PE20011287A1 - Derivados de imidazopirimidina y derivados de triazolopirimidina - Google Patents
Derivados de imidazopirimidina y derivados de triazolopirimidinaInfo
- Publication number
- PE20011287A1 PE20011287A1 PE2001000382A PE2001000382A PE20011287A1 PE 20011287 A1 PE20011287 A1 PE 20011287A1 PE 2001000382 A PE2001000382 A PE 2001000382A PE 2001000382 A PE2001000382 A PE 2001000382A PE 20011287 A1 PE20011287 A1 PE 20011287A1
- Authority
- PE
- Peru
- Prior art keywords
- derivatives
- imidazo
- pyrimidin
- alkyl
- imidazopyrimidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Otolaryngology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A DERIVADOS DE IMIDAZOPIRIMIDINA Y DERIVADOS DE TRIAZOLOPIRIMIDINA DE FORMULA I DONDE R1 ES OR11, SR11, SOR11, SO2R11, NHR11, NR12R13, ENTRE OTROS; R11 ES H, FENILCARBONILO, TIENILO CON COOR111 (SIENDO R111 H, ALQUILO C1-C6), PIRIMIDILO, ALQUENILO C2-C6, ENTRE OTROS; R12 ES ALQUILO C1-C6, -(CH2)q-OH, -(CH2)q-CN DONDE q ES 0-6, ENTRE OTROS; R13 ES IGUAL A R11; R12 Y R13 JUNTO A N FORMAN UN ANILLO HETEROCICLICO DE 4-6 MIEMBROS; Y ES CH, N; R2 ES H, ALQUILO C1-C6. CARBAMOILO; R3 ES TIENILO, PIRIDILO CON HALOGENO, ALCOXI C1-C6, NAFTILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS [7-(3,4-DIMETOXIFENIL)IMIDAZO[1,2-c]PIRIMIDIN-5-IL]-(1H-INDAZOL-6-IL)AMINA; 2-[7-(3,4-DIMETOXIFENIL)IMIDAZO[1,2-c]PIRIMIDIN-5-ILAMINA]BENZAMIDA; 2-[7-(3,4-DIMETOXIFENIL)IMIDAZO[1,2-c]PIRIMIDIN-5-ILAMINA]-5-METOXIBENZAMIDA; ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION Y UNA COMPOSICION FARMACEUTICA. LOS DERIVADOS DE IMIDAZOPIRIMIDINA Y DERIVADOS DE TRIAZOLOPIRIMIDINA SON INHIBIDORES DE LA TIROSINA QUINASA (SyK) Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES ALERGICAS, ASMA, RINITIS ALERGICA, DERMATITIS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000128870A JP2001302667A (ja) | 2000-04-28 | 2000-04-28 | イミダゾピリミジン誘導体およびトリアゾロピリミジン誘導体 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20011287A1 true PE20011287A1 (es) | 2002-02-27 |
Family
ID=18638240
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2001000382A PE20011287A1 (es) | 2000-04-28 | 2001-04-27 | Derivados de imidazopirimidina y derivados de triazolopirimidina |
Country Status (38)
Country | Link |
---|---|
US (1) | US6911443B2 (es) |
EP (1) | EP1278750B1 (es) |
JP (2) | JP2001302667A (es) |
KR (1) | KR20030009456A (es) |
CN (1) | CN1263756C (es) |
AR (1) | AR033367A1 (es) |
AT (1) | ATE272639T1 (es) |
AU (1) | AU783043B2 (es) |
BG (1) | BG107166A (es) |
BR (1) | BR0110404A (es) |
CA (1) | CA2407531A1 (es) |
CZ (1) | CZ20023551A3 (es) |
DE (1) | DE60104671T2 (es) |
DK (1) | DK1278750T3 (es) |
DO (1) | DOP2001000151A (es) |
EE (1) | EE200200606A (es) |
ES (1) | ES2225546T3 (es) |
HK (1) | HK1058362A1 (es) |
HR (1) | HRP20020943A2 (es) |
HU (1) | HUP0300846A2 (es) |
IL (1) | IL151919A0 (es) |
MA (1) | MA25746A1 (es) |
MX (1) | MXPA02010579A (es) |
MY (1) | MY141578A (es) |
NO (1) | NO20025154D0 (es) |
NZ (2) | NZ522241A (es) |
PE (1) | PE20011287A1 (es) |
PL (1) | PL358106A1 (es) |
PT (1) | PT1278750E (es) |
RU (1) | RU2306313C2 (es) |
SI (1) | SI1278750T1 (es) |
