RS20050806A - 4-substituted quinolein derivatives,preparation methods and intermediates and pharmaceutical compositions compraising same - Google Patents

4-substituted quinolein derivatives,preparation methods and intermediates and pharmaceutical compositions compraising same

Info

Publication number
RS20050806A
RS20050806A YUP-2005/0806A YUP20050806A RS20050806A RS 20050806 A RS20050806 A RS 20050806A YU P20050806 A YUP20050806 A YU P20050806A RS 20050806 A RS20050806 A RS 20050806A
Authority
RS
Serbia
Prior art keywords
substituted
compraising
intermediates
pharmaceutical compositions
same
Prior art date
Application number
YUP-2005/0806A
Other languages
Serbian (sr)
Inventor
Antony Bigot
Michel Cheve
Youssef El Ahmad
Jean-Luc Malleron
Jean-Paul Martin
Serge Mignani
Guy Pantel
Baptiste Ronan
Michel Tabart
Fabrice Viviani
Original Assignee
Aventis Pharma S.A.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma S.A., filed Critical Aventis Pharma S.A.,
Publication of RS20050806A publication Critical patent/RS20050806A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

The invention concerns 4-substituted quinoline derivatives active as antimicrobial agents, of general formula (I), wherein: X1, X2, X3, X4 and X5 respectively represent >C-R'1 to >C-R'5, or not more than one represents N; Y represents CHR, CO, CROH, CRNH2, CRF or CF2, R being hydrogen or alkyl; m is 1, 2, or 3 and n is 0, 1 or 2; Z is CH2 or Z represents O, S, SO, SO2 and, in that case, n is equal to 2; R2 represents -CO2R, -CH2CO2R, -CH2-CH2CO2R, -CH2OH or -CH2-CH2OH, R being as defined above; R3 represents phenyl, heteroaryl or alk-R°3, wherein alk is an alkyl and R°3 represents various groups, optionally oxygenated, sulphured or aminated, in their enantiomeric or diastereoisomeric forms or mixtures thereof, and optionally in their syn or anti forms or mixtures thereof, as well as their salts.
YUP-2005/0806A 2003-03-28 2004-03-29 4-substituted quinolein derivatives,preparation methods and intermediates and pharmaceutical compositions compraising same RS20050806A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0303812A FR2852954B1 (en) 2003-03-28 2003-03-28 QUINOLINE-4-SUBSTITUTED DERIVATIVES, METHODS AND PREPARATION INTERMEDIATES THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
PCT/FR2004/000783 WO2004087647A2 (en) 2003-03-28 2004-03-29 4-substituted quinolein derivatives with antimicrobial activity

Publications (1)

Publication Number Publication Date
RS20050806A true RS20050806A (en) 2007-12-31

Family

ID=32947235

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-2005/0806A RS20050806A (en) 2003-03-28 2004-03-29 4-substituted quinolein derivatives,preparation methods and intermediates and pharmaceutical compositions compraising same

Country Status (13)

Country Link
EP (1) EP1611127A2 (en)
JP (1) JP2006522779A (en)
KR (1) KR20050115321A (en)
CN (1) CN1795191A (en)
AR (1) AR043941A1 (en)
AU (1) AU2004226207A1 (en)
CA (1) CA2520764A1 (en)
EA (1) EA010403B1 (en)
FR (1) FR2852954B1 (en)
HR (1) HRP20050855A2 (en)
RS (1) RS20050806A (en)
TW (1) TW200505899A (en)
WO (1) WO2004087647A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2816618B1 (en) * 2000-11-15 2002-12-27 Aventis Pharma Sa HETEROCYCLYLALCOYL PIPERIDINE DERIVATIVES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM
TW200409637A (en) 2002-06-26 2004-06-16 Glaxo Group Ltd Compounds
TW200406413A (en) 2002-06-26 2004-05-01 Glaxo Group Ltd Compounds
WO2004096982A2 (en) 2002-11-05 2004-11-11 Smithkline Beecham Corporation Antibacterial agents
ES2312839T3 (en) 2002-12-04 2009-03-01 Glaxo Group Limited QUINOLINAS AND ITS NITROGEN DERIVATIVES AND ITS USE AS ANTIBACTERIAL AGENTS.
GB0326148D0 (en) * 2003-11-10 2003-12-17 Lilly Co Eli Morpholine derivatives
JP2008502689A (en) 2004-06-15 2008-01-31 グラクソ　グループ　リミテッド Antibacterial agent
MY150958A (en) * 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
DE602007009205D1 (en) 2006-04-06 2010-10-28 Glaxo Group Ltd PYRROLOCHINOXALINONE DERIVATIVES AS ANTIBACTERIAL AGENTS
EP1992628A1 (en) 2007-05-18 2008-11-19 Glaxo Group Limited Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
EP2080761A1 (en) 2008-01-18 2009-07-22 Glaxo Group Limited Compounds
CA2713187C (en) 2008-02-22 2016-06-07 Actelion Pharmaceuticals Ltd Oxazolidinone derivatives
JP2012505866A (en) 2008-10-17 2012-03-08 グラクソ グループ リミテッド Tricyclic nitrogen compounds used as antibacterial agents
US8318940B2 (en) 2009-01-15 2012-11-27 Glaxo Group Limited Naphthyridin-2 (1 H)-one compounds useful as antibacterials
AR089929A1 (en) 2012-02-10 2014-10-01 Actelion Pharmaceuticals Ltd PROCESS TO MANUFACTURE A NAFTIRIDINE DERIVATIVE
EP3639824A1 (en) 2014-08-22 2020-04-22 GlaxoSmithKline Intellectual Property Development Limited Tricyclic nitrogen containing compounds for treating neisseria gonorrhoea infection
UY36851A (en) 2015-08-16 2017-03-31 Glaxosmithkline Ip Dev Ltd COMPOUNDS FOR USE IN ANTIBACTERIAL APPLICATIONS

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9917408D0 (en) * 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
GB0012240D0 (en) * 2000-05-19 2000-07-12 Merck Sharp & Dohme Therapeutic agents
FR2816618B1 (en) * 2000-11-15 2002-12-27 Aventis Pharma Sa HETEROCYCLYLALCOYL PIPERIDINE DERIVATIVES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM
CA2434205A1 (en) * 2001-01-11 2002-07-18 Dupont Pharmaceuticals Company 1,1-disubstituted cyclic inhibitors of matrix metalloprotease and tnf-.alpha.

Also Published As

Publication number Publication date
EA200501526A1 (en) 2006-04-28
JP2006522779A (en) 2006-10-05
CA2520764A1 (en) 2004-10-14
HRP20050855A2 (en) 2005-12-31
FR2852954B1 (en) 2006-07-14
TW200505899A (en) 2005-02-16
FR2852954A1 (en) 2004-10-01
CN1795191A (en) 2006-06-28
AU2004226207A1 (en) 2004-10-14
WO2004087647A2 (en) 2004-10-14
EP1611127A2 (en) 2006-01-04
WO2004087647A3 (en) 2005-01-27
EA010403B1 (en) 2008-08-29
AR043941A1 (en) 2005-08-17
KR20050115321A (en) 2005-12-07

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