MX2021014751A - Forma cristalina novedosa de derivado de acido 3-(4-(benciloxi)fenil)hex-4-inoico. - Google Patents

Forma cristalina novedosa de derivado de acido 3-(4-(benciloxi)fenil)hex-4-inoico.

Info

Publication number
MX2021014751A
MX2021014751A MX2021014751A MX2021014751A MX2021014751A MX 2021014751 A MX2021014751 A MX 2021014751A MX 2021014751 A MX2021014751 A MX 2021014751A MX 2021014751 A MX2021014751 A MX 2021014751A MX 2021014751 A MX2021014751 A MX 2021014751A
Authority
MX
Mexico
Prior art keywords
crystal form
benzyloxy
hex
phenyl
acid derivative
Prior art date
Application number
MX2021014751A
Other languages
English (en)
Inventor
Su Kyoung Choi
Jin Woong Kim
Kyu Hwan Lee
Jeong Un Hwang
Eun Young Kim
Original Assignee
Hyundai Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hyundai Pharm Co Ltd filed Critical Hyundai Pharm Co Ltd
Publication of MX2021014751A publication Critical patent/MX2021014751A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se refiere a una forma cristalina novedosa de un derivado de ácido 3-(4-(benciloxi)fenil)hex-4-inoico, un método de preparación para la misma y una composición farmacéutica que comprende la misma. Una forma cristalina I de un compuesto de fórmula química 1, de acuerdo con la presente invención, muestra propiedades fisicoquímicas más excelentes tales como estabilidad térmica, capacidad de inducir electricidad estática, compresibilidad, etc. en comparación con una forma amorfa o una forma cristalina II y, por tanto, es especialmente útil para preparación y almacenamiento a largo plazo.
MX2021014751A 2019-05-31 2020-05-29 Forma cristalina novedosa de derivado de acido 3-(4-(benciloxi)fenil)hex-4-inoico. MX2021014751A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20190064586 2019-05-31
PCT/KR2020/007018 WO2020242252A1 (ko) 2019-05-31 2020-05-29 3-(4-(벤질옥시)페닐)헥스-4-이노익산 유도체의 신규 결정형

Publications (1)

Publication Number Publication Date
MX2021014751A true MX2021014751A (es) 2022-01-18

Family

ID=73552394

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021014751A MX2021014751A (es) 2019-05-31 2020-05-29 Forma cristalina novedosa de derivado de acido 3-(4-(benciloxi)fenil)hex-4-inoico.

Country Status (10)

Country Link
US (1) US20220213051A1 (es)
EP (1) EP3978485A4 (es)
JP (1) JP2022535778A (es)
KR (1) KR102453388B1 (es)
CN (1) CN113906015B (es)
AU (1) AU2020283307A1 (es)
BR (1) BR112021023784A2 (es)
CA (1) CA3139772A1 (es)
MX (1) MX2021014751A (es)
WO (1) WO2020242252A1 (es)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060093564A (ko) * 2005-02-22 2006-08-25 종근당바이오 주식회사 무수 시부트라민 말산염 및 이의 제조 방법
EP2970164B1 (en) * 2013-03-13 2017-05-03 Theravance Biopharma Antibiotics IP, LLC Crystalline form of a substituted thiazolylacetic acid triethylamine salt
KR101569522B1 (ko) 2013-04-18 2015-11-17 현대약품 주식회사 신규한 3-(4-(벤질옥시)페닐)헥스-4-이노익 산 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 대사성 질환의 예방 또는 치료용 약학적 조성물
AU2015331074B2 (en) * 2014-10-17 2018-11-15 Hyundai Pharm Co., Ltd. Composite preparation, containing novel 3-(4-(benzyloxy)phenyl)hex-4-inoic acid derivative and another active ingredient, for preventing or treating metabolic diseases

Also Published As

Publication number Publication date
EP3978485A4 (en) 2023-04-26
CN113906015A (zh) 2022-01-07
EP3978485A1 (en) 2022-04-06
WO2020242252A1 (ko) 2020-12-03
JP2022535778A (ja) 2022-08-10
CN113906015B (zh) 2024-03-01
CA3139772A1 (en) 2020-12-03
KR20200138078A (ko) 2020-12-09
BR112021023784A2 (pt) 2022-01-04
AU2020283307A1 (en) 2022-01-06
US20220213051A1 (en) 2022-07-07
KR102453388B1 (ko) 2022-10-12

Similar Documents

Publication Publication Date Title
PE20090813A1 (es) Inhibidores de la 11b-hidroxiesteroide-deshidrogenasa
MY150980A (en) Method for preparing 5-haloalkyl-4,5-dihydroisoxazole derivatives
TW200635585A (en) Monocyclic substituted methanones
PE20091033A1 (es) Derivados de nicotinamida como agentes anticancerosos y su preparacion
HUP0301463A2 (hu) Eljárás szubsztituált oktanoil-amid-származékok elżállítására, valamint az elżállításhoz alkalmazott közbensż termékek
PE20070829A1 (es) Inhibidores cetp heterociclicos
SG11201901962QA (en) Polymorphic form of kinase inhibitor compound, pharmaceutical composition containing same, and preparation method therefor and use thereof
AR058705A1 (es) Compuestos de bencimidazol como inhibidores del receptor vaniloide 1 (vr1)
WO2010012762A3 (de) Farbstabiler superabsorber
MX2010003849A (es) Antagonistas de cgrp.
MY139454A (en) 4-(aminomethyl)-piperidine benzamides as 5ht4-antagonists
CR20230529A (es) Inhibidores de nlrp3
RS20050806A (en) 4-substituted quinolein derivatives,preparation methods and intermediates and pharmaceutical compositions compraising same
PH12020551892A1 (en) Dienal compound and flavor composition
TW200744453A (en) Fungicidal composition containing carboxylic acid amide derivative
MX2023009045A (es) Derivados novedosos de pirimidin-2-il sulfonamida.
DOP2006000240A (es) Un inhibidor de fosfodiesterasa-4 4-oxo-1-(3-sustituido fenil)-1,4-dihidro-1,8-naftiridin-3-carboxamida y un procedimiento de preparación del mismo
MX2021014751A (es) Forma cristalina novedosa de derivado de acido 3-(4-(benciloxi)fenil)hex-4-inoico.
TW200619201A (en) Process for the preparation of pyrazoles
TW200700419A (en) 5,6-dialkyl-7-aminoazolopyrimidines, their preparation and their use for controlling harmful fungi, and compositions comprising these compounds
MX338663B (es) Compuestos de axido (alcoxi o ariloxi carbonil)-4-metil-6-(2,6,6-t rimetilciclohex-1-enil)hex-2-enoico, su preparacion y uso.
MXPA05008601A (es) Derivados de benzamida como agonistas de oxitocina y antagonistas de vasopresina.
MX2023002429A (es) Derivado de biarilo novedoso util como inhibidor de diacilglicerol aciltransferasa 2 y uso del mismo.
CY1107097T1 (el) 5ht4-ανταγωνιστικα βενζαμιδια 4-( αμινομεθυλ) - πιπεριδινης
MX2022002941A (es) Cristal de derivado de 1,3,5-triazina o solvato del mismo y metodo para producir el mismo.