EA200600509A1 - Соединения пиримидотиофена - Google Patents
Соединения пиримидотиофенаInfo
- Publication number
- EA200600509A1 EA200600509A1 EA200600509A EA200600509A EA200600509A1 EA 200600509 A1 EA200600509 A1 EA 200600509A1 EA 200600509 A EA200600509 A EA 200600509A EA 200600509 A EA200600509 A EA 200600509A EA 200600509 A1 EA200600509 A1 EA 200600509A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alk
- optionally substituted
- hydrogen
- group
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Соединения формулы (I) являются ингибиторами активности HSP90 in vitro или in vivo и применимы в лечении среди прочего ракагде Rпредставляет собой группу формулы -(Ar)-(Alk)-(Z)-(Alk)-Q, в которой Arпредставляет собой необязательно замещенный арильный или гетероарильный радикал, Alkи Alkявляются необязательно замещенными двухвалентными C-Салкиленовым или С-Салкениленовым радикалами, m, р, r и s независимо равны 0 или 1, Z представляет собой группу -О-, -S-, -(C=O)-, -(C=S)-, -SO-, -С(=O)O-, -C(=O)NR-, -C(=S)NR-, -SONR-, -NRC(=O)-, -NRSO- или -NR-, в которой Rпредставляет собой водород или C-Салкил и Q представляет собой водород или необязательно замещенный карбоциклический или гетероциклический радикал; Rпредставляет собой водород, необязательный заместитель или необязательно замещенный (C-С)алкильный, арильный или гетероарильный радикал; и Rпредставляет собой сложноэфирную, карбоксамидную или сульфонамидную группу.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0320300A GB0320300D0 (en) | 2003-08-29 | 2003-08-29 | Pyrimidothiophene compounds |
GB0327924A GB0327924D0 (en) | 2003-12-02 | 2003-12-02 | Pyrimidothiophene compounds |
GB0414467A GB0414467D0 (en) | 2004-06-29 | 2004-06-29 | Pyrimidothiophene compounds |
PCT/GB2004/003641 WO2005021552A1 (en) | 2003-08-29 | 2004-08-26 | Pyrimidothiophene compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200600509A1 true EA200600509A1 (ru) | 2006-08-25 |
EA009920B1 EA009920B1 (ru) | 2008-04-28 |
Family
ID=34279360
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200600509A EA009920B1 (ru) | 2003-08-29 | 2004-08-26 | Соединения пиримидотиофена |
Country Status (13)
Country | Link |
---|---|
US (2) | US7820658B2 (ru) |
EP (1) | EP1675861B1 (ru) |
JP (1) | JP4783731B2 (ru) |
KR (1) | KR101139314B1 (ru) |
AU (1) | AU2004268820B2 (ru) |
BR (1) | BRPI0413861A (ru) |
CA (1) | CA2537135C (ru) |
EA (1) | EA009920B1 (ru) |
ES (1) | ES2559779T3 (ru) |
HK (1) | HK1095591A1 (ru) |
NO (1) | NO20061416L (ru) |
NZ (1) | NZ546044A (ru) |
WO (1) | WO2005021552A1 (ru) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0416168D0 (en) * | 2004-07-20 | 2004-08-18 | Vernalis Cambridge Ltd | Pyrmidothiophene compounds |
GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
GB0420719D0 (en) * | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
WO2006085149A2 (en) * | 2004-12-22 | 2006-08-17 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
EA013522B1 (ru) * | 2005-03-30 | 2010-06-30 | Конформа Терапьютикс Корпорейшн | Алкинилпирролопиримидины и их применение в качестве ингибиторов hsp90 |
DE102005022977A1 (de) * | 2005-05-19 | 2006-12-07 | Merck Patent Gmbh | Phenylchinazolinderivate |
FR2885904B1 (fr) | 2005-05-19 | 2007-07-06 | Aventis Pharma Sa | Nouveaux derives du fluorene, compositions les contenant et utilisation |
CA2633752A1 (en) * | 2005-12-21 | 2007-07-19 | Abbott Laboratories | Anti-viral compounds |
US20080004271A1 (en) * | 2006-01-17 | 2008-01-03 | Mckenna Jeffrey M | Inhibitors of TNFalpha, PDE4 and B-RAF, compositions thereof and methods of use therewith |
KR20090007319A (ko) * | 2006-03-11 | 2009-01-16 | 베르날리스 (알 앤드 디) 리미티드 | Hsp90 억제제로서 사용되는 피롤로피리미딘 유도체 |
AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
WO2007131034A1 (en) * | 2006-05-03 | 2007-11-15 | The Regents Of The University Of Michigan | Pyrimidone derivatives which are modulators of heat shock protein (hsp) 70 |
AR061185A1 (es) | 2006-05-26 | 2008-08-13 | Chugai Pharmaceutical Co Ltd | Compuestos heterociclicos como inhibidores de hsp90. composiciones farmaceuticas. |
HUE064514T2 (hu) | 2006-10-12 | 2024-03-28 | Bellus Health Inc | Módszerek, vegyületek, kompozíciók és közegek 3-amino-1-propánszulfonsav szervezetbe juttatására |
FR2907453B1 (fr) | 2006-10-24 | 2008-12-26 | Sanofi Aventis Sa | Nouveaux derives du fluorene,compositions les contenant et utilisation |
WO2008059368A2 (en) * | 2006-11-17 | 2008-05-22 | Pfizer Products Inc. | Fused 2-amino pyrimidine compounds and their use for the treatment of cancer |
CA2675677A1 (en) | 2007-02-01 | 2008-08-07 | Astrazeneca Ab | 5,6,7,8-tetrahydropteridine derivatives as hsp90 inhibitors |
AU2008220009A1 (en) | 2007-03-01 | 2008-09-04 | Chugai Seiyaku Kabushiki Kaisha | Macrocyclic compound |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
DE102007028521A1 (de) * | 2007-06-21 | 2008-12-24 | Merck Patent Gmbh | Indazolamidderivate |
KR101533440B1 (ko) | 2007-09-14 | 2015-07-03 | 얀센 파마슈티칼스 인코포레이티드 | 1´,3´-이치환된-4-페닐-3,4,5,6-테트라히드로-2h,1´h-[1,4´]비피리디닐-2´-온 |
BRPI0817101A2 (pt) | 2007-09-14 | 2017-05-09 | Addex Pharmaceuticals Sa | 4-(aril-x-fenil)-1h-piridin-2-onas 1,3-dissubstituídas |
US8722894B2 (en) | 2007-09-14 | 2014-05-13 | Janssen Pharmaceuticals, Inc. | 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones |
GB0718433D0 (en) * | 2007-09-21 | 2007-10-31 | Vernalis R&D Ltd | New chemical compounds |
AU2008323287B2 (en) | 2007-11-14 | 2011-07-14 | Addex Pharma S.A. | Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
ES2439291T3 (es) | 2008-09-02 | 2014-01-22 | Janssen Pharmaceuticals, Inc. | Derivados de 3-azabiciclo[3.1.0]hexilo como moduladores de receptores de glutamato metabotrópicos |
US8697689B2 (en) | 2008-10-16 | 2014-04-15 | Janssen Pharmaceuticals, Inc. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
US8691813B2 (en) | 2008-11-28 | 2014-04-08 | Janssen Pharmaceuticals, Inc. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
MY161325A (en) | 2009-05-12 | 2017-04-14 | Janssen Pharmaceuticals Inc | 1, 2, 4-triazolo[4,3-a]pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders |
EA020671B1 (ru) | 2009-05-12 | 2014-12-30 | Янссен Фармасьютикалз, Инк. | ПРОИЗВОДНЫЕ 1,2,4-ТРИАЗОЛО[4,3-a]ПИРИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ПОЛОЖИТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2 |
AR077405A1 (es) | 2009-07-10 | 2011-08-24 | Sanofi Aventis | Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer |
US9567318B2 (en) * | 2009-08-17 | 2017-02-14 | Memorial Sloan-Kettering Cancer Center | Substituted pyrimidine compounds and uses thereof |
FR2949467B1 (fr) | 2009-09-03 | 2011-11-25 | Sanofi Aventis | Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation |
PT2649069E (pt) | 2010-11-08 | 2015-11-20 | Janssen Pharmaceuticals Inc | Derivados de 1,2,4-triazolo[4,3-a]piridina e sua utilização como moduladores alostéricos positivos de recetores mglur2 |
JP5852666B2 (ja) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | 1,2,4−トリアゾロ[4,3−a]ピリジン誘導体およびmGluR2受容体のポジティブアロステリックモジュレーターとしてのそれらの使用 |
CA2814998C (en) | 2010-11-08 | 2019-10-29 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
AU2012282903A1 (en) | 2011-07-08 | 2014-02-13 | Sloan-Kettering Institute For Cancer Research | Uses of labeled HSP90 inhibitors |
CA2842190A1 (en) | 2011-07-19 | 2013-01-24 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
