PE20020467A1 - Compuestos de 1,4-dihidropiridina como antagonistas de bradicinina - Google Patents
Compuestos de 1,4-dihidropiridina como antagonistas de bradicininaInfo
- Publication number
- PE20020467A1 PE20020467A1 PE2001000796A PE2001000796A PE20020467A1 PE 20020467 A1 PE20020467 A1 PE 20020467A1 PE 2001000796 A PE2001000796 A PE 2001000796A PE 2001000796 A PE2001000796 A PE 2001000796A PE 20020467 A1 PE20020467 A1 PE 20020467A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- bradycinin
- antagonists
- methyl
- phenyl
- Prior art date
Links
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical class C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title abstract 2
- -1 PIPERIDINYL Chemical class 0.000 abstract 5
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 150000003973 alkyl amines Chemical class 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical class C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
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- Rheumatology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
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- Dermatology (AREA)
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- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I DONDE A ES HALO; Y ES -(CH2)m-, -C(O)-, -S(O)-; R1 Y R2 SON ALQUILO C1-C4; R3 ES AZACICLO, AZABICICLO, AZATRICICLO-ALQUILO C7-C14, H, ALQUILO C1-C7, PIPERIDINILO, CICLOALQUILO, ENTRE OTROS; R4 ES FENILO SUSTITUIDO EN LA POSICION 2 CON ALQUILO C1-C4, ALQUILO C5-C7, ALCOXI C1-C4, TIOALQUILO C1-C4, AMINO, ALQUILAMINO C1-C4, PIPERAZINILCARBONILO, ENTRE OTROS; R5 ES H, ALQUILO C1-C4; m ES 0-2; n ES 0-5. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION. SON COMPUESTOS PREFERIDOS 2-(2-{2-[(2-AMINOETOXI)METIL]FENIL}ETIL)-4-(2,6-DICLOROFENIL)-6-{2-[4-(8-METIL-8-AZABICICLO[3.2.1]OCT-3-IL)-1-PIPERAZINIL]-2-OXOETIL}-1,4-DIHIDRO-3,5-PIRIDINODICARBOXILATO DE DIMETILO, 2-{2-[2-(2-AMINOETOXI)FENIL]ETIL)-4-(2,6-DICLOROFENIL)-6-{2-[4-(8-METIL-8-AZABICICLO[3.2.1]OCT-3-IL)-1-PIPERAZINIL]-2-OXOETIL}-1,4-DIHIDRO-3,5-PIRIDINODICARBOXILATO DE DIMETILO, ENTRE OTROS. LOS COMPUESTOS DE 1,4-DIHIDROPIRIDINA SON ANTAGONISTAS DE BRADICININA Y SON UTILES PARA EL TRATAMIENTO DE INFLAMACION, ASMA, RINITIS ALERGICA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22455800P | 2000-08-10 | 2000-08-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20020467A1 true PE20020467A1 (es) | 2002-06-14 |
Family
ID=22841188
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2001000796A PE20020467A1 (es) | 2000-08-10 | 2001-08-08 | Compuestos de 1,4-dihidropiridina como antagonistas de bradicinina |
Country Status (21)
Country | Link |
---|---|
US (1) | US6653313B2 (es) |
EP (1) | EP1307449B1 (es) |
JP (1) | JP2004505973A (es) |
AP (1) | AP2001002238A0 (es) |
AR (1) | AR034555A1 (es) |
AT (1) | ATE312099T1 (es) |
AU (1) | AU2001270947A1 (es) |
BR (1) | BR0113071A (es) |
CA (1) | CA2418908C (es) |
CR (1) | CR6859A (es) |
DE (1) | DE60115661T2 (es) |
ES (1) | ES2257422T3 (es) |
GT (1) | GT200100153A (es) |
IL (1) | IL153224A0 (es) |
IS (1) | IS6639A (es) |
MX (1) | MXPA03001204A (es) |
PA (1) | PA8525001A1 (es) |
PE (1) | PE20020467A1 (es) |
SV (1) | SV2003000588A (es) |
TN (1) | TNSN01124A1 (es) |
WO (1) | WO2002012235A1 (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10111843A1 (de) * | 2001-03-13 | 2002-09-19 | Boehringer Ingelheim Pharma | Verbindungen zur Behandlung von inflammatorischen Erkrankungen |
