EA200870192A1 - Новые серосодержащие производные циклической мочевины, их получение и их фармацевтическое применение в качестве ингибиторов киназ - Google Patents

Новые серосодержащие производные циклической мочевины, их получение и их фармацевтическое применение в качестве ингибиторов киназ

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Publication number
EA200870192A1
EA200870192A1 EA200870192A EA200870192A EA200870192A1 EA 200870192 A1 EA200870192 A1 EA 200870192A1 EA 200870192 A EA200870192 A EA 200870192A EA 200870192 A EA200870192 A EA 200870192A EA 200870192 A1 EA200870192 A1 EA 200870192A1
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EA
Eurasian Patent Office
Prior art keywords
sero
new
receiving
cyclic urea
containing derivatives
Prior art date
Application number
EA200870192A
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English (en)
Inventor
Франк Алле
Юссеф Эль-Амад
Виктор Серталь
Хартмут Штробель
Курт Риттер
Свен Руф
Анн Дагалье
Коринн Вено
Original Assignee
Авентис Фарма С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Авентис Фарма С.А. filed Critical Авентис Фарма С.А.
Publication of EA200870192A1 publication Critical patent/EA200870192A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Abstract

Изобретение относится к новым продуктам формулы (I), в которой n означает 0 или 2; R означает пиридил или пиримидинил, замещенные радикалом NR1R2, причем один из R1 и R2 означает водород или алкил, а другой из R1 и R2 означает водород или необязательно замещенный алкил, циклоалкил, гетероциклоалкил, фенил, пиримидинил, пиридил и CO-R3, где R3 выбирают среди аминогруппы, алкоксила, гетероциклоалкила, арила, арилоксигруппы и гетероарила; причем все эти радикалы необязательно замещены; и их солям.
EA200870192A 2006-01-23 2007-01-17 Новые серосодержащие производные циклической мочевины, их получение и их фармацевтическое применение в качестве ингибиторов киназ EA200870192A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0600566A FR2896503B1 (fr) 2006-01-23 2006-01-23 Nouveaux derives soufres d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
PCT/FR2007/000080 WO2008000922A1 (fr) 2006-01-23 2007-01-17 Derives soufres d ' uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases

Publications (1)

Publication Number Publication Date
EA200870192A1 true EA200870192A1 (ru) 2009-12-30

Family

ID=36717140

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200870192A EA200870192A1 (ru) 2006-01-23 2007-01-17 Новые серосодержащие производные циклической мочевины, их получение и их фармацевтическое применение в качестве ингибиторов киназ

Country Status (18)

Country Link
US (1) US20090082329A1 (ru)
EP (1) EP2035408A1 (ru)
JP (1) JP2009542586A (ru)
KR (1) KR20080095860A (ru)
AR (1) AR059085A1 (ru)
AU (1) AU2007264848A1 (ru)
BR (1) BRPI0710438A2 (ru)
CA (1) CA2631506A1 (ru)
CL (1) CL2007000161A1 (ru)
EA (1) EA200870192A1 (ru)
FR (1) FR2896503B1 (ru)
IL (1) IL192440A0 (ru)
MA (1) MA30225B1 (ru)
NO (1) NO20082976L (ru)
PE (1) PE20071112A1 (ru)
TW (1) TW200738684A (ru)
UY (1) UY30105A1 (ru)
WO (1) WO2008000922A1 (ru)

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DE3715391A1 (de) * 1987-05-08 1988-12-01 Gerhard Mederer Brennkraftmaschine oder sonstiger antrieb
TWI491605B (zh) 2008-11-24 2015-07-11 Boehringer Ingelheim Int 新穎化合物
AR074209A1 (es) 2008-11-24 2010-12-29 Boehringer Ingelheim Int Derivados de pirimidina utiles para el tratamiento del cancer
MX2011006426A (es) * 2008-12-24 2011-07-20 Syngenta Ltd Metodos para la preparacion de arilamidas.
EP2417127B1 (en) 2009-04-06 2014-02-26 University Health Network Kinase inhibitors and method of treating cancer with same
ES2603613T3 (es) 2010-04-06 2017-02-28 University Health Network Inhibidores de quinasa y su uso en el tratamiento del cáncer
WO2012000103A1 (en) 2010-07-02 2012-01-05 University Health Network Methods of targeting pten mutant diseases and compositions therefor
JP6096219B2 (ja) 2012-01-13 2017-03-15 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ キナーゼ阻害剤として有用なトリアゾリルまたはトリアジアゾリル置換されたピリジル化合物
US9242975B2 (en) 2012-01-13 2016-01-26 Bristol-Myers Squibb Company Heterocyclic-substituted pyridyl compounds useful as kinase inhibitors
JP6096807B2 (ja) 2012-01-13 2017-03-15 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ キナーゼ阻害剤として有用なトリアゾリル置換されたピリジル化合物
US9657009B2 (en) 2012-11-08 2017-05-23 Bristol-Myers Squibb Company Heteroaryl substituted pyridyl compounds useful as kinase modulators
US9546153B2 (en) 2012-11-08 2017-01-17 Bristol-Myers Squibb Company Bicyclic heterocycle substituted pyridyl compounds useful as kinase modulators
UY35935A (es) 2014-01-03 2015-06-30 Bristol Myers Squibb Company Una Corporación Del Estado De Delaware Compuestos de nicotinamida sustituida con heteroarilo como inhibidores de quinasa y moduladores de irak-4
US20170281641A1 (en) * 2014-09-03 2017-10-05 Genzyme Corporation CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) iNHIBITORS
US10618903B2 (en) 2015-06-24 2020-04-14 Bristol-Myers Squibb Company Heteroaryl substituted aminopyridine compounds
UY36748A (es) 2015-06-24 2016-12-30 Bristol Myers Squibb Company Una Corporación Del Estado De Delaware Compuestos de aminopiridina sustituida con heteroarilo como inhibidores de quinasa y moduladores de irak-4, y composiciones farmacéuticas que los contienen
TW201713663A (zh) 2015-06-24 2017-04-16 必治妥美雅史谷比公司 經雜芳基取代之胺基吡啶化合物
EP3621960B1 (en) 2017-05-11 2021-08-04 Bristol-Myers Squibb Company Thienopyridines and benzothiophenes useful as irak4 inhibitors
AU2020242287A1 (en) 2019-03-21 2021-09-02 INSERM (Institut National de la Santé et de la Recherche Médicale) A Dbait molecule in combination with kinase inhibitor for the treatment of cancer
US20220401436A1 (en) 2019-11-08 2022-12-22 INSERM (Institute National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use

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Also Published As

Publication number Publication date
NO20082976L (no) 2008-09-10
US20090082329A1 (en) 2009-03-26
MA30225B1 (fr) 2009-02-02
UY30105A1 (es) 2007-08-31
TW200738684A (en) 2007-10-16
BRPI0710438A2 (pt) 2011-08-09
CL2007000161A1 (es) 2008-05-30
FR2896503B1 (fr) 2012-07-13
CA2631506A1 (fr) 2008-01-03
PE20071112A1 (es) 2007-12-13
EP2035408A1 (fr) 2009-03-18
KR20080095860A (ko) 2008-10-29
WO2008000922A1 (fr) 2008-01-03
AR059085A1 (es) 2008-03-12
AU2007264848A1 (en) 2008-01-03
FR2896503A1 (fr) 2007-07-27
JP2009542586A (ja) 2009-12-03
IL192440A0 (en) 2009-02-11

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