TW200505899A - 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them - Google Patents
4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing themInfo
- Publication number
- TW200505899A TW200505899A TW093107677A TW93107677A TW200505899A TW 200505899 A TW200505899 A TW 200505899A TW 093107677 A TW093107677 A TW 093107677A TW 93107677 A TW93107677 A TW 93107677A TW 200505899 A TW200505899 A TW 200505899A
- Authority
- TW
- Taiwan
- Prior art keywords
- quinoline derivatives
- substituted quinoline
- intermediates
- preparation
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention relates to 4-substituted quinoline derivatives of general formula: , which are active as antimicrobials, in which: X1, X2, X3, X4 and X5 represent >C-R'1 to >C-R'5 respectively, or alternatively at most one represents N, Y represents CHR, CO, CROH, CRNH2 CRF or CF2, R being a hydrogen or alkyl, m is 1,2 or 3 and n is 0, 1 or 2, Z is CH2 or Z represents 0, S, SO, SO2 and, in this case, n is equal to 2, R2 represents -CO2R, -CH2CO2R, -CH2-CH2CO2R, -CH2OH or -CH2-CH2OH, R being as defined above, R3 represents phenyl, heteroaryl or alk-Ro3, where alk is alkyl and Ro3 represents various groups, where appropriate containing oxygen, sulfur or amine, in their enantiomeric or diastereoisomeric forms or their mixtures, and/or where appropriate in the syn or anti form or their mixtures, and their salts.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0303812A FR2852954B1 (en) | 2003-03-28 | 2003-03-28 | QUINOLINE-4-SUBSTITUTED DERIVATIVES, METHODS AND PREPARATION INTERMEDIATES THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Publications (1)
Publication Number | Publication Date |
---|---|
TW200505899A true TW200505899A (en) | 2005-02-16 |
Family
ID=32947235
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW093107677A TW200505899A (en) | 2003-03-28 | 2004-03-22 | 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP1611127A2 (en) |
JP (1) | JP2006522779A (en) |
KR (1) | KR20050115321A (en) |
CN (1) | CN1795191A (en) |
AR (1) | AR043941A1 (en) |
AU (1) | AU2004226207A1 (en) |
CA (1) | CA2520764A1 (en) |
EA (1) | EA010403B1 (en) |
FR (1) | FR2852954B1 (en) |
HR (1) | HRP20050855A2 (en) |
RS (1) | RS20050806A (en) |
TW (1) | TW200505899A (en) |
WO (1) | WO2004087647A2 (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2816618B1 (en) * | 2000-11-15 | 2002-12-27 | Aventis Pharma Sa | HETEROCYCLYLALCOYL PIPERIDINE DERIVATIVES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM |
AR040335A1 (en) | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | CYCLLOHEXAN OR CYCLHEXENE COMPOUND, USE OF THE SAME TO PREPARE A MEDICINAL PRODUCT, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, PROCEDURE AND INTERMEDIATE COMPOUNDS OF UTILITY TO PREPARE SUCH COMPOUND |
AR040336A1 (en) | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | PIPERIDINE COMPOUND, USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND PROCEDURE TO PREPARE SUCH COMPOUND |
DE60331849D1 (en) | 2002-11-05 | 2010-05-06 | Glaxosmithkline Llc | ANTIBACTERIAL ACTIVE SUBSTANCES |
EP1567520B1 (en) | 2002-12-04 | 2008-10-15 | Glaxo Group Limited | Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents |
GB0326148D0 (en) | 2003-11-10 | 2003-12-17 | Lilly Co Eli | Morpholine derivatives |
EP1796466A4 (en) | 2004-06-15 | 2009-09-02 | Glaxo Group Ltd | Antibacterial agents |