PT1545548E (pt) * | 2002-08-30 | 2010-09-02 | Nycomed Gmbh | Utilização da combinação de ciclesonida e anti-histamínicos para o tratamento de rinite alérgica |
MXPA05007843A (es) * | 2003-01-24 | 2005-10-18 | Elan Pharm Inc | Composicion y tratamiento de enfermedades desmielinizantes y paralisis por administracion de agentes de remielinizantes. |
US20060217362A1 (en) * | 2004-12-29 | 2006-09-28 | Tung Jay S | Novel compounds useful for bradykinin B1 receptor antagonism |
CA2727199C (en) * | 2008-06-09 | 2016-11-22 | Bayer Schering Pharma Aktiengesellschaft | Annellated 4-(indazolyl)-1,4-dihydropyridine derivatives and methods of use thereof |
WO2010127381A1 (en) * | 2009-05-08 | 2010-11-11 | James Cook University | Diagnosis, monitoring, prognosis, prevention and treatment of aneurysms |
JP5637710B2 (ja) * | 2010-03-24 | 2014-12-10 | 株式会社トクヤマ | {2−アミノ−1,4−ジヒドロ−6−メチル−4−(3−ニトロフェニル)−3,5−ピリジンジカルボン酸3−(1−ジフェニルメチルアゼチジン−3−イル)エステル5−イソプロピルエステル}の製造方法 |
LT2797416T (lt) | 2011-12-28 | 2017-10-25 | Global Blood Therapeutics, Inc. | Pakeistieji benzaldehido junginiai ir jų panaudojimo būdai, didinant audinių aprūpinimą deguonimi |
ES2790358T3 (es) | 2011-12-28 | 2020-10-27 | Global Blood Therapeutics Inc | Compuestos de heteroaril aldehído sustituido y métodos para su uso en el aumento de la oxigenación tisular |
MX2015011445A (es) | 2013-03-15 | 2016-04-20 | Global Blood Therapeutics Inc | Compuestos y usos de estos para la modulacion de la hemoglobina. |
US9802900B2 (en) | 2013-03-15 | 2017-10-31 | Global Blood Therapeutics, Inc. | Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin |
WO2014145040A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation |
US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US20140274961A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
AU2014237348C1 (en) | 2013-03-15 | 2019-02-07 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
KR20150132146A (ko) | 2013-03-15 | 2015-11-25 | 글로벌 블러드 테라퓨틱스, 인크. | 헤모글로빈 조정을 위한 화합물 및 이의 용도 |
US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9604999B2 (en) | 2013-03-15 | 2017-03-28 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
JP6458023B2 (ja) | 2013-10-25 | 2019-01-23 | ブループリント メディシンズ コーポレイション | 繊維芽細胞成長因子受容体の阻害剤 |
EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
BR112015032160B1 (pt) | 2014-02-07 | 2021-11-30 | Global Blood Therapeutics, Inc | Ansolvato cristalino de composto, composição e composição farmacêutica |
MA41841A (fr) | 2015-03-30 | 2018-02-06 | Global Blood Therapeutics Inc | Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs |
MA43373A (fr) | 2015-12-04 | 2018-10-10 | Global Blood Therapeutics Inc | Régimes posologiques pour 2-hydroxy-6-((2- (1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)méthoxy)benzaldéhyde |
TWI663160B (zh) | 2016-05-12 | 2019-06-21 | 全球血液治療公司 | 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法 |
TW202332423A (zh) | 2016-10-12 | 2023-08-16 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
WO2020072377A1 (en) | 2018-10-01 | 2020-04-09 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin for the treatment of sickle cell disease |
JP2023509584A (ja) * | 2019-12-13 | 2023-03-09 | ローディア オペレーションズ | ベンゼン誘導体の製造 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
