IL153224A0 - 1,4-dihydropyridines as bradykinin antagonists - Google Patents

1,4-dihydropyridines as bradykinin antagonists

Info

Publication number
IL153224A0
IL153224A0 IL15322401A IL15322401A IL153224A0 IL 153224 A0 IL153224 A0 IL 153224A0 IL 15322401 A IL15322401 A IL 15322401A IL 15322401 A IL15322401 A IL 15322401A IL 153224 A0 IL153224 A0 IL 153224A0
Authority
IL
Israel
Prior art keywords
dihydropyridines
bradykinin antagonists
bradykinin
antagonists
Prior art date
Application number
IL15322401A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL153224A0 publication Critical patent/IL153224A0/xx

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Animal Behavior & Ethology (AREA)
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  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
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  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
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  • Immunology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
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IL15322401A 2000-08-10 2001-07-26 1,4-dihydropyridines as bradykinin antagonists IL153224A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22455800P 2000-08-10 2000-08-10
PCT/IB2001/001346 WO2002012235A1 (en) 2000-08-10 2001-07-26 1,4-dihydropyridines as bradykinin antagonists

Publications (1)

Publication Number Publication Date
IL153224A0 true IL153224A0 (en) 2003-07-06

Family

ID=22841188

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15322401A IL153224A0 (en) 2000-08-10 2001-07-26 1,4-dihydropyridines as bradykinin antagonists

Country Status (21)

Country Link
US (1) US6653313B2 (es)
EP (1) EP1307449B1 (es)
JP (1) JP2004505973A (es)
AP (1) AP2001002238A0 (es)
AR (1) AR034555A1 (es)
AT (1) ATE312099T1 (es)
AU (1) AU2001270947A1 (es)
BR (1) BR0113071A (es)
CA (1) CA2418908C (es)
CR (1) CR6859A (es)
DE (1) DE60115661T2 (es)
ES (1) ES2257422T3 (es)
GT (1) GT200100153A (es)
IL (1) IL153224A0 (es)
IS (1) IS6639A (es)
MX (1) MXPA03001204A (es)
PA (1) PA8525001A1 (es)
PE (1) PE20020467A1 (es)
SV (1) SV2003000588A (es)
TN (1) TNSN01124A1 (es)
WO (1) WO2002012235A1 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10111843A1 (de) * 2001-03-13 2002-09-19 Boehringer Ingelheim Pharma Verbindungen zur Behandlung von inflammatorischen Erkrankungen
SI1545548T1 (sl) * 2002-08-30 2010-11-30 Nycomed Gmbh Uporaba kombinacije ciklezonida in antihistaminikov za zdravljenje alergijskega rinitisa
KR101260497B1 (ko) * 2003-01-24 2013-09-12 엘란 파마슈티칼스, 인크. 수초재생제의 투여에 의한 탈수초성 질환 및 마비의 치료 및 조성물
WO2006071775A2 (en) * 2004-12-29 2006-07-06 Elan Pharmaceuticals, Inc. Novel compounds useful for bradykinin b1 receptor antagonism
CA2727199C (en) * 2008-06-09 2016-11-22 Bayer Schering Pharma Aktiengesellschaft Annellated 4-(indazolyl)-1,4-dihydropyridine derivatives and methods of use thereof
WO2010127381A1 (en) * 2009-05-08 2010-11-11 James Cook University Diagnosis, monitoring, prognosis, prevention and treatment of aneurysms
JP5637710B2 (ja) * 2010-03-24 2014-12-10 株式会社トクヤマ ｛２−アミノ−１，４−ジヒドロ−６−メチル−４−（３−ニトロフェニル）−３，５−ピリジンジカルボン酸３−（１−ジフェニルメチルアゼチジン−３−イル）エステル５−イソプロピルエステル｝の製造方法
US9012450B2 (en) 2011-12-28 2015-04-21 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
EP4289813A3 (en) 2011-12-28 2024-05-15 Global Blood Therapeutics, Inc. Intermediates to obtain substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation
PE20161035A1 (es) 2013-03-15 2016-11-13 Global Blood Therapeutics Inc Compuestos y usos de estos para la modulacion de la hemoglobina
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
EP3919056A1 (en) 2013-03-15 2021-12-08 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
EP2968299B1 (en) 2013-03-15 2021-01-20 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US20140274961A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
US10100043B2 (en) 2013-03-15 2018-10-16 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
JP6458023B2 (ja) 2013-10-25 2019-01-23 ブループリント メディシンズ コーポレイション 繊維芽細胞成長因子受容体の阻害剤
EA202092627A1 (ru) 2013-11-18 2021-09-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
DK3102208T3 (da) 2014-02-07 2021-03-08 Global Blood Therapeutics Inc Krystallinsk polymorf af den frie base af 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyd
MA41841A (fr) 2015-03-30 2018-02-06 Global Blood Therapeutics Inc Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
SG11201804647TA (en) 2015-12-04 2018-06-28 Global Blood Therapeutics Inc Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
TWI825524B (zh) 2016-05-12 2023-12-11 美商全球血液治療公司 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法
TWI778983B (zh) 2016-10-12 2022-10-01 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
US11014884B2 (en) 2018-10-01 2021-05-25 Global Blood Therapeutics, Inc. Modulators of hemoglobin
CN114867702A (zh) * 2019-12-13 2022-08-05 罗地亚经营管理公司 苯衍生物的生产

