoxi-piridopirimidinas

Info

Publication number
AR040787A1
AR040787A1 AR20030102800A ARP030102800A AR040787A1 AR 040787 A1 AR040787 A1 AR 040787A1 AR 20030102800 A AR20030102800 A AR 20030102800A AR P030102800 A ARP030102800 A AR P030102800A AR 040787 A1 AR040787 A1 AR 040787A1
Authority
AR
Argentina
Prior art keywords
haloalkyl
aryl
alkyl
cycloalkyl
hydrogen
Prior art date
Application number
AR20030102800A
Other languages
English (en)
Inventor
David Michael Goldstein
Julie Anne Lim
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR040787A1 publication Critical patent/AR040787A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P27/16—Otologicals
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • AIDS & HIV (AREA)
  • Biotechnology (AREA)

Abstract

Reivindicación 1: Un compuesto de fórmula (1): o una sal, hidrato o prodroga farmacéuticamente aceptable, caracterizado porque: Z es N o CH; X1 es O, NR4 (donde R4 es hidrógeno o alquilo), S o C=O; R1 es alquilo, cicloalquilo, cicloalquilalquilo, o -CH2-alquenilo; R2 es hidrógeno, alquilo, cicloalquilo, cicloalquilalquilo, arilo, aralquilo, haloalquilo, heteroalquilo, cianoalquilo, alquileno-C(O)R21 (donde R21 es hidrógeno, alquilo, hidroxi, alcoxi, amino, monoalquilamino o dialquilamino), amino, monoalquilamino, dialquilamino, acilo, o NR22-Y-R23 (donde Y es -C(O), -C(O)O-, -C(O)NR24, S(O)2 o S(O)2NR25; R22, R234 y R25 son independientemente hidrógeno o alquilo; y R23 es hidrógeno, alquilo, cicloalquilo, cicloalquilalquilo, heteroalquilo, o fenilo opcionalmente sustituido); y R3 es alquilo, haloalquilo, arilo, aralquilo, heteroarilo, heteroaralquilo, cicloalquilo, cicloalquilalquilo, cicloalquilo sustituido por heteroalquilo, cicloalquilo heterosustituido, heteroalquilo, cianoalquilo, heterociclilo, heterociclilalquilo, o -heterocicloamino-SO2-R12 (donde R12 es haloalquilo, arilo, arialquilo, heteroarilo o heteroaralquilo).
AR20030102800A 2002-08-06 2003-08-05 6-alcoxi-piridopirimidinas AR040787A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40149102P 2002-08-06 2002-08-06

Publications (1)

Publication Number Publication Date
AR040787A1 true AR040787A1 (es) 2005-04-20

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ID=31715709

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AR20030102800A AR040787A1 (es) 2002-08-06 2003-08-05 6-alcoxi-piridopirimidinas

Country Status (15)

Country Link
US (4) US6965030B2 (es)
EP (1) EP1539755B1 (es)
JP (1) JP4252534B2 (es)
CN (1) CN100432073C (es)
AR (1) AR040787A1 (es)
AT (1) ATE374201T1 (es)
AU (1) AU2003251661A1 (es)
BR (1) BR0313297A (es)
CA (1) CA2492112A1 (es)
DE (1) DE60316581T2 (es)
ES (1) ES2293064T3 (es)
MX (1) MXPA05001332A (es)
PL (1) PL375403A1 (es)
RU (1) RU2324695C2 (es)
WO (1) WO2004014907A1 (es)

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