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WO1996006083A1 (en) | 1994-08-24 | 1996-02-29 | Pfizer Pharmaceuticals Inc. | 2-(piperazinyl-1-carbonylmethyl)-1,4-dihydropyridines as bradykinin antagonists |
US6048523A (en) | 1996-02-13 | 2000-04-11 | Global Art Co. Ltd. | Polyester cyclic compounds, their complexes and bonded bodies |
TNSN97037A1 (fr) * | 1996-02-19 | 2005-03-15 | Pfizer | Derives de 1,4 -dihydropyridine, procede pour leur preparation et compositions pharmaceutiques les contenant. |
MX9701245A (es) | 1996-02-19 | 1998-04-30 | Pfizer | Compuestos de 1,4 dihidropiridina. |
JPH11106375A (ja) | 1997-08-18 | 1999-04-20 | Pfizer Pharmaceut Inc | ブラジキニンアンタゴニストとしての光学的に活性な1,4−ジヒドロピリジン化合物 |
DE60001535T2 (de) | 1999-12-10 | 2003-10-02 | Pfizer | Substituierte 1,4-Dihydropyridinverbindungen zur Verwendung als Bradykininantagonisten |
DE60007603T2 (de) | 1999-12-10 | 2004-06-24 | Pfizer Inc. | 5-Ring Heteroarylsubstituierte 1,4-Dihydropyridine als Bradykinin Antagonisten |
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2001
- 2001-07-11 US US09/903,157 patent/US6653313B2/en not_active Expired - Fee Related
- 2001-07-26 AU AU2001270947A patent/AU2001270947A1/en not_active Abandoned
- 2001-07-26 AT AT01949836T patent/ATE312099T1/de not_active IP Right Cessation
- 2001-07-26 DE DE60115661T patent/DE60115661T2/de not_active Expired - Fee Related
- 2001-07-26 CA CA002418908A patent/CA2418908C/en not_active Expired - Fee Related
- 2001-07-26 BR BR0113071-4A patent/BR0113071A/pt not_active IP Right Cessation
- 2001-07-26 ES ES01949836T patent/ES2257422T3/es not_active Expired - Lifetime
- 2001-07-26 JP JP2002518210A patent/JP2004505973A/ja active Pending
- 2001-07-26 EP EP01949836A patent/EP1307449B1/en not_active Expired - Lifetime
- 2001-07-26 MX MXPA03001204A patent/MXPA03001204A/es unknown
- 2001-07-26 AP APAP/P/2001/002238A patent/AP2001002238A0/en unknown
- 2001-07-26 IL IL15322401A patent/IL153224A0/xx unknown
- 2001-07-26 WO PCT/IB2001/001346 patent/WO2002012235A1/en active IP Right Grant
- 2001-07-27 GT GT200100153A patent/GT200100153A/es unknown
- 2001-08-08 PE PE2001000796A patent/PE20020467A1/es not_active Application Discontinuation
- 2001-08-09 SV SV2001000588A patent/SV2003000588A/es not_active Application Discontinuation
- 2001-08-09 AR ARP010103819A patent/AR034555A1/es not_active Application Discontinuation
- 2001-08-09 TN TNTNSN01124A patent/TNSN01124A1/fr unknown
- 2001-08-10 PA PA20018525001A patent/PA8525001A1/es unknown
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- 2002-12-13 CR CR6859A patent/CR6859A/es not_active Application Discontinuation
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AR034555A1 (es) | 2004-03-03 |
CA2418908A1 (en) | 2002-02-14 |
ATE312099T1 (de) | 2005-12-15 |
CR6859A (es) | 2003-11-25 |
SV2003000588A (es) | 2003-01-13 |
AP2001002238A0 (en) | 2001-09-30 |
PA8525001A1 (es) | 2002-08-26 |
TNSN01124A1 (fr) | 2005-11-10 |
JP2004505973A (ja) | 2004-02-26 |
IL153224A0 (en) | 2003-07-06 |
GT200100153A (es) | 2002-07-03 |
EP1307449A1 (en) | 2003-05-07 |
BR0113071A (pt) | 2003-07-01 |
CA2418908C (en) | 2006-05-09 |
MXPA03001204A (es) | 2003-06-30 |
ES2257422T3 (es) | 2006-08-01 |
IS6639A (is) | 2002-11-28 |
US20020161006A1 (en) | 2002-10-31 |
AU2001270947A1 (en) | 2002-02-18 |
US6653313B2 (en) | 2003-11-25 |
WO2002012235A1 (en) | 2002-02-14 |
EP1307449B1 (en) | 2005-12-07 |
DE60115661T2 (de) | 2006-08-24 |
DE60115661D1 (de) | 2006-01-12 |
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