TW200505899A - 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them - Google Patents

4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them

Info

Publication number
TW200505899A
TW200505899A TW093107677A TW93107677A TW200505899A TW 200505899 A TW200505899 A TW 200505899A TW 093107677 A TW093107677 A TW 093107677A TW 93107677 A TW93107677 A TW 93107677A TW 200505899 A TW200505899 A TW 200505899A
Authority
TW
Taiwan
Prior art keywords
quinoline derivatives
substituted quinoline
intermediates
preparation
pharmaceutical compositions
Prior art date
Application number
TW093107677A
Other languages
Chinese (zh)
Inventor
Antony Bigot
Ahmad Youssef El
Jean-Luc Malleron
Jean-Paul Martin
Serge Mignani
Guy Pantel
Baptiste Ronan
Michel Tabart
Michel Cheve
Fabrice Viviani
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of TW200505899A publication Critical patent/TW200505899A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to 4-substituted quinoline derivatives of general formula: , which are active as antimicrobials, in which: X1, X2, X3, X4 and X5 represent >C-R'1 to >C-R'5 respectively, or alternatively at most one represents N, Y represents CHR, CO, CROH, CRNH2 CRF or CF2, R being a hydrogen or alkyl, m is 1,2 or 3 and n is 0, 1 or 2, Z is CH2 or Z represents 0, S, SO, SO2 and, in this case, n is equal to 2, R2 represents -CO2R, -CH2CO2R, -CH2-CH2CO2R, -CH2OH or -CH2-CH2OH, R being as defined above, R3 represents phenyl, heteroaryl or alk-Ro3, where alk is alkyl and Ro3 represents various groups, where appropriate containing oxygen, sulfur or amine, in their enantiomeric or diastereoisomeric forms or their mixtures, and/or where appropriate in the syn or anti form or their mixtures, and their salts.
TW093107677A 2003-03-28 2004-03-22 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them TW200505899A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0303812A FR2852954B1 (en) 2003-03-28 2003-03-28 QUINOLINE-4-SUBSTITUTED DERIVATIVES, METHODS AND PREPARATION INTERMEDIATES THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Publications (1)

Publication Number Publication Date
TW200505899A true TW200505899A (en) 2005-02-16

Family

ID=32947235

Family Applications (1)

Application Number Title Priority Date Filing Date
TW093107677A TW200505899A (en) 2003-03-28 2004-03-22 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them

Country Status (13)

Country Link
EP (1) EP1611127A2 (en)
JP (1) JP2006522779A (en)
KR (1) KR20050115321A (en)
CN (1) CN1795191A (en)
AR (1) AR043941A1 (en)
AU (1) AU2004226207A1 (en)
CA (1) CA2520764A1 (en)
EA (1) EA010403B1 (en)
FR (1) FR2852954B1 (en)
HR (1) HRP20050855A2 (en)
RS (1) RS20050806A (en)
TW (1) TW200505899A (en)
WO (1) WO2004087647A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2816618B1 (en) * 2000-11-15 2002-12-27 Aventis Pharma Sa HETEROCYCLYLALCOYL PIPERIDINE DERIVATIVES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM
AR040335A1 (en) 2002-06-26 2005-03-30 Glaxo Group Ltd CYCLLOHEXAN OR CYCLHEXENE COMPOUND, USE OF THE SAME TO PREPARE A MEDICINAL PRODUCT, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, PROCEDURE AND INTERMEDIATE COMPOUNDS OF UTILITY TO PREPARE SUCH COMPOUND
AR040336A1 (en) 2002-06-26 2005-03-30 Glaxo Group Ltd PIPERIDINE COMPOUND, USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND PROCEDURE TO PREPARE SUCH COMPOUND
DE60331849D1 (en) 2002-11-05 2010-05-06 Glaxosmithkline Llc ANTIBACTERIAL ACTIVE SUBSTANCES
EP1567520B1 (en) 2002-12-04 2008-10-15 Glaxo Group Limited Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents
GB0326148D0 (en) 2003-11-10 2003-12-17 Lilly Co Eli Morpholine derivatives
EP1796466A4 (en) 2004-06-15 2009-09-02 Glaxo Group Ltd Antibacterial agents
MY150958A (en) * 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
US7709483B2 (en) 2006-04-06 2010-05-04 Glaxo Group Limited Pyrrolo-quinoxalinone derivatives as antibacterials
EP1992628A1 (en) 2007-05-18 2008-11-19 Glaxo Group Limited Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
EP2080761A1 (en) 2008-01-18 2009-07-22 Glaxo Group Limited Compounds
JP5404652B2 (en) * 2008-02-22 2014-02-05 アクテリオン ファーマシューティカルズ リミテッド Oxazolidinone derivatives
WO2010043714A1 (en) 2008-10-17 2010-04-22 Glaxo Group Limited Tricyclic nitrogen compounds used as antibacterials
WO2010081874A1 (en) 2009-01-15 2010-07-22 Glaxo Group Limited Naphthyridin-2 (1 h)-one compounds useful as antibacterials
AR089929A1 (en) 2012-02-10 2014-10-01 Actelion Pharmaceuticals Ltd PROCESS TO MANUFACTURE A NAFTIRIDINE DERIVATIVE
KR20170043603A (en) 2014-08-22 2017-04-21 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 Tricyclic nitrogen containing compounds for treating neisseria gonorrhoea infection
UY36851A (en) 2015-08-16 2017-03-31 Glaxosmithkline Ip Dev Ltd COMPOUNDS FOR USE IN ANTIBACTERIAL APPLICATIONS

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9917408D0 (en) * 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
GB0012240D0 (en) * 2000-05-19 2000-07-12 Merck Sharp & Dohme Therapeutic agents
FR2816618B1 (en) * 2000-11-15 2002-12-27 Aventis Pharma Sa HETEROCYCLYLALCOYL PIPERIDINE DERIVATIVES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM
EP1355901A2 (en) * 2001-01-11 2003-10-29 Bristol-Myers Squibb Pharma Company 1,1-DISUBSTITUTED CYCLIC INHIBITORS OF MATRIX METALLOPROTEASE AND TNF-$g(a)

Also Published As

Publication number Publication date
EA010403B1 (en) 2008-08-29
FR2852954B1 (en) 2006-07-14
EP1611127A2 (en) 2006-01-04
WO2004087647A3 (en) 2005-01-27
EA200501526A1 (en) 2006-04-28
FR2852954A1 (en) 2004-10-01
RS20050806A (en) 2007-12-31
JP2006522779A (en) 2006-10-05
KR20050115321A (en) 2005-12-07
HRP20050855A2 (en) 2005-12-31
CA2520764A1 (en) 2004-10-14
WO2004087647A2 (en) 2004-10-14
AR043941A1 (en) 2005-08-17
AU2004226207A1 (en) 2004-10-14
CN1795191A (en) 2006-06-28

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