DE60115661D1 - 1,4-dihydropyridine als bradykininantagonisten - Google Patents

1,4-dihydropyridine als bradykininantagonisten

Info

Publication number
DE60115661D1
DE60115661D1 DE60115661T DE60115661T DE60115661D1 DE 60115661 D1 DE60115661 D1 DE 60115661D1 DE 60115661 T DE60115661 T DE 60115661T DE 60115661 T DE60115661 T DE 60115661T DE 60115661 D1 DE60115661 D1 DE 60115661D1
Authority
DE
Germany
Prior art keywords
dihydropyridines
bradykinin antagonists
bradykinin
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60115661T
Other languages
English (en)
Other versions
DE60115661T2 (de
Inventor
Takafumi Ikeda
Tomoki Kato
Yasuhiro Katsu
Makoto Kawai
Mitsuhiro Kawamura
Yuji Shishido
Noriaki Murase
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Japan Inc
Original Assignee
Pfizer Pharmaceuticals KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Pharmaceuticals KK filed Critical Pfizer Pharmaceuticals KK
Publication of DE60115661D1 publication Critical patent/DE60115661D1/de
Application granted granted Critical
Publication of DE60115661T2 publication Critical patent/DE60115661T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • C—CHEMISTRY; METALLURGY
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
DE60115661T 2000-08-10 2001-07-26 1,4-dihydropyridine als bradykininantagonisten Expired - Fee Related DE60115661T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22455800P 2000-08-10 2000-08-10
US224558P 2000-08-10
PCT/IB2001/001346 WO2002012235A1 (en) 2000-08-10 2001-07-26 1,4-dihydropyridines as bradykinin antagonists

Publications (2)

Publication Number Publication Date
DE60115661D1 true DE60115661D1 (de) 2006-01-12
DE60115661T2 DE60115661T2 (de) 2006-08-24

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DE60115661T Expired - Fee Related DE60115661T2 (de) 2000-08-10 2001-07-26 1,4-dihydropyridine als bradykininantagonisten

Country Status (21)

Country Link
US (1) US6653313B2 (de)
EP (1) EP1307449B1 (de)
JP (1) JP2004505973A (de)
AP (1) AP2001002238A0 (de)
AR (1) AR034555A1 (de)
AT (1) ATE312099T1 (de)
AU (1) AU2001270947A1 (de)
BR (1) BR0113071A (de)
CA (1) CA2418908C (de)
CR (1) CR6859A (de)
DE (1) DE60115661T2 (de)
ES (1) ES2257422T3 (de)
GT (1) GT200100153A (de)
IL (1) IL153224A0 (de)
IS (1) IS6639A (de)
MX (1) MXPA03001204A (de)
PA (1) PA8525001A1 (de)
PE (1) PE20020467A1 (de)
SV (1) SV2003000588A (de)
TN (1) TNSN01124A1 (de)
WO (1) WO2002012235A1 (de)

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JP5637710B2 (ja) * 2010-03-24 2014-12-10 株式会社トクヤマ ｛２−アミノ−１，４−ジヒドロ−６−メチル−４−（３−ニトロフェニル）−３，５−ピリジンジカルボン酸３−（１−ジフェニルメチルアゼチジン−３−イル）エステル５−イソプロピルエステル｝の製造方法
WO2013102145A1 (en) 2011-12-28 2013-07-04 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
SI3141542T1 (sl) 2011-12-28 2020-11-30 Global Blood Therapeutics, Inc. Substituirane spojine benzaldehida in metode njihove uporabe pri povečanju oksigenacije tkiva
CN105073728A (zh) 2013-03-15 2015-11-18 全球血液疗法股份有限公司 化合物及其用于调节血红蛋白的用途
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KR101971385B1 (ko) 2013-03-15 2019-04-22 글로벌 블러드 테라퓨틱스, 인크. 헤모글로빈 조정을 위한 화합물 및 이의 용도
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
EP3060560A1 (de) 2013-10-25 2016-08-31 Blueprint Medicines Corporation Inhibitoren des fibroblastenwachstumsfaktor-rezeptors
EA202092627A1 (ru) 2013-11-18 2021-09-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
EA028529B1 (ru) 2014-02-07 2017-11-30 Глобал Блад Терапьютикс, Инк. Кристаллические полиморфные формы свободного основания 2-гидрокси-6-((2-(1-изопропил-1н-пиразол-5-ил)пиридин-3-ил)метокси)бензальдегида
MA41841A (fr) 2015-03-30 2018-02-06 Global Blood Therapeutics Inc Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
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TWI778983B (zh) 2016-10-12 2022-10-01 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
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TNSN97037A1 (fr) * 1996-02-19 2005-03-15 Pfizer Derives de 1,4 -dihydropyridine, procede pour leur preparation et compositions pharmaceutiques les contenant.
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WO2002012235A1 (en) 2002-02-14
CA2418908C (en) 2006-05-09
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JP2004505973A (ja) 2004-02-26
IL153224A0 (en) 2003-07-06
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TNSN01124A1 (fr) 2005-11-10
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CR6859A (es) 2003-11-25
IS6639A (is) 2002-11-28
EP1307449B1 (de) 2005-12-07
AU2001270947A1 (en) 2002-02-18
US20020161006A1 (en) 2002-10-31
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SV2003000588A (es) 2003-01-13
ATE312099T1 (de) 2005-12-15
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