RS20050806A - 4-substituted quinolein derivatives,preparation methods and intermediates and pharmaceutical compositions compraising same - Google Patents

4-substituted quinolein derivatives,preparation methods and intermediates and pharmaceutical compositions compraising same

Info

Publication number
RS20050806A
RS20050806A YUP-2005/0806A YUP20050806A RS20050806A RS 20050806 A RS20050806 A RS 20050806A YU P20050806 A YUP20050806 A YU P20050806A RS 20050806 A RS20050806 A RS 20050806A
Authority
RS
Serbia
Prior art keywords
substituted
compraising
intermediates
pharmaceutical compositions
same
Prior art date
Application number
YUP-2005/0806A
Other languages
English (en)
Inventor
Antony Bigot
Michel Cheve
Youssef El Ahmad
Jean-Luc Malleron
Jean-Paul Martin
Serge Mignani
Guy Pantel
Baptiste Ronan
Michel Tabart
Fabrice Viviani
Original Assignee
Aventis Pharma S.A.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma S.A., filed Critical Aventis Pharma S.A.,
Publication of RS20050806A publication Critical patent/RS20050806A/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Ovaj pronalazak odnosi se na 4-supstituisane hinolin derivate sa antibikrobnom aktivnošću, opšte formule I gde X1, X2, X3, X4 i X5 redom predstavljaju : C-R'1 do >C-R'5 redom, ili ne više od jednog predstavljanja N, Y predstavlja grupu CHR, CO, CROH, CRNH2, CRF ili CF2, R je vodonik ili alkil; m je 1, 2 ili 3 i n je 0, 1 ili 2; Z predstavlja O, S, SO SO2 i u tom slučaju, n je jednako 2; R2 predstavlja -CO2R, -CH2CO2R, -CH2CH2CO2R, -CH2OH ili -CH2-CH2-CO2OH ili -CH2-CH2-OH, R je kao što je gore opisano; R3 predstavlja radikal fenil, heteroaril ili alk-R°3 za koji alk je jedan alkil i R°3 predstavlja različite grupe, opcionalno oksigenovane ili sumporovane ili aminovane, enantiomernim ili diastereoizomernim oblicima ili njihove smeše i opcionalno u njihovim sin ili anti oblicima ili njihovim smešama, kao i njihove soli.
YUP-2005/0806A 2003-03-28 2004-03-29 4-substituted quinolein derivatives,preparation methods and intermediates and pharmaceutical compositions compraising same RS20050806A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0303812A FR2852954B1 (fr) 2003-03-28 2003-03-28 Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR2004/000783 WO2004087647A2 (fr) 2003-03-28 2004-03-29 Derives de quinoleines-4-substituees avec une activite antimicrobienne

Publications (1)

Publication Number Publication Date
RS20050806A true RS20050806A (en) 2007-12-31

Family

ID=32947235

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-2005/0806A RS20050806A (en) 2003-03-28 2004-03-29 4-substituted quinolein derivatives,preparation methods and intermediates and pharmaceutical compositions compraising same

Country Status (13)

Country Link
EP (1) EP1611127A2 (sr)
JP (1) JP2006522779A (sr)
KR (1) KR20050115321A (sr)
CN (1) CN1795191A (sr)
AR (1) AR043941A1 (sr)
AU (1) AU2004226207A1 (sr)
CA (1) CA2520764A1 (sr)
EA (1) EA010403B1 (sr)
FR (1) FR2852954B1 (sr)
HR (1) HRP20050855A2 (sr)
RS (1) RS20050806A (sr)
TW (1) TW200505899A (sr)
WO (1) WO2004087647A2 (sr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2816618B1 (fr) * 2000-11-15 2002-12-27 Aventis Pharma Sa Derives heterocyclylalcoyl piperidine, leur preparation et les compositions qui les contiennent
AR040335A1 (es) 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de ciclohexano o ciclohexeno, uso del mismo para preparar un medicamento, composicion farmaceutica que lo comprende, procedimiento y compuestos intermediarios de utilidad para preparar dicho compuesto
AR040336A1 (es) 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
DE60331849D1 (de) 2002-11-05 2010-05-06 Glaxosmithkline Llc Antibakterielle wirkstoffe
EP1567520B1 (en) 2002-12-04 2008-10-15 Glaxo Group Limited Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents
GB0326148D0 (en) 2003-11-10 2003-12-17 Lilly Co Eli Morpholine derivatives
EP1796466A4 (en) 2004-06-15 2009-09-02 Glaxo Group Ltd ANTIBACTERIAL AGENTS
MY150958A (en) * 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
US7709483B2 (en) 2006-04-06 2010-05-04 Glaxo Group Limited Pyrrolo-quinoxalinone derivatives as antibacterials
EP1992628A1 (en) 2007-05-18 2008-11-19 Glaxo Group Limited Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
EP2080761A1 (en) 2008-01-18 2009-07-22 Glaxo Group Limited Compounds
JP5404652B2 (ja) * 2008-02-22 2014-02-05 アクテリオン ファーマシューティカルズ リミテッド オキサゾリジノン誘導体
WO2010043714A1 (en) 2008-10-17 2010-04-22 Glaxo Group Limited Tricyclic nitrogen compounds used as antibacterials
WO2010081874A1 (en) 2009-01-15 2010-07-22 Glaxo Group Limited Naphthyridin-2 (1 h)-one compounds useful as antibacterials
AR089929A1 (es) 2012-02-10 2014-10-01 Actelion Pharmaceuticals Ltd Proceso para manufacturar un derivado de naftiridina
KR20170043603A (ko) 2014-08-22 2017-04-21 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 네이세리아 고노레아에 감염을 치료하기 위한 트리시클릭 질소 함유 화합물
UY36851A (es) 2015-08-16 2017-03-31 Glaxosmithkline Ip Dev Ltd Compuestos para uso en aplicaciones antibacterianas

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9917408D0 (en) * 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
GB0012240D0 (en) * 2000-05-19 2000-07-12 Merck Sharp & Dohme Therapeutic agents
FR2816618B1 (fr) * 2000-11-15 2002-12-27 Aventis Pharma Sa Derives heterocyclylalcoyl piperidine, leur preparation et les compositions qui les contiennent
EP1355901A2 (en) * 2001-01-11 2003-10-29 Bristol-Myers Squibb Pharma Company 1,1-DISUBSTITUTED CYCLIC INHIBITORS OF MATRIX METALLOPROTEASE AND TNF-$g(a)

Also Published As

Publication number Publication date
EA010403B1 (ru) 2008-08-29
FR2852954B1 (fr) 2006-07-14
EP1611127A2 (fr) 2006-01-04
WO2004087647A3 (fr) 2005-01-27
EA200501526A1 (ru) 2006-04-28
FR2852954A1 (fr) 2004-10-01
JP2006522779A (ja) 2006-10-05
KR20050115321A (ko) 2005-12-07
HRP20050855A2 (en) 2005-12-31
CA2520764A1 (en) 2004-10-14
WO2004087647A2 (fr) 2004-10-14
TW200505899A (en) 2005-02-16
AR043941A1 (es) 2005-08-17
AU2004226207A1 (en) 2004-10-14
CN1795191A (zh) 2006-06-28

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