SK (1) | SK15332002A3 (es) |
SV (1) | SV2001000416A (es) |
TR (1) | TR200402300T4 (es) |
TW (1) | TWI222974B (es) |
UA (1) | UA72615C2 (es) |
WO (1) | WO2001083485A1 (es) |
ZA (1) | ZA200207676B (es) |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1767525A1 (en) | 2001-04-09 | 2007-03-28 | Novartis Vaccines and Diagnostics, Inc. | Guanidino compounds as melanocortin-4 receptor (MC4-R) agonists |
ATE316077T1 (de) | 2003-04-25 | 2006-02-15 | Actimis Pharmaceuticals Inc | Pyrimidin-essigsäure derivate geeignet zur behandlung von crth2-bedingten krankheiten |
JPWO2005037837A1 (ja) * | 2003-10-17 | 2006-12-28 | 日本化薬株式会社 | 置換2−アミノ−[1,2,4]トリアゾロ[1,5−a]ピリミジン誘導体及びその用途 |
US7572914B2 (en) | 2003-12-19 | 2009-08-11 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
JP4996257B2 (ja) | 2004-01-31 | 2012-08-08 | アクチミス ファーマシューティカルズ インコーポレーテッド | イミダゾ[1,2−c]ピリミジニル酢酸誘導体 |
EP1765825A1 (en) * | 2004-06-25 | 2007-03-28 | Amgen Inc. | Condensed triazoles and indazoles useful in treating citokines mediated diseases and other diseases |
US7550598B2 (en) | 2004-08-18 | 2009-06-23 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
EP1781645A1 (en) | 2004-08-23 | 2007-05-09 | Wyeth | Oxazolo-naphthyl acids as plasminogen activator inhibitor type-1(pai-1) modulators useful in the treatment of thrombosis and cardiovascular diseases |
DE602005023333D1 (de) * | 2004-10-15 | 2010-10-14 | Takeda Pharmaceutical | Kinaseinhibitoren |
NZ561000A (en) | 2005-02-28 | 2010-01-29 | Japan Tobacco Inc | Novel aminopyridine compound with Syk inhibitory activity |
US7442700B2 (en) | 2005-07-01 | 2008-10-28 | Bristol-Myers Squibb Company | Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith |
US8119655B2 (en) * | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
AU2006301435A1 (en) * | 2005-10-13 | 2007-04-19 | Glaxo Group Limited | Pyrrolopyrimidine derivatives as Syk inhibitors |
CL2007002617A1 (es) * | 2006-09-11 | 2008-05-16 | Sanofi Aventis | Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto. |
JP2010505961A (ja) * | 2006-10-09 | 2010-02-25 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
EA200970361A1 (ru) | 2006-10-09 | 2010-02-26 | Такеда Фармасьютикал Компани Лимитед | Ингибиторы киназы |
AU2007323725B2 (en) * | 2006-11-22 | 2014-02-20 | Incyte Holdings Corporation | Imidazotriazines and imidazopyrimidines as kinase inhibitors |
KR20090103897A (ko) | 2006-12-28 | 2009-10-01 | 다이쇼 세이야꾸 가부시끼가이샤 | 피라졸로피리미딘 화합물 |
DE102007012645A1 (de) * | 2007-03-16 | 2008-09-18 | Bayer Healthcare Ag | Substituierte Imidazo- und Triazolopyrimidine |
RU2491279C2 (ru) | 2007-09-25 | 2013-08-27 | Актимис Фармасьютикалз, Инк. | 2-s-бензилзамещенные пиримидины в качестве антагонистов crth2 |
BRPI0817319A2 (pt) | 2007-09-25 | 2015-03-17 | Actimis Pharmaceuticals Inc | Composto, composição farmacêutica, e, método para tratamento ou profilaxia de uma doença ou condição ou um ou mais sintomas da mesma. |
DE102008023801A1 (de) | 2008-05-15 | 2009-11-19 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Imidazo- und Triazolopyrimidine, Imidazo- und Pyrazolopyrazine und Imidazotriazine |