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996006083A1 (en) 1994-08-24 1996-02-29 Pfizer Pharmaceuticals Inc. 2-(piperazinyl-1-carbonylmethyl)-1,4-dihydropyridines as bradykinin antagonists
WO1997030042A1 (en) 1996-02-13 1997-08-21 Global Art Co. Ltd. Polyester cyclic compounds, their complexes and bonded bodies
MX9701245A (es) 1996-02-19 1998-04-30 Pfizer Compuestos de 1,4 dihidropiridina.
TNSN97037A1 (fr) * 1996-02-19 2005-03-15 Pfizer Derives de 1,4 -dihydropyridine, procede pour leur preparation et compositions pharmaceutiques les contenant.
JPH11106375A (ja) 1997-08-18 1999-04-20 Pfizer Pharmaceut Inc ブラジキニンアンタゴニストとしての光学的に活性な１，４−ジヒドロピリジン化合物
ATE233760T1 (de) 1999-12-10 2003-03-15 Pfizer Substituierte 1,4-dihydropyridinverbindungen zur verwendung als bradykininantagonisten
DK1106614T3 (da) 1999-12-10 2004-04-13 Pfizer 5-leddede, heteroarylsubstituerede 1,4-dihydropyridinforbindelser som bradykininantagonister

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EP1307449A1 (en) 2003-05-07
CR6859A (es) 2003-11-25
AR034555A1 (es) 2004-03-03
CA2418908C (en) 2006-05-09
CA2418908A1 (en) 2002-02-14
PE20020467A1 (es) 2002-06-14
TNSN01124A1 (fr) 2005-11-10
EP1307449B1 (en) 2005-12-07
DE60115661T2 (de) 2006-08-24
JP2004505973A (ja) 2004-02-26
PA8525001A1 (es) 2002-08-26
IS6639A (is) 2002-11-28
BR0113071A (pt) 2003-07-01
US20020161006A1 (en) 2002-10-31
GT200100153A (es) 2002-07-03
MXPA03001204A (es) 2003-06-30
AU2001270947A1 (en) 2002-02-18
US6653313B2 (en) 2003-11-25
WO2002012235A1 (en) 2002-02-14
ATE312099T1 (de) 2005-12-15
AP2001002238A0 (en) 2001-09-30
SV2003000588A (es) 2003-01-13
ES2257422T3 (es) 2006-08-01
DE60115661D1 (de) 2006-01-12

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