BR112015010314A8 - Composto ou sais farmaceuticamente aceitáveis ou isômeros dos mesmos, composição farmacêutica, secretagogo de insulina ou agente hipoglicêmico, e, agonista do receptor gpr40 - Google Patents

Composto ou sais farmaceuticamente aceitáveis ou isômeros dos mesmos, composição farmacêutica, secretagogo de insulina ou agente hipoglicêmico, e, agonista do receptor gpr40

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Publication number
BR112015010314A8
BR112015010314A8 BR112015010314A BR112015010314A BR112015010314A8 BR 112015010314 A8 BR112015010314 A8 BR 112015010314A8 BR 112015010314 A BR112015010314 A BR 112015010314A BR 112015010314 A BR112015010314 A BR 112015010314A BR 112015010314 A8 BR112015010314 A8 BR 112015010314A8
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BR
Brazil
Prior art keywords
pharmaceutical composition
receptor agonist
isomers
compound
pharmaceutically acceptable
Prior art date
Application number
BR112015010314A
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English (en)
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BR112015010314A2 (pt
BR112015010314B1 (pt
Inventor
Bae Lee Sung
Yup Paek Seung
Kyung Yoon Sook
Hyun Yoon Seung
Soon Choi Jeung
Original Assignee
Lg Life Sciences Ltd
Lg Chemical Ltd
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Publication date
Application filed by Lg Life Sciences Ltd, Lg Chemical Ltd filed Critical Lg Life Sciences Ltd
Publication of BR112015010314A2 publication Critical patent/BR112015010314A2/pt
Publication of BR112015010314A8 publication Critical patent/BR112015010314A8/pt
Publication of BR112015010314B1 publication Critical patent/BR112015010314B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

COMPOSTO OU SAIS FARMACEUTICAMENTE ACEITÁVEIS OU ISÔMEROS DOS MESMOS, COMPOSIÇÃO FARMACÊUTICA, SECRETAGOGO DE INSULINA OU AGENTE HIPOGLICÊMICO, AGONISTA DO RECEPTOR GPR40, E, MÉTODO PARA TRATAR DOENÇAS OU DISTÚRBIOS. A presente invenção refere-se a um composto novo tendo atividade do agonista do receptor GPR40 que promove secreção de insulina e inibe a elevação de açúcar no sangue após carga de glicose, e é assim utilizável para o tratamento de diabetes e complicações da mesma, o método de preparação do mesmo e composição farmacêutica contendo o mesmo como um ingrediente ativo.
BR112015010314-6A 2012-11-09 2013-11-08 Composto ou sais farmaceuticamente aceitáveis ou isômeros dos mesmos, composição farmacêutica, secretagogo de insulina ou agente hipoglicêmico, e, agonista do receptor gpr40 BR112015010314B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20120127005 2012-11-09
KR10-2012-0127005 2012-11-09
PCT/KR2013/010135 WO2014073904A1 (en) 2012-11-09 2013-11-08 Gpr40 receptor agonist, methods of preparing the same, and pharmaceutical compositions containing the same as an active ingredient

Publications (3)

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JP2016503409A (ja) 2016-02-04
KR101984629B1 (ko) 2019-05-31
US9988379B2 (en) 2018-06-05
WO2014073904A1 (en) 2014-05-15
RU2015121948A (ru) 2017-01-10
CA2889505C (en) 2020-12-29
CN110003169A (zh) 2019-07-12
CA2889505A1 (en) 2014-05-15
EP2917180A4 (en) 2016-04-27
RU2650506C2 (ru) 2018-04-16
BR112015010314A2 (pt) 2017-07-11
TWI692469B (zh) 2020-05-01
JP6442787B2 (ja) 2018-12-26
US20150291584A1 (en) 2015-10-15
KR20140060242A (ko) 2014-05-19
BR112015010314B1 (pt) 2021-11-16
AU2013341945B2 (en) 2018-07-12
TW201427943A (zh) 2014-07-16
CN104837816A (zh) 2015-08-12
MX2015005418A (es) 2015-07-23
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