DK2987791T3 - 3-(4-(Benzyloxy)phenyl)hex-4-insyre-derivat, egnet til forebyggelse og behandling af metaboliske sygdomme - Google Patents
3-(4-(Benzyloxy)phenyl)hex-4-insyre-derivat, egnet til forebyggelse og behandling af metaboliske sygdomme Download PDFInfo
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- DK2987791T3 DK2987791T3 DK14786040.7T DK14786040T DK2987791T3 DK 2987791 T3 DK2987791 T3 DK 2987791T3 DK 14786040 T DK14786040 T DK 14786040T DK 2987791 T3 DK2987791 T3 DK 2987791T3
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- Prior art keywords
- acid
- benzyloxy
- hex
- phenyl
- prevention
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- 239000002253 acid Substances 0.000 title 2
- -1 4- (Benzyloxy) phenyl Chemical group 0.000 title 1
- 208000030159 metabolic disease Diseases 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Indole Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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KR20130043100 | 2013-04-18 | ||
KR1020140045343A KR101569522B1 (ko) | 2013-04-18 | 2014-04-16 | 신규한 3-(4-(벤질옥시)페닐)헥스-4-이노익 산 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 대사성 질환의 예방 또는 치료용 약학적 조성물 |
PCT/KR2014/003355 WO2014171762A1 (ko) | 2013-04-18 | 2014-04-17 | 신규한 3-(4-(벤질옥시)페닐)헥스-4-이노익 산 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 대사성 질환의 예방 또는 치료용 약학적 조성물 |
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DK2987791T3 true DK2987791T3 (da) | 2019-10-14 |
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DK14786040.7T DK2987791T3 (da) | 2013-04-18 | 2014-04-17 | 3-(4-(Benzyloxy)phenyl)hex-4-insyre-derivat, egnet til forebyggelse og behandling af metaboliske sygdomme |
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US (1) | US9969723B2 (da) |
EP (1) | EP2987791B1 (da) |
JP (2) | JP6174784B2 (da) |
KR (1) | KR101569522B1 (da) |
CN (1) | CN105121423B (da) |
AU (1) | AU2014254555B2 (da) |
BR (1) | BR112015025072B1 (da) |
CA (1) | CA2908398C (da) |
DK (1) | DK2987791T3 (da) |
ES (1) | ES2745746T3 (da) |
HK (1) | HK1214822A1 (da) |
MX (1) | MX367769B (da) |
PL (1) | PL2987791T3 (da) |
PT (1) | PT2987791T (da) |
RU (1) | RU2628077C2 (da) |
WO (1) | WO2014171762A1 (da) |
Families Citing this family (14)
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EA201690888A1 (ru) * | 2013-11-14 | 2016-10-31 | Кадила Хелзкэр Лимитед | Новые гетероциклические соединения |
CN111423408A (zh) | 2014-10-17 | 2020-07-17 | 现代药品株式会社 | 代谢性疾病的预防或治疗用复合制剂 |
CN109516914A (zh) * | 2017-09-20 | 2019-03-26 | 华东师范大学 | 苯丙炔酸类小分子有机化合物及其合成方法和用途 |
SG11202004891PA (en) * | 2017-12-01 | 2020-06-29 | Hyundai Pharm Co Ltd | Novel use of 3-(4-(benzyloxy)phenyl)hex-4-inoic acid derivative |
CN110092774B (zh) * | 2018-01-29 | 2022-04-08 | 中国科学院上海药物研究所 | 芳香丙酸类衍生物、及其制备方法和用途 |
PE20210640A1 (es) | 2018-02-13 | 2021-03-23 | Gilead Sciences Inc | Inhibidores pd-1/pd-l1 |
TWI712412B (zh) | 2018-04-19 | 2020-12-11 | 美商基利科學股份有限公司 | Pd‐1/pd‐l1抑制劑 |
ES2962674T3 (es) | 2018-07-13 | 2024-03-20 | Gilead Sciences Inc | Inhibidores PD-1/PD-L1 |
CN112955435B (zh) | 2018-10-24 | 2024-09-06 | 吉利德科学公司 | Pd-1/pd-l1抑制剂 |
JP7297199B2 (ja) | 2019-02-04 | 2023-06-26 | 美里工業株式会社 | 電動格納式車両用周辺視認装置 |
MX2021014751A (es) * | 2019-05-31 | 2022-01-18 | Hyundai Pharm Co Ltd | Forma cristalina novedosa de derivado de acido 3-(4-(benciloxi)fenil)hex-4-inoico. |
KR102270026B1 (ko) * | 2020-01-31 | 2021-06-28 | 현대약품 주식회사 | (3s)-3-(4-(3-(1,4-다이옥사스파이로[4,5]데스-7-엔-8-일)벤질옥시)페닐)헥스-4-이노익산의 품질 평가 방법 |
CN116829542A (zh) * | 2021-01-29 | 2023-09-29 | 韩国化学研究院 | 苯并噻唑及苯并咪唑衍生物、药学上可接受的盐、其制备方法以及包含其作为活性成分的药物组合物 |
KR102699076B1 (ko) * | 2021-04-01 | 2024-08-27 | 현대약품 주식회사 | 3-(4-(벤질옥시)페닐)헥스-4-이노익산 유도체의 신규 용도 |
Family Cites Families (12)