AU2013266086B2 (en) | 2012-05-25 | 2018-03-01 | Berg Llc | Methods of treating a metabolic syndrome by modulating heat shock protein (HSP) 90-beta |
GB201217704D0 (en) * | 2012-10-03 | 2012-11-14 | Ucb Pharma Sa | Therapeutic agents |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
US20150031697A1 (en) * | 2013-07-26 | 2015-01-29 | Wisconsin Alumni Research Foundation | Method for preventing ultraviolet radiation-induced cutaneous damage and development of squamous cell carcinomas |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
KR20220039824A (ko) | 2014-01-21 | 2022-03-29 | 얀센 파마슈티카 엔.브이. | 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도 |
IL279202B2 (en) | 2014-01-21 | 2023-09-01 | Janssen Pharmaceutica Nv | Combinations containing positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic subtype 2 receptor and their use |
AU2015228386A1 (en) * | 2014-03-11 | 2016-09-22 | Godavari Biorefineries Limited | Cancer stem cell targeting compounds |
EP3116882A4 (en) * | 2014-03-11 | 2017-08-02 | Godavari Biorefineries Ltd. | Compounds for eradicating or inhibiting proliferation of cancer stem cells |
JP6607870B2 (ja) | 2014-05-13 | 2019-11-20 | メモリアル スローン ケタリング キャンサー センター | Hsp70モジュレーターならびにその作製および使用方法 |
US10023864B2 (en) | 2014-06-06 | 2018-07-17 | Berg Llc | Methods of treating a metabolic syndrome by modulating heat shock protein (HSP) 90-beta |
CA2952230C (en) * | 2014-06-13 | 2023-03-21 | Yuma Therapeutics, Inc. | Pyrimidine compounds and methods using the same |
US10945998B2 (en) * | 2015-03-08 | 2021-03-16 | Case Western Reserve University | Inhibitors of short-chain dehydrogenase activity for treating fibrosis |
FR3037957B1 (fr) * | 2015-06-23 | 2019-01-25 | Les Laboratoires Servier | Nouveaux derives d'hydroxyester, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
EP3548035A4 (en) | 2016-11-30 | 2020-07-22 | Case Western Reserve University | COMBINATIONS OF 15 PGDH INHIBITORS WITH CORTICOSTEROIDS AND / OR TNF INHIBITORS AND USES THEREOF |
WO2018145080A1 (en) | 2017-02-06 | 2018-08-09 | Case Western Reserve University | Compositions and methods of modulating short-chain dehydrogenase activity |
AU2018249956A1 (en) | 2017-04-07 | 2019-11-14 | Board Of Regents Of The Univeristy Of Texas | Inhibitors of short-chain dehydrogenase activity for treating coronary disorders |
PL3904350T3 (pl) * | 2018-04-12 | 2024-02-19 | Bayer Aktiengesellschaft | Pochodne N-(cyklopropylometylo)-5-(metylosulfonylo)-N-{1-[1-(pirymidyn-2-ylo)-1H-1,2,4-triazol-5-ilo]etylo}benzamidu oraz odpowiednie pochodne pirydyno-karboksyamidu jako pestycydy |
WO2022089449A1 (zh) * | 2020-10-26 | 2022-05-05 | 山东大学 | 一种特异性热休克蛋白90α亚型抑制剂制备及其应用 |
CN115124550B (zh) * | 2020-10-26 | 2024-04-02 | 山东大学 | 一种特异性热休克蛋白90α亚型抑制剂制备及其应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0438261A3 (en) * | 1990-01-16 | 1992-02-26 | Takeda Chemical Industries, Ltd. | Condensed heterocyclic glutamic acid derivatives, their production and use |
JPH0578362A (ja) * | 1990-01-16 | 1993-03-30 | Takeda Chem Ind Ltd | 縮合複素環化合物,その製造法,用途及び中間体 |
CA2464031A1 (en) * | 2001-10-30 | 2003-05-08 | Conforma Therapeutics Corporation | Purine analogs having hsp90-inhibiting activity |
DE10163991A1 (de) * | 2001-12-24 | 2003-07-03 | Merck Patent Gmbh | Pyrrolo-pyrimidine |
-
2004
- 2004-08-26 EA EA200600509A patent/EA009920B1/ru not_active IP Right Cessation
- 2004-08-26 EP EP04768197.8A patent/EP1675861B1/en active Active
- 2004-08-26 JP JP2006524418A patent/JP4783731B2/ja not_active Expired - Fee Related
- 2004-08-26 WO PCT/GB2004/003641 patent/WO2005021552A1/en active Application Filing
- 2004-08-26 US US10/569,287 patent/US7820658B2/en not_active Expired - Fee Related
