PE20020976A1 - Pirido-pirimidinas 6-sustituidas como inhibidores de quinasas - Google Patents
Pirido-pirimidinas 6-sustituidas como inhibidores de quinasasInfo
- Publication number
- PE20020976A1 PE20020976A1 PE2002000097A PE2002000097A PE20020976A1 PE 20020976 A1 PE20020976 A1 PE 20020976A1 PE 2002000097 A PE2002000097 A PE 2002000097A PE 2002000097 A PE2002000097 A PE 2002000097A PE 20020976 A1 PE20020976 A1 PE 20020976A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- aryl
- aralkyl
- difluorophenoxy
- pyrid
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE REFIERE A DERIVADOS DE PIRIDOPIRIMIDINAS, EN PARTICULAR 7-OXO-PIRIDO[2,3-d]PIRIMIDINAS 2,6-DISUSTITUIDO DE FORMULA I DONDE Z ES N, CH; W ES NR2; X1 ES O, NR4, CO, S, CR5R6, C=O; R4, R5, R6 Y R7 SON H, ALQUILO; X2 ES O, NR7; Ar1 ES ARILO, HETEROARILO; R2 ES H, ALQUILO, ACILO, ALCOXICARBONILO, ARILOXICARBONILO, HETEROALQUILCARBONILO, HETEROALQUILOXICARBONILO, -R21R22; R21 ES ALQUILENO, CO; R22 ES ALQUILO, ALCOXILO; R1 ES H, ALQUILO, HALOALQUILO, ARILO, ARALQUILO, HETEROARILO, HETEROARALQUILO, CICLOALQUILO, R12-SO2-HETEROCICLOAMINO, ENTRE OTROS; R12 ES HALOALQUILO, ARILO, ARALQUILO, HETEROARILO, HETEROARALQUILO, ENTRE OTROS; R3 ES H, ALQUILO, CICLOALQUILO, CICLOALQUILALQUILO, ARILO, ARALQUILO, HALOALQUILO, ENTRE OTROS; R8 Y R9 SON H, ALQUILO ARILO, ARALQUILO, CICLOALQUILO, CICLOALQUILALQUILO, HETEROALQUILO, ENTRE OTROS; SON COMPUESTOS PREFERIDOS 6-(2,4-DIFLUOROFENOXI)-8-METIL-2-(TETRAHIDRO-2H-PIRAN-4-ILAMINO)PIRIDO[2,3-d]PIRIMIDIN-7(8H)-ONA, 6-(2,4-DIFLUOROFENOXI)-8-PROPIL-2-(TETRAHIDRO-2H-PIRAN-4-ILAMINO)PIRIDO[2,3-d]PIRIMIDIN-7(8H)-ONA, 6-(2,4-DIFLUOROFENOXI)-8-CICLOPROPIL-2-(TETRAHIDRO-2H-PIRAN-4-ILAMINO)PIRIDO[2,3-d]PIRIMIDIN-7(8H)-ONA, TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS SON INHIBIDORES DE QUINASAS DE PREFERENCIA QUINASA p38 Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE ARTRITIS, ENFERMEDAD DE CROHN, SINDROME DE INTESTINO IRRITABLE, SINDROME DE DOLOR RESPIRATORIO, ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26837501P | 2001-02-12 | 2001-02-12 | |
US33465401P | 2001-11-30 | 2001-11-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20020976A1 true PE20020976A1 (es) | 2002-10-29 |
Family
ID=26953040
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2002000097A PE20020976A1 (es) | 2001-02-12 | 2002-02-08 | Pirido-pirimidinas 6-sustituidas como inhibidores de quinasas |
Country Status (32)
Country | Link |
---|---|
US (3) | US6696566B2 (es) |
EP (1) | EP1361880B1 (es) |
JP (1) | JP4064818B2 (es) |
KR (1) | KR100639772B1 (es) |
CN (1) | CN100376571C (es) |
AR (1) | AR035854A1 (es) |
AT (1) | ATE305303T1 (es) |
AU (1) | AU2002256615B2 (es) |
BR (1) | BRPI0207172B8 (es) |
CA (1) | CA2434834C (es) |
CZ (1) | CZ20032416A3 (es) |
DE (1) | DE60206363T2 (es) |
DK (1) | DK1361880T3 (es) |
ES (1) | ES2249574T3 (es) |
HK (1) | HK1066170A1 (es) |
HR (1) | HRP20030624B1 (es) |
HU (1) | HU229604B1 (es) |
