ATE538114T1 - 4-(pyridin-4-yl)-1h-ä1,3,5ütriazin-2-onderivate als gsk3-beta-inhibitoren zur behandlung neurodegenerativer krankheiten - Google Patents

4-(pyridin-4-yl)-1h-ä1,3,5ütriazin-2-onderivate als gsk3-beta-inhibitoren zur behandlung neurodegenerativer krankheiten

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Publication number
ATE538114T1
ATE538114T1 AT09769671T AT09769671T ATE538114T1 AT E538114 T1 ATE538114 T1 AT E538114T1 AT 09769671 T AT09769671 T AT 09769671T AT 09769671 T AT09769671 T AT 09769671T AT E538114 T1 ATE538114 T1 AT E538114T1
Authority
AT
Austria
Prior art keywords
5utriazine
pyridine
derivatives
treatment
neurodegenerative diseases
Prior art date
Application number
AT09769671T
Other languages
English (en)
Inventor
Alistair Lochead
Mourad Saady
Philippe Yaiche
Original Assignee
Mitsubishi Tanabe Pharma Corp
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corp, Sanofi Sa filed Critical Mitsubishi Tanabe Pharma Corp
Application granted granted Critical
Publication of ATE538114T1 publication Critical patent/ATE538114T1/de

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
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    • A61P35/00—Antineoplastic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
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  • Tropical Medicine & Parasitology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
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  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
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  • Epidemiology (AREA)
AT09769671T 2008-06-26 2009-06-25 4-(pyridin-4-yl)-1h-ä1,3,5ütriazin-2-onderivate als gsk3-beta-inhibitoren zur behandlung neurodegenerativer krankheiten ATE538114T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08290617A EP2138488A1 (de) 2008-06-26 2008-06-26 4-(Pyridin-4-yl)-1H-[1,3,5]Triazin-2-one-Verbindungen als GSK3-beta Hemmer zur Behandlung neurodegenerative Erkrankungen
PCT/IB2009/006463 WO2009156860A2 (en) 2008-06-26 2009-06-25 Substituted triazinone derivatives

Publications (1)

Publication Number Publication Date
ATE538114T1 true ATE538114T1 (de) 2012-01-15

Family

ID=39832570

Family Applications (1)

Application Number Title Priority Date Filing Date
AT09769671T ATE538114T1 (de) 2008-06-26 2009-06-25 4-(pyridin-4-yl)-1h-ä1,3,5ütriazin-2-onderivate als gsk3-beta-inhibitoren zur behandlung neurodegenerativer krankheiten

Country Status (23)

Country Link
US (1) US8592580B2 (de)
EP (2) EP2138488A1 (de)
JP (1) JP5581318B2 (de)
KR (1) KR20110025219A (de)
CN (1) CN102137854A (de)
AR (1) AR072227A1 (de)
AT (1) ATE538114T1 (de)
AU (1) AU2009263846A1 (de)
BR (1) BRPI0914662A2 (de)
CA (1) CA2729115A1 (de)
CY (1) CY1112642T1 (de)
DK (1) DK2321295T3 (de)
EA (1) EA201170095A1 (de)
ES (1) ES2379220T3 (de)
IL (1) IL210174A0 (de)
MX (1) MX2010014235A (de)
NZ (1) NZ590116A (de)
PL (1) PL2321295T3 (de)
PT (1) PT2321295E (de)
SI (1) SI2321295T1 (de)
TW (1) TW201004935A (de)
WO (1) WO2009156860A2 (de)
ZA (1) ZA201100026B (de)