- 2004-08-26 AU AU2004268820A patent/AU2004268820B2/en not_active Ceased
- 2004-08-26 ES ES04768197.8T patent/ES2559779T3/es active Active
- 2004-08-26 KR KR1020067004012A patent/KR101139314B1/ko active IP Right Grant
- 2004-08-26 BR BRPI0413861-9A patent/BRPI0413861A/pt active Search and Examination
- 2004-08-26 NZ NZ546044A patent/NZ546044A/en not_active IP Right Cessation
- 2004-08-26 CA CA2537135A patent/CA2537135C/en not_active Expired - Fee Related
-
2006
- 2006-03-28 NO NO20061416A patent/NO20061416L/no not_active Application Discontinuation
-
2007
- 2007-03-08 HK HK07102556.5A patent/HK1095591A1/xx not_active IP Right Cessation
-
2010
- 2010-01-21 US US12/690,983 patent/US8642594B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EA009920B1 (ru) | 2008-04-28 |
NO20061416L (no) | 2006-05-23 |
WO2005021552A1 (en) | 2005-03-10 |
ES2559779T3 (es) | 2016-02-15 |
AU2004268820A1 (en) | 2005-03-10 |
US8642594B2 (en) | 2014-02-04 |
AU2004268820B2 (en) | 2011-07-21 |
HK1095591A1 (en) | 2007-05-11 |
NZ546044A (en) | 2009-09-25 |
KR20070055414A (ko) | 2007-05-30 |
CA2537135C (en) | 2013-10-08 |
US20070043044A1 (en) | 2007-02-22 |
JP2007533611A (ja) | 2007-11-22 |
US7820658B2 (en) | 2010-10-26 |
BRPI0413861A (pt) | 2006-10-24 |
JP4783731B2 (ja) | 2011-09-28 |
US20100120767A1 (en) | 2010-05-13 |
KR101139314B1 (ko) | 2012-04-26 |
EP1675861A1 (en) | 2006-07-05 |
EP1675861B1 (en) | 2015-12-23 |
CA2537135A1 (en) | 2005-03-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA200600509A1 (ru) | Соединения пиримидотиофена | |
EA200701779A1 (ru) | Производные (1,5-дифенил-1н-пиразол-3-ил)оксадиазола, их получение и их применение в терапии | |
EA200970311A1 (ru) | ПРОИЗВОДНЫЕ 2-АРИЛ-6-ФЕНИЛИМИДАЗО[1,2-α]ПИРИДИНОВ, ИХ ПОЛУЧЕНИЕ И ПРИМЕНЕНИЕ В ТЕРАПИИ | |
ATE449099T1 (de) | Derivate des 2-trifluormethyl-6-aminopurins als phosphodiesterase 4 inhibitoren | |
MXPA04001016A (es) | Derivados de sulfonamida como inhibidores de la gamma secretasa. | |
RS52978B (en) | FUSIONED AMINO PIRIDIN AS HSP90 INHIBITORS | |
CY1111083T1 (el) | Παραγωγα νικοτιναμιδιου χρησιμα ως αναστολεις της p38 | |
ATE282614T1 (de) | Phenylharnstoff und phenylthioharnstoffderivate | |
ATE377004T1 (de) | Proteinkinaseinhibitoren | |
DE60331187D1 (de) | Kinaseinhibitoren | |
ME00411B (me) | Nova jedinjenja koja imaju inhibitorno dejstvo na transporter glukoze zavistan od natrijuma | |
EA200700188A1 (ru) | Производные замещенного 2-алкилхиназолинона как ингибиторы parp | |
EA200870192A1 (ru) | Новые серосодержащие производные циклической мочевины, их получение и их фармацевтическое применение в качестве ингибиторов киназ | |
TW200635585A (en) | Monocyclic substituted methanones | |
IS6309A (is) | Kínasólínafleiður | |
EA200701780A1 (ru) | Противоопухолевое средство | |
HRP20070286T3 (en) | Substituted diketopiperazines and their use as oxytocyn antagonists | |
EA200501730A1 (ru) | Производные n-пирролидин-3-ил-амида в качестве ингибиторов обратного захвата серотонина и норадреналина | |
CY1109085T1 (el) | Νεα αλατα | |
EA200301100A1 (ru) | Новые фталазиноны | |
EA201000101A1 (ru) | Производные пиримидина 934 | |
NO20050871L (no) | 6-amino-1H-indazol- og 4-aminobenzofuranforbindelser som fosfodiesterase 4-inhibitorer | |
WO2003082861A3 (en) | Morpholinyl-urea derivatives for use of the treatment of inflammatory diseases | |
NO20082226L (no) | 6-heteroarylpyridoindolonderivater, deres fremstilling og terapeutisk anvendelse derav | |
EA200600601A1 (ru) | Производные аминопиридина в качестве ингибиторов индуцируемой no-синтазы |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
|
PC4A | Registration of transfer of a eurasian patent by assignment | ||
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |