MX367769B - Nuevo derivado de acido 3-(4-(benciloxi)fenil)hex-4-inoico, metodo de preparacion del mismo y composicion farmaceutica para la prevencion y tratamiento de la enfermedad metabolica que incluye el mismo como ingrediente activo. - Google Patents

Nuevo derivado de acido 3-(4-(benciloxi)fenil)hex-4-inoico, metodo de preparacion del mismo y composicion farmaceutica para la prevencion y tratamiento de la enfermedad metabolica que incluye el mismo como ingrediente activo.

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Publication number
MX367769B
MX367769B MX2015013893A MX2015013893A MX367769B MX 367769 B MX367769 B MX 367769B MX 2015013893 A MX2015013893 A MX 2015013893A MX 2015013893 A MX2015013893 A MX 2015013893A MX 367769 B MX367769 B MX 367769B
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MX
Mexico
Prior art keywords
benzyloxy
hex
phenyl
novel
acid derivative
Prior art date
Application number
MX2015013893A
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English (en)
Other versions
MX2015013893A (es
Inventor
Yang Jin
Woong Kim Jin
Kyu Lee Han
Hyun Kim Jae
Mo Son Chang
Hwan Lee Kyu
Choi Hyung-Ho
Kim Daehoon
Ha Tae-Young
Rhee Jaekeol
Original Assignee
Hyundai Pharm Co Ltd
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Publication date
Application filed by Hyundai Pharm Co Ltd filed Critical Hyundai Pharm Co Ltd
Publication of MX2015013893A publication Critical patent/MX2015013893A/es
Publication of MX367769B publication Critical patent/MX367769B/es

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Abstract

La presente invención se refiere a un nuevo derivado del ácido 3-(4-(benciloxi) fenil) hex-4-inoico, a un método de preparación del mismo, y a una composición farmacéutica para la prevención y el tratamiento de una enfermedad metabólica que incluye el mismo como ingrediente efectivo. El nuevo derivado del ácido 3-(4-(benciloxi) fenil) hex-4-inoico, el isómero óptico del mismo, o la sal del mismo farmacéuticamente aceptable, de acuerdo con la presente invención, tienen un excelente efecto sobre la activación de la proteína de GPR40 y por consiguiente tienen un efecto promotor excelente de secreción de insulina; no son tóxicos cuando son co-administrados con otros fármacos y posiblemente son co-administrados con otros fármacos; y tienen un excelente efecto de eficacia de la activación de la proteína de GPR40 in vivo. Por lo tanto, una composición que incluye el nuevo derivado del ácido 3-(4-(benciloxi) fenil) hex-4-inoico, el isómero óptico del mismo, o la sal del mismo farmacéuticamente aceptable, pueden ser utilizados adecuadamente en una composición farmacéutica para prevenir y tratar una enfermedad metabólica tal como la obesidad, la diabetes del tipo I, la diabetes del tipo II, la tolerancia a la glucosa incompatible, la tolerancia a la insulina, la hiperglucemia, la hiperlipidemia, la hipertrigliceridemia, la hipercolesterolemia, la dislipidemia, el síndrome X, etc.
MX2015013893A 2013-04-18 2014-04-17 Nuevo derivado de acido 3-(4-(benciloxi)fenil)hex-4-inoico, metodo de preparacion del mismo y composicion farmaceutica para la prevencion y tratamiento de la enfermedad metabolica que incluye el mismo como ingrediente activo. MX367769B (es)

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KR20130043100 2013-04-18
KR1020140045343A KR101569522B1 (ko) 2013-04-18 2014-04-16 신규한 3-(4-(벤질옥시)페닐)헥스-4-이노익 산 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 대사성 질환의 예방 또는 치료용 약학적 조성물
PCT/KR2014/003355 WO2014171762A1 (ko) 2013-04-18 2014-04-17 신규한 3-(4-(벤질옥시)페닐)헥스-4-이노익 산 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 대사성 질환의 예방 또는 치료용 약학적 조성물

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MX367769B true MX367769B (es) 2019-09-05

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BR112015025072A2 (pt) 2017-07-18
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EP2987791A1 (en) 2016-02-24
EP2987791B1 (en) 2019-07-17
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CA2908398A1 (en) 2014-10-23
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US20160024063A1 (en) 2016-01-28
PL2987791T3 (pl) 2020-03-31
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