CN102307581B (zh) | 2008-12-08 | 2016-08-17 | 吉利德康涅狄格股份有限公司 | 咪唑并哌嗪syk抑制剂 |
SI2716157T1 (sl) * | 2008-12-08 | 2016-10-28 | Gilead Connecticut, Inc., c/o Gilead Sciences, Inc. | Imidazopirazinski Syk-inhibitorji |
WO2010147898A2 (en) * | 2009-06-15 | 2010-12-23 | Rigel Pharmaceuticals, Inc. | Small molecule inhibitors of spleen tyrosine kinase (syk) |
EA021568B1 (ru) | 2009-12-23 | 2015-07-30 | Такеда Фармасьютикал Компани Лимитед | Конденсированные гетероароматические пирролидиноны как ингибиторы syk |
AU2011226689B2 (en) | 2010-03-11 | 2016-09-01 | Kronos Bio, Inc. | Imidazopyridines Syk inhibitors |
SG184870A1 (en) * | 2010-04-14 | 2012-11-29 | Array Biopharma Inc | 5, 7-substituted-imidazo [1, 2-c] pyrimidines as inhibitors of jak kinases |
EP2706852B1 (en) | 2011-05-10 | 2018-08-22 | Merck Sharp & Dohme Corp. | Bipyridylaminopyridines as syk inhibitors |
AU2012253886A1 (en) | 2011-05-10 | 2013-10-31 | Merck Sharp & Dohme Corp. | Pyridyl aminopyridines as Syk inhibitors |
AU2012253885A1 (en) | 2011-05-10 | 2013-10-31 | Merck Sharp & Dohme Corp. | Aminopyrimidines as Syk inhibitors |
WO2012167423A1 (en) | 2011-06-08 | 2012-12-13 | Hutchison Medipharma Limited | Substituted pyridopyrazines as novel syk inhibitors |
JP6026525B2 (ja) | 2011-06-22 | 2016-11-16 | 武田薬品工業株式会社 | 置換6−アザ−イソインドリン−1−オン誘導体 |
US9199975B2 (en) | 2011-09-30 | 2015-12-01 | Asana Biosciences, Llc | Biaryl imidazole derivatives for regulating CYP17 |
WO2013052391A1 (en) | 2011-10-05 | 2013-04-11 | Merck Sharp & Dohme Corp. | PHENYL CARBOXAMIDE-CONTAINING SPLEEN TYROSINE KINASE (Syk) INHIBITORS |
US9216173B2 (en) | 2011-10-05 | 2015-12-22 | Merck Sharp & Dohme Corp. | 2-Pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors |
US8987456B2 (en) | 2011-10-05 | 2015-03-24 | Merck Sharp & Dohme Corp. | 3-pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors |
US20140228349A1 (en) * | 2011-10-12 | 2014-08-14 | Array Biopharma Inc. | 5,7-substituted-imidazo[1,2-c]pyrimidines |
NZ627250A (en) * | 2011-12-28 | 2016-04-29 | Fujifilm Corp | Novel nicotinamide derivative or salt thereof |
WO2013192125A1 (en) | 2012-06-20 | 2013-12-27 | Merck Sharp & Dohme Corp. | Pyrazolyl derivatives as syk inhibitors |
US9487504B2 (en) | 2012-06-20 | 2016-11-08 | Merck Sharp & Dohme Corp. | Imidazolyl analogs as syk inhibitors |
WO2013192088A1 (en) | 2012-06-22 | 2013-12-27 | Merck Sharp & Dohme Corp. | SUBSTITUTED DIAZINE AND TRIAZINE SPLEEN TYROSINE KINASE (Syk) INHIBITORS |
WO2013192098A1 (en) | 2012-06-22 | 2013-12-27 | Merck Sharp & Dohme Corp. | SUBSTITUTED PYRIDINE SPLEEN TYROSINE KINASE (Syk) INHIBITORS |
WO2014031438A2 (en) | 2012-08-20 | 2014-02-27 | Merck Sharp & Dohme Corp. | SUBSTITUTED PHENYL SPLEEN TYROSINE KINASE (Syk) INHIBITORS |
EP2900665B1 (en) | 2012-09-28 | 2018-01-03 | Merck Sharp & Dohme Corp. | Triazolyl derivatives as syk inhibitors |
EP2931281B1 (en) | 2012-12-12 | 2018-01-17 | Merck Sharp & Dohme Corp. | Amino-pyrimidine-containing spleen tyrosine kinase inhibitors |
US9598405B2 (en) | 2012-12-21 | 2017-03-21 | Merck Sharp & Dohme Corp. | Thiazole-substituted aminopyridines as spleen tyrosine kinase inhibitors |