IL (2) | IL156872A0 (es) |
JO (1) | JO2410B1 (es) |
MA (1) | MA26993A1 (es) |
MX (1) | MXPA03007166A (es) |
MY (1) | MY131518A (es) |
NO (1) | NO326133B1 (es) |
NZ (1) | NZ526961A (es) |
PA (1) | PA8539201A1 (es) |
PE (1) | PE20020976A1 (es) |
PL (1) | PL366918A1 (es) |
RU (1) | RU2269527C2 (es) |
SK (1) | SK11322003A3 (es) |
WO (1) | WO2002064594A2 (es) |
YU (1) | YU63703A (es) |
ZA (1) | ZA200305938B (es) |
Families Citing this family (40)
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US7053070B2 (en) * | 2000-01-25 | 2006-05-30 | Warner-Lambert Company | Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors |
HU229604B1 (en) | 2001-02-12 | 2014-02-28 | Hoffmann La Roche | 6-substituted pyrido-pyrimidines, process for their preparation and pharmaceutical compositions containing them |
PL220952B1 (pl) | 2002-01-22 | 2016-01-29 | Warner Lambert Co | 2-(Pirydyn-2-yloamino)pirydo[2,3-d]pirymidyn-7-ony |
WO2003082871A1 (en) | 2002-04-03 | 2003-10-09 | F. Hoffmann-La Roche Ag | Imidazo fused compounds |
BR0313297A (pt) * | 2002-08-06 | 2005-06-21 | Hoffmann La Roche | 6-alcóxi-pirido-pirimidinas como inibidores de p-38 map cinase |
EP1594459B1 (en) | 2002-12-30 | 2010-02-17 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
RS53118B (en) * | 2003-02-26 | 2014-06-30 | Sugen Inc. | AMINOHETEROARYL UNITS AS PROTEIN KINASE INHIBITORS |
CN1774250A (zh) * | 2003-04-16 | 2006-05-17 | 霍夫曼-拉罗奇有限公司 | 作为治疗诸如类风湿性关节炎的炎性疾病的p38激酶抑制剂的(6-(苯氧基)-吡啶并[3,4-d]嘧啶-2-基)-胺衍生物 |
DE602004005238T2 (de) * | 2003-11-13 | 2007-11-08 | F. Hoffmann-La Roche Ag | Hydroxyalkylsubstituierte pyrido-7-pyrimidin-7-one |
WO2006056863A1 (en) * | 2004-11-23 | 2006-06-01 | Ranbaxy Laboratories Limited | Pyrido’2, 3-d!pyrimidines as anti-inflammatory agents |
US20060142312A1 (en) * | 2004-12-23 | 2006-06-29 | Pfizer Inc | C6-aryl and heteroaryl substituted pyrido[2,3-D] pyrimidin-7-ones |
US20090036472A1 (en) * | 2005-02-02 | 2009-02-05 | Palle Venkata P | Azabicyclo derivatives as anti-inflammatory agents |
ES2552804T3 (es) * | 2005-05-04 | 2015-12-02 | Evotec Ag | Compuestos heterocíclicos condensados, y sus composiciones y usos |
ES2336603T3 (es) * | 2005-07-21 | 2010-04-14 | F. Hoffmann-La Roche Ag | Compuestos de pirido(2,3-d)pirimidina-2,4-diamina como inhibidores de ptp1b. |
PL2099797T3 (pl) * | 2005-08-09 | 2011-03-31 | Irm Llc | Związki i kompozycje jako inhibitory kinaz białkowych |
US8686002B2 (en) | 2005-08-21 | 2014-04-01 | AbbVie Deutschland GmbH & Co. KG | Heterocyclic compounds and their use as binding partners for 5-HT5 receptors |
JO2783B1 (en) * | 2005-09-30 | 2014-03-15 | نوفارتيس ايه جي | Compounds 2-Amino-7, 8-dihydro-6H-Bayredo (3,4-D) Pyrimidine-5-Ones |
WO2008150260A1 (en) * | 2007-06-06 | 2008-12-11 | Gpc Biotech, Inc. | 8-oxy-2-aminopyrido (2, 3-d) pyrimidin-7-one derivatives as kinase inhibitors and anticancer agents |
WO2008078249A1 (en) * | 2006-12-21 | 2008-07-03 | Ranbaxy Laboratories Limited | Anti-inflammatory agents |
