DK1361880T3 - 6-substituerede pyrido-pyrimidiner - Google Patents

6-substituerede pyrido-pyrimidiner

Info

Publication number
DK1361880T3
DK1361880T3 DK02726103T DK02726103T DK1361880T3 DK 1361880 T3 DK1361880 T3 DK 1361880T3 DK 02726103 T DK02726103 T DK 02726103T DK 02726103 T DK02726103 T DK 02726103T DK 1361880 T3 DK1361880 T3 DK 1361880T3
Authority
DK
Denmark
Prior art keywords
pyrimidines
substituted pyrido
pyrido
substituted
Prior art date
Application number
DK02726103T
Other languages
English (en)
Inventor
Jian Jeffrey Chen
James Patrick Dunn
David Michael Goldstein
Christoph Martin Stahl
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK1361880T3 publication Critical patent/DK1361880T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
DK02726103T 2001-02-12 2002-02-04 6-substituerede pyrido-pyrimidiner DK1361880T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26837501P 2001-02-12 2001-02-12
US33465401P 2001-11-30 2001-11-30

Publications (1)

Publication Number Publication Date
DK1361880T3 true DK1361880T3 (da) 2006-01-23

Family

ID=26953040

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02726103T DK1361880T3 (da) 2001-02-12 2002-02-04 6-substituerede pyrido-pyrimidiner

Country Status (32)

Country Link
US (3) US6696566B2 (da)
EP (1) EP1361880B1 (da)
JP (1) JP4064818B2 (da)
KR (1) KR100639772B1 (da)
CN (1) CN100376571C (da)
AR (1) AR035854A1 (da)
AT (1) ATE305303T1 (da)
AU (1) AU2002256615B2 (da)
BR (1) BRPI0207172B8 (da)
CA (1) CA2434834C (da)
CZ (1) CZ20032416A3 (da)
DE (1) DE60206363T2 (da)
DK (1) DK1361880T3 (da)
ES (1) ES2249574T3 (da)
HK (1) HK1066170A1 (da)
HR (1) HRP20030624B1 (da)
HU (1) HU229604B1 (da)
IL (2) IL156872A0 (da)
JO (1) JO2410B1 (da)
MA (1) MA26993A1 (da)
MX (1) MXPA03007166A (da)
MY (1) MY131518A (da)
NO (1) NO326133B1 (da)
NZ (1) NZ526961A (da)
PA (1) PA8539201A1 (da)
PE (1) PE20020976A1 (da)
PL (1) PL366918A1 (da)
RU (1) RU2269527C2 (da)
SK (1) SK11322003A3 (da)
WO (1) WO2002064594A2 (da)
YU (1) YU63703A (da)
ZA (1) ZA200305938B (da)

