EA200501526A1 - DERIVATIVES OF 4-SUBSTITUTED QUINOLINES, METHOD AND INTERMEDIATE PRODUCTS FOR THEIR RECEIVING AND CONTAINING THEIR PHARMACEUTICAL COMPOSITIONS - Google Patents

DERIVATIVES OF 4-SUBSTITUTED QUINOLINES, METHOD AND INTERMEDIATE PRODUCTS FOR THEIR RECEIVING AND CONTAINING THEIR PHARMACEUTICAL COMPOSITIONS

Info

Publication number
EA200501526A1
EA200501526A1 EA200501526A EA200501526A EA200501526A1 EA 200501526 A1 EA200501526 A1 EA 200501526A1 EA 200501526 A EA200501526 A EA 200501526A EA 200501526 A EA200501526 A EA 200501526A EA 200501526 A1 EA200501526 A1 EA 200501526A1
Authority
EA
Eurasian Patent Office
Prior art keywords
derivatives
substituted quinolines
receiving
pharmaceutical compositions
intermediate products
Prior art date
Application number
EA200501526A
Other languages
Russian (ru)
Other versions
EA010403B1 (en
Inventor
Антони Биго
Мишель Шев
Юссеф Эль Амад
Жан-Люк Маллерон
Жан-Поль Мартэн
Серж Миньяни
Ги Пантель
Батист Ронан
Мишель Табар
Фабрис Вивьяни
Original Assignee
Авентис Фарма С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Авентис Фарма С.А. filed Critical Авентис Фарма С.А.
Publication of EA200501526A1 publication Critical patent/EA200501526A1/en
Publication of EA010403B1 publication Critical patent/EA010403B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Изобретение относится к производным 4-замещенных хинолинов, которые активны в качестве антимикробных средств, общей формулы (I), в которой X, X, X, Xи Xпринимают значения, соответственно от >C-R'до >C-R'или же самое большее один означает N; Y означает CHR, CO, CROH, CRNH, CRF или CF, причем R означает атом водорода или алкил; m означает 1, 2 или 3 и n означает 0, 1 или 2; Z означает CHили Z означает O, S, SO, SOи в этом случае n равно 2; Rозначает -COR, -CHCOR, -CH-CH-COR, -CHOH или -CH-CH-OH, причем R имеет вышеуказанное значение; Rозначает фенил, гетероарил или alk-R°, где alk означает алкил и R°означает различные группы, в случае необходимости, кислородсодержащие, серосодержащие или аминированные; в их энантиомерных или диастереоизомерных формах или в виде их смесей, и/или, в случае необходимости, в син- или антиформе или в виде их смесей, а также к их солям.The invention relates to derivatives of 4-substituted quinolines, which are active as antimicrobial agents, of general formula (I), in which X, X, X, X and X take values, respectively, from> C-R'to> C-R'or the same larger one means N; Y is CHR, CO, CROH, CRNH, CRF or CF, and R is a hydrogen atom or an alkyl; m is 1, 2 or 3 and n is 0, 1 or 2; Z means CH or Z means O, S, SO, SO and in this case n is 2; R5 is -COR, -CHCOR, -CH-CH-COR, -CHOH or -CH-CH-OH, wherein R has the above meaning; Rz is phenyl, heteroaryl or alk-R °, where alk means alkyl and R ° means different groups, if necessary, oxygen-containing, sulfur-containing or aminated; in their enantiomeric or diastereoisomeric forms or in the form of their mixtures, and / or, if necessary, in syn - or antiform or in the form of their mixtures, as well as their salts.

EA200501526A 2003-03-28 2004-03-29 4-substituted quinonoline derivatives, preparation methods and intermediates and pharmaceutical composition comprising same EA010403B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0303812A FR2852954B1 (en) 2003-03-28 2003-03-28 QUINOLINE-4-SUBSTITUTED DERIVATIVES, METHODS AND PREPARATION INTERMEDIATES THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
PCT/FR2004/000783 WO2004087647A2 (en) 2003-03-28 2004-03-29 4-substituted quinolein derivatives with antimicrobial activity

Publications (2)

Publication Number Publication Date
EA200501526A1 true EA200501526A1 (en) 2006-04-28
EA010403B1 EA010403B1 (en) 2008-08-29