WO2008136948A1 (en) | 2007-05-07 | 2008-11-13 | Amgen Inc. | Pyrazolo-pyridinone and pyrazolo-pyrazinone compounds as p38 modulators, process for their preparation, and their pharmaceutical use |
CN101679211A (zh) | 2007-06-15 | 2010-03-24 | 霍夫曼-拉罗奇有限公司 | 用于制备3-氨基-戊-1,5-二醇的新方法 |
WO2009117156A1 (en) | 2008-03-21 | 2009-09-24 | Amgen Inc. | Pyrazolo-pyrazinone compounds and methods of use thereof |
EP2112150B1 (en) | 2008-04-22 | 2013-10-16 | Forma Therapeutics, Inc. | Improved raf inhibitors |
CA2734037A1 (en) * | 2008-10-22 | 2010-04-29 | F. Hoffmann-La Roche Ag | Pyrimidinyl pyridone inhibitors of jnk |
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KR20120104200A (ko) * | 2009-10-09 | 2012-09-20 | 아프락시스 인코포레이티드 | Cns 장애의 치료를 위한 8에틸6(아릴)피리도[2,3d]피리미딘7(8h)온 |
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MY195671A (en) | 2016-06-08 | 2023-02-03 | Support Venture Gmbh | Pharmaceutical Combinations for Treating Cancer |
ES2876411T3 (es) | 2016-08-15 | 2021-11-12 | Pfizer | Inhibidores de piridopirimdinona CDK2/4/6 |
EP3500258A1 (en) | 2016-08-17 | 2019-06-26 | Support-Venture GmbH | Method of preventing or treating hearing loss |
US11117858B2 (en) | 2017-01-11 | 2021-09-14 | The General Hospital Corporation | Voltage gated sodium channel imaging agents |
KR20190137854A (ko) * | 2017-04-04 | 2019-12-11 | 스트리킨 아게 | 안과 질병의 예방 또는 치료 방법 |
JP2021501123A (ja) * | 2017-08-31 | 2021-01-14 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | Egfrおよび/またはher2の阻害剤ならびに使用方法 |
LT3691620T (lt) | 2017-10-05 | 2022-09-26 | Fulcrum Therapeutics, Inc. | P38 kinazės inhibitoriai, sumažinantys dux4 ir pasrovinių genų raišką, skirti fshd gydymui |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
US20210261547A1 (en) * | 2018-06-27 | 2021-08-26 | Tufts Medical Center, Inc. | Pyridopyrimidine compounds and methods of their use |
SG11202012775SA (en) | 2018-07-13 | 2021-02-25 | Kinarus Ag | Combinations of ppar agonists and p38 kinase inhibitors for preventing or treating fibrotic diseases |
TW202112368A (zh) | 2019-06-13 | 2021-04-01 | 荷蘭商法西歐知識產權股份有限公司 | 用於治療有關dux4表現之疾病的抑制劑組合 |
US20230263803A1 (en) | 2020-08-11 | 2023-08-24 | Kinarus Ag | Methods of preventing or treating covid-19 and related viral diseases or disorders |
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TW458977B (en) * | 1997-04-16 | 2001-10-11 | Abbott Lab | 6,7-disubstituted-4-aminopyrido[2,3-D] pyrimidine compounds |
HUP0001434A3 (en) | 1997-04-16 | 2001-01-29 | Abbott Lab | 5,7-disubstituted 4-aminopyrido[2,3-d]pyrimidine compounds, pharmaceutical compouads thereof and process for their preparation |
IL131617A0 (en) | 1997-04-16 | 2001-01-28 | Abbott Lab | 5,6,7-Trisubstituted-4-aminopyridol ¬2,3-d¾ pyrimidine compounds |
HUP0102514A3 (en) | 1998-05-26 | 2002-03-28 | Warner Lambert Co | Pyrido-pyrimidin and pyrimido-pyrimidin derivatives as inhibitors of cellular proliferation and pharmaceutical compositions thereof |