WO2014176210A1 (en) | 2013-04-26 | 2014-10-30 | Merck Sharp & Dohme Corp. | Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors |
WO2014176216A1 (en) | 2013-04-26 | 2014-10-30 | Merck Sharp & Dohme Corp. | Thiazole-substituted aminopyrimidines as spleen tyrosine kinase inhibitors |
HUE052090T2 (hu) | 2013-07-30 | 2021-04-28 | Kronos Bio Inc | A SYK inhibitorok polimorfja |
AP2016009007A0 (en) | 2013-07-30 | 2016-01-31 | Gilead Connecticut Inc | Formulation of syk inhibitors |
PT3076976T (pt) | 2013-12-04 | 2020-12-07 | Kronos Bio Inc | Métodos para tratar cancros |
WO2015095444A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors |
US9783531B2 (en) | 2013-12-20 | 2017-10-10 | Merck Sharp & Dohme Corp. | Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors |
US9822107B2 (en) | 2013-12-20 | 2017-11-21 | Merck Sharp & Dohme Corp. | Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors |
US9290505B2 (en) | 2013-12-23 | 2016-03-22 | Gilead Sciences, Inc. | Substituted imidazo[1,2-a]pyrazines as Syk inhibitors |
UY35898A (es) | 2013-12-23 | 2015-07-31 | Gilead Sciences Inc | ?compuestos inhibidores de syk y composiciones que los comprenden?. |
EP3116506B1 (en) | 2014-03-13 | 2019-04-17 | Merck Sharp & Dohme Corp. | 2-pyrazine carboxamides as spleen tyrosine kinase inhibitors |
CN106255689B (zh) | 2014-03-19 | 2019-09-17 | 勃林格殷格翰国际有限公司 | 杂芳基syk抑制剂 |
SG11201610551TA (en) | 2014-07-14 | 2017-01-27 | Gilead Sciences Inc | Combinations for treating cancers |
EA033978B1 (ru) | 2015-09-11 | 2019-12-16 | Бёрингер Ингельхайм Интернациональ Гмбх | Пиразолилзамещенные гетероарилы и их применение в качестве лекарственных средств |
KR20220070056A (ko) | 2017-08-25 | 2022-05-27 | 길리애드 사이언시즈, 인코포레이티드 | Syk 억제제의 다형체 |
MX2020004155A (es) | 2017-10-19 | 2020-08-03 | Bayer Animal Health Gmbh | Uso de pirrolidonas heteroaromaticas fusionadas para el tratamiento y prevencion de enfermedades en animales. |
CN111936136A (zh) | 2017-11-14 | 2020-11-13 | 儿童医学中心公司 | 新咪唑并嘧啶化合物及其用途 |
KR20200088398A (ko) | 2017-11-14 | 2020-07-22 | 칠드런'즈 메디컬 센터 코포레이션 | 인간 면역 반응을 조정하기 위한 이미다조피리미딘의 용도 |
WO2019235572A1 (ja) * | 2018-06-06 | 2019-12-12 | 富士フイルム株式会社 | 固形がんの処置剤および医薬組成物 |
EP3804722A4 (en) * | 2018-06-06 | 2022-04-13 | National University Corporation Hokkaido University | TREATMENT AGENT AND PHARMACEUTICAL COMPOSITION AGAINST GLIOMA |
WO2019235571A1 (ja) * | 2018-06-06 | 2019-12-12 | 富士フイルム株式会社 | 血液がんの処置剤および医薬組成物 |
CN112969505B (zh) | 2018-10-31 | 2023-11-14 | 吉利德科学公司 | 具有hpk1抑制活性的取代的6-氮杂苯并咪唑化合物 |
MX2021005047A (es) | 2018-10-31 | 2021-09-08 | Gilead Sciences Inc | Compuestos de 6-azabenzimidazol sustituidos como inhibidores de hpk1. |
CA3130848A1 (en) | 2019-02-22 | 2020-08-27 | Kronos Bio, Inc. | Solid forms of condensed pyrazines as syk inhibitors |
EA202192575A1 (ru) | 2019-03-21 | 2022-01-14 | Онксео | Соединения dbait в сочетании с ингибиторами киназ для лечения рака |
TWI826690B (zh) | 2019-05-23 | 2023-12-21 | 美商基利科學股份有限公司 | 經取代之烯吲哚酮化物及其用途 |
US20220401436A1 (en) | 2019-11-08 | 2022-12-22 | INSERM (Institute National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
