ATE540042T1 - Annelierte 4-(indazolyl)-1,4- dihydropyridinderivate als c-met-mediatoren - Google Patents

Annelierte 4-(indazolyl)-1,4- dihydropyridinderivate als c-met-mediatoren

Info

Publication number
ATE540042T1
ATE540042T1 AT09761399T AT09761399T ATE540042T1 AT E540042 T1 ATE540042 T1 AT E540042T1 AT 09761399 T AT09761399 T AT 09761399T AT 09761399 T AT09761399 T AT 09761399T AT E540042 T1 ATE540042 T1 AT E540042T1
Authority
AT
Austria
Prior art keywords
met
indazolyl
annated
mediators
dihydropyridine derivatives
Prior art date
Application number
AT09761399T
Other languages
English (en)
Inventor
Martin Michels
Markus Follmann
Alexandros Vakalopoulos
Katja Zimmermann
Nicole Teusch
Karen Engel
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Application granted granted Critical
Publication of ATE540042T1 publication Critical patent/ATE540042T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT09761399T 2008-06-09 2009-05-29 Annelierte 4-(indazolyl)-1,4- dihydropyridinderivate als c-met-mediatoren ATE540042T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08010423 2008-06-09
PCT/EP2009/003837 WO2009149836A1 (en) 2008-06-09 2009-05-29 Annellated 4- (indazolyl) -1,4-dihydropyridine derivatives and methods of use thereof

Publications (1)

Publication Number Publication Date
ATE540042T1 true ATE540042T1 (de) 2012-01-15

Family

ID=40933643

Family Applications (1)

Application Number Title Priority Date Filing Date
AT09761399T ATE540042T1 (de) 2008-06-09 2009-05-29 Annelierte 4-(indazolyl)-1,4- dihydropyridinderivate als c-met-mediatoren

Country Status (7)

Country Link
US (1) US8642595B2 (de)
EP (1) EP2300482B1 (de)
JP (1) JP5480891B2 (de)
AT (1) ATE540042T1 (de)
CA (1) CA2727199C (de)
ES (1) ES2377809T3 (de)
WO (1) WO2009149836A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2767476A1 (en) 2009-07-10 2011-01-13 Bayer Pharma Aktiengesellschaft Indazolyl-substituted dihydroisoxazolopyridines and methods of use thereof
DE102009056886A1 (de) * 2009-12-03 2011-06-09 Bayer Schering Pharma Aktiengesellschaft cMet-Inhibitoren zur Behandlung der Endometriose
EP2649065A1 (de) 2010-12-09 2013-10-16 Amgen Inc. Bicyclische verbindungen als pim-inhibitoren
JP2014510105A (ja) 2011-03-22 2014-04-24 アムジエン・インコーポレーテツド Ｐｉｍ阻害剤としてのアゾール化合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6653313B2 (en) * 2000-08-10 2003-11-25 Warner-Lambert Company Llc 1,4-dihydropyridine compounds as bradykinin antagonists
GB2392910A (en) * 2002-09-10 2004-03-17 Bayer Ag 2-Oxopyrimidine derivatives and their use as human leukocyte elastase inhibitors
BR0314186A (pt) * 2002-09-10 2005-08-09 Bayer Healthcare Ag Derivados de pirimidinona como agentes terapêuticos contra processos inflamatórios, isquêmicos e remodeladores, agudos e crÈnicos
EP1730121B1 (de) * 2004-02-26 2013-08-07 Bayer Intellectual Property GmbH 1,4-diaryldihydropyrimidin-2-one und deren verwendung als inhibitoren der humanen neutrophilen elastase
JP4825194B2 (ja) * 2004-02-26 2011-11-30 バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト １，４−ジアリール−ジヒドロピリミジン−２−オン化合物およびヒト好中球エラスターゼ阻害剤としてのそれらの使用
AU2007224020A1 (en) * 2006-03-07 2007-09-13 Array Biopharma Inc. Heterobicyclic pyrazole compounds and methods of use
RU2008145225A (ru) * 2006-04-19 2010-05-27 Новартис АГ (CH) Соединения индазола и способы ингибирования cd7
SG177200A1 (en) * 2006-12-14 2012-01-30 Bayer Schering Pharma Ag Dihydropyridine derivatives useful as protein kinase inhibitors

Also Published As

Publication number Publication date
JP5480891B2 (ja) 2014-04-23
US8642595B2 (en) 2014-02-04
EP2300482A1 (de) 2011-03-30
CA2727199C (en) 2016-11-22
ES2377809T3 (es) 2012-04-02
EP2300482B1 (de) 2012-01-04
CA2727199A1 (en) 2009-12-17
US20110172221A1 (en) 2011-07-14
WO2009149836A1 (en) 2009-12-17
JP2011524348A (ja) 2011-09-01

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