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ATE305303T1 (de) 2001-02-12 2005-10-15 Hoffmann La Roche 6-substituierte pyridopyrimidine
ATE314370T1 (de) 2002-01-22 2006-01-15 Warner Lambert Co 2-(pyridin-2-ylamino)-pyrido(2,3-d)pyrimidin-7- one
BR0308937A (pt) 2002-04-03 2005-01-04 Hoffmann La Roche Compostos imidazo fundidos
CN100432073C (zh) * 2002-08-06 2008-11-12 霍夫曼-拉罗奇有限公司 作为p-38map激酶抑制剂的6-烷氧基-吡啶并-嘧啶
JP2006516548A (ja) 2002-12-30 2006-07-06 アンジオテック インターナショナル アクツィエン ゲゼルシャフト 迅速ゲル化ポリマー組成物からの薬物送達法
PL216368B1 (pl) * 2003-02-26 2014-03-31 Sugen Związki aminoheteroarylowe oraz ich zastosowanie
MXPA05010975A (es) * 2003-04-16 2005-11-28 Hoffmann La Roche Derivados de (6-(fenoxi)-pirido[3,4-d]pirimidin-2-il)-amina como inhibidores de p38 cinasa para el tratamiento de condiciones inflamatorias como artritis reumatoide.
KR100816321B1 (ko) * 2003-11-13 2008-03-24 에프. 호프만-라 로슈 아게 히드록시알킬 치환 피리도-7-피리미딘-7-온
US20090131430A1 (en) * 2004-11-23 2009-05-21 Palle Venkata P Pyrido'2,3-dipyrimidines as anti-inflammatory agents
US20060142312A1 (en) * 2004-12-23 2006-06-29 Pfizer Inc C6-aryl and heteroaryl substituted pyrido[2,3-D] pyrimidin-7-ones
EP1846403A1 (en) * 2005-02-02 2007-10-24 Ranbaxy Laboratories Limited Azabicyclo derivatives as anti-inflammatory agents
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BRPI0614804A2 (pt) * 2005-08-09 2011-04-12 Irm Llc compostos e composições como inibidores de proteìna cinase
EP1917245A1 (de) 2005-08-21 2008-05-07 Abbott GmbH & Co. KG Heterocyclische verbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren
JO2783B1 (en) * 2005-09-30 2014-03-15 نوفارتيس ايه جي Compounds 2-Amino-7, 8-dihydro-6H-Bayredo (3,4-D) Pyrimidine-5-Ones
WO2008150260A1 (en) * 2007-06-06 2008-12-11 Gpc Biotech, Inc. 8-oxy-2-aminopyrido (2, 3-d) pyrimidin-7-one derivatives as kinase inhibitors and anticancer agents
WO2008078249A1 (en) * 2006-12-21 2008-07-03 Ranbaxy Laboratories Limited Anti-inflammatory agents
WO2008136948A1 (en) 2007-05-07 2008-11-13 Amgen Inc. Pyrazolo-pyridinone and pyrazolo-pyrazinone compounds as p38 modulators, process for their preparation, and their pharmaceutical use
CN101679211A (zh) 2007-06-15 2010-03-24 霍夫曼-拉罗奇有限公司 用于制备3-氨基-戊-1,5-二醇的新方法
WO2009117156A1 (en) 2008-03-21 2009-09-24 Amgen Inc. Pyrazolo-pyrazinone compounds and methods of use thereof
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WO2010046273A2 (en) * 2008-10-22 2010-04-29 F. Hoffmann-La Roche Ag Pyrimidinyl pyridone inhibitors of jnk
US8674095B2 (en) 2008-12-19 2014-03-18 Afraxis Holdings, Inc. Compounds for treating neuropsychiatric conditions
WO2011044535A2 (en) 2009-10-09 2011-04-14 Afraxis, Inc. 8-ethyl-6-(aryl)pyrido[2,3-d]pyrimidin-7(8h)-ones for the treatment of cns disorders
US8889696B2 (en) * 2009-12-18 2014-11-18 Temple University—Of the Commonwealth System of Higher Education Substituted pyrido[2,3-d]pyrimidin-7(8H)-ones and therapeutic uses thereof
AU2015296322B2 (en) 2014-07-26 2019-09-19 Sunshine Lake Pharma Co., Ltd. 2-amino-pyrido[2,3-d]pyrimidin-7(8h)-one derivatives as CDK inhibitors and uses thereof
WO2017211830A1 (en) * 2016-06-08 2017-12-14 Support-Venture Gmbh Pharmaceutical combinations for treating cancer
MX2019001849A (es) 2016-08-15 2019-05-09 Pfizer Inhibidores de cdk2/4/6 de piridopirimidinona.
EP3500258A1 (en) * 2016-08-17 2019-06-26 Support-Venture GmbH Method of preventing or treating hearing loss
WO2018132550A1 (en) * 2017-01-11 2018-07-19 The General Hospital Corporation Voltage gated sodium channel imaging agents
WO2018185098A1 (en) 2017-04-04 2018-10-11 Strekin Ag Methods of preventing or treating ophthalmic diseases
CA3074459A1 (en) * 2017-08-31 2019-03-07 Dana-Farber Cancer Institute, Inc. Inhibitors of egfr and/or her2 and methods of use
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
CA3128468A1 (en) 2017-10-05 2019-04-11 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd
WO2020006210A1 (en) * 2018-06-27 2020-01-02 Tufts Medical Center, Inc. Pyridopyrimidine compounds and methods of their use
KR20210031909A (ko) 2018-07-13 2021-03-23 키나루스 아게 섬유증 질환을 예방 또는 치료하기 위한 ppar 효능제 및 p38 키나제 억제제의 조합물
TW202112368A (zh) 2019-06-13 2021-04-01 荷蘭商法西歐知識產權股份有限公司 用於治療有關dux4表現之疾病的抑制劑組合
EP4196120A1 (en) 2020-08-11 2023-06-21 Kinarus AG Methods of preventing or treating covid-19 and related viral diseases or disorders

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Also Published As

Publication number Publication date
JP4064818B2 (ja) 2008-03-19
NO20033540D0 (no) 2003-08-11
MXPA03007166A (es) 2003-11-18
NO20033540L (no) 2003-08-11
SK11322003A3 (en) 2004-10-05
CA2434834A1 (en) 2002-08-22
WO2002064594A3 (en) 2003-01-09
AR035854A1 (es) 2004-07-21
HRP20030624B1 (en) 2007-03-31
BRPI0207172B1 (pt) 2019-04-09
CA2434834C (en) 2010-09-14
DE60206363T2 (de) 2006-07-06
HUP0303458A3 (en) 2012-12-28
CZ20032416A3 (cs) 2004-07-14
HUP0303458A2 (hu) 2004-01-28
KR20040018254A (ko) 2004-03-02
US20070135458A1 (en) 2007-06-14
NZ526961A (en) 2005-03-24
ZA200305938B (en) 2005-01-26
ATE305303T1 (de) 2005-10-15
EP1361880B1 (en) 2005-09-28
BRPI0207172B8 (pt) 2021-05-25
CN1503672A (zh) 2004-06-09
PA8539201A1 (es) 2004-08-31
US7169794B2 (en) 2007-01-30
BR0207172A (pt) 2004-03-30
US20030171584A1 (en) 2003-09-11
YU63703A (sh) 2006-05-25
MA26993A1 (fr) 2004-12-20
PE20020976A1 (es) 2002-10-29
DE60206363D1 (de) 2006-02-09
US20040116698A1 (en) 2004-06-17
ES2249574T3 (es) 2006-04-01
WO2002064594A2 (en) 2002-08-22
EP1361880A2 (en) 2003-11-19
HK1066170A1 (en) 2005-03-18
CN100376571C (zh) 2008-03-26
AU2002256615B2 (en) 2007-09-13
HU229604B1 (en) 2014-02-28
IL156872A (en) 2009-07-20
MY131518A (en) 2007-08-30
US6696566B2 (en) 2004-02-24
HRP20030624A2 (en) 2005-06-30
US7449581B2 (en) 2008-11-11
IL156872A0 (en) 2004-02-08
PL366918A1 (en) 2005-02-07
JO2410B1 (en) 2007-06-17
JP2004525896A (ja) 2004-08-26
RU2003125887A (ru) 2005-03-20
NO326133B1 (no) 2008-10-06
RU2269527C2 (ru) 2006-02-10
KR100639772B1 (ko) 2006-10-30

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