MY150958A (en) * | 2005-06-16 | 2014-03-31 | Astrazeneca Ab | Compounds for the treatment of multi-drug resistant bacterial infections |
US7709483B2 (en) | 2006-04-06 | 2010-05-04 | Glaxo Group Limited | Pyrrolo-quinoxalinone derivatives as antibacterials |
EP1992628A1 (en) | 2007-05-18 | 2008-11-19 | Glaxo Group Limited | Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones |
EP2080761A1 (en) | 2008-01-18 | 2009-07-22 | Glaxo Group Limited | Compounds |
JP5404652B2 (en) * | 2008-02-22 | 2014-02-05 | アクテリオン ファーマシューティカルズ リミテッド | Oxazolidinone derivatives |
WO2010043714A1 (en) | 2008-10-17 | 2010-04-22 | Glaxo Group Limited | Tricyclic nitrogen compounds used as antibacterials |
WO2010081874A1 (en) | 2009-01-15 | 2010-07-22 | Glaxo Group Limited | Naphthyridin-2 (1 h)-one compounds useful as antibacterials |
AR089929A1 (en) | 2012-02-10 | 2014-10-01 | Actelion Pharmaceuticals Ltd | PROCESS TO MANUFACTURE A NAFTIRIDINE DERIVATIVE |
KR20170043603A (en) | 2014-08-22 | 2017-04-21 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | Tricyclic nitrogen containing compounds for treating neisseria gonorrhoea infection |
UY36851A (en) | 2015-08-16 | 2017-03-31 | Glaxosmithkline Ip Dev Ltd | COMPOUNDS FOR USE IN ANTIBACTERIAL APPLICATIONS |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9917408D0 (en) * | 1999-07-23 | 1999-09-22 | Smithkline Beecham Plc | Compounds |
GB0012240D0 (en) * | 2000-05-19 | 2000-07-12 | Merck Sharp & Dohme | Therapeutic agents |
FR2816618B1 (en) * | 2000-11-15 | 2002-12-27 | Aventis Pharma Sa | HETEROCYCLYLALCOYL PIPERIDINE DERIVATIVES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM |
EP1355901A2 (en) * | 2001-01-11 | 2003-10-29 | Bristol-Myers Squibb Pharma Company | 1,1-DISUBSTITUTED CYCLIC INHIBITORS OF MATRIX METALLOPROTEASE AND TNF-$g(a) |
-
2003
- 2003-03-28 FR FR0303812A patent/FR2852954B1/en not_active Expired - Fee Related
-
2004
- 2004-03-22 TW TW093107677A patent/TW200505899A/en unknown
- 2004-03-26 AR ARP040101023A patent/AR043941A1/en not_active Application Discontinuation
- 2004-03-29 RS YUP-2005/0806A patent/RS20050806A/en unknown
- 2004-03-29 CN CNA2004800145109A patent/CN1795191A/en active Pending
- 2004-03-29 AU AU2004226207A patent/AU2004226207A1/en not_active Abandoned
- 2004-03-29 CA CA002520764A patent/CA2520764A1/en not_active Abandoned
- 2004-03-29 WO PCT/FR2004/000783 patent/WO2004087647A2/en active Application Filing
- 2004-03-29 EP EP04742385A patent/EP1611127A2/en not_active Withdrawn
- 2004-03-29 JP JP2006505763A patent/JP2006522779A/en active Pending
- 2004-03-29 EA EA200501526A patent/EA010403B1/en not_active IP Right Cessation
- 2004-03-29 KR KR1020057018388A patent/KR20050115321A/en not_active Application Discontinuation
-
2005
- 2005-09-27 HR HR20050855A patent/HRP20050855A2/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EA010403B1 (en) | 2008-08-29 |
FR2852954B1 (en) | 2006-07-14 |
EP1611127A2 (en) | 2006-01-04 |
WO2004087647A3 (en) | 2005-01-27 |
EA200501526A1 (en) | 2006-04-28 |
FR2852954A1 (en) | 2004-10-01 |
RS20050806A (en) | 2007-12-31 |
JP2006522779A (en) | 2006-10-05 |
KR20050115321A (en) | 2005-12-07 |
HRP20050855A2 (en) | 2005-12-31 |
CA2520764A1 (en) | 2004-10-14 |
WO2004087647A2 (en) | 2004-10-14 |
AR043941A1 (en) | 2005-08-17 |
AU2004226207A1 (en) | 2004-10-14 |
CN1795191A (en) | 2006-06-28 |
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