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EP2138495A1 (de) * 2008-06-26 2009-12-30 sanofi-aventis Substituierte Pyrimido[2,1-a]isochinolin-4-on-Derivate
EP2138485A1 (de) * 2008-06-26 2009-12-30 sanofi-aventis Substituierte N-Oxid-Pyrazin-Derivate
EP2138494A1 (de) * 2008-06-26 2009-12-30 Sanofi-Aventis Substituierte Alkylpyrimidin-4-one-Derivate
EP2138492A1 (de) * 2008-06-26 2009-12-30 Sanofi-Aventis Substituierte Pyrimidin-4-one-Derivate
EP2138493A1 (de) * 2008-06-26 2009-12-30 Sanofi-Aventis Substituierte Pyrimidon-Derivate
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (de) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridin-4-carbonsäureamidderivate als kinaseinhibitoren
MX353470B (es) * 2012-03-30 2018-01-15 Nissan Chemical Ind Ltd Compuesto de triazinona e inhibidor de canal de calcio tipo t.
JP6378171B2 (ja) 2012-04-24 2018-08-22 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Ｄｎａ−ｐｋ阻害剤
SI3527563T1 (sl) 2013-03-12 2022-01-31 Vertex Pharmaceuticals Incorporated Inhibitorji DNA-PK
RU2675270C2 (ru) 2013-10-17 2018-12-18 Вертекс Фармасьютикалз Инкорпорейтед Сокристаллы и содержащие их фармацевтические композиции
TWI651310B (zh) * 2014-02-20 2019-02-21 日商日本煙草產業股份有限公司 三化合物及其醫藥用途
EP3154953B1 (de) * 2014-06-13 2018-04-04 Fondazione Istituto Italiano di Tecnologia Duale hemmerverbindungen zur verwendung bei der behandlung von neurodegenerativen erkrankungen und morbus alzheimer
PE20180951A1 (es) * 2015-08-17 2018-06-11 Japan Tobacco Inc Compuestos de hidroxitriazina y usos medicos de los mismos
RU2758669C2 (ru) 2016-09-27 2021-11-01 Вертекс Фармасьютикалз Инкорпорейтед Способ лечения рака с применением сочетания днк-поражающих агентов и ингибиторов днк-пк
CN115087643B (zh) * 2021-01-15 2023-10-27 中国医药研究开发中心有限公司 稠和杂环类化合物及其制备方法和医药用途

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EP2138485A1 (de) 2008-06-26 2009-12-30 sanofi-aventis Substituierte N-Oxid-Pyrazin-Derivate
EP2138492A1 (de) 2008-06-26 2009-12-30 Sanofi-Aventis Substituierte Pyrimidin-4-one-Derivate
EP2138495A1 (de) 2008-06-26 2009-12-30 sanofi-aventis Substituierte Pyrimido[2,1-a]isochinolin-4-on-Derivate
EP2138494A1 (de) 2008-06-26 2009-12-30 Sanofi-Aventis Substituierte Alkylpyrimidin-4-one-Derivate

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US20110144114A1 (en) 2011-06-16
KR20110025219A (ko) 2011-03-09
EP2321295A2 (de) 2011-05-18
ES2379220T3 (es) 2012-04-23
SI2321295T1 (sl) 2012-04-30
CY1112642T1 (el) 2016-02-10
AU2009263846A1 (en) 2009-12-30
JP2011525905A (ja) 2011-09-29
PL2321295T3 (pl) 2012-06-29
EA201170095A1 (ru) 2011-08-30
EP2138488A1 (de) 2009-12-30
DK2321295T3 (da) 2012-04-10
CN102137854A (zh) 2011-07-27
BRPI0914662A2 (pt) 2015-10-20
IL210174A0 (en) 2011-03-31
MX2010014235A (es) 2011-06-24
AR072227A1 (es) 2010-08-11
WO2009156860A3 (en) 2010-03-04
PT2321295E (pt) 2012-03-23
CA2729115A1 (en) 2009-12-30
ZA201100026B (en) 2012-04-25
US8592580B2 (en) 2013-11-26
TW201004935A (en) 2010-02-01
WO2009156860A2 (en) 2009-12-30
JP5581318B2 (ja) 2014-08-27
EP2321295B1 (de) 2011-12-21
NZ590116A (en) 2011-10-28

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