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US7053070B2 (en) * | 2000-01-25 | 2006-05-30 | Warner-Lambert Company | Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors |
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2002
- 2002-02-04 HU HU0303458A patent/HU229604B1/hu unknown
- 2002-02-04 DK DK02726103T patent/DK1361880T3/da active
- 2002-02-04 KR KR1020037010562A patent/KR100639772B1/ko active IP Right Grant
- 2002-02-04 AU AU2002256615A patent/AU2002256615B2/en not_active Expired
- 2002-02-04 NZ NZ526961A patent/NZ526961A/en unknown
- 2002-02-04 WO PCT/EP2002/001106 patent/WO2002064594A2/en not_active Application Discontinuation
- 2002-02-04 AT AT02726103T patent/ATE305303T1/de active
- 2002-02-04 RU RU2003125887/04A patent/RU2269527C2/ru not_active IP Right Cessation
- 2002-02-04 JP JP2002564525A patent/JP4064818B2/ja not_active Expired - Lifetime
- 2002-02-04 MX MXPA03007166A patent/MXPA03007166A/es active IP Right Grant
- 2002-02-04 CN CNB028048342A patent/CN100376571C/zh not_active Expired - Lifetime
- 2002-02-04 DE DE60206363T patent/DE60206363T2/de not_active Expired - Lifetime
- 2002-02-04 BR BRPI0207172-0 patent/BRPI0207172B8/pt not_active IP Right Cessation
- 2002-02-04 PL PL02366918A patent/PL366918A1/xx not_active Application Discontinuation
- 2002-02-04 EP EP02726103A patent/EP1361880B1/en not_active Expired - Lifetime
- 2002-02-04 ES ES02726103T patent/ES2249574T3/es not_active Expired - Lifetime
- 2002-02-04 CZ CZ20032416A patent/CZ20032416A3/cs unknown
- 2002-02-04 SK SK11322003A patent/SK11322003A3/sk unknown
- 2002-02-04 YU YU63703A patent/YU63703A/sh unknown
- 2002-02-04 IL IL15687202A patent/IL156872A0/xx unknown
- 2002-02-04 CA CA2434834A patent/CA2434834C/en not_active Expired - Lifetime
- 2002-02-06 JO JO200212A patent/JO2410B1/en active
- 2002-02-08 PE PE2002000097A patent/PE20020976A1/es not_active Application Discontinuation
- 2002-02-08 PA PA20028539201A patent/PA8539201A1/es unknown
- 2002-02-11 US US10/073,845 patent/US6696566B2/en not_active Expired - Lifetime
- 2002-02-11 AR ARP020100430A patent/AR035854A1/es unknown
- 2002-02-11 MY MYPI20020491A patent/MY131518A/en unknown
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2003
- 2003-07-10 IL IL156872A patent/IL156872A/en unknown
- 2003-07-31 ZA ZA2003/05938A patent/ZA200305938B/en unknown
- 2003-08-01 HR HR20030624A patent/HRP20030624B1/xx not_active IP Right Cessation
- 2003-08-11 MA MA27273A patent/MA26993A1/fr unknown
- 2003-08-11 NO NO20033540A patent/NO326133B1/no not_active IP Right Cessation
- 2003-11-25 US US10/722,703 patent/US7169794B2/en not_active Expired - Lifetime
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2004
- 2004-11-19 HK HK04109141A patent/HK1066170A1/xx not_active IP Right Cessation
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2007
- 2007-01-09 US US11/651,302 patent/US7449581B2/en not_active Expired - Lifetime
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