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DE69941777D1 (de) | 1998-03-10 | 2010-01-21 | Ono Pharmaceutical Co | Carbonsäurederivate und medikamente die diese als aktiven wirkstoff enthalten |
GB0214149D0 (en) | 2002-06-19 | 2002-07-31 | Glaxo Group Ltd | Chemical compounds |
EP1737809B1 (en) * | 2004-02-27 | 2013-09-18 | Amgen, Inc | Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders |
JP4859665B2 (ja) | 2004-03-30 | 2012-01-25 | 武田薬品工業株式会社 | アルコキシフェニルプロパン酸誘導体 |
US7687526B2 (en) * | 2006-09-07 | 2010-03-30 | Amgen Inc. | Benzo-fused compounds for use in treating metabolic disorders |
CA2662305C (en) * | 2006-09-07 | 2012-04-17 | Amgen Inc. | Heterocyclic gpr40 modulators |
JP2010524932A (ja) * | 2007-04-16 | 2010-07-22 | アムジエン・インコーポレーテツド | 置換ビフェニルフェノキシ−、チオフェニル−及びアミノフェニルプロパン酸gpr40調節物質 |
WO2009048527A1 (en) * | 2007-10-10 | 2009-04-16 | Amgen Inc. | Substituted biphenyl gpr40 modulators |
WO2009054479A1 (ja) * | 2007-10-26 | 2009-04-30 | Japan Tobacco Inc. | スピロ環化合物及びその医薬用途 |
CA2716352C (en) * | 2008-03-06 | 2013-05-28 | Amgen Inc. | Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders |
AR078522A1 (es) * | 2009-10-15 | 2011-11-16 | Lilly Co Eli | Compuesto de espiropiperidina, composicion farmaceutica que lo comprende, su uso para preparar un medicamento util para tratar diabetes y compuesto intermediario para su sintesis |
EA201690888A1 (ru) * | 2013-11-14 | 2016-10-31 | Кадила Хелзкэр Лимитед | Новые гетероциклические соединения |
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2014
- 2014-04-16 KR KR1020140045343A patent/KR101569522B1/ko active IP Right Grant
- 2014-04-17 PL PL14786040T patent/PL2987791T3/pl unknown
- 2014-04-17 ES ES14786040T patent/ES2745746T3/es active Active
- 2014-04-17 WO PCT/KR2014/003355 patent/WO2014171762A1/ko active Application Filing
- 2014-04-17 MX MX2015013893A patent/MX367769B/es active IP Right Grant
- 2014-04-17 RU RU2015141278A patent/RU2628077C2/ru active
- 2014-04-17 BR BR112015025072-6A patent/BR112015025072B1/pt active IP Right Grant
- 2014-04-17 DK DK14786040.7T patent/DK2987791T3/da active
- 2014-04-17 AU AU2014254555A patent/AU2014254555B2/en active Active
- 2014-04-17 CN CN201480019721.5A patent/CN105121423B/zh active Active
- 2014-04-17 PT PT147860407T patent/PT2987791T/pt unknown
- 2014-04-17 JP JP2016508871A patent/JP6174784B2/ja active Active
- 2014-04-17 EP EP14786040.7A patent/EP2987791B1/en active Active
- 2014-04-17 CA CA2908398A patent/CA2908398C/en active Active
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2015
- 2015-10-01 US US14/872,745 patent/US9969723B2/en active Active
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2016
- 2016-03-10 HK HK16102795.5A patent/HK1214822A1/zh unknown
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2017
- 2017-04-07 JP JP2017076799A patent/JP2017149747A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
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RU2628077C2 (ru) | 2017-08-14 |
US20160024063A1 (en) | 2016-01-28 |
WO2014171762A1 (ko) | 2014-10-23 |
CN105121423A (zh) | 2015-12-02 |
JP2017149747A (ja) | 2017-08-31 |
CA2908398A1 (en) | 2014-10-23 |
BR112015025072A2 (pt) | 2017-07-18 |
RU2015141278A (ru) | 2017-05-25 |
KR20140126248A (ko) | 2014-10-30 |
ES2745746T3 (es) | 2020-03-03 |
MX367769B (es) | 2019-09-05 |
CN105121423B (zh) | 2017-06-09 |
AU2014254555A1 (en) | 2015-10-29 |
AU2014254555B2 (en) | 2016-11-10 |
BR112015025072B1 (pt) | 2022-03-15 |
PT2987791T (pt) | 2019-10-24 |
CA2908398C (en) | 2019-01-15 |
PL2987791T3 (pl) | 2020-03-31 |
US9969723B2 (en) | 2018-05-15 |
KR101569522B1 (ko) | 2015-11-17 |
JP6174784B2 (ja) | 2017-08-02 |
EP2987791B1 (en) | 2019-07-17 |
EP2987791A4 (en) | 2016-11-23 |
JP2016518366A (ja) | 2016-06-23 |
EP2987791A1 (en) | 2016-02-24 |
HK1214822A1 (zh) | 2016-08-05 |
MX2015013893A (es) | 2015-12-11 |
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