WO2021173476A1 (en) * | 2020-02-24 | 2021-09-02 | The Trustees Of Columbia University In The City Of New York | Compounds, pharmaceutical formulations, and methods for treatment of cancer |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4483987A (en) * | 1983-06-20 | 1984-11-20 | G. D. Searle & Co. | 8-Substituted 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines and amides |
JP2001518470A (ja) * | 1997-09-26 | 2001-10-16 | メルク エンド カムパニー インコーポレーテッド | 新規な血管形成阻害剤 |
ES2308821T3 (es) * | 1997-12-15 | 2008-12-01 | Astellas Pharma Inc. | Nuevos derivados de pirimidin-5-carboxamida. |
US6673564B2 (en) * | 1999-10-18 | 2004-01-06 | Millennium Pharmaceuticals, Inc. | Methods for using 22045, a human cyclic nucleotide phosphodiesterase |
-
2000
- 2000-04-28 JP JP2000128870A patent/JP2001302667A/ja active Pending
-
2001
- 2001-04-17 US US10/258,628 patent/US6911443B2/en not_active Expired - Fee Related
- 2001-04-17 RU RU2002132193/04A patent/RU2306313C2/ru not_active IP Right Cessation
- 2001-04-17 AT AT01936242T patent/ATE272639T1/de not_active IP Right Cessation
- 2001-04-17 IL IL15191901A patent/IL151919A0/xx unknown
- 2001-04-17 JP JP2002500795A patent/JP2003535067A/ja active Pending
- 2001-04-17 AU AU62204/01A patent/AU783043B2/en not_active Ceased
- 2001-04-17 DK DK01936242T patent/DK1278750T3/da active
- 2001-04-17 KR KR1020027014441A patent/KR20030009456A/ko not_active Application Discontinuation
- 2001-04-17 SI SI200130178T patent/SI1278750T1/xx unknown
- 2001-04-17 EP EP01936242A patent/EP1278750B1/en not_active Expired - Lifetime
- 2001-04-17 ES ES01936242T patent/ES2225546T3/es not_active Expired - Lifetime
- 2001-04-17 PT PT01936242T patent/PT1278750E/pt unknown
- 2001-04-17 NZ NZ522241A patent/NZ522241A/en unknown
- 2001-04-17 TR TR2004/02300T patent/TR200402300T4/xx unknown
- 2001-04-17 UA UA2002119418A patent/UA72615C2/uk unknown
- 2001-04-17 WO PCT/EP2001/004357 patent/WO2001083485A1/en active IP Right Grant
- 2001-04-17 CZ CZ20023551A patent/CZ20023551A3/cs unknown
- 2001-04-17 DE DE60104671T patent/DE60104671T2/de not_active Expired - Fee Related
- 2001-04-17 NZ NZ526221A patent/NZ526221A/en unknown
- 2001-04-17 MX MXPA02010579A patent/MXPA02010579A/es active IP Right Grant
- 2001-04-17 CN CNB018117201A patent/CN1263756C/zh not_active Expired - Fee Related
- 2001-04-17 HU HU0300846A patent/HUP0300846A2/hu unknown
- 2001-04-17 EE EEP200200606A patent/EE200200606A/xx unknown
- 2001-04-17 BR BR0110404-7A patent/BR0110404A/pt not_active IP Right Cessation
- 2001-04-17 PL PL01358106A patent/PL358106A1/xx not_active Application Discontinuation
- 2001-04-17 CA CA002407531A patent/CA2407531A1/en not_active Abandoned
- 2001-04-17 SK SK1533-2002A patent/SK15332002A3/sk unknown
- 2001-04-25 DO DO2001000151A patent/DOP2001000151A/es unknown
- 2001-04-26 MY MYPI20011983A patent/MY141578A/en unknown
- 2001-04-27 TW TW090110055A patent/TWI222974B/zh not_active IP Right Cessation
- 2001-04-27 SV SV2001000416A patent/SV2001000416A/es not_active Application Discontinuation
- 2001-04-27 PE PE2001000382A patent/PE20011287A1/es not_active Application Discontinuation