Family

ID=32947235

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200501526A EA010403B1 (en) 2003-03-28 2004-03-29 4-substituted quinonoline derivatives, preparation methods and intermediates and pharmaceutical composition comprising same

Country Status (13)

Country Link
EP (1) EP1611127A2 (en)
JP (1) JP2006522779A (en)
KR (1) KR20050115321A (en)
CN (1) CN1795191A (en)
AR (1) AR043941A1 (en)
AU (1) AU2004226207A1 (en)
CA (1) CA2520764A1 (en)
EA (1) EA010403B1 (en)
FR (1) FR2852954B1 (en)
HR (1) HRP20050855A2 (en)
RS (1) RS20050806A (en)
TW (1) TW200505899A (en)
WO (1) WO2004087647A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2816618B1 (en) * 2000-11-15 2002-12-27 Aventis Pharma Sa HETEROCYCLYLALCOYL PIPERIDINE DERIVATIVES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM
TW200406413A (en) 2002-06-26 2004-05-01 Glaxo Group Ltd Compounds
TW200409637A (en) 2002-06-26 2004-06-16 Glaxo Group Ltd Compounds
ES2340484T3 (en) 2002-11-05 2010-06-04 Glaxo Group Limited ANTIBACTERIAL AGENTS.
EP1567520B1 (en) 2002-12-04 2008-10-15 Glaxo Group Limited Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents
GB0326148D0 (en) * 2003-11-10 2003-12-17 Lilly Co Eli Morpholine derivatives
WO2006002047A2 (en) 2004-06-15 2006-01-05 Glaxo Group Limited Antibacterial agents
MY150958A (en) * 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
ATE481406T1 (en) 2006-04-06 2010-10-15 Glaxo Group Ltd PYRROLOQUINOXALINONE DERIVATIVES AS ANTIBACTERIAL AGENTS
EP1992628A1 (en) 2007-05-18 2008-11-19 Glaxo Group Limited Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
EP2080761A1 (en) 2008-01-18 2009-07-22 Glaxo Group Limited Compounds
WO2009104159A1 (en) * 2008-02-22 2009-08-27 Actelion Pharmaceuticals Ltd Oxazolidinone derivatives
JP2012505866A (en) 2008-10-17 2012-03-08 グラクソ グループ リミテッド Tricyclic nitrogen compounds used as antibacterial agents
WO2010081874A1 (en) 2009-01-15 2010-07-22 Glaxo Group Limited Naphthyridin-2 (1 h)-one compounds useful as antibacterials
AR089929A1 (en) 2012-02-10 2014-10-01 Actelion Pharmaceuticals Ltd PROCESS TO MANUFACTURE A NAFTIRIDINE DERIVATIVE
SG11201700566SA (en) 2014-08-22 2017-03-30 Glaxosmithkline Ip Dev Ltd Tricyclic nitrogen containing compounds for treating neisseria gonorrhoea infection
UY36851A (en) 2015-08-16 2017-03-31 Glaxosmithkline Ip Dev Ltd COMPOUNDS FOR USE IN ANTIBACTERIAL APPLICATIONS

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9917408D0 (en) * 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
GB0012240D0 (en) * 2000-05-19 2000-07-12 Merck Sharp & Dohme Therapeutic agents
FR2816618B1 (en) * 2000-11-15 2002-12-27 Aventis Pharma Sa HETEROCYCLYLALCOYL PIPERIDINE DERIVATIVES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM
CA2434205A1 (en) * 2001-01-11 2002-07-18 Dupont Pharmaceuticals Company 1,1-disubstituted cyclic inhibitors of matrix metalloprotease and tnf-.alpha.

Also Published As

Publication number Publication date
KR20050115321A (en) 2005-12-07
CN1795191A (en) 2006-06-28
JP2006522779A (en) 2006-10-05
RS20050806A (en) 2007-12-31
WO2004087647A3 (en) 2005-01-27
WO2004087647A2 (en) 2004-10-14
FR2852954B1 (en) 2006-07-14
TW200505899A (en) 2005-02-16
FR2852954A1 (en) 2004-10-01
EP1611127A2 (en) 2006-01-04
EA010403B1 (en) 2008-08-29
CA2520764A1 (en) 2004-10-14
AR043941A1 (en) 2005-08-17
AU2004226207A1 (en) 2004-10-14
HRP20050855A2 (en) 2005-12-31

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM