UA117103C2 - Сполука, яка має активність агоніста глюкагону - Google Patents

Сполука, яка має активність агоніста глюкагону

Info

Publication number
UA117103C2
UA117103C2 UAA201500436A UAA201500436A UA117103C2 UA 117103 C2 UA117103 C2 UA 117103C2 UA A201500436 A UAA201500436 A UA A201500436A UA A201500436 A UAA201500436 A UA A201500436A UA 117103 C2 UA117103 C2 UA 117103C2
Authority
UA
Ukraine
Prior art keywords
compound
agonist activity
glucagon agonist
relates
hypoglycemia
Prior art date
Application number
UAA201500436A
Other languages
English (en)
Inventor
Дітте Рібер
Лізе Гіем
Original Assignee
Зіленд Фарма А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Зіленд Фарма А/С filed Critical Зіленд Фарма А/С
Publication of UA117103C2 publication Critical patent/UA117103C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

Винахід стосується сполуки або її фармацевтично прийнятної солі або сольвату, яка має активність агоніста глюкагону. Винахід також стосується конструкції нуклеїнової кислоти, вектора, клітини-хазяїна, фармацевтичної композиції, яка містить дану сполуку, способу лікування захворювання або стану у суб’єкта, який потребує цього, та застосування сполуки при отриманні лікарського препарату для лікування гіпоглікемії.
UAA201500436A 2012-07-23 2013-07-23 Сполука, яка має активність агоніста глюкагону UA117103C2 (uk)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261674706P 2012-07-23 2012-07-23
US201361785611P 2013-03-14 2013-03-14
DKPA201300360 2013-06-14
PCT/EP2013/065519 WO2014016300A1 (en) 2012-07-23 2013-07-23 Glucagon analogues

Publications (1)

Publication Number Publication Date
UA117103C2 true UA117103C2 (uk) 2018-06-25

Family

ID=49996630

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201500436A UA117103C2 (uk) 2012-07-23 2013-07-23 Сполука, яка має активність агоніста глюкагону

Country Status (27)

Country Link
US (3) US10442847B2 (uk)
EP (1) EP2875043B1 (uk)
JP (3) JP6534927B2 (uk)
KR (1) KR102129235B1 (uk)
CN (2) CN109456400A (uk)
AR (1) AR091866A1 (uk)
AU (1) AU2013295035B2 (uk)
BR (1) BR112015001451B1 (uk)
CA (1) CA2878991C (uk)
DK (1) DK2875043T3 (uk)
EA (1) EA033399B1 (uk)
ES (1) ES2620111T3 (uk)
FI (1) FIC20240034I1 (uk)
FR (1) FR24C1043I2 (uk)
IL (1) IL236554B (uk)
IN (1) IN2015DN00544A (uk)
MX (1) MX356957B (uk)
MY (1) MY170671A (uk)
NL (1) NL301294I2 (uk)
NZ (1) NZ704043A (uk)
PH (1) PH12015500115A1 (uk)
PL (1) PL2875043T3 (uk)
SG (1) SG11201500375PA (uk)
TW (1) TWI642682B (uk)
UA (1) UA117103C2 (uk)
WO (1) WO2014016300A1 (uk)
ZA (1) ZA201702364B (uk)

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UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
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TWI791539B (zh) 2017-06-16 2023-02-11 丹麥商西蘭製藥公司 用於投予類升糖素胜肽-2(glp-2)類似物的給藥方案
GB201710822D0 (en) * 2017-07-05 2017-08-16 Zealand Pharma As Methods and medical uses relating to the treatment of hypoglycaemia
CN110913888A (zh) 2017-07-14 2020-03-24 Xeris药物公司 治疗先天性高胰岛素血症的方法
CN111936159A (zh) * 2018-01-23 2020-11-13 Xeris药物公司 使用微剂量的稳定胰高血糖素治疗减肥术后低血糖症
EP4121003B1 (en) * 2020-03-16 2025-08-06 Zealand Pharma A/S Liquid formulations of glucagon analogues
US20230405088A1 (en) * 2020-12-16 2023-12-21 Zealand Pharma A/S Pharmaceutical Composition of GLP-1/GLP-2 Dual Agonists
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