- 2001-04-27 AR ARP010102006A patent/AR033367A1/es not_active Application Discontinuation
-
2002
- 2002-09-25 ZA ZA200207676A patent/ZA200207676B/xx unknown
- 2002-10-03 BG BG107166A patent/BG107166A/bg unknown
- 2002-10-25 NO NO20025154A patent/NO20025154D0/no not_active Application Discontinuation
- 2002-10-28 MA MA26885A patent/MA25746A1/fr unknown
- 2002-11-28 HR HR20020943A patent/HRP20020943A2/hr not_active Application Discontinuation
-
2004
- 2004-02-18 HK HK04101162A patent/HK1058362A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20011287A1 (es) | Derivados de imidazopirimidina y derivados de triazolopirimidina | |
HUP0400326A2 (hu) | Orexin receptor antagonistákként alkalmazható ciklikus N-(aril-karbonil)-amin-származékok és ezeket tartalmazó gyógyszerkészítmények | |
AR031627A1 (es) | Activadores heteroaromaticos fusionados de la glucoquinasa | |
HUP0300413A2 (hu) | Amidcsoportot viselő benzolgyűrűs csoporttal helyettesített piperidint tartalmazó és rokonszerkezetű vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
PE20020467A1 (es) | Compuestos de 1,4-dihidropiridina como antagonistas de bradicinina | |
RS50932B (sr) | N-oksidi kao prolekovi 4-fenil-piridinskih derivata koji su antagonisti nk1 receptora | |
PE20020976A1 (es) | Pirido-pirimidinas 6-sustituidas como inhibidores de quinasas | |
EA200400830A1 (ru) | ПИРИМИДИНОВЫЕ СОЕДИНЕНИЯ, ОТНОСЯЩИЕСЯ К A2b-СЕЛЕКТИВНЫМ АНТАГОНИСТАМ, ИХ СИНТЕЗ И ПРИМЕНЕНИЕ | |
PE20030761A1 (es) | Derivados del 7-amino-benzotiazol | |
WO1999042465A3 (en) | Sulphonamide derivatives being 5-ht6 receptor antagonists and process for their preparation | |
PE20120814A1 (es) | Compuestos y composiciones como inhibidores de la proteina cinasa | |
EA200200643A1 (ru) | ПИРИДО[2,3-d]ПИРИМИДИН-2,7-ДИАМИНОВЫЕ ИНГИБИТОРЫ КИНАЗ | |
TW200735876A (en) | Process for preparing pyrido[2,3-d]pyrimidin-7-one and 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one derivatives | |
PE20121352A1 (es) | Derivados de heteroarilo que contienen n como inhibidores de cinasa jak3 | |
BRPI0409110A (pt) | derivados de 4-(4-heterociclilalcoxi)fenil-1-(heterociclil-carboni l)piridina e compostos relacionados como antagonistas de histamina h3 para o tratamento de doenças neurológicas tais como alzheimer | |
DE60219672D1 (de) | Imidazopyridine, -pyrimidine und -triazine als gaba-a alpha 5 rezeptor subtyp liganden zur verbesserung kognitiver eigenschaften | |
PE20011114A1 (es) | Decahidro-isoquinolinas | |
PE20020219A1 (es) | Derivados de 6-fenilpirrolpirimidindiona como inhibidores de fosfodiesterasa 5 | |
NO964698L (no) | Bicykliske aminderivater som inhibitorer av nitrogenoksid-syntetase | |
TR200102585T2 (tr) | Bifenil türevleri | |
ATE276257T1 (de) | Pyrazinonderivate | |
HRP20030610B1 (en) | Process for the preparation of mesylates of piperazine derivatives | |
PE20030719A1 (es) | Derivados de 8-[bis(2-halofenil)metil]-3-heteroaril-8-azabiciclo[3.2.1] octan-3-ol como agonistas del receptor de nociceptina orl-1 | |
JO2307B1 (en) | Papermidine derivatives | |
BR0213177A (pt) | Derivados de 5-metóxi-8-aril-[1,2,4]triazolo[1,